CN111135111A - Laminin skin repair agent and preparation method thereof - Google Patents
Laminin skin repair agent and preparation method thereof Download PDFInfo
- Publication number
- CN111135111A CN111135111A CN201811304164.8A CN201811304164A CN111135111A CN 111135111 A CN111135111 A CN 111135111A CN 201811304164 A CN201811304164 A CN 201811304164A CN 111135111 A CN111135111 A CN 111135111A
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- Prior art keywords
- laminin
- parts
- sod
- chitosan
- hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A laminin skin repair agent and a preparation method thereof are disclosed, wherein laminin is used as a main component, and small molecular peptide, SOD, hyaluronic acid, chitosan and sterile physiological saline are added, the specific component weight ratio is that 0.1-5 parts of laminin, 1-6 parts of small molecular peptide, 1-6 parts of SOD, 1-6 parts of hyaluronic acid, 1-5 parts of chitosan and the sterile physiological saline are supplemented to 100 parts, the laminin skin repair agent has the functions of ① the laminin is used as the main component, not only can the cosmetic dermatitis face repair be accelerated, but also the germ infection can be prevented, ② the laminin skin repair agent has the synergistic effect of the laminin, the small molecular peptide, the SOD, the hyaluronic acid and the chitosan, has good functions of repair, moisture absorption, moisture retention, aging resistance and the like, ③ the laminin skin repair agent is a natural preparation, has no stimulation to skin, is a green and environment-friendly product, and is suitable for large-scale production.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a laminin skin repair agent.
Background
People who love beauty are all well, the living standard of the masses is generally improved since the reform and the opening of China, the requirement of people for beauty is also increasingly improved, the requirement is rapidly changed into huge social demand, various cosmetics are rapidly emerged, but the substantial classification is mostly chemical synthetic products, the cosmetic dermatitis has the functions of protecting and beautifying the human body, can volatilize various harmful substances, has great stimulation effect on the skin of the human body, and can cause skin edema, pruritus, macula and the like. With the development of biotechnology, people gradually recognize the natural advantages of biological products, and the active ingredients of biological tissues are increasingly showing excellent quality and huge market demand in the cosmetic field.
Laminin (LN) is a non-collagen glycoprotein that forms the intercellular matrix, is synthesized in the liver mainly by endothelial cells and lipid-storing cells, and forms a component of the basement membrane together with collagen, which is produced mainly by epithelial cells and endothelial cells and is the earliest component of the extracellular matrix in embryonic development. A large number of researches and clinical applications prove that LN plays an important role in the repair and healing of wounds, has a remarkable effect in the healing treatment of wounds which are difficult to heal, and is a key substance for promoting the wounds which are difficult to heal.
At present, LN is mostly applied to the aspects of burns, wounds, congenital muscular dystrophy infection and the like, and related products which take laminin as an effective component and are applied to the beauty and skin care industry are not seen on the market.
Object of the Invention
The invention aims to solve the problems in the prior art and is a laminin skin repair agent which is specially developed, can accelerate the repair of cosmetic dermatitis faces, can keep the skin moist and glossy, can increase the skin elasticity, can provide nutrition for the skin and has the anti-aging effect.
The purpose of the invention is realized by the following scheme:
the laminin skin repair agent is prepared by taking laminin as a main component, adding small molecular peptide, SOD (superoxide dismutase), hyaluronic acid and chitosan, and adding sterile normal saline in balance.
The weight parts of the components are as follows: 0.1-5 parts of laminin; 1-6 parts of small molecular peptide; 1-6 parts of SOD; 1-6 parts of hyaluronic acid; 1-5 parts of chitosan and sterile normal saline to make up to 100 parts.
The preparation method of the laminin skin repair agent comprises the following specific steps:
(1) accurately weighing the required formula amount, fully mixing laminin, small molecular peptide, SOD, hyaluronic acid and chitosan in a container, adding sterile normal saline, mixing, and stirring uniformly to obtain a mixed solution for later use;
(2) and (2) sterilizing the solution obtained in the step (1) by a 0.22-micron filter membrane, and canning in a sterile bottle according to the specification requirement, thus obtaining the laminin skin repair agent product.
The small molecule peptide has double functions on cells, namely, the small molecule peptide can supplement nutrition requirements to repair defects and improve functional states. While having the dual duties of carrying tools and materials. The curative effect of the small molecular peptide on wound healing is miraculous because the small molecular peptide can promote cell repair, supplement substances which are lacked by damaged tissues and enable wounds to recover quickly, and simultaneously participate in enzyme synthesis, so that the activity of the enzyme is stimulated, the function of the enzyme is strengthened and the stability of the enzyme is maintained.
