CN111134324A - Composition for improving and balancing intestinal microorganisms and preparation method thereof - Google Patents
Composition for improving and balancing intestinal microorganisms and preparation method thereof Download PDFInfo
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- CN111134324A CN111134324A CN202010158628.XA CN202010158628A CN111134324A CN 111134324 A CN111134324 A CN 111134324A CN 202010158628 A CN202010158628 A CN 202010158628A CN 111134324 A CN111134324 A CN 111134324A
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Abstract
The invention belongs to the technical field of medicines, medical health-care foods and foods, and particularly relates to a composition for improving and balancing intestinal microorganisms and a preparation method thereof.
Description
Technical Field
The invention belongs to the technical field of medicines, medical health-care foods and foods, and particularly relates to a composition for improving and balancing intestinal microorganisms and a preparation method thereof.
Background
In the age of rapid development of economy, health becomes a topic of increasing concern, and the incidence rates of heart diseases, myocardial infarction, hypertension, diabetes, anxiety, depression, insomnia, senile dementia, intestinal diseases and the like are extremely high. Scientists have found that many diseases are closely related to intestinal microorganisms, such as diabetes, anxiety, depression, autism, parkinson, senile dementia, cancer, aging, obesity, intestinal diseases (intestinal cancer, constipation, diarrhea), etc. Especially, in recent years, the application of gene sequencing method in intestinal microorganism analysis, researchers further prove that human health is closely related to intestinal microorganisms, and imbalance and disorder of the intestinal microorganisms induce different diseases.
The improvement of intestinal microbial therapy and the adjuvant therapy of various diseases are receiving more and more attention. The research and development of medicines, medical health-care foods and foods for improving intestinal microorganisms by using Chinese herbal medicines, particularly medicine and food raw materials arouses great interest. We are dedicated to developing deep application of Chinese herbal medicines and medicinal and edible plants.
Disclosure of Invention
The composition for improving and balancing intestinal microorganisms has the effects of improving human immunity, improving body functions, assisting in treating constipation, diarrhea, hyperlipidemia, hypertension, hyperuricemia (gout), hyperglycemia, depression and anxiety, insomnia, Parkinson and dysmenorrheal, improving male functions, beautifying, improving physical strength and the like.
The specific technical scheme of the invention is as follows:
a composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
4-15 parts of nitraria tangutorum bobr, 3-9 parts of medlar and 2-7 parts of Chinese yam.
Preferably, the composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
6-12 parts of nitraria tangutorum bobr, 5-8 parts of medlar and 3-6 parts of Chinese yam.
More preferably, the composition for improving and balancing intestinal microorganisms is characterized in that: also comprises 1 to 9 parts of ginseng by weight.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized in that: the lycopene feed also comprises 2-15 parts of lycopene by weight.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized in that: the blueberry fruit juice also comprises 3-8 parts of blueberries in parts by weight.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized in that: and 2-15 parts of dried orange peel.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized by further comprising the following components in parts by weight:
3-12 parts of sea buckthorn, 5-10 parts of Chinese date, 2-10 parts of oat, 1-8 parts of snow chrysanthemum and 3-15 parts of natto.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized by further comprising the following components in parts by weight:
5-10 parts of sea buckthorn, 7-9 parts of Chinese date, 4-9 parts of oat, 3-6 parts of snow chrysanthemum and 4-13 parts of natto.
Or more preferably, the composition for improving and balancing intestinal microorganisms is characterized by further comprising the following components in parts by weight:
7 parts of sea buckthorn, 8 parts of Chinese date, 5 parts of oat, 4 parts of snow chrysanthemum and 6 parts of natto.
The preparation method of the composition for improving and balancing intestinal microorganisms is characterized by comprising the following steps:
(1) weighing the components according to the claim 1, washing, sterilizing and crushing to obtain the mixed raw material.
(2) Putting the mixed raw material obtained in the step (1) into a fermentation tank, adding 25-60 ℃ warm water according to the mass ratio of 25-60% of the mixed raw material, inoculating activated and cultured saccharomycetes and lactobacillus into a compound strain prepared by mixing the saccharomycetes and the lactobacillus according to the mass ratio of 2-4: 1 or inoculating any strain of the saccharomycetes and the lactobacillus into the fermentation tank, uniformly stirring, and carrying out sealed fermentation for 2-45 hours at the temperature of 25-55 ℃;
(3) the fermentation product obtained in the step (2) is the composition for improving and balancing intestinal microorganisms.
