CN111109289A - Stable solid hydrogen peroxide adduct and application thereof in livestock and poultry and aquaculture fields - Google Patents
Stable solid hydrogen peroxide adduct and application thereof in livestock and poultry and aquaculture fields Download PDFInfo
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 113
- 239000007787 solid Substances 0.000 title claims abstract description 44
- 244000144972 livestock Species 0.000 title claims abstract description 19
- 244000144977 poultry Species 0.000 title claims abstract description 16
- 238000009360 aquaculture Methods 0.000 title claims abstract description 15
- 244000144974 aquaculture Species 0.000 title claims abstract description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 73
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 52
- 239000011780 sodium chloride Substances 0.000 claims abstract description 38
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 26
- 239000007832 Na2SO4 Substances 0.000 claims abstract description 17
- 229910052938 sodium sulfate Inorganic materials 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 230000035484 reaction time Effects 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 10
- QOSATHPSBFQAML-UHFFFAOYSA-N hydrogen peroxide;hydrate Chemical compound O.OO QOSATHPSBFQAML-UHFFFAOYSA-N 0.000 claims description 10
- 239000012265 solid product Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 6
- 239000003242 anti bacterial agent Substances 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 244000063299 Bacillus subtilis Species 0.000 abstract description 3
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract description 3
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004040 coloring Methods 0.000 abstract description 2
- 230000007797 corrosion Effects 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- -1 stable property Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 47
- 241000238557 Decapoda Species 0.000 description 11
- 230000001276 controlling effect Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000013505 freshwater Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 239000008149 soap solution Substances 0.000 description 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K63/00—Receptacles for live fish, e.g. aquaria; Terraria
- A01K63/04—Arrangements for treating water specially adapted to receptacles for live fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/20—Nature of the water, waste water, sewage or sludge to be treated from animal husbandry
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
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- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Organic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
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Abstract
The invention relates to the technical field of livestock and poultry and aquaculture, and discloses a stable solid hydrogen peroxide adduct and application thereof in the field of livestock and poultry and aquaculture, wherein the stable solid hydrogen peroxide adduct comprises the following formula raw materials and components: NaCl, Na2SO4、H2O2，Na2CO3·1.5H2O2The mass ratio of the components is 4:2.1-2.3:1: 0.002-0.006. By regulating Na2SO4、H2O2NaCl and stabilizer Na2CO3·1.5H2O2The solution concentration, the reaction temperature, the reaction time and the drying temperature to prepare the high-chemical-stability solid hydrogen peroxide adduct 4Na2SO4·2H2O2NaCl can be used as a disinfectant and an antibacterial agent, has strong sterilization capability, quick action, long service life, no harm to human and animals, no corrosion to articles, no odor and no coloring of the medicament, stable property, water solubility, no flammability and explosiveness, convenient mass transportation, mass production and supply, low cost and easy acquisition, and has the antibacterial rate of 88.9-97.2% to escherichia coli. The antibacterial rate to bacillus subtilis reaches 89.7-96.6%.
Description
Technical Field
The invention relates to the technical field of livestock and poultry and aquaculture, in particular to a stable solid hydrogen peroxide adduct and application thereof in the field of livestock and poultry and aquaculture.
Background
In the present day that the animal husbandry is increasingly developed to intensification and standardization, the prevention and treatment of various infectious diseases are more important. The more intensive the breeding, the more frequent the contact probability of the animals and the faster the spread speed of pathogenic microorganisms, and once the infection occurs, remedial measures are taken, which may be late and cause great economic loss to the owners of the animals. Therefore, in order to reduce the morbidity of livestock and poultry and reduce the use of medicines, farmers hope to reduce the number of pathogenic microorganisms in the environment to the minimum extent without reaching pathogenic concentration by carrying out regular environmental disinfection on livestock and poultry houses, thereby ensuring the healthy and continuous development of livestock production.
