CN103961308A - Method for preparing ibuprofen inflatable cotton candy - Google Patents
Method for preparing ibuprofen inflatable cotton candy Download PDFInfo
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- CN103961308A CN103961308A CN201410219165.8A CN201410219165A CN103961308A CN 103961308 A CN103961308 A CN 103961308A CN 201410219165 A CN201410219165 A CN 201410219165A CN 103961308 A CN103961308 A CN 103961308A
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Abstract
The invention discloses a method for preparing an ibuprofen inflatable cotton candy and relates to the method for preparing the ibuprofen inflatable cotton candy, and the method can be used for solving the problems that the existing preparations such as ibuprofen granules, tablets and capsules are inconvenient to take, a common preparation is slow in effect taking, and inpatient children are poor in medication compliance. The method for preparing the ibuprofen inflatable cotton candy comprises the following steps: sieving raw and auxiliary materials; 2, weighing raw and auxiliary materials; 3, dissolving sol; 4, preparing a rubber block; 5, sugaring off; 6, mixing and inflating; 7, drying starch; 8, molding; 9, drying; 10, sieving and purifying; 11, choosing and packaging. The prepared ibuprofen inflatable cotton candy is good in mouthfeeel, quick in effect taking, high in oral bioavailability, good in compliance and applicable to industrial production, children are willing to take, and modern food and drug production equipment is adopted. The method disclosed by the invention is applied to the field of preparation of anti-inflammatory drugs, antalgic drugs and antipyretic drugs.
Description
Technical field
The present invention relates to the preparation method for antiinflammatory, analgesia, influenza defervesce medicine ibuprofen inflation cotton candy.
Background technology
The function that there is antiinflammatory, pain relieving, brings down a fever due to ibuprofen, be used for alleviating mild to moderate pain as headache, arthralgia, migraine, toothache, myalgia, neuralgia, dysmenorrhea etc., also the heating causing for common cold or influenza, is with a wide range of applications clinical.Due to the agent of many granulations of preparation, tablet, the capsule of the existing preparation of ibuprofen, it is slow that dosage form absorbs onset, and bioavailability is low; Ibuprofen is made dispersible tablet, oral cavity disintegration tablet mouthfeel is bad, is unfavorable for children taking; Making suspensoid, syrup is not easy to transportation and portably uses; And oral ibuprofen stimulates coat of the stomach, causes discomfort.Ibuprofen injection patient poor compliance; Therefore existing preparation can not meet clinical at present, the needs of child patient especially, so the scope of application is limited by very large.
The weak point of the existing technique of Motrin is: ibuprofen granule, tablet, capsule bioavailability are low, and onset is slow, and mouthfeel is bad; Ibuprofen oral cavity disintegration tablet, dispersible tablet mouthfeel are bad; Ibuprofen injection clinical practice patient poor compliance.
Summary of the invention
The object of the invention is to exist product oral bioavailability low in order to solve existing ibuprofen medicine, mouthfeel is bad, stimulates coat of the stomach, the problem of patient's poor compliance, and provide a kind of ibuprofen to inflate the preparation method of cotton candy.
