CN111096742B - 3D chronic brain electrode adjusting device for experiments - Google Patents
3D chronic brain electrode adjusting device for experiments Download PDFInfo
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- CN111096742B CN111096742B CN201911281676.1A CN201911281676A CN111096742B CN 111096742 B CN111096742 B CN 111096742B CN 201911281676 A CN201911281676 A CN 201911281676A CN 111096742 B CN111096742 B CN 111096742B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
The invention relates to a 3D chronic brain electrode adjusting device for experiments, which comprises a plurality of brain electrodes, wherein the brain electrodes are all provided with a support, the support is of a stepped cylindrical structure, the middle part of a small-diameter end of the support is provided with a circular through hole, the brain electrodes penetrate through the circular through hole and are fixedly connected with the support, the support is provided with a shell, and the shell is used for protecting the brain electrodes and the support from being damaged in a non-experimental state; the shell includes upper portion and lower part, and upper portion is the open cylindrical structure of inside cavity lower extreme, and the lower part is the pipe shape structure, is provided with the fixed plate in the lower part, and a plurality of mounting holes have been seted up on the last plane of fixed plate, and a plurality of mounting holes are circular through-hole, and a plurality of mounting holes use the centre of a circle of fixed plate to be multilayer annular array as the central point, and brain electrode and support pass mounting hole and lower part fixed connection, and upper portion and lower part are passed through the screw thread and can be dismantled the connection. The invention is provided with a plurality of brackets and a shell for placing the brackets, and can realize long-term observation on the premise of ensuring simultaneous detection of a plurality of brain electrodes.
Description
Technical Field
The invention relates to the field of electroencephalogram acquisition, in particular to a 3D chronic electroencephalogram electrode adjusting device for experiments.
Background
Current extraction modalities for brain signals include: extraction of scalp electrical signals (EEG), intracranial brain surface recordings (EcoG), and intracerebral microelectrode arrays. Compared with extraction of scalp electrical signals (EEG) and intracranial brain surface recording (EcoG), the intracerebral microelectrode array has the characteristics of recording action potentials of single neurons, and has higher signal resolution than the former two.
The existing electroencephalogram acquisition device is generally suitable for extraction of scalp electrical signals (EEG) and intracranial brain surface recording (EcoG), and for example, a patent document with a patent publication number of CN107693013A named as 'an electroencephalogram acquisition support' discloses an electroencephalogram acquisition device suitable for extraction of scalp electrical signals, which can fix brain electrodes, reduce the signal-to-noise ratio of the electroencephalogram signals and improve the measurement accuracy.
When the microelectrode array in the brain is used for stimulating and recording the electrical activity of brain neurons, the brain electrodes need to be implanted into the brain, so that the process is complex and has certain risks. In order to meet experimental requirements, a plurality of brain electrodes need to be implanted in different experimental stages, and the brain electrodes need to be taken out in non-experimental stages, so that the process is extremely complicated. Particularly, the joint part of the brain electrode exposed outside the cerebral cortex is provided with a large number of brain electrodes, so that the brain electrodes are protected from external interference in a non-experimental stage on the premise of ensuring that the plurality of brain electrodes are detected simultaneously by an adjusting device, and long-term monitoring is achieved.
Disclosure of Invention
The invention provides a 3D chronic brain electrode adjusting device for experiments, which aims to solve the problems that an existing intracerebral microelectrode array needs to be repeatedly installed during long-term detection and a plurality of brain electrodes cannot be simultaneously monitored.
In order to achieve the purpose, the technical scheme of the invention is as follows:
A3D chronic brain electrode adjusting device for experiments comprises a plurality of brain electrodes, wherein the brain electrodes are provided with supports, the supports are used for fixing the brain electrodes and are of stepped cylindrical structures, a circular through hole is formed in the middle of a small-diameter end of each support, the brain electrodes penetrate through the circular through holes and are fixedly connected with the supports, and the supports are provided with shells used for protecting the brain electrodes and the supports from being damaged in a non-experimental state;
the shell includes upper portion and lower part, upper portion is the open cylindrical structure of inside cavity lower extreme, the lower part is the pipe-shaped structure, is provided with the fixed plate in the lower part, the fixed plate is the circular slab, and fixed plate and lower part structure as an organic whole, and a plurality of mounting holes have been seted up on the last plane of fixed plate, and are a plurality of the mounting hole is circular through-hole, and a plurality of mounting holes use the centre of a circle of fixed plate to be multilayer annular array as the central point, brain electrode and support pass mounting hole and lower part fixed connection, upper portion and lower part pass through the screw thread and can dismantle the connection.
