CN111165511A - Pesticide containing ethylicin and fosthiazate and preparation method and application thereof - Google Patents
Pesticide containing ethylicin and fosthiazate and preparation method and application thereof Download PDFInfo
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- CN111165511A CN111165511A CN202010050418.9A CN202010050418A CN111165511A CN 111165511 A CN111165511 A CN 111165511A CN 202010050418 A CN202010050418 A CN 202010050418A CN 111165511 A CN111165511 A CN 111165511A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds
- A01N57/32—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds containing heterocyclic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/08—Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
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Abstract
The invention relates to the field of pesticides, in particular to a pesticide containing ethylicin and fosthiazate. The pesticide comprises, by weight, 20-80 wt% of a pharmaceutical composition, 5-20 wt% of a solvent, 10-25 wt% of a wetting agent, 5-10 wt% of an emulsifier, and the balance of water, wherein the pharmaceutical composition comprises ethylicin and fosthiazate in a weight ratio of (1-10): 1, the dosage form is microemulsion. The pesticide provided by the invention is prepared into microemulsion by compounding active ingredients in a specific ratio and assisting with a specific wetting agent, an emulsifying agent and a solvent, so that the control effect of the pesticide on the root-knot nematodes of cucumbers is effectively improved, the pesticide does not have a harmful effect on the cucumbers and other crops, the crops have good growth vigor and high yield, and in addition, the compatibility of each component in a system is enhanced, and the storage stability of the pesticide is further improved.
Description
Technical Field
The invention relates to the field of pesticides, in particular to a pesticide containing ethylicin and fosthiazate, a preparation method and application thereof.
Background
The root-knot nematode is a highly specialized parasitic plant pathogenic nematode, seriously harms the growth of cucumber, mainly harms the root of the cucumber, and makes the root swell and malform in a chicken claw shape. At present, the varieties of medicaments for preventing and treating the root-knot nematodes of cucumbers are more, but the medicament effect is slow, the duration is short, residues are easy to remain on the surfaces of the cucumbers, and the health of people is influenced.
Ethylicin, also known as antimicrobial 402, zhi ji ke, yi ji ke, english name: ethylicin, molecular formula: c4H10O2S2Molecular weight: 154.251, is a high-efficiency non-pollution broad-spectrum bionic bactericide, has the function of plant growth regulation, can promote germination, improve germination rate, increase yield and improve quality, and is a preferred raw material of compound bactericide pesticide.
Fosthiazate, also known as fu qi duo, fu xiao bao, dai xiao, english name: fosthizate, molecular formula: c9H18NO3PS2Molecular weight: 283.35, is an organophosphorus nematicide, has the main action mode of synthesizing acetylcholinesterase of root-knot nematodes, can be used for preventing and treating various root-knot nematodes, and has the advantages of good quick action, long lasting period, low toxicity and low residue.
At present, although the research on the compound use of two active ingredients of ethylicin and fosthiazate is related, the research on the application of the compound to the root-knot nematode of cucumber is not available mainly for the rice aphelenchoides besseyi, and the research on the dosage form, the auxiliary agent, the dosage and the like of pesticide containing ethylicin and fosthiazate is not available.
Disclosure of Invention
In order to solve the technical problems, the invention provides a pharmaceutical composition in a first aspect, which comprises ethylicin and fosthiazate in a weight ratio of (1-10): 1.
the invention provides the pesticide containing ethylicin and fosthiazate, and the pesticide comprises the pharmaceutical composition, wherein the pharmaceutical composition accounts for 20-80 wt% of the pesticide.
As a preferable technical scheme of the invention, the pesticide also comprises a solvent, a wetting agent, an emulsifier and water.
According to a preferable technical scheme, the pesticide further comprises, by weight, 5-20% of a solvent, 10-25% of a wetting agent, 5-10% of an emulsifier, and the balance of water.
In a preferred embodiment of the present invention, the solvent is at least one selected from the group consisting of ethanol, n-butanol, isobutanol, acetone, rosin-based vegetable oil, epoxidized soybean oil, mineral oil, and methyl oleate.
As a preferable technical scheme of the present invention, the wetting agent is at least one selected from the group consisting of phenethylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, fatty amine polyoxyethylene ether, and alkylolamide polyoxyethylene ether.
