CN106236089A - A kind of implanted multi-functional microneedle array brain electrode - Google Patents

A kind of implanted multi-functional microneedle array brain electrode Download PDF

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Publication number
CN106236089A
CN106236089A CN201610817579.XA CN201610817579A CN106236089A CN 106236089 A CN106236089 A CN 106236089A CN 201610817579 A CN201610817579 A CN 201610817579A CN 106236089 A CN106236089 A CN 106236089A
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CN
China
Prior art keywords
electrode
detection electrode
brain
electric pulse
pulse stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610817579.XA
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Chinese (zh)
Inventor
徐科飞
冀亮亮
周希
周莉
裴东杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoppers (suzhou) Brain Computer Technology Co Ltd
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Hoppers (suzhou) Brain Computer Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoppers (suzhou) Brain Computer Technology Co Ltd filed Critical Hoppers (suzhou) Brain Computer Technology Co Ltd
Priority to CN201610817579.XA priority Critical patent/CN106236089A/en
Publication of CN106236089A publication Critical patent/CN106236089A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • A61B5/279Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685Microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6868Brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0539Anchoring of brain electrode systems, e.g. within burr hole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Neurology (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The invention discloses a kind of implanted multi-functional microneedle array brain electrode, including outside framework, pcb board, electrode loading plate, electric pulse stimulation electrode, brain electro-detection electrode and electrochemical detection electrode, the lower surface of described outside framework is installed with electrode loading plate, and the lower surface of electrode loading plate is provided with electric pulse stimulation electrode, brain electro-detection electrode and electrochemical detection electrode, it is configured to electrod-array;Wire connecting PCB board is passed through on the top of described electric pulse stimulation electrode, described brain electro-detection electrode and described electrochemical detection electrode, and pcb board uses the mode of gluing to be fixed on the upside of outside framework;The outside of described electric pulse stimulation electrode, described brain electro-detection electrode and described electrochemical detection electrode is all enclosed with up big and down small tapered oversheath, and to post thickness be 0.15mm 0.35mm plaster in the bottom of oversheath.The present invention is possible not only to reduce hair and impacts testing result, meanwhile, effectively carries out anti-inflammation to thrusting position, thus prevents from scalp is caused damage.

Description

A kind of implanted multi-functional microneedle array brain electrode
Technical field
The present invention relates to brain wave acquisition, specifically a kind of implanted multi-functional microneedle array brain electrode.
Background technology
In recent years, continuous along with MEMS (MEMS:Micro-Electro-MechanicalSystems) technology Development and maturation so that the microsystem range of application such as microelectronic device and microsensor constantly expands, and is widely used to the people With fields such as, medical science, military affairs.The research of probe microelectrode based on micro fabrication is developed rapidly.Microelectrode structure Mainly having planar microelectrode and different planar microelectrode and planar microelectrode is assembled into the microelectrode of array configuration, these are different The microelectrode of structure all has respective feature.
Traditional electroencephalogramsignal signal collection equipment is based on wet electrode.User using before electroencephalogramsignal signal collection equipment, Have to coating conductive paste, to reduce the impact of the horny layer EEG signals on collecting.Electrode is also easily used by hair simultaneously Impact, for piercing electrode, scalp wound surface is the most preferably processed.
Summary of the invention
It is an object of the invention to provide a kind of implanted multi-functional microneedle array brain electrode, to solve above-mentioned background technology The problem of middle proposition.
For achieving the above object, the present invention provides following technical scheme: a kind of implanted multi-functional microneedle array brain electrode, Including outside framework, pcb board, electrode loading plate, electric pulse stimulation electrode, brain electro-detection electrode and electrochemical detection electrode, housing The lower surface of frame is installed with electrode loading plate, and the lower surface of electrode loading plate is provided with electric pulse stimulation electrode, brain electricity Detecting electrode and electrochemical detection electrode, be configured to electrod-array;Electric pulse stimulation electrode, brain electro-detection electrode and electrochemistry inspection Wire connecting PCB board is passed through on the top surveying electrode, and pcb board uses the mode of gluing to be fixed on the upside of outside framework;
Preferably, the outside of electric pulse stimulation electrode, brain electro-detection electrode and electrochemical detection electrode is all enclosed with up big and down small Tapered oversheath, and the bottom of oversheath posts the plaster that thickness is 0.15mm-0.35mm.
Preferably, the bottom of electric pulse stimulation electrode, brain electro-detection electrode and electrochemical detection electrode all extends to plaster Bottom outside 0.05mm-0.15mm.
Compared with prior art, the invention has the beneficial effects as follows: the present invention is possible not only to reduce hair and makes testing result Become impact, increase plaster formula structure simultaneously so that overall can effectively resist thrusting position in the process thrusting scalp Bacterium antiinflammatory, thus prevent from scalp is caused damage.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of implanted of the present invention multi-functional microneedle array brain electrode.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments wholely.Based on Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under not making creative work premise Embodiment, broadly falls into the scope of protection of the invention.
Refer to Fig. 1, in the embodiment of the present invention, a kind of implanted multi-functional microneedle array brain electrode, including outside framework 1, Pcb board 2, electrode loading plate 3, electric pulse stimulation electrode 4, brain electro-detection electrode 5 and electrochemical detection electrode 6, outside framework 1 time Surface is installed with electrode loading plate 3, and the lower surface of electrode loading plate 3 is provided with electric pulse stimulation electrode 4, brain electro-detection Electrode 5 and electrochemical detection electrode 6, be configured to electrod-array;Electric pulse stimulation electrode 4, brain electro-detection electrode 5 and electrochemistry inspection Wire connecting PCB board 2 is passed through on the top surveying electrode 6, and pcb board 2 uses the mode of gluing to be fixed on the upside of outside framework 1;Electricity The outside of impulse stimulation electrode 4, brain electro-detection electrode 5 and electrochemical detection electrode 6 be all enclosed with up big and down small tapered outside Sheath 7, and the bottom of oversheath 7 posts the plaster 8 that thickness is 0.15mm-0.35mm;Electric pulse stimulation electrode 4, brain electro-detection The bottom of electrode 5 and electrochemical detection electrode 6 all extends to plaster 8 bottom outside 0.05mm-0.15mm.
The operation principle of the present invention is: during work, and oversheath 7 uses isolation material to make, and utilizes oversheath 7 to prevent hair Interfering electrode, plaster 8 is posted in the bottom of oversheath 7, and plaster 8 uses the ointment with bactericidal action to make, and utilizes medicine Patch 8 is possible to prevent electrode to thrust the wound infection of position, thus avoids scalp damage occur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim Change is included in the present invention.Should not be considered as limiting involved claim by any reference in claim.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment May be appreciated other embodiments.