The preparation method of a kind of ibuprofen inflation of the present invention cotton candy is to carry out according to the following steps:
One, sieve: get ibuprofen crude drug, cross 200 mesh sieves; Corn starch, crosses 80 mesh sieves, and the part of getting under sieve is standby;
Two, weigh: the ibuprofen raw material medicated powder of 100～150 parts after taking step 1 and sieve by mass fraction, the starch of 100～150 parts, the Saccharum Sinensis Roxb. of 600～900 parts, the glucose of 400～600 parts, the jelly powder of 100～300 parts, the sodium alginate of 1～3 part, the stevioside of 1～3 part, the Fructus Citri Limoniae essence of 1～3 part, the citric acid of 6～8 parts, the Sal of 10～15 parts, the water of 100～400 parts, the lemon yellow of the sorbitol of 1～3 part and 0.05～0.08 part;
Three, colloidal sol: the jelly powder that step 2 is taken, sodium alginate join in the water of 65 ℃～75 ℃ and stir 10～30 minutes, obtain gelatin mixed solution; By gelatin mixed solution be placed in the vacuum that adopts 0.7～0.9 MPa in vacuum tank, 40 ℃～50 ℃ temperature are dissolved 50～100 minutes;
Four, glue piece: the gelatin solution that step 3 is dissolved filters with 20～30 mesh sieves, puts container interior cooling 4～6 hours, and stripping and slicing is standby;
Five, stir off: step 2 is taken sucrose and glucose, citric acid, Sal, stevioside and benzyl alcohol be dissolved in 80～90 ℃ water in, stir, with 200 order silks, filter while hot, filtrate adopt 110～120 ℃ of heat boil to syrup concentration be 85～95%;
Six, Mixing and aeration: the syrup that step 5 is made is placed in air agitation pot, be controlled at temperature and be under the condition of 80～85 ℃, the blob of viscose that adds step 4 to make, then add ibuprofen raw material medicated powder, lemon yellow and Fructus Citri Limoniae essence that step 2 weighs to stir 3～5 minutes with the speed of 100～200 revs/min, after mix homogeneously, then stir 10～15 minutes with the speed of 400～600 revs/min;
Seven, dry starch: the starch that step 2 is taken adopts 80～85 ℃ of heat dryings 2～4 hours;
Eight, moulding: the dried starch that step 7 is dry is evenly sieved in mould, the mixing that step 6 is made slurry is poured into mould, and moulding by casting obtains ibuprofen inflation cotton candy;
Nine, dry: the ibuprofen inflation cotton candy that step 8 is made is put in baking oven and adopted 35～40 ℃ to be dried 18～24 hours;
Ten, sub-sieve and clear powder: the dry ibuprofen inflation cotton candy making of step 9 is sieved to unnecessary starch gently;
11, select packing: step 10 is sieved to the ibuprofen inflation cotton candy after powder, select, subpackage, obtains.
The present invention comprises following beneficial effect:
The syrup that Saccharum Sinensis Roxb. in the present invention, glucose boil is in the main molding filler of inflation cotton candy, is the main component as confection type cotton candy medicine, and Saccharum Sinensis Roxb. and the good sweet taste of glucose can be covered the bad mouthfeel of ibuprofen pharmaceutical simultaneously; Gelatin is as the main filler of inflation cotton candy and inflation stabilizing agent, make to inflate cotton candy simultaneously and there is good toughness and colloid mouthfeel, and can form a glue-line at tongue surface in the present invention, hide the disagreeable taste of ibuprofen, and in gastric mucosa, form colloid protective layer, prevent that ibuprofen from stimulating coat of the stomach, reduces untoward reaction; Sodium alginate has the inflation of auxiliary gelatin and ibuprofen suspending agent, guarantee medicine all with stability, sodium alginate also has well covering medicine mouthfeel and protecting the effect of gastric mucosa of gelatin simultaneously; Stevioside, Sal, citric acid, Fructus Citri Limoniae essence can effectively strengthen the sugariness of Saccharum Sinensis Roxb. and glucose, tart up, and improve mouthfeel, make the present invention have better patient's application compliance; Sorbitol has good antisepsis, can effectively guarantee the present invention's medicine stability before the deadline; Lemon yellow regulates color and luster of the present invention, makes to have good visual effect, coordinates citric acid, Fructus Citri Limoniae essence, has the taste of Fructus Citri Limoniae fruit, more easily allows child patient accept; Pure water keeps certain ratio in prescription, can make dosage form of the present invention stable, there will not be the problem stiff, mouthfeel is bad, keeps the good shape of outward appearance; Starch is for adsorbing the moisture on cotton candy surface, and the sugared body that protection is easily sticked together, keeps good shape outward appearance, is easy to subpackage, storage.