The composition for improving and balancing intestinal microorganisms of the present invention can be prepared into medicines and health foods for medical treatment or into commonly used functional foods by adding auxiliary materials such as binders, disintegrants, lubricants, flavoring agents, etc.
The composition for improving and balancing intestinal microorganisms can be prepared into different types of preparations such as granules, capsules, powder, tablets, pills, namely oral liquid and the like according to actual needs in the actual application process.
The invention has the beneficial effects that:
(1) the composition for improving and balancing intestinal microorganisms is prepared by taking medicinal and edible substances such as Chinese yam, medlar, nitraria tangutorum bobr as main components, or adding nutritional components such as Chinese date, sea buckthorn, ginseng, lycopene, natto, oat, plains coreopsis, dried orange peel and blueberry and the like, and performing fermentation technology; the composition can be applied to the preparation of medical medicines and medical health-care foods in different dosage forms or the preparation of functional foods which are practical in daily life;
(2) the composition for improving and balancing intestinal microorganisms can be used for assisting in treating and improving symptoms such as constipation and diarrhea of a human body by improving and balancing the intestinal microorganisms, has the effects of reducing blood fat, reducing blood pressure, assisting in treating diabetes and gout (hyperuricemia), also has the effects of improving anxiety, depression, improving sleep, improving physical strength, beautifying, improving female dysmenorrheal, relieving Parkinson's disease and improving male functions, such as impotence, premature ejaculation, spermatorrhea, oligospermia, poor sperm development, intolerance of cold and cold limbs, waist soreness and leg weakness, fatigue, short breath, deficient sweat, cold scrotum and the like caused by kidney-yang deficiency;
(2) the preparation method of the composition for improving and balancing intestinal microorganisms takes the mixture of saccharomycetes and lactic acid bacteria as a fermentation strain or takes any one of the saccharomycetes and the lactic acid bacteria as a fermentation strain, effective nutrient substances of the components can be fully released in the fermentation process, the effective substances are kept to be fully absorbed, the utilization rate of the effective components is improved, and the prepared medicine, medical health-care food or food fully retains the effective components of the components, so that the composition has obvious effects on improving the intestinal microorganisms and maintaining the intestinal microorganism balance; in addition, the preparation method is simple and easy to implement, free of pollutants and environment-friendly.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments.
Example 1
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
4 parts of nitraria tangutorum bobr, 3 parts of medlar and 2 parts of yam;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, sterilizing and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding 25 ℃ warm water according to 25% of the mass ratio of the mixed raw material, inoculating 0.1% of the mass ratio of the mixed raw material into a compound strain formed by mixing saccharomycetes and lactic acid bacteria according to the mass ratio of 2:1, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 25 ℃, and the fermentation time is 2 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 2
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
15 parts of nitraria tangutorum bobr, 9 parts of medlar and 7 parts of Chinese yam;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding 60 ℃ warm water according to 60% of the mass ratio of the mixed raw material, inoculating activated and cultured yeast and lactobacillus to form a compound strain according to the mass ratio of 4:1 according to the proportion of 20% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 38 ℃, and the fermentation time is 15 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 3
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
10 parts of nitraria tangutorum bobr, 6 parts of medlar and 5 parts of yam;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 35 ℃ according to 45% of the mass ratio of the mixed raw material, inoculating yeast subjected to activation culture according to the proportion of 10% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 30 ℃, and the fermentation time is 20 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 4
A composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
6 parts of nitraria tangutorum bobr, 5 parts of medlar, 3 parts of yam and 1 part of ginseng;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water of 40 ℃ according to 30% of the mass ratio of the mixed raw material, inoculating activated cultured lactobacillus according to the proportion of 0.5% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 30 ℃ and the fermentation time is 15 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 5
The difference between the embodiment and the embodiment 4 is that the ginseng is 9 parts or 5 parts, and the rest is the same as the embodiment 4.