Furthermore, a plurality of fixing holes are formed in the large-diameter end and the small-diameter end of the support, the fixing holes are circular through holes, and the fixing holes are in an annular array by taking the circle center of the large-diameter end of the support as a central point.
Furthermore, be provided with the spliced pole between the fixed orifices of support major diameter end and the planar mounting hole on the fixed plate, the spliced pole is the cylinder structure, and the surface of spliced pole is provided with the screw thread, and the top of spliced pole is provided with cross recess, the support passes through spliced pole fixed connection with the fixed plate.
Furthermore, a connecting column is arranged between the brain electrode and the fixing hole of the small-diameter end of the support, the connecting column is of a cylindrical structure, threads are arranged on the outer surface of the connecting column, a cross-shaped groove is formed in the top of the connecting column, and the brain electrode is fixedly connected with the support through the connecting column.
Furthermore, the inner side wall of the circular through hole in the middle of the small-diameter end of the support is provided with a damage prevention sleeve, the damage prevention sleeve is of a circular tubular structure, and the damage prevention sleeve is used for protecting the brain electrode.
Further, the upper part is a cylindrical structure which is made of stainless steel and is hollow inside and is provided with an opening at the lower end, and the lower part is a round tube-shaped structure made of stainless steel.
Furthermore, a rectangular groove is formed in the upper end face of the upper portion.
Through the technical scheme, the invention has the beneficial effects that:
1. the invention is provided with a bracket, the bracket is used for fixing brain electrodes and is fixedly connected with a shell, a plurality of brain electrodes can be arranged in one shell, 3D waveforms can be output by adjusting the plurality of brain electrodes, and the shell is used for protecting the plurality of brain electrodes and the bracket from being damaged in a non-experimental state; the shell comprises an upper part and a lower part, wherein the lower part is of a round tubular structure and is convenient for craniotomy implantation. During operation, the brain electrodes penetrate through the middle circular through hole at the small-diameter end of the support, then the brain electrodes are fixed with the support, the plurality of supports with the brain electrodes are fixed with the fixing plate, and after the brain electrodes are implanted, the upper part and the lower part are finally connected through threads. The upper portion is taken off during the experiment, is connected brain electrode connector and relevant brain check out test set, and is fixed upper portion and lower part at non-experimental stage, and the support all is in the inside of shell with the brain electrode this moment, and the shell can effectively protect brain electrode and support not damaged.
2. The invention is provided with a fixing plate, wherein the upper plane of the fixing plate is provided with a plurality of mounting holes, the mounting holes are all circular through holes, and the mounting holes are in a multilayer annular array by taking the circle center of the fixing plate as a central point. When the bracket with the brain electrodes is installed on the fixing plate, the relative position between the bracket and the bracket can be manually adjusted, so that the brain electrodes can be adjusted through different mounting holes.
Drawings
Fig. 1 is a schematic structural view of an experimental 3D chronic electroencephalogram adjusting apparatus according to the present invention before installation.
Fig. 2 is a schematic structural view of an experimental 3D chronic electroencephalogram adjustment apparatus according to the present invention after being installed.
Fig. 3 is a structural view illustrating a non-installed upper portion of the experimental 3D chronic electroencephalograph adjustment apparatus of the present invention.
Fig. 4 is a schematic view showing the structure of the lower part and the fixing plate of the 3D chronic electroencephalograph adjusting apparatus for experiments according to the present invention.
Fig. 5 is a schematic structural diagram of a bracket, a connecting column and a brain electrode of the experimental 3D chronic brain electrode adjusting device.
Fig. 6 is a schematic diagram of the lower structure of an experimental 3D chronic electroencephalogram adjusting apparatus of the present invention.
The reference numbers in the drawings are as follows: 1 is the lower part, 2 is the fixed plate, 3 is the upper part, 4 is the brain electrode, 5 is the support, 6 is the spliced pole, 7 is the loss prevention cover.