Many types of disinfectants are currently used clinically, for example: sodium hydroxide (caustic soda), potassium permanganate (grey manganese oxide), formaldehyde solution (formalin), coal phenol soap solution (sodium hydrosulfite), lime milk, plant ash water, chlorine-containing lime (bleaching powder), liquid hydrogen peroxide and the like are not ideal disinfectants, and have the defects of strong corrosivity, strong irritation, easy explosion, difficult long-term storage and the like. Under the current culture technical conditions, the objective requirement of the market is to research and develop the stable formulation of the disinfectant in order to ensure the low morbidity of large-scale and intensive livestock and poultry and aquaculture.
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a stable solid hydrogen peroxide adduct and application thereof in the field of livestock and aquatic product cultivation.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a stable solid hydrogen peroxide adduct and application thereof in the field of livestock, poultry and aquaculture comprise the following formula raw materials and components: NaCl, Na2SO4、H2O2，Na2CO3·1.5H2O2The mass ratio of the four components is 4:2.1-2.3:1: 0.002-0.006.
Preferably, the preparation method of the stable solid hydrogen peroxide adduct comprises the following steps:
(1) adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.1-2.3:1:0.002-0.006, the solution is placed in a low-temperature constant-temperature reactor, the reaction is carried out by uniform stirring, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier for drying, and the stable solid hydrogen peroxide adduct is prepared, wherein the chemical expression is 4Na2SO4·2H2O2·NaCl。
Preferably, the total mass fraction of the solution is controlled to be 35-55%.
Preferably, the reaction temperature of the low-temperature constant-temperature reactor is 10-25 ℃, and the reaction time is 1-4 h.
Preferably, the drying temperature of the air-blast dryer is 45-55 ℃, and the drying time is 30-90 min.
(III) advantageous technical effects
Compared with the prior art, the invention has the following beneficial technical effects:
the stable solid hydrogen peroxide adductThe product can be used in livestock, fowl and aquaculture field by regulating Na2SO4、H2O2NaCl and stabilizer Na2CO3·1.5H2O2The solution concentration, the reaction temperature, the reaction time and the drying temperature to prepare the high-chemical-stability solid hydrogen peroxide adduct 4Na2SO4·2H2O2NaCl can be used as a disinfectant and an antibacterial agent, has strong sterilization capability, quick action, long service life, no harm to human and animals, no corrosion to articles, no odor and no coloring of the medicament, stable property, water solubility, no flammability and explosiveness, convenient mass transportation, mass production and supply, low cost and easy acquisition, and has the antibacterial rate of 88.9-97.2% to escherichia coli. The antibacterial rate to bacillus subtilis reaches 89.7-96.6%.
Detailed Description
To achieve the above object, the present invention provides the following embodiments and examples: a stable solid hydrogen peroxide adduct and application thereof in the field of livestock, poultry and aquaculture comprise the following formula raw materials and components: NaCl, Na2SO4、H2O2，Na2CO3·1.5H2O2The mass ratio of the four components is 4:2.1-2.3:1: 0.002-0.006.
The preparation method of the stable solid hydrogen peroxide adduct comprises the following steps:
(1) adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.1-2.3:1:0.002-0.006, the total mass fraction of the solution is controlled to be 35-55%, the solution is placed in a low-temperature constant-temperature reactor, the reaction is carried out for 1-4h at the temperature of 10-25 ℃ by uniform stirring, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier, and the drying is carried out at the temperature of 45-55 DEG CDrying for 30-90min to obtain stable solid hydrogen peroxide adduct with chemical expression of 4Na2SO4·2H2O2·NaCl。
Example 1
(1) Preparation of stable solid hydrogen peroxide adduct 1: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.1:1:0.002, the total mass fraction of the solution is controlled to be 35%, the solution is placed in a low-temperature constant-temperature reactor and is stirred at a constant speed at 10 ℃ for reaction for 1 hour, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier and is dried for 30 minutes at 45 ℃, and the stable solid hydrogen peroxide adduct 1 is prepared, wherein the chemical expression is 4Na2SO4·2H2O2·NaCl。
Example 2