Example 6
A composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
6 parts of nitraria tangutorum bobr, 5 parts of medlar, 3 parts of Chinese yam and 2 parts of lycopene;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 30 ℃ according to 40% of the mass ratio of the mixed raw material, inoculating activated and cultured lactic acid bacteria according to the proportion of 1% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 30 ℃ and the fermentation time is 3 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 7
The difference between this example and example 6 is that the lycopene ingredient is 10 parts or 15 parts, and the rest is the same as that in example 6.
Example 8
A composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
6 parts of nitraria tangutorum bobr, 5 parts of medlar, 3 parts of Chinese yam and 3 parts of blueberry;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 28 ℃ according to 45% of the mass ratio of the mixed raw material, inoculating yeast subjected to activation culture according to the proportion of 15% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 30 ℃, and the fermentation time is 10 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 9
The difference between the embodiment and the embodiment 8 is that the blueberry ingredient is 5 parts or 8 parts, and the rest is the same as the embodiment 8.
Example 10
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
10 parts of nitraria tangutorum bobr, 6 parts of medlar, 5 parts of yam and 10 parts of dried orange peel;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 35 ℃ according to 45% of the mass ratio of the mixed raw material, inoculating yeast subjected to activation culture according to the proportion of 8% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 30 ℃, and the fermentation time is 20 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 11
The difference between the embodiment and the embodiment 10 is that the part by weight of the tangerine peel is 2 parts or 15 parts, and the rest is the same as the embodiment 10.
Example 12
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
10 parts of nitraria tangutorum bobr, 6 parts of medlar, 5 parts of yam, 7 parts of ginseng, 12 parts of lycopene, 7 parts of blueberry and 12 parts of dried orange peel;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components according to the weight parts, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 38 ℃ according to 50% of the mass ratio of the mixed raw material, inoculating a compound strain formed by mixing the yeast and the lactic acid bacteria after activation culture according to the mass ratio of 2:1 according to the proportion of 5% of the mass ratio of the mixed raw material, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 28 ℃, and the fermentation time is 35 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 13
A composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
12 parts of nitraria tangutorum bobr, 10 parts of sea buckthorn, 8 parts of medlar, 6 parts of Chinese yam, 9 parts of Chinese date, 10 parts of oat, 8 parts of snow chrysanthemum, 15 parts of dried orange peel, 5 parts of ginseng, 8 parts of lycopene and 8 parts of blueberry;
the preparation method of the composition for improving and balancing intestinal microorganisms comprises the following steps:
(1) weighing the components in parts by weight, washing, drying and crushing to obtain a mixed raw material;
(2) putting the mixed raw material in the step (1) into a fermentation tank, adding warm water at 38 ℃ according to 50% of the mass ratio of the mixed raw material, inoculating a compound strain formed by mixing the yeast and the lactic acid bacteria after activation culture according to the mass ratio of 4:1, uniformly stirring, sealing and fermenting, wherein the fermentation temperature is 28 ℃, and the fermentation time is 35 hours;
(3) preparing the fermentation product obtained in the step (2) into different preparations to obtain the finished product of the composition for improving and balancing the intestinal microorganisms.
Example 14
This example differs from example 13 in that:
the composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
8 parts of nitraria tangutorum bobr, 9 parts of sea buckthorn, 7 parts of medlar, 4 parts of Chinese yam, 8 parts of Chinese date, 4 parts of oat, 3 parts of snow chrysanthemum, 7 parts of dried orange peel, 6 parts of ginseng, 6 parts of lycopene and 5 parts of blueberry;
the rest is the same as example 3.
Example 15
This example differs from example 14 in that:
the composition for improving and balancing intestinal microorganisms comprises the following components in parts by weight:
10 parts of nitraria tangutorum bobr, 7 parts of sea buckthorn, 6 parts of medlar, 5 parts of Chinese yam, 8 parts of Chinese date, 9 parts of oat, 6 parts of snow chrysanthemum, 12 parts of dried orange peel, 3 parts of ginseng, 11 parts of lycopene and 7 parts of blueberry;
the rest is the same as example 14.