Claims (3)

1. an implanted multi-functional microneedle array brain electrode, it is characterised in that include a kind of multi-functional microneedle array of implanted Brain electrode, including outside framework, pcb board, electrode loading plate, electric pulse stimulation electrode, brain electro-detection electrode and Electrochemical Detection electricity Pole, the lower surface of described outside framework is installed with electrode loading plate, and the lower surface of electrode loading plate is provided with electric pulse thorn Swash electrode, brain electro-detection electrode and electrochemical detection electrode, be configured to electrod-array;Described electric pulse stimulation electrode, described brain Wire connecting PCB board is passed through on the top of electro-detection electrode and described electrochemical detection electrode, and pcb board uses the mode of gluing admittedly It is scheduled on the upside of outside framework.
Implanted the most according to claim 1 multi-functional microneedle array brain electrode, it is characterised in that: described electric pulse stimulation The outside of electrode, described brain electro-detection electrode and described electrochemical detection electrode is all enclosed with up big and down small tapered outer protect Overlap, and the plaster that thickness is 0.15mm-0.35mm is posted in the bottom of oversheath.
Implanted the most according to claim 1 multi-functional microneedle array brain electrode, it is characterised in that: described electric pulse stimulation The bottom of electrode, described brain electro-detection electrode and described electrochemical detection electrode all extends to plaster bottom outside 0.05mm- 0.15mm。
CN201610817579.XA 2016-09-13 2016-09-13 A kind of implanted multi-functional microneedle array brain electrode Pending CN106236089A (en)

Priority Applications (1)

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Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
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Publications (1)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111096742A (en) * 2019-12-13 2020-05-05 开封市学国生物科技有限公司 3D chronic brain electrode adjusting device for experiments
CN111631813A (en) * 2020-05-27 2020-09-08 武汉联影智融医疗科技有限公司 Automatic sequencing method, sequencing system, equipment and computer-readable storage medium for implantable electrodes
CN117770822A (en) * 2024-01-23 2024-03-29 中国科学院半导体研究所 Patch device based on dry-wet combined microneedle electrode

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102334989A (en) * 2011-07-29 2012-02-01 上海交通大学 Different-plane microneedle array brain electrical dry electrode with controllable puncturing depth
CN102755691A (en) * 2012-06-19 2012-10-31 吉林大学 Medical high-sensitivity micro needle array electrode
CN105561469A (en) * 2015-12-12 2016-05-11 西安交通大学 Implanted multifunctional double-side micro brain electrode array chip
CN105769182A (en) * 2016-02-22 2016-07-20 武汉智普天创科技有限公司 Electroencephalogram signal wireless collecting system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102334989A (en) * 2011-07-29 2012-02-01 上海交通大学 Different-plane microneedle array brain electrical dry electrode with controllable puncturing depth
CN102755691A (en) * 2012-06-19 2012-10-31 吉林大学 Medical high-sensitivity micro needle array electrode
CN105561469A (en) * 2015-12-12 2016-05-11 西安交通大学 Implanted multifunctional double-side micro brain electrode array chip
CN105769182A (en) * 2016-02-22 2016-07-20 武汉智普天创科技有限公司 Electroencephalogram signal wireless collecting system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111096742A (en) * 2019-12-13 2020-05-05 开封市学国生物科技有限公司 3D chronic brain electrode adjusting device for experiments
CN111631813A (en) * 2020-05-27 2020-09-08 武汉联影智融医疗科技有限公司 Automatic sequencing method, sequencing system, equipment and computer-readable storage medium for implantable electrodes
CN117770822A (en) * 2024-01-23 2024-03-29 中国科学院半导体研究所 Patch device based on dry-wet combined microneedle electrode

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