(1) Preparation of stable solid hydrogen peroxide adduct 2: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.1:1:0.003, the total mass fraction of the solution is controlled to be 40%, the solution is placed in a low-temperature constant-temperature reactor and is stirred at a constant speed at 10 ℃ for reaction for 1 hour, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier and is dried for 30 minutes at 55 ℃, and the stable solid hydrogen peroxide adduct 2 is prepared, wherein the chemical expression is 4Na2SO4·2H2O2·NaCl。
Example 3
(1) Preparation of stable solid hydrogen peroxide adduct 3: into a reaction flaskAdding distilled water solvent, NaCl and Na2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.2:1:0.0035, the total mass fraction of the solution is controlled to be 40%, the solution is placed in a low-temperature constant-temperature reactor, the reaction is carried out for 2h at 25 ℃ by uniform stirring, the solution is filtered to remove the solvent, the solid product is placed in a blast drier, the drying is carried out for 60min at 45 ℃, and the stable solid hydrogen peroxide adduct 3 with the chemical expression of 4Na is prepared2SO4·2H2O2·NaCl。
Example 4
(1) Preparation of stable solid hydrogen peroxide adduct 4: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.2:1:0.002, the total mass fraction of the solution is controlled to be 50%, the solution is placed in a low-temperature constant-temperature reactor and is stirred at a constant speed at 20 ℃ for reaction for 3 hours, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier and is dried for 50 minutes at 50 ℃, and the stable solid hydrogen peroxide adduct 4 with the chemical expression of 4Na is prepared2SO4·2H2O2·NaCl。
Example 5
(1) Preparation of stable solid hydrogen peroxide adduct 5: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.3:1:0.005, the total mass fraction of the solution is controlled to be 55 percent, the solution is placed in a low-temperature constant-temperature reactor and is stirred at a constant speed for reaction for 4 hours at the temperature of 18 ℃, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier and is dried for 80 minutes at the temperature of 50 ℃, and the stable solid hydrogen peroxide adduct 5 is prepared, wherein the chemical expression is 4Na2SO4·2H2O2·NaCl。
Example 6
(1) Preparation of stable solid hydrogen peroxide adduct 6: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.3:1:0.002, the total mass fraction of the solution is controlled to be 35%, the solution is placed in a low-temperature constant-temperature reactor and is stirred at a constant speed at 25 ℃ for reaction for 4 hours, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier and is dried for 90 minutes at 55 ℃, and the stable solid hydrogen peroxide adduct 6 is prepared, wherein the chemical expression is 4Na2SO4·2H2O2·NaCl。
Example 7
(1) Preparation of stable solid hydrogen peroxide adduct 7: adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.3:1:0.006, the total mass fraction of the solution is controlled to be 55%, the solution is placed in a low-temperature constant-temperature reactor, the reaction is carried out for 4 hours at 25 ℃ under uniform stirring, the solution is filtered to remove the solvent, the solid product is placed in a forced air drier, the drying is carried out for 90 minutes at 55 ℃,preparing to obtain a stable solid hydrogen peroxide adduct 7 with a chemical expression of 4Na2SO4·2H2O2·NaCl。
The stable solid hydrogen peroxide adducts 1-7 prepared in the examples were subjected to antibacterial experiments, and the preparation of the strains and the bacterial suspensions of Escherichia coli and Bacillus subtilis were provided by the animal Hospital microbiology research group of Nanjing university of agriculture, and the culture medium was ordinary nutrient agar and nutrient broth.
Determination of minimum inhibitory concentration: diluting the stable solid hydrogen peroxide adduct by 1:10, 1:20, 1:80, 1:320 and 1:1280 times respectively with sterilized normal saline, mixing 2ml of antibacterial agent solution with each concentration with an equal amount of nutrient broth, inoculating 0.1ml of 2 bacterial suspensions into a test tube, observing the antibacterial effect after 35 ℃ for 48 hours, wherein the antibacterial effect is observed if bacteria grow, the broth is turbid, some visible bacterial membranes or bacterial rings are marked as (+), the broth is clear and transparent when the bacteria grow aseptically, and is marked as (-) and the highest dilution multiple of the disinfectant capable of inhibiting the growth and the reproduction of the bacteria is the minimum antibacterial concentration of the disinfectant on test bacteria.