In the preparation process of ibuprofen of the present invention inflation cotton candy, adopt food technology to prepare ibuprofen confectionery formulations, preparation mouthfeel is good, due to the protective effect that has sugar and gelatin to gastric mucosa, reduces the GI irritation effect of ibuprofen.The convenient storage of preparation carried, and taking convenience can be taken under without drinking water condition, is convenient to field man and uses.
The preparation method of ibuprofen inflation cotton candy of the present invention, the preparation method of the inflation cotton candy of employing food service industry, technique is simple, can meet the needs of most domestic manufacturer production present situation, putting into production, it is few to newly increase equipment investment, and production technology is simple, and industrialization level is high.
The present invention is in conjunction with modern food, pharmaceutical production technology and the method for inspection, summed up the technological parameter comparatively mating with ibuprofen inflation cotton candy preparation, and take determination of ibuprofen as monitor control index, guarantee safety, effectiveness, the stability of ibuprofen inflation cotton candy, guarantee performance antiinflammatory, antipyretic, analgesic function.The ibuprofen inflation cotton candy onset rapidly that the present invention makes, reduces GI irritation, has positive clinical treatment meaning and social meaning.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the preparation method of a kind of ibuprofen inflation cotton candy of present embodiment is to carry out according to the following steps:
One, sieve: get ibuprofen crude drug, cross 200 mesh sieves; Corn starch, crosses 80 mesh sieves, and the part of getting under sieve is standby;
Two, weigh: the ibuprofen raw material medicated powder of 100～150 parts after taking step 1 and sieve by mass fraction, the starch of 100～150 parts, the Saccharum Sinensis Roxb. of 600～900 parts, the glucose of 400～600 parts, the jelly powder of 100～300 parts, the sodium alginate of 1～3 part, the stevioside of 1～3 part, the Fructus Citri Limoniae essence of 1～3 part, the citric acid of 6～8 parts, the Sal of 10～15 parts, the water of 100～400 parts, the lemon yellow of the sorbitol of 1～3 part and 0.05～0.08 part;
Three, colloidal sol: the jelly powder that step 2 is taken, sodium alginate join in the water of 65 ℃～75 ℃ and stir 10～30 minutes, obtain gelatin mixed solution; By gelatin mixed solution be placed in the vacuum that adopts 0.7～0.9 MPa in vacuum tank, 40 ℃～50 ℃ temperature are dissolved 50～100 minutes;
Four, glue piece: the gelatin solution that step 3 is dissolved filters with 20～30 mesh sieves, puts container interior cooling 4～6 hours, and stripping and slicing is standby;
Five, stir off: step 2 is taken sucrose and glucose, citric acid, Sal, stevioside and benzyl alcohol be dissolved in 80～90 ℃ water in, stir, with 200 order silks, filter while hot, filtrate adopt 110～120 ℃ of heat boil to syrup concentration be 85～95%;
Six, Mixing and aeration: the syrup that step 5 is made is placed in air agitation pot, be controlled at temperature and be under the condition of 80～85 ℃, the blob of viscose that adds step 4 to make, then add ibuprofen raw material medicated powder, lemon yellow and Fructus Citri Limoniae essence that step 2 weighs to stir 3～5 minutes with the speed of 100～200 revs/min, after mix homogeneously, then stir 10～15 minutes with the speed of 400～600 revs/min;
Seven, dry starch: the starch that step 2 is taken adopts 80～85 ℃ of heat dryings 2～4 hours;
Eight, moulding: the dried starch that step 7 is dry is evenly sieved in mould, the mixing that step 6 is made slurry is poured into mould, and moulding by casting obtains ibuprofen inflation cotton candy;
Nine, dry: the ibuprofen inflation cotton candy that step 8 is made is put in baking oven and adopted 35～40 ℃ to be dried 18～24 hours;
Ten, sub-sieve and clear powder: the dry ibuprofen inflation cotton candy making of step 9 is sieved to unnecessary starch gently;
11, select packing: step 10 is sieved to the ibuprofen inflation cotton candy after powder, select, subpackage, obtains.