In a preferred embodiment of the present invention, the emulsifier is at least one selected from the group consisting of ammonium dodecylbenzene sulfonate, dodecylbenzene sulfonate and dodecylbenzene sulfonic acid.
As a preferable technical scheme of the invention, the pesticide is in the form of microemulsion.
In a third aspect, the invention provides a preparation method of the pesticide containing ethylicin and fosthiazate, which comprises the following steps: adding a solvent into a reaction container, and stirring; then adding the pharmaceutical composition thereto, and stirring; adding wetting agent and emulsifier, mixing, and stirring; and finally, adding water and stirring to obtain the pesticide containing ethylicin and fosthiazate.
In a fourth aspect, the invention provides an application of the pesticide containing ethylicin and fosthiazate, and the pesticide is used for preventing and treating root-knot nematodes of cucumbers.
Has the advantages that: the invention provides a pesticide containing ethylicin and fosthiazate, which is prepared into microemulsion by compounding two active components of ethylicin and fosthiazate and assisting with a specific solvent, a wetting agent and an emulsifier, thereby effectively enhancing the control effect of the pesticide on root-knot nematodes of cucumbers, achieving 84.14 percent of control effect after 1 root irrigation treatment, having little dosage and not influencing the growth and development of cucumbers; in addition, the compatibility of each component in the product is better, the storage period is long, and the stability of the drug effect is ensured.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the invention provides a pharmaceutical composition in a first aspect, which comprises ethylicin and fosthiazate in a weight ratio of (1-10): 1.
in a preferred embodiment, the weight ratio of ethylicin to fosthiazate in the pharmaceutical composition is (1-5): 1.
in a more preferred embodiment, the weight ratio of ethylicin to fosthiazate in the pharmaceutical composition is 3: 1.
the invention provides the pesticide containing ethylicin and fosthiazate, and the pesticide comprises the pharmaceutical composition, wherein the pharmaceutical composition accounts for 20-80 wt% of the pesticide.
In a preferred embodiment, the pharmaceutical composition accounts for 30 to 50 wt% of the pesticidal agent.
In a more preferred embodiment, the pharmaceutical composition comprises 40 wt% of the pesticidal agent.
Ethylicin
Ethylicin, also known as antimicrobial 402, zhi ji ke, yi ji ke, english name: ethylicin, molecular formula: c4H10O2S2Molecular weight: 154.251, is a high-efficiency non-pollution broad-spectrum bionic bactericide, has the function of plant growth regulation, can promote germination, improve germination rate, increase yield and improve quality, and is a preferred raw material of compound bactericide pesticide. The ethylicin is 95% in mass concentration and is purchased from Kaifeng geodetic agroforestry Co., Ltd.
Thiazolylphosphines
Fosthiazate, also known as fu qi duo, fu xiao bao, dai xiao, english name: fosthizate, molecular formula: c9H18NO3PS2Molecular weight: 283.35, is an organophosphorus nematicide, has the main action mode of inhibiting the synthesis of acetylcholinesterase of root-knot nematodes, can be used for preventing and treating various root-knot nematodes, and has the advantages of good quick action, long lasting period, low toxicity and low residue. Hair brushThe fosthiazate in Ming is fosthiazate with the mass concentration of 96 percent, and is purchased from agriculture and chemical industry Co., Ltd, Sannong, Hebei.
The fosthiazate is a relatively efficient organic phosphorus nematicide and has a good effect of preventing and controlling root-knot nematodes, but the applicant finds that the direct dilution of fosthiazate with water for root irrigation can cause premature senility of cucumbers and further reduce the yield of the cucumbers, and the application of ethylicin alone has a poor effect of preventing and controlling the root-knot nematodes. The applicant unexpectedly finds that the two active ingredients of fosthiazate and ethylicin are compounded for use, so that after the cucumber root is irrigated, the control effect on root-knot nematodes is very good, the cucumber plants grow well, and the cucumber-forming rate is high. Presumably, the ethylicin has the plant growth regulating effect, and when the pesticide is absorbed and permeated into root nodules of the cucumbers to kill root-knot nematodes, the ethylicin can promote the growth and division of cells at the roots of the plants and promote the development of fibrous roots, and in addition, the combination of the ethylicin and the pesticide reduces the volatility of the pharmaceutical composition, enhances the control effect and prolongs the efficacy duration through the mutual influence between molecular structures.