Detailed Description
The invention is further described with reference to the following figures and detailed description:
as shown in fig. 1 to 6, the experimental 3D chronic electroencephalograph adjusting device comprises a plurality of electroencephalographs 4, wherein the plurality of electroencephalographs 4 are all provided with a support 5, the support 5 is used for fixing the electroencephalographs 4, the support 5 is of a stepped cylindrical structure, a circular through hole is formed in the middle of a small-diameter end of the support 5, the electroencephalographs 4 penetrate through the circular through hole to be fixedly connected with the support 5, the support 5 is provided with a shell, and the shell is used for protecting the plurality of electroencephalographs 4 and the support 5 from being damaged in a non-experimental state;
the shell includes upper portion 3 and lower part 1, upper portion 3 is the open cylindrical structure of inside cavity lower extreme, lower part 1 is the pipe-shaped structure, is provided with fixed plate 2 in the lower part 1, fixed plate 2 is the circular slab, and fixed plate 2 and lower part 1 be the integral structure, and a plurality of mounting holes have been seted up on the last plane of fixed plate 2, and are a plurality of the mounting hole is circular through-hole, and a plurality of mounting holes use the centre of a circle of fixed plate 2 to be multilayer annular array as the central point, brain electrode 4 and support 5 pass mounting hole and lower part 1 fixed connection, upper portion 3 and lower part 1 can dismantle the connection through the screw thread.
For optimizing product structure, be convenient for support 5 and fixed plate 2 to dismantle and the installation, a plurality of fixed orificess have all been seted up to the big footpath end and the path end of support 5, the fixed orifices is circular through-hole, the fixed orifices uses the centre of a circle of the big footpath end of support 5 to be the annular array as the central point. Be provided with spliced pole 6 between the planar mounting hole on the fixed orifices of 5 big footpaths ends of support and fixed plate 2, spliced pole 6 is the cylinder structure, and the surface of spliced pole 6 is provided with the screw thread, and the top of spliced pole 6 is provided with cross groove, support 5 passes through spliced pole 6 fixed connection with fixed plate 2.
For optimizing the product structure, be convenient for dismantle and install between support 5 and the brain electrode 4, be provided with spliced pole 6 between the fixed orifices of brain electrode 4 and 5 footpath ends of support, spliced pole 6 is the cylinder structure, and spliced pole 6's surface is provided with the screw thread, and spliced pole 6's top is provided with the cross recess, brain electrode 4 passes through spliced pole 6 fixed connection with support 5.
In order to optimize the product structure and further protect the brain electrode 4 from being damaged, a damage prevention sleeve 7 is arranged on the inner side wall of the circular through hole in the middle of the small-diameter end of the support 5, and the damage prevention sleeve 7 is of a circular tubular structure.
In order to optimize the product structure and improve the biocompatibility of the shell, the upper part 3 is a cylindrical structure which is made of stainless steel and is hollow inside and has an open lower end, and the lower part 1 is a round tube-shaped structure made of stainless steel.
In order to facilitate the removal of the upper part 3, a rectangular groove is formed in the upper end face of the upper part 3.
Before the brain electrode 4 is implanted, the brain electrode 4 is firstly installed, the tail end of the brain electrode 4 penetrates through the damage-preventing sleeve 7 and is placed in the circular through hole at the small diameter end of the support 5, the tail end of the brain electrode 4 penetrates through the support 5, the connector of the brain electrode 4 is placed above the damage-preventing sleeve 7, and the connecting column 6 is installed between the support 5 and the connector of the brain electrode 4 through a tool so as to fix the two connectors. Next, a plurality of the holders 5 to which the brain electrodes 4 are attached are fitted into the casing, the number of the brain electrodes 4 being three in the present embodiment, and the number of the corresponding holders 5 being three, the three brain electrodes 4 providing three-axis coordinate data of X, Y, and Z, respectively. When the brain electrode fixing device is installed, firstly, the tail end of the brain electrode 4 penetrates through the fixing plate 2, after the relative position between the brain electrodes 4 is determined, the connecting column 6 is installed between the fixing hole of the large-diameter end of the support 5 and the installing hole of the fixing plate 2 through a tool, the support 5 is fixed on the upper surface of the fixing plate 2, therefore, the support 5 is fixed with the lower portion 1, and finally, the upper portion 3 and the lower portion 1 are fixed through threads.
When the brain electrode 4 is implanted, a hole is firstly formed in the tested brain area of the experimental body, then the part of the lower part 1 and the tail end of the brain electrode 4 are implanted into the corresponding brain area, and the lower part 1 and the skull of the experimental body are fixed through silica gel after the implantation is finished. In the test, the upper part 3 is separated from the lower part 1, and the connectors of the plurality of brain electrodes 4 provided in the lower part 1 are connected to a detection device, thereby performing the study of stimulating and recording the electrical activity of the brain neurons. During non-experimental periods, the upper part 3 and the lower part 1 are fixed, and the connector of the brain electrode 4 is completely embedded in the casing, so that the brain electrode 4 is prevented from being damaged in the period.
The above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the scope of the invention, so that equivalent changes or modifications in the structure, features and principles of the invention described in the claims should be included in the claims.