In the preparation process of the ibuprofen inflation cotton candy of present embodiment, adopt food technology to prepare ibuprofen confectionery formulations, preparation mouthfeel is good, due to the protective effect that has sugar and gelatin to gastric mucosa, reduces the GI irritation effect of ibuprofen.The convenient storage of preparation carried, and taking convenience can taken without quoting under water condition, is convenient to field man and uses.Better stability of preparation, uniformity of dosage units stable uniform, the exposure experiments to light in influence factor, hot test are all more stable, and under high humidity experimental condition, content has no significant change.
The preparation method of the ibuprofen inflation cotton candy of present embodiment, the preparation method of the inflation cotton candy of employing food service industry, technique is simple, can meet the needs of most domestic manufacturer production present situation, putting into production, it is few to newly increase equipment investment, and production technology is simple, and industrialization level is high.
Present embodiment is in conjunction with modern food, pharmaceutical production technology and the method for inspection, summed up the technological parameter comparatively mating with ibuprofen inflation cotton candy preparation, and take determination of ibuprofen as monitor control index, guarantee safety, effectiveness, the stability of ibuprofen inflation cotton candy, guarantee performance antiinflammatory, antipyretic, analgesic function.The ibuprofen inflation cotton candy onset rapidly that the present invention makes, reduces GI irritation, has positive clinical treatment meaning and social meaning.
The specific embodiment two: present embodiment is different from the specific embodiment one: step takes the ibuprofen raw material medicated powder of 100～120 parts, the corn starch of 100～120 parts, the Saccharum Sinensis Roxb. of 600～900 parts, the glucose of 500～600 parts, the jelly powder of 100～200 parts, the sodium alginate of 1～2 part, the stevioside of 1～2 part, the Fructus Citri Limoniae essence of 1～2 part, the citric acid of 6～7 parts, the Sal of 10～12 parts, the water of 200～300 parts described in step 2, the lemon yellow of the sorbitol of 1～2 part and 0.05～0.07 part.Other is identical with the specific embodiment one.
The specific embodiment three: present embodiment is different from the specific embodiment one or two: take the ibuprofen raw material medicated powder of 100～110 parts, the corn starch of 100～110 parts, the Saccharum Sinensis Roxb. of 700～900 parts, the glucose of 550～600 parts, the jelly powder of 110～200 parts, the sodium alginate of 1～2 part, the stevioside of 1～2 part, the Fructus Citri Limoniae essence of 1～2 part, the citric acid of 6.5～7.5 parts, the Sal of 10～11 parts, the water of 150～300 parts described in step 2, the sorbitol of 1～2 part, the lemon yellow of 0.05～0.07 part.Other is identical with the specific embodiment one or two.
The specific embodiment four: present embodiment is different from one of specific embodiment one to three: take the ibuprofen raw material medicated powder of 100 parts, the starch of 100 parts, the Saccharum Sinensis Roxb. of 774.94 parts, the glucose of 580 parts, the jelly powder of 160 parts, the sodium alginate of 2 parts, the stevioside of 2 parts, the Fructus Citri Limoniae essence of 2 parts, the citric acid of 7 parts, the Sal of 10 parts, the pure water of 260 parts described in step 2, the sorbitol of 2 parts, the lemon yellow of 0.06 part.Other is identical with one of specific embodiment one to three.
The specific embodiment five: present embodiment is different from one of specific embodiment one to four: stirring 10～30 minutes in the water of 70 ℃～75 ℃ described in step 3.Other is identical with one of specific embodiment one to four.