In some embodiments, the pesticidal insecticide further comprises a solvent, a wetting agent, an emulsifier, water.
In some embodiments, the pesticide further comprises 5-20% of a solvent, 10-25% of a wetting agent, 5-10% of an emulsifier and the balance of water by weight percentage.
In a preferred embodiment, the pesticide further comprises 13% of a solvent, 19% of a wetting agent, 8% of an emulsifier and the balance of water by weight percentage.
In some embodiments, the solvent is selected from at least one of ethanol, n-butanol, isobutanol, acetone, rosin-based vegetable oil, epoxidized soybean oil, mineral oil, methyl oleate.
In a preferred embodiment, the solvent is a mixture of n-butanol, rosin-based vegetable oil, epoxidized soybean oil.
In a more preferred embodiment, the weight ratio of n-butanol, rosin-based vegetable oil and epoxidized soybean oil in the solvent is (1-10): (1-10): 3; preferably, the weight ratio of n-butanol, rosin-based vegetable oil and epoxidized soybean oil in the solvent is 5: 5: 3.
the applicant finds that the medicinal composition is dispersed in water, the precipitation phenomenon is easy to occur, the product quality is unstable, a small amount of n-butyl alcohol is added into the system, the stability of the medicinal composition in the system can be effectively improved, but the stability maintaining time of the system is short, and the applicant surprisingly finds that the rosin-based vegetable oil and epoxidized soybean oil are additionally introduced into the system, so that the product cannot be precipitated during long-term storage, and the medicinal effect of the product is further ensured. Presumably, the addition of n-butanol improves the solubility of the pharmaceutical composition in the system, while the rosin-based vegetable oil and the epoxidized soybean oil enhance the compatibility of the components in the system, particularly the compatibility of the epoxidized soybean oil with the pharmaceutical composition, and the epoxy bonds carried by the epoxidized soybean oil improve the stability of the product, so that the product has a longer shelf life.
In some embodiments, the wetting agent is selected from at least one of phenethylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, fatty amine polyoxyethylene ether, and alkylolamide polyoxyethylene ether.
In a preferred embodiment, the wetting agent is a mixture of phenethylphenol polyoxyethylene polyoxypropylene ether and castor oil polyoxyethylene ether.
In a more preferred embodiment, the weight ratio of phenylethylphenol polyoxyethylene polyoxypropylene ether to castor oil polyoxyethylene ether in the wetting agent is 13: (1-10); preferably, the weight ratio of the phenethyl phenol polyoxyethylene polyoxypropylene ether to the castor oil polyoxyethylene ether in the wetting agent is 13: 1.
the n-butyl alcohol, the rosin-based vegetable oil and the epoxidized soybean oil are all commercially available products, the phenethyl phenol polyoxyethylene polyoxypropylene ether is purchased from Nanjing Taihua chemical company Limited, and the castor oil polyoxyethylene ether is purchased from Cangzhou Hongyuan agricultural chemical company Limited.
In some embodiments, the emulsifier is selected from at least one of ammonium dodecylbenzene sulfonate, dodecylbenzene sulfonic acid.
In a preferred embodiment, the emulsifier is an ammonium dodecylbenzene sulfonate salt.
The ammonium dodecylbenzenesulfonate of the present invention was purchased from Cangzhou Hongyuan agricultural chemical Co., Ltd.
In some embodiments, the formulation of the pesticidal insecticide is a microemulsion.
In a third aspect, the invention provides a preparation method of the pesticide containing ethylicin and fosthiazate, which comprises the following steps: adding a solvent into a reaction container, and stirring; then adding the pharmaceutical composition thereto, and stirring; adding wetting agent and emulsifier, mixing, and stirring; and finally, adding water and stirring to obtain the pesticide containing ethylicin and fosthiazate.
In a preferred embodiment, the method for preparing the pesticidal agent includes the steps of: provides a preparation method of the pesticide containing ethylicin and fosthiazate, which comprises the following steps: adding the solvent into a reaction container, and stirring for 10 min; then adding the pharmaceutical composition therein, and stirring for 10 min; adding wetting agent and emulsifier, mixing, and stirring for 20 min; and finally, adding water, and stirring for 30min to obtain the pesticide containing ethylicin and fosthiazate.