Quantitative sterilization test: by adopting a suspension method, placing test tubes containing 4.5ml of disinfectants with different dilutions (the concentration is the same as 1.2.2) in a water bath at 20 ℃ for preheating, taking 0.5ml of bacteria liquid, adding the bacteria liquid into disinfectant with different concentrations, taking 0.5ml of bacteria-medicine mixed liquid respectively after 5min, adding the bacteria-medicine mixed liquid into the test tubes containing 4.5ml of neutralizing agent, mixing uniformly, neutralizing for 10min, taking 1ml, diluting by 10 times in an increasing manner, counting plates, and calculating the bacteria content after disinfection.
The practical application is as follows: three suitable culture pond openings are selected and arranged, each pond opening is about 20 mu, each mu is 600-1200 crab seedlings, the specification of each seedling is 7-10g, the putting amount of the individual large crab seedlings can be correspondingly reduced, after the crab seedlings grow, the crab seedlings are cultured in ponds according to the size and the density, so the putting amount is within the range, no special limitation exists, the stable solid hydrogen peroxide adduct 1-7 is put into the culture ponds as an antibacterial agent, and the specification of the crabs entering the river on the market is measured and calculated when the crabs are harvested from the end of the year: male crabs generally reach more than 0.3 kg, female crabs generally reach more than 0.25 kg; the river crab recapture rate reaches more than 90 percent; the river crab has the advantages of transportation resistance, enough delicate flavor and good taste.
Selecting and sorting three suitable culture pond openings, wherein each pond opening is about 15 mu, 7000-one-year-old young freshwater shrimps are released and cultured per mu, 1600-year-old young shrimp specifications per kilogram are 1400-year-old young shrimp, the release amount of the large freshwater shrimp seedlings can be correspondingly reduced, after the freshwater shrimp seedlings grow, pond-divided culture can be carried out according to the size and the density, so that the release amount can be within the range without special limitation, the stable solid hydrogen peroxide adduct 1-7 is used as an antibacterial agent to be released into the culture pond, and the specifications of the freshwater shrimps on the market are measured and calculated when the freshwater shrimp is harvested from the end of the year: about 5-8 cm per tail, and 30-45 kg per mu yield.
Claims (5)
1. A stable solid hydrogen peroxide adduct and application thereof in the field of livestock, poultry and aquaculture comprise the following formula raw materials and components, and are characterized in that: NaCl, Na2SO4、H2O2，Na2CO3·1.5H2O2The mass ratio of the four components is 4:2.1-2.3:1: 0.002-0.006.
2. The stable solid hydrogen peroxide adduct of claim 1 and its application in livestock and poultry and aquaculture field, wherein the stable solid hydrogen peroxide adduct comprises: the preparation method of the stable solid hydrogen peroxide adduct comprises the following steps:
(1) adding distilled water solvent, NaCl and Na into a reaction bottle2SO4、Na2CO3·1.5H2O2And 30% hydrogen peroxide water solution by mass percent, and controlling NaCl and Na2SO4H in aqueous hydrogen peroxide solution2O2And Na2CO3·1.5H2O2The mass ratio of the four is 4:2.1-2.3:1:0.002-0.006, and the solution is placed at low temperature and constant temperatureStirring at constant speed in a warm reaction instrument for reaction, filtering the solution to remove the solvent, and drying the solid product in a forced air drier to obtain a stable solid hydrogen peroxide adduct with the chemical expression of 4Na2SO4·2H2O2·NaCl。
3. The stable solid hydrogen peroxide adduct of claim 2 and its application in livestock and poultry and aquaculture field, wherein the stable solid hydrogen peroxide adduct comprises: the total mass fraction of the solution is controlled to be 35-55%.
4. The stable solid hydrogen peroxide adduct of claim 2 and its application in livestock and poultry and aquaculture field, wherein the stable solid hydrogen peroxide adduct comprises: the reaction temperature of the low-temperature constant-temperature reactor is 10-25 ℃, and the reaction time is 1-4 h.
5. The stable solid hydrogen peroxide adduct of claim 2 and its application in livestock and poultry and aquaculture field, wherein the stable solid hydrogen peroxide adduct comprises: the drying temperature of the forced air dryer is 45-55 ℃, and the drying time is 30-90 min.
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