The specific embodiment six: present embodiment is different from one of specific embodiment one to five: the vacuum of employing 0.8～0.9 MPa described in step 3,45 ℃～50 ℃ temperature are dissolved 50～100 minutes.Other is identical with one of specific embodiment one to five.
The specific embodiment seven: present embodiment is different from one of specific embodiment one to six: stirring off at 115～120 ℃ of temperature described in step 5.Other is identical with one of specific embodiment one to six.
The specific embodiment eight: present embodiment is different from one of specific embodiment one to seven: the syrup concentration described in step 5 is 90～95%.Other is identical with one of specific embodiment one to seven.
The specific embodiment nine: present embodiment is different from one of specific embodiment one to eight: the temperature that is controlled at described in step 6 is under the condition of 82～85 ℃, the blob of viscose that adds step 4 to make.Other is identical with one of specific embodiment one to eight.
The specific embodiment ten: present embodiment is different from one of specific embodiment one to nine: the ibuprofen fine powder, lemon yellow and the Fructus Citri Limoniae essence that add step 2 weighing described in step 6 stirs 3～5 minutes with the speed of 100～150 revs/min, after mix homogeneously, then stir 10～15 minutes with the speed of 500～600 revs/min.Other is identical with one of specific embodiment one to nine.
The specific embodiment 11: present embodiment is different from one of specific embodiment one to ten: 82～85 ℃ of heat dryings of the employing described in step 7 2～4 hours.Other is identical with one of specific embodiment one to ten.
The specific embodiment 12: present embodiment is different from one of specific embodiment one to 11: dry 18～24 hours of 38～40 ℃ of employings described in step 9.Other is identical with one of specific embodiment one to 11.
By following examples, verify beneficial effect of the present invention:
Embodiment 1
The preparation method of a kind of ibuprofen inflation cotton candy of the present embodiment is to carry out according to the following steps:
One, sieve: get ibuprofen crude drug, cross 200 mesh sieves; Corn starch, crosses 80 mesh sieves.The part of getting under sieve is standby;
Two, weigh: 100g ibuprofen raw material medicated powder, 100g starch, 774.94g Saccharum Sinensis Roxb. 580g glucose, 160g jelly powder, 2g sodium alginate, 2g stevioside, 2g Fructus Citri Limoniae essence, 7g citric acid, 10g Sal, 260g pure water after taking step 1 and sieve by ratio of quality and the number of copies, 2g sorbitol, 0.06g lemon yellow;
Three, colloidal sol: the jelly powder that step 2 is taken, sodium alginate join in the warm water of 65 ℃～75 ℃ and stir 25 minutes, without agglomerate; By gelatin solution put the vacuum that adopts 0.7～0.9 MPa in vacuum tank, 40 ℃～50 ℃ temperature are dissolved 80 minutes;
Four, glue piece: the gelatin solution that step 3 is dissolved filters with 24 mesh sieves, puts container interior cooling 5 hours, and stripping and slicing is standby;
Five, stir off: step 2 is taken sucrose and glucose, citric acid, Sal, stevioside, benzyl alcohol be dissolved in warm water, stir, with 200 order silks, filter while hot, 115 ℃ of heat of filtrate employing boil 30 minutes, syrup concentration is about 88%;
Six, Mixing and aeration: the syrup that step 5 is made is placed in air agitation pot, be controlled at temperature and be under the condition of 80～85 ℃, the blob of viscose that adds step 4 to make, the ibuprofen fine powder that step 2 weighs, lemon yellow, Fructus Citri Limoniae essence, slowly stirs 5 minutes with the speed of 100～200 revs/min, after mix homogeneously, again with the speed rapid stirring of 400～600 revs/min 10 minutes, make to reach the inflation effect needing;
Seven, dry starch: the starch that step 2 is taken adopts 80～85 ℃ of heat dryings 3 hours;
Eight, moulding: the dried starch that step 7 is dry is evenly sieved in mould while hot, the mixing that step 6 is made slurry is poured into mould, moulding by casting.