In a fourth aspect, the invention provides an application of the pesticide containing ethylicin and fosthiazate, and the pesticide is used for preventing and treating root-knot nematodes of cucumbers.
Root-knot nematodes, known by the foreign language of Meloidogyne, are highly obligate parasitic plant pathogenic nematodes which seriously damage cucumber growth, mainly damage cucumber roots and cause the roots to swell and deform in a chicken claw shape.
Examples
Example 1
The embodiment provides a pesticide containing ethylicin and fosthiazate, which comprises the following raw materials, by weight, 30% of ethylicin, 10% of fosthiazate, 5% of n-butyl alcohol, 5% of rosin-based vegetable oil, 3% of epoxidized soybean oil, 13% of phenethyl phenol polyoxyethylene polyoxypropylene ether, 6% of castor oil polyoxyethylene ether, 8% of ammonium dodecyl benzene sulfonate and the balance of water;
the ethylicin is 95% of ethylicin in mass concentration, is purchased from Kaifeng geodetic agro-chemical technology company, the thiazole phosphine is 96% of thiazole phosphine in mass concentration, is purchased from Hebei Sannong agricultural chemical company Limited, the n-butyl alcohol, the rosin-based vegetable oil and the epoxidized soybean oil are all commercially available products, the phenethyl phenol polyoxyethylene polyoxypropylene ether is purchased from Nanjing Taihua chemical company Limited, the castor oil polyoxyethylene ether is purchased from Cangzhou Hongyuan agricultural chemical company Limited, and the dodecyl benzene sulfonic acid ammonium salt is purchased from Cangzhou Hongyuan agricultural chemical company Limited.
The embodiment also provides a preparation method of the pesticide, which comprises the following steps: adding the solvent into a reaction container, and stirring for 10 min; then adding the pharmaceutical composition therein, and stirring for 10 min; adding wetting agent and emulsifier, mixing, and stirring for 20 min; and finally adding water, and stirring for 30min to obtain the pesticide containing ethylicin and fosthiazate, wherein the dosage form is microemulsion.
The dosage of the active ingredients is 420 g/hectare when the composition is applied, and the dosage of the composition is 70 ml/mu.
Example 2
The embodiment provides a pesticide containing ethylicin and fosthiazate, which comprises the following raw materials, by weight, 30% of ethylicin, 10% of fosthiazate, 5% of n-butyl alcohol, 5% of rosin-based vegetable oil, 3% of epoxidized soybean oil, 13% of phenethyl phenol polyoxyethylene polyoxypropylene ether, 6% of castor oil polyoxyethylene ether, 8% of ammonium dodecyl benzene sulfonate and the balance of water;
the ethylicin is 95% of ethylicin in mass concentration, is purchased from Kaifeng geodetic agro-chemical technology company, the thiazole phosphine is 96% of thiazole phosphine in mass concentration, is purchased from Hebei Sannong agricultural chemical company Limited, the n-butyl alcohol, the rosin-based vegetable oil and the epoxidized soybean oil are all commercially available products, the phenethyl phenol polyoxyethylene polyoxypropylene ether is purchased from Nanjing Taihua chemical company Limited, the castor oil polyoxyethylene ether is purchased from Cangzhou Hongyuan agricultural chemical company Limited, and the dodecyl benzene sulfonic acid ammonium salt is purchased from Cangzhou Hongyuan agricultural chemical company Limited.
The embodiment also provides a preparation method of the pesticide, which comprises the following steps: adding the solvent into a reaction container, and stirring for 10 min; then adding the pharmaceutical composition therein, and stirring for 10 min; adding wetting agent and emulsifier, mixing, and stirring for 20 min; and finally adding water, and stirring for 30min to obtain the pesticide containing ethylicin and fosthiazate, wherein the dosage form is microemulsion.
The dosage of the effective components is 600 g/hectare when the composition is applied, and the dosage of the composition is 100 ml/mu.