Claims (3)
1. The experimental 3D chronic brain electrode adjusting device comprises a plurality of brain electrodes (4), and is characterized in that the brain electrodes (4) are provided with supports (5), the supports (5) are used for fixing the brain electrodes (4), the supports (5) are of stepped cylindrical structures, a circular through hole is formed in the middle of the small-diameter end of each support (5), the brain electrodes (4) penetrate through the circular through holes to be fixedly connected with the supports (5), the supports (5) are provided with shells, and the shells are used for protecting the brain electrodes (4) and the supports (5) from being damaged in a non-experimental state;
the casing comprises an upper part (3) and a lower part (1), the upper part (3) is a cylindrical structure with a hollow interior and an open lower end, the lower part (1) is a circular tube-shaped structure, a fixing plate (2) is arranged in the lower part (1), the fixing plate (2) is a circular plate, the fixing plate (2) and the lower part (1) are of an integrated structure, the upper plane of the fixing plate (2) is provided with a plurality of mounting holes, the mounting holes are all circular through holes, the mounting holes are in a multilayer annular array by taking the circle center of the fixing plate (2) as the central point, the brain electrodes (4) and the support (5) penetrate through the mounting holes to be fixedly connected with the lower part (1), and the upper part (3) and the lower part (1) are detachably connected through threads;
the large-diameter end and the small-diameter end of the support (5) are both provided with a plurality of fixing holes, the fixing holes are circular through holes, and the fixing holes are in an annular array by taking the circle center of the large-diameter end of the support (5) as a center point;
a connecting column (6) is arranged between a fixing hole at the large-diameter end of the support (5) and a mounting hole on the upper plane of the fixing plate (2), the connecting column (6) is of a cylindrical structure, threads are arranged on the outer surface of the connecting column (6), a cross-shaped groove is formed in the top of the connecting column (6), and the support (5) and the fixing plate (2) are fixedly connected through the connecting column (6);
a connecting column (6) is arranged between the brain electrode (4) and a fixing hole at the small-diameter end of the support (5), the connecting column (6) is of a cylindrical structure, threads are arranged on the outer surface of the connecting column (6), a cross-shaped groove is formed in the top of the connecting column (6), and the brain electrode (4) is fixedly connected with the support (5) through the connecting column (6);
the brain electrode protection device is characterized in that a damage prevention sleeve (7) is arranged on the inner side wall of the circular through hole in the middle of the small diameter end of the support (5), the damage prevention sleeve (7) is of a circular tubular structure, and the damage prevention sleeve (7) is used for protecting the brain electrode (4).
2. The experimental 3D chronic brain electrode adjusting device according to claim 1, wherein the upper part (3) is a cylindrical structure made of stainless steel with a hollow inside and an open lower end, and the lower part (1) is a circular tube-shaped structure made of stainless steel.
3. The experimental 3D chronic electroencephalograph adjustment device according to claim 1, wherein the upper end face of the upper part (3) is provided with a rectangular groove.
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| CN201911281676.1A CN111096742B (en) | 2019-12-13 | 2019-12-13 | 3D chronic brain electrode adjusting device for experiments |
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| CN201911281676.1A CN111096742B (en) | 2019-12-13 | 2019-12-13 | 3D chronic brain electrode adjusting device for experiments |
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| CN111096742B true CN111096742B (en) | 2022-10-18 |
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| CN110384859A (en) * | 2019-07-24 | 2019-10-29 | 开封市学国生物科技有限公司 | The self defocusing microelectrode array for recording and stimulating for acute and chronic deep brain signal |
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| JP2013512062A (en) * | 2009-12-01 | 2013-04-11 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ | Microfabricated surface nerve stimulation device and methods of making and using the same |
| CN102334989B (en) * | 2011-07-29 | 2013-03-27 | 上海交通大学 | Different-plane microneedle array brain electrical dry electrode with controllable puncturing depth |
| CN105769182B (en) * | 2016-02-22 | 2018-08-17 | 武汉智普天创科技有限公司 | EEG signals wireless acquisition system |
| CN106236089A (en) * | 2016-09-13 | 2016-12-21 | 科斗（苏州）脑机科技有限公司 | A kind of implanted multi-functional microneedle array brain electrode |
| CN109124626B (en) * | 2018-07-26 | 2021-11-23 | 天津大学 | Novel passive flexible optical electrode |
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| CN110384859A (en) * | 2019-07-24 | 2019-10-29 | 开封市学国生物科技有限公司 | The self defocusing microelectrode array for recording and stimulating for acute and chronic deep brain signal |
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