Nine, dry: the ibuprofen inflation cotton candy that step 8 is made is put baking oven and adopted 35～40 ℃ to be dried 20 hours;
Ten, sub-sieve and clear powder: the dry ibuprofen inflation cotton candy making of step 9 is sieved to unnecessary starch gently;
11, select packing: step 10 is sieved to the ibuprofen inflation cotton candy after powder, select, certified products are packed, and obtain ibuprofen inflation cotton candy.
In the preparation process of the ibuprofen inflation cotton candy of present embodiment, adopt food technology to prepare ibuprofen confectionery formulations, preparation mouthfeel is good, owing to having sugar and gelatin adjuvant, therefore gastric mucosa had to certain protective effect, reduces the GI irritation of ibuprofen.The convenient storage of preparation carried, and taking convenience can be taken under without drinking water condition, is convenient to field man and uses.Formulation content uniformity stable uniform, safe and effective.
The preparation method of the ibuprofen inflation cotton candy of present embodiment, the preparation method of the inflation cotton candy of employing food service industry, technique is simple, can meet the needs of most domestic manufacturer production present situation, putting into production, it is few to newly increase equipment investment, and production technology is simple, and industrialization level is high.
Present embodiment is in conjunction with modern food, pharmaceutical production technology and the method for inspection, summed up the technological parameter comparatively mating with ibuprofen inflation cotton candy preparation, and take determination of ibuprofen as monitor control index, guarantee safety, effectiveness, the stability of ibuprofen inflation cotton candy, assurance this product can be brought into play antiinflammatory, antipyretic, analgesic function.The ibuprofen inflation cotton candy onset rapidly that the present invention makes, reduces GI irritation, has positive clinical treatment meaning and social meaning.
Embodiment 2
The preparation method of a kind of ibuprofen inflation cotton candy of the present embodiment is to carry out according to the following steps:
One, sieve: get ibuprofen crude drug, cross 200 mesh sieves; Corn starch, crosses 80 mesh sieves.The part of getting under sieve is standby;
Two, weigh: 100g ibuprofen raw material medicated powder, 120g starch, 712.96g Saccharum Sinensis Roxb., 600g glucose, 200g jelly powder, 4g sodium alginate, 4g stevioside, 4g Fructus Citri Limoniae essence, 6g citric acid, 8g Sal, 240g pure water after taking step 1 and sieve by ratio of quality and the number of copies, 1g sorbitol and 0.04g lemon yellow;
Three, colloidal sol: the jelly powder that step 2 is taken, sodium alginate join in the warm water of 65 ℃～75 ℃ and stir 25 minutes, without agglomerate; By gelatin solution put the vacuum that adopts 0.7～0.9 MPa in vacuum tank, 40 ℃～50 ℃ temperature are dissolved 80 minutes;
Four, glue piece: the gelatin solution that step 3 is dissolved filters with 24 mesh sieves, puts container interior cooling 5 hours, and stripping and slicing is standby;
Five, stir off: step 2 is taken sucrose and glucose, citric acid, Sal, stevioside, benzyl alcohol be dissolved in warm water, stir, with 200 order silks, filter while hot, 115 ℃ of heat of filtrate employing boil 30 minutes, syrup concentration is about 88%;
Six, Mixing and aeration: the syrup that step 5 is made is placed in air agitation pot, be controlled at temperature and be under the condition of 80～85 ℃, the blob of viscose that adds step 4 to make, the ibuprofen fine powder that step 2 weighs, lemon yellow, Fructus Citri Limoniae essence, slowly stirs 5 minutes, after mix homogeneously, rapid stirring is 10 minutes, makes to reach the inflation effect needing;
Seven, dry starch: the starch that step 2 is taken adopts 80～85 ℃ of heat dryings 3 hours;
Eight, moulding: the dried starch that step 7 is dry is evenly sieved in mould while hot, the mixing that step 6 is made slurry is poured into mould, moulding by casting.