Example 3
The embodiment provides a pesticide containing ethylicin and fosthiazate, which comprises the following raw materials, by weight, 30% of ethylicin, 10% of fosthiazate, 5% of n-butyl alcohol, 5% of rosin-based vegetable oil, 3% of epoxidized soybean oil, 13% of phenethyl phenol polyoxyethylene polyoxypropylene ether, 6% of castor oil polyoxyethylene ether, 8% of ammonium dodecyl benzene sulfonate and the balance of water;
the ethylicin is 95% of ethylicin in mass concentration, is purchased from Kaifeng geodetic agro-chemical technology company, the thiazole phosphine is 96% of thiazole phosphine in mass concentration, is purchased from Hebei Sannong agricultural chemical company Limited, the n-butyl alcohol, the rosin-based vegetable oil and the epoxidized soybean oil are all commercially available products, the phenethyl phenol polyoxyethylene polyoxypropylene ether is purchased from Nanjing Taihua chemical company Limited, the castor oil polyoxyethylene ether is purchased from Cangzhou Hongyuan agricultural chemical company Limited, and the dodecyl benzene sulfonic acid ammonium salt is purchased from Cangzhou Hongyuan agricultural chemical company Limited.
The embodiment also provides a preparation method of the pesticide, which comprises the following steps: adding the solvent into a reaction container, and stirring for 10 min; then adding the pharmaceutical composition therein, and stirring for 10 min; adding wetting agent and emulsifier, mixing, and stirring for 20 min; and finally adding water, and stirring for 30min to obtain the pesticide containing ethylicin and fosthiazate, wherein the dosage form is microemulsion.
When the composition is applied, the dosage of the active ingredients is 780 g/hectare, and the dosage of the composition is 130 ml/mu.
Comparative example 1
This comparative example is a 20% aqueous emulsion of fosthiazate purchased from north Hei, Wigner Biochemical Co., Ltd, under the batch number 20190506701.
The effective component is 600 g/hectare when the pesticide is applied, and the preparation dosage is 200 g/mu.
Comparative example 2
The comparative example is 30% ethylicin emulsifiable concentrate, purchased from Wei high-tech chemical Co., Ltd, Hebei, under the batch number of 20190607.
The effective component is 360 g/hectare when the composition is applied, and the preparation dosage is 80 g/mu.
Control group
Control group was administered with clear water.
Evaluation of Performance
1. Test of field drug effect
The test conditions are as follows:
1.1 crop and target:
crop/cucumber, target/cucumber root knot nematode (caused by Meloidogyne incognita, naturally occurring)
1.2 specific conditions:
the test is carried out in Zhao village of Wang Jizhen county in suining county, Jiangsu province, the planting years are 8 years, the soil type is sandy loam, the organic matter content is medium, and the fertility is uniform. The cucumber is planted in the field in 4 days per 8 months, the planting density is 1500-1600 plants/mu, the cucumber growth vigor in each cell is better and uniform, the fertilizer and water management is carried out according to the convention, and other agents for preventing and controlling cucumber root-knot nematodes are not applied in the test period.
1.3 cell arrangement
1.3.1 cell arrangement: the cells are arranged in random blocks, see table 1.
1.3.2 cell area and repetition: 4 repetitions, cell area 15m2And a protection row is arranged among the cells.
1.4 modes of application
1.4.1 application time and times: after the cucumber is planted and survived, namely 10 days after transplanting, the cucumber is treated by the medicament, and the cucumber is irrigated for 1 time after 8 months and 14 days.
1.4.2 application method: diluting with water, and irrigating roots with water of 200ml per seedling.
Investigation and results:
2.1 investigation method:
and (3) searching damaged suspicious plants, adopting a diagonal five-point sampling or random sampling method in each cell, investigating two plants at each point, and calculating the morbidity, disease index and prevention and treatment effect.
The grading method of diseased plants comprises the following steps:
grade 0, no disease (root system without insect gall);
grade 1, the root system has only a few small galls;
grade 3, 2/3 root system is covered with small galls;
grade 5, the root system is full of small galls and the raw galls exist;
and 7, the root system forms a fibrous root group.
2.2 survey time and number:
after the cucumber is planted, the seedlings are pulled uniformly to investigate the root system, and disease index and control effect are investigated in 11 months and 15 days.
2.3 the calculation method of the drug effect:
disease index [ Σ (number of diseased plants at each stage × (relative stage value)/(total number of surveys × 7) ] × 100;
the disease fingers of the untreated areas in the area are used as a reference, and the repeated control effects are calculated as follows:
the preventing and treating effect (%) is [ disease index of control region-disease index of treatment region ]/disease index of control region 100 [ ]
2.4 effects on crops and other organisms:
is safe to cucumber and has no influence on other non-target organisms.