The SOD is an active substance originated from living bodies and can eliminate harmful substances generated in the metabolism process of the living bodies. Has special anti-aging effect on continuously supplementing SOD to human body. SOD is regarded as the most magical enzyme in life science and technology and the rubbish scavenger in human body. SOD is the natural enemy of oxygen free radicals, is the first killer of oxygen free radicals in organisms, and is the basis of life and health. The level of SOD in the organism means the visual index of aging and death; it has been confirmed that the diseases caused by oxygen radicals are as many as 60. It can resist and block the damage of oxygen free radical to cell, repair damaged cell and restore the damage of free radical to cell. Due to modern living pressure, environmental pollution, various radiation and excessive motion, a great amount of oxygen radicals are formed; therefore, the position of SOD in the biological antioxidant mechanism is becoming more and more important.
The hyaluronic acid is an acidic mucopolysaccharide, has a special water retention effect, is the best natural moisture retention substance discovered at present, and is called as idealNatural moisturizing factor. A2% pure hyaluronic acid aqueous solution can firmly maintain 98% of water. The aging process of human skin also changes with the content and metabolism of hyaluronic acid, and it can improve skin nutrition metabolism, make skin tender and smooth, remove wrinkle, increase elasticity, prevent aging, and keep moistureIs also a good percutaneous absorption enhancer. The nutrient can be used together with other nutrient components to achieve the more ideal effect of promoting nutrient absorption.
The special chitosan for the cosmetics has good functions of moisture absorption, moisture preservation, conditioning, bacteriostasis and the like; the chitosan is used as the component of the current advanced cosmeceutical on the skin care product and is used forPulsed lightAfter medical cosmetology such as radio frequency, dot matrix, fruit acid and the likeNatural antibioticThe chitosan has the functions of resisting the generation of sensitivity and inflammation, quickly repairing basal heat injury, quickly healing wounds and repairing epidermal barriers, and the chitosan skin care product also has the function of metabolizing heavy metals.
The main functions and advantages of the product of the invention are as follows:
① the product of the invention uses laminin sediment as the main component, which can accelerate the face repair of cosmetic dermatitis and prevent the infection of germs, ② the product of the invention combines laminin, small molecular peptide, SOD, hyaluronic acid and chitosan to play a synergistic effect, can provide nutrition for skin, keep the skin moist and lustrous, increase the skin elasticity, and has good functions of repair, moisture absorption, moisture retention, aging resistance, etc. ③ the product of the invention is a natural preparation, has no stimulation to skin, is nontoxic and harmless to human body, and is a green and environment-friendly product.
Detailed Description
The invention is further described below with reference to the formulation method of the specific examples:
example 1:
the laminin skin repair agent of the embodiment is composed of laminin precipitate as a main component, small molecule peptide, SOD, hyaluronic acid, chitosan and the balance of sterile physiological saline.
The weight parts of the components are as follows: 2 parts of laminin; 2 parts of small molecule peptide; 3 parts of SOD; 3 parts of hyaluronic acid; 2 parts of chitosan, and the balance of sterile normal saline.
The preparation method comprises the following specific steps:
(1) accurately weighing 2 parts of laminin; 2 parts of small molecule peptide; 3 parts of SOD; 3 parts of hyaluronic acid; 2 parts of chitosan, namely fully mixing laminin, small molecular peptide, SOD, hyaluronic acid and chitosan in a container, supplementing sterile normal saline to 100 parts, mixing, and uniformly stirring to obtain a mixed solution for later use;
(2) and (2) sterilizing the solution obtained in the step (1) by a 0.22-micron filter membrane, and canning in a sterile bottle according to the specification requirement, thus obtaining the laminin skin repair agent product.
And (5) detecting according to the requirements of a sterile detection method of pharmacopoeia, wherein the product is sterile.
The product can be directly sprayed on cleaned skin.
Example 2:
the laminin skin repair agent of the embodiment is composed of laminin precipitate as a main component, small molecule peptide, SOD, hyaluronic acid, chitosan and the balance of sterile physiological saline.
The weight parts of the components are as follows: laminin 2.5 parts; 2.5 parts of small molecule peptide; 4 parts of SOD; 4 parts of hyaluronic acid; 3 parts of chitosan, and the balance of sterile normal saline.
The preparation method comprises the following specific steps:
(1) accurately weighing 2.5 parts of laminin; 2.5 parts of small molecule peptide; 4 parts of SOD; 4 parts of hyaluronic acid; 3 parts of chitosan, namely fully mixing laminin, small molecular peptide, SOD, hyaluronic acid and chitosan in a container, supplementing sterile normal saline to 100 parts, mixing, and uniformly stirring to obtain a mixed solution for later use;
(2) and (2) sterilizing the solution obtained in the step (1) by a 0.22-micron filter membrane, and canning in a sterile bottle according to the specification requirement, thus obtaining the laminin skin repair agent product.