Nine, dry: the ibuprofen inflation cotton candy that step 8 is made is put baking oven and adopted 35～40 ℃ to be dried 20 hours;
Ten, sub-sieve and clear powder: the dry ibuprofen inflation cotton candy making of step 9 is sieved to unnecessary starch gently;
11, select packing: step 10 is sieved to the ibuprofen inflation cotton candy after powder, select, certified products are packed, and obtain ibuprofen inflation cotton candy.
In the preparation process of the ibuprofen inflation cotton candy of present embodiment, adopt food technology to prepare ibuprofen confectionery formulations, preparation mouthfeel is good, owing to having sugar and gelatin adjuvant, therefore gastric mucosa had to certain protective effect, reduces the GI irritation of ibuprofen.The convenient storage of preparation carried, and taking convenience can be taken under without drinking water condition, is convenient to field man and uses.Formulation content uniformity stable uniform, safe and effective.
The preparation method of the ibuprofen inflation cotton candy of present embodiment, the preparation method of the inflation cotton candy of employing food service industry, technique is simple, can meet the needs of most domestic manufacturer production present situation, putting into production, it is few to newly increase equipment investment, and production technology is simple, and industrialization level is high.
Present embodiment is in conjunction with modern food, pharmaceutical production technology and the method for inspection, summed up the technological parameter comparatively mating with ibuprofen inflation cotton candy preparation, and take determination of ibuprofen as monitor control index, guarantee safety, effectiveness, the stability of ibuprofen inflation cotton candy, assurance this product can be brought into play antiinflammatory, antipyretic, analgesic function.The ibuprofen inflation cotton candy onset rapidly that the present invention makes, reduces GI irritation, has positive clinical treatment meaning and social meaning.
Claims (10)
1. ibuprofen is inflated a preparation method for cotton candy, it is characterized in that the preparation method of ibuprofen inflation cotton candy is to carry out according to the following steps:
One, sieve: get ibuprofen crude drug, cross 200 mesh sieves; Corn starch, crosses 80 mesh sieves, and the part of getting under sieve is standby;
Two, weigh: the ibuprofen raw material medicated powder of 100～150 parts after taking step 1 and sieve by mass fraction, the starch of 100～150 parts, the Saccharum Sinensis Roxb. of 600～900 parts, the glucose of 400～600 parts, the jelly powder of 100～300 parts, the sodium alginate of 1～3 part, the stevioside of 1～3 part, the Fructus Citri Limoniae essence of 1～3 part, the citric acid of 6～8 parts, the Sal of 10～15 parts, the water of 100～400 parts, the lemon yellow of the sorbitol of 1～3 part and 0.05～0.08 part;
Three, colloidal sol: the jelly powder that step 2 is taken, sodium alginate join in the water of 65 ℃～75 ℃ and stir 10～30 minutes, obtain gelatin mixed solution; By gelatin mixed solution be placed in the vacuum that adopts 0.7～0.9 MPa in vacuum tank, 40 ℃～50 ℃ temperature are dissolved 50～100 minutes;
Four, glue piece: the gelatin solution that step 3 is dissolved filters with 20～30 mesh sieves, puts container interior cooling 4～6 hours, and stripping and slicing is standby;
Five, stir off: step 2 is taken sucrose and glucose, citric acid, Sal, stevioside and benzyl alcohol be dissolved in 80～90 ℃ water in, stir, with 200 order silks, filter while hot, filtrate adopt 110～120 ℃ of heat boil to syrup concentration be 85～95%;
Six, Mixing and aeration: the syrup that step 5 is made is placed in air agitation pot, be controlled at temperature and be under the condition of 80～85 ℃, the blob of viscose that adds step 4 to make, then add ibuprofen raw material medicated powder, lemon yellow and Fructus Citri Limoniae essence that step 2 weighs to stir 3～5 minutes with the speed of 100～200 revs/min, after mix homogeneously, then stir 10～15 minutes with the speed of 400～600 revs/min;
Seven, dry starch: the starch that step 2 is taken adopts 80～85 ℃ of heat dryings 2～4 hours;
Eight, moulding: the dried starch that step 7 is dry is evenly sieved in mould, the mixing that step 6 is made slurry is poured into mould, and moulding by casting obtains ibuprofen inflation cotton candy;
Nine, dry: the ibuprofen inflation cotton candy that step 8 is made is put in baking oven and adopted 35～40 ℃ to be dried 18～24 hours;
Ten, sub-sieve and clear powder: the dry ibuprofen inflation cotton candy making of step 9 is sieved to unnecessary starch gently;
11, select packing: step 10 is sieved to the ibuprofen inflation cotton candy after powder, select, subpackage, obtains.
2. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that taking the ibuprofen raw material medicated powder of 100～110 parts, the corn starch of 100～110 parts, the Saccharum Sinensis Roxb. of 700～900 parts, the glucose of 550～600 parts, the jelly powder of 110～200 parts, the sodium alginate of 1～2 part, the stevioside of 1～2 part, the Fructus Citri Limoniae essence of 1～2 part, the citric acid of 6.5～7.5 parts, the Sal of 10～11 parts, the water of 150～300 parts, the sorbitol of 1～2 part and the lemon yellow of 0.05～0.07 part described in step 2.
3. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that stirring 10～30 minutes in the water of 70 ℃～75 ℃ described in step 3.
4. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that the vacuum of employing 0.8～0.9 MPa described in step 3,45 ℃～50 ℃ temperature dissolve 50～100 minutes.
5. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that stirring off at 115～120 ℃ of temperature described in step 5.
6. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that the syrup concentration described in step 5 is 90～95%.
7. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that the temperature that is controlled at described in step 6 is under the condition of 82～85 ℃, the blob of viscose that adds step 4 to make.
8. the preparation method that a kind of ibuprofen according to claim 1 is inflated cotton candy, it is characterized in that add ibuprofen fine powder, lemon yellow and the Fructus Citri Limoniae essence that step 2 weighs described in step 6 stirs 3～5 minutes with the speed of 100～150 revs/min, after mix homogeneously, then stir 10～15 minutes with the speed of 500～600 revs/min.
9. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that 82～85 ℃ of heat dryings of the employing described in step 7 2～4 hours.
10. the preparation method of a kind of ibuprofen inflation cotton candy according to claim 1, is characterized in that 38～40 ℃ of the employings described in step 9 are dried 18～24 hours.
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| CN201410219165.8A CN103961308B (en) | 2014-05-22 | 2014-05-22 | A kind of preparation method of ibuprofen inflation cotton candy |
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| CN201410219165.8A CN103961308B (en) | 2014-05-22 | 2014-05-22 | A kind of preparation method of ibuprofen inflation cotton candy |
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| CN109275769A (en) * | 2018-10-18 | 2019-01-29 | 江西师范大学 | A kind of production method of isinglass cotton candy |
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| EP0950402A2 (en) * | 1998-02-23 | 1999-10-20 | McNEIL-PPC, Inc. | Chewable pharmaceutical composition with gelatin matrix |
| CN101112216A (en) * | 2006-07-25 | 2008-01-30 | 李财兴 | Pneumatic sirup |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0950402A2 (en) * | 1998-02-23 | 1999-10-20 | McNEIL-PPC, Inc. | Chewable pharmaceutical composition with gelatin matrix |
| CN101112216A (en) * | 2006-07-25 | 2008-01-30 | 李财兴 | Pneumatic sirup |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109275769A (en) * | 2018-10-18 | 2019-01-29 | 江西师范大学 | A kind of production method of isinglass cotton candy |
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