Clinical trial
The test method comprises the following steps:
the medicine, medical health food or food prepared in example 3 is used as a test sample, sub-health people with different diseases are randomly selected as volunteers, during the test period, the improvement conditions of different sub-health people in aspects of fasting blood sugar, constipation, diarrhea, sleep quality, physical strength, Parkinson disease, dysmenorrheal, gout, skin and the like are tracked and observed, and the disease improvement conditions of people with andropathy are tracked and observed, and the results are as follows:
(1) sub-healthy population with hyperglycemia
Volunteers: 17 hyperglycemia patients (fasting blood sugar 6.9-9.5 without medication, 10 men, 7 women); the test course was maintained for 80 days, with the results:
fasting plasma glucose was improved in 13 (8 men, 5 women);
wherein in 1 of said 13 hyperglycemic patients, 10 sky fasting glucose is improved; 4 patients, 20 with improved fasting glucose in the sky; 3 patients, 30 sky abdominal blood sugar was improved; the blood sugar of 6 patients, 40 sky abdominal blood, was improved;
(2) sub-healthy population with constipation
Volunteers: 18 constipation patients (12 men, 6 women, the test procedure was maintained for 50 days with the results:
14 patients with constipation were improved;
wherein 1 patient improved in 10 days; 3 patients, improved in 15 days; 5 patients, improved in 20 days; 5 patients, improved in 50 days;
(3) sub-healthy population with diarrhea
Volunteers: 16 patients with chronic habitual diarrhea (11 men, 5 women), the test course was maintained for 50 days, with the results:
diarrhea symptoms disappeared in 15 patients (10 men, 5 women);
wherein, 1 patient had no symptoms of diarrhea in 2 days; 3 patients had diarrhea symptoms disappeared in 10 days; 3 patients had diarrhea symptoms disappeared in 15 days; in 2 patients, the diarrhea symptom disappears after 20 days; in 5 patients, the diarrhea symptom disappears in 50 days;
(4) sub-healthy population with sleep disorders
Volunteers: 18 patients with long-term insomnia (8 men and 10 women) maintained the test for 50 days, with the results:
sleep was improved in 18 patients (8 men, 10 women);
wherein 1 patient improved in 10 days; improvement was obtained in 20 days for 6 patients; improvement was obtained in 50 days for 12 patients;
(5) sub-health population with weak body ability
Volunteers: 29 patients (18 stars, 11 women), the course of the trial was maintained for 25 days with the results:
the improvement was evident in 27 patients (16 men, 13 women);
wherein, 2 patients are obviously improved in 10 days; the 10 patients are obviously improved in 15 days; the 10 patients are obviously improved in 25 days;
(6) sub-healthy population with Parkinson's disease
Volunteers: 7 Parkinson patients (3 men, 4 women), the course of the experiment was maintained for 60 days with the results:
the improvement was evident in 6 patients (3 males, 3 females);
wherein, 1 patient is obviously improved in 15 days; the improvement is obvious in 45 days for 3 patients; the improvement is obvious for 3 patients in 60 days;
(7) sub-healthy population with skin disorders
Volunteers: 19 persons (11 women, 8 men), the test procedure was maintained for 40 days with results:
skin improvement in 17 persons (11 women, 6 men);
of these, 5 improved in 20 days; 6 persons improved in 30 days; 6 persons improved 40 days;
(8) female sub-healthy population suffering from dysmenorrhea
Volunteers: 11 patients (16-49 years old) and the test course was maintained for 30 days with the following results:
pain disappeared in 3 patients, pain improved in 5 patients, and no change in 3 patients;
(9) male sub-healthy population with male disorders
Volunteers: 21 male patients, the course of the test was maintained for 20 days with the results:
the functions of 20 patients were improved;
of these, 2 patients improved in 7 days; 5 patients, improved in 10 days; 13 patients, improved in 20 days;
(10) male population with gout (hyperuricemia)
Volunteers: 11 subjects with gout (hyperuricemia) who lasted the course of the trial for 60 days, with the results:
the hyperuricemia of 7 patients is obviously improved after 60 days of trial.
Claims (10)
1. A composition for improving and balancing intestinal microorganisms is characterized by comprising the following components in parts by weight:
4-15 parts of nitraria tangutorum bobr, 3-9 parts of medlar and 2-7 parts of Chinese yam.