2.5 test results:
2.5.1 prevention and treatment effects: see table 2, where the data are the average of 4 replicates.
TABLE 1
TABLE 2
According to the results in the table 2, the pesticide microemulsion containing ethylicin and fosthiazate prepared by the invention has better control effect on the root-knot nematodes of cucumber under the effective content of 420-780 g/ha, the average control effect is 65.62%, 73.69% and 84.14%, and the control effect is increased remarkably with the increase of the use amount. In addition, the 20% fosthiazate water emulsion (600 g/ha) and 30% ethylicin emulsifiable concentrate (360 g/ha) in the comparative example had average control effects on meloidogyne cucumis of 76.44% and 47.02%, respectively. The control effect of the example 1 is obviously different from that of the comparative example 2, and the control effect of the example 2 is equivalent to that of the comparative example 1 and is obviously different from that of the comparative example 2. Through experimental observation, the pesticide containing ethylicin and fosthiazate provided by the invention has good stability, is not easy to precipitate and deteriorate, has a long storage period at room temperature, and ensures the lasting stability of the pesticide effect.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The pharmaceutical composition is characterized by comprising ethylicin and fosthiazate in a weight ratio of (1-10): 1.
2. an agricultural chemical containing ethylicin and fosthiazate according to claim 1, wherein the agricultural chemical comprises the pharmaceutical composition according to claim 1, and the pharmaceutical composition is 20 to 80 wt% of the agricultural chemical.
3. The pesticidal agent according to claim 2, which further comprises a solvent, a wetting agent, an emulsifier, and water.
4. The pesticide according to claim 3, wherein the pesticide further comprises 5-20 wt% of a solvent, 10-25 wt% of a wetting agent, 5-10 wt% of an emulsifier, and the balance water.
5. An agricultural chemical containing ethylicin and fosthiazate according to claim 3 wherein the solvent is at least one selected from the group consisting of ethanol, n-butanol, isobutanol, acetone, rosin-based vegetable oil, epoxidized soybean oil, mineral oil, and methyl oleate.
6. An agricultural chemical containing ethylicin and fosthiazate as claimed in claim 3 wherein the wetting agent is at least one selected from the group consisting of phenethylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, fatty amine polyoxyethylene ether, and alkylolamide polyoxyethylene ether.
7. An agricultural chemical containing ethylicin and fosthiazate according to claim 3 wherein the emulsifier is at least one selected from the group consisting of ammonium dodecylbenzenesulfonate, dodecylbenzenesulfonate and dodecylbenzenesulfonate.
8. The pesticidal agent according to any one of claims 2 to 7, which comprises ethylicin and fosthiazate, wherein the pesticidal agent is in the form of a microemulsion.
9. A process for producing an ethylicin-and fosthiazate-containing pesticidal agent according to any one of claims 2 to 7, comprising the steps of: adding a solvent into a reaction container, and stirring; then adding the pharmaceutical composition thereto, and stirring; adding wetting agent and emulsifier, mixing, and stirring; and finally, adding water and stirring to obtain the pesticide containing ethylicin and fosthiazate.
10. The use of the ethylicin and fosthiazate-containing pesticide as claimed in any one of claims 2 to 7 for controlling root-knot nematodes in cucumbers.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112586505A (en) * | 2020-11-19 | 2021-04-02 | 华南农业大学 | Application of carvacrol, derivatives and analogs thereof in eliminating or reducing thiazole phosphine phytotoxicity |
| CN113994960A (en) * | 2021-12-01 | 2022-02-01 | 江西省农业科学院植物保护研究所 | Pharmaceutical composition and pharmaceutical preparation for preventing and treating peanut root-knot nematode and preparation method thereof |
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| CN112586505A (en) * | 2020-11-19 | 2021-04-02 | 华南农业大学 | Application of carvacrol, derivatives and analogs thereof in eliminating or reducing thiazole phosphine phytotoxicity |
| CN112586505B (en) * | 2020-11-19 | 2022-05-03 | 华南农业大学 | Application of carvacrol, derivatives and analogs thereof in eliminating or reducing thiazole phosphine phytotoxicity |
| CN113994960A (en) * | 2021-12-01 | 2022-02-01 | 江西省农业科学院植物保护研究所 | Pharmaceutical composition and pharmaceutical preparation for preventing and treating peanut root-knot nematode and preparation method thereof |
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