And (5) detecting according to the requirements of a sterile detection method of pharmacopoeia, wherein the product is sterile.
The product can be directly sprayed on cleaned skin.
Example 3:
the laminin skin repair agent of the embodiment is composed of laminin precipitate as a main component, small molecule peptide, SOD, hyaluronic acid, chitosan and the balance of sterile physiological saline.
The weight parts of the components are as follows: 4 parts of laminin; 4 parts of small molecule peptide; 2 parts of SOD; 2 parts of hyaluronic acid; 3 parts of chitosan, and the balance of sterile normal saline.
The preparation method comprises the following specific steps:
(1) accurately weighing 4 parts of laminin; 4 parts of small molecule peptide; 2 parts of SOD; 2 parts of hyaluronic acid; 3 parts of chitosan, namely fully mixing laminin, small molecular peptide, SOD, hyaluronic acid and chitosan in a container, supplementing sterile normal saline to 100 parts, mixing, and uniformly stirring to obtain a mixed solution for later use;
(2) and (2) sterilizing the solution obtained in the step (1) by a 0.22-micron filter membrane, and canning in a sterile bottle according to the specification requirement, thus obtaining the laminin skin repair agent product.
And (5) detecting according to the requirements of a sterile detection method of pharmacopoeia, wherein the product is sterile.
The product can be directly sprayed on cleaned skin.
Claims (2)
1. A laminin skin repair agent and a preparation method thereof are characterized in that: the laminin-containing biological preparation is prepared from laminin serving as a main component, small molecular peptide, SOD, hyaluronic acid, chitosan and sterile physiological saline, and comprises the following components in parts by weight: 0.1-5 parts of laminin; 1-6 parts of small molecular peptide; 1-6 parts of SOD; 1-6 parts of hyaluronic acid; 1-5 parts of chitosan and sterile normal saline to make up to 100 parts.
2. The laminin skin repair agent of claim 1, characterized in that: the preparation method comprises the following specific steps:
(1) accurately weighing the required formula amount, fully mixing laminin, small molecular peptide, SOD, hyaluronic acid and chitosan in a container, adding sterile normal saline, mixing, and stirring uniformly to obtain a mixed solution for later use;
(2) and (2) sterilizing the solution obtained in the step (1) by a 0.22-micron filter membrane, and canning in a sterile bottle according to the specification requirement, thus obtaining the laminin skin repair agent product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811304164.8A CN111135111A (en) | 2018-11-06 | 2018-11-06 | Laminin skin repair agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811304164.8A CN111135111A (en) | 2018-11-06 | 2018-11-06 | Laminin skin repair agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111135111A true CN111135111A (en) | 2020-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811304164.8A Pending CN111135111A (en) | 2018-11-06 | 2018-11-06 | Laminin skin repair agent and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN111135111A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101873854A (en) * | 2007-10-09 | 2010-10-27 | 内华达高等教育系统董事会,代表内华达大学雷诺校区 | Laminin, derivant and comprise their compositions and their therapeutic application process |
| CN101965357A (en) * | 2007-08-15 | 2011-02-02 | 特拉维夫大学拉莫特有限公司 | Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair |
| CN107261116A (en) * | 2017-06-17 | 2017-10-20 | 河南艾尔恩生物技术有限公司 | A kind of promotion organization Regeneration and Repair agent |
| CN107519123A (en) * | 2017-09-30 | 2017-12-29 | 广州昕生医学材料有限公司 | Face repairs anti-inflammatory composition and its application |
-
2018
- 2018-11-06 CN CN201811304164.8A patent/CN111135111A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965357A (en) * | 2007-08-15 | 2011-02-02 | 特拉维夫大学拉莫特有限公司 | Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair |
| CN101873854A (en) * | 2007-10-09 | 2010-10-27 | 内华达高等教育系统董事会,代表内华达大学雷诺校区 | Laminin, derivant and comprise their compositions and their therapeutic application process |
| CN107261116A (en) * | 2017-06-17 | 2017-10-20 | 河南艾尔恩生物技术有限公司 | A kind of promotion organization Regeneration and Repair agent |
| CN107519123A (en) * | 2017-09-30 | 2017-12-29 | 广州昕生医学材料有限公司 | Face repairs anti-inflammatory composition and its application |
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| TA01 | Transfer of patent application right |
Effective date of registration: 20220411 Address after: 471000 group 13, Yuquan village, Liuquan Town, Yiyang County, Luoyang City, Henan Province Applicant after: Xu Yihui Address before: 471600 Han Cheng Zhen Qin Wang Cun, Yiyang County, Luoyang City, Henan Province Applicant before: Wang Congfei |
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Application publication date: 20200512 |
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