2. The composition for improving and balancing intestinal microorganisms according to claim 1, characterized by consisting of the following components in parts by weight:
6-12 parts of nitraria tangutorum bobr, 5-8 parts of medlar and 3-6 parts of Chinese yam.
3. Composition for improving and balancing intestinal microorganisms according to claim 1, characterized in that: also comprises 1 to 9 parts of ginseng by weight.
4. Composition for improving and balancing intestinal microorganisms according to claim 1, characterized in that: the lycopene feed also comprises 2-15 parts of lycopene by weight.
5. Composition for improving and balancing intestinal microorganisms according to claim 1, characterized in that: the blueberry fruit juice also comprises 3-8 parts of blueberries in parts by weight.
6. Composition for improving and balancing intestinal microorganisms according to claim 1, characterized in that: and 2-15 parts of dried orange peel.
7. The composition for improving and balancing intestinal microorganisms according to any one of claims 1 to 6, further comprising the following components in parts by weight:
3-12 parts of sea buckthorn, 5-10 parts of Chinese date, 2-10 parts of oat, 1-8 parts of snow chrysanthemum and 3-15 parts of natto.
8. The composition for improving and balancing intestinal microorganisms according to any one of claims 1 to 6, further comprising the following components in parts by weight:
5-10 parts of sea buckthorn, 7-9 parts of Chinese date, 4-9 parts of oat, 3-6 parts of snow chrysanthemum and 4-13 parts of natto.
9. The composition for improving and balancing intestinal microorganisms according to any one of claims 1 to 6, further comprising the following components in parts by weight:
7 parts of sea buckthorn, 8 parts of Chinese date, 5 parts of oat, 4 parts of snow chrysanthemum and 6 parts of natto.
10. The method for preparing a composition for improving and balancing intestinal microorganisms according to claim 1, comprising the steps of:
(1) weighing the components according to the claim 1, washing, sterilizing and crushing to obtain mixed raw materials;
(2) putting the mixed raw material obtained in the step (1) into a fermentation tank, adding 25-60 ℃ warm water according to the mass ratio of 25-60% of the mixed raw material, inoculating activated and cultured saccharomycetes and lactobacillus into a compound strain prepared by mixing the saccharomycetes and the lactobacillus according to the mass ratio of 2-4: 1 or inoculating any strain of the saccharomycetes and the lactobacillus into the fermentation tank, uniformly stirring, and carrying out sealed fermentation for 2-45 hours at the temperature of 25-55 ℃;
(3) the fermentation product obtained in the step (2) is the composition for improving and balancing intestinal microorganisms.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943441A (en) * | 2017-02-22 | 2017-07-14 | 浙江大学 | Dichromatism coreopsis extract and its application in antidepressant is prepared |
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| CN1362069A (en) * | 2000-12-30 | 2002-08-07 | 中国科学院西北高原生物研究所 | Composite medicine for treating hyperglycaemia |
| US20090142304A1 (en) * | 2005-10-13 | 2009-06-04 | Koichiro Murashima | Composition for Improving Intestinal Flora |
| CN105595349A (en) * | 2015-09-08 | 2016-05-25 | 青海华牛生物科技有限公司 | Plateau plant solid ferment food |
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- 2020-03-09 CN CN202010158628.XA patent/CN111134324A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362069A (en) * | 2000-12-30 | 2002-08-07 | 中国科学院西北高原生物研究所 | Composite medicine for treating hyperglycaemia |
| US20090142304A1 (en) * | 2005-10-13 | 2009-06-04 | Koichiro Murashima | Composition for Improving Intestinal Flora |
| CN105595349A (en) * | 2015-09-08 | 2016-05-25 | 青海华牛生物科技有限公司 | Plateau plant solid ferment food |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943441A (en) * | 2017-02-22 | 2017-07-14 | 浙江大学 | Dichromatism coreopsis extract and its application in antidepressant is prepared |
| CN106943441B (en) * | 2017-02-22 | 2022-05-31 | 浙江大学 | Coreopsis tinctoria extract and application thereof in preparation of antidepressant drugs |
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