CN111084856A - Traditional Chinese medicine preparation for treating hypertension and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating hypertension and preparation method thereof Download PDF

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Publication number
CN111084856A
CN111084856A CN201811240945.5A CN201811240945A CN111084856A CN 111084856 A CN111084856 A CN 111084856A CN 201811240945 A CN201811240945 A CN 201811240945A CN 111084856 A CN111084856 A CN 111084856A
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parts
traditional chinese
chinese medicine
preparation
water
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陈石良
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a Chinese medicinal preparation for treating hypertension and a preparation method thereof, wherein the raw materials comprise: extracting Prunellae Spica, radix Puerariae, rhizoma Gastrodiae, Eucommiae cortex, Coptidis rhizoma, radix astragali, fructus crataegi, Saviae Miltiorrhizae radix and semen Cassiae with water and ethanol, concentrating under reduced pressure, vacuum drying, pulverizing, selecting enteric capsule shell, and making into enteric capsule; the traditional Chinese medicine is prepared from 9 pure natural traditional Chinese medicines, has excellent formula, low cost and no toxic or side effect, has the best effect on the headache, dizziness, bitter taste in mouth, insomnia, vexation, numbness of hands and feet, deafness, tinnitus and the like of the existing hypertension patients, and has the effective rate of over 98 percent and the cure rate of over 90 percent.

Description

Traditional Chinese medicine preparation for treating hypertension and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating hypertension and a preparation method thereof.
Background
Hypertension is a disease of persistent hypertension, which causes diseases such as stroke, heart disease, hemangioma, renal failure, etc., and is a systemic disease characterized by an increase in arterial pressure and accompanied by functional or organic changes in organs such as heart, blood vessels, brain and kidney, and is classified into primary hypertension and secondary hypertension. The causes of hypertension are many, and can be divided into genetic and environmental aspects. Along with the improvement of living standard of people, hypertension people are gradually enlarged and younger, and the main reasons are that people do not pay attention to self dietary habits, eat foods with overhigh cholesterol excessively, drink excessively, pay no attention to sleep rest, lack of exercise and the like. The existing clinical blood pressure reduction generally adopts western medicine treatment, and the blood pressure reduction western medicines on the market are various, generally comprise heartache, nimodipine, byciclovir, captopril, lotusin, valsartan, losartan, atenolol, betalaxel, daliflu-quan, terazosin and the like, but are accompanied by side effects and dependence of different degrees, most of the patients with hypertension are old people, and excessive side effects are not beneficial to the health of the old people.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides the traditional Chinese medicine preparation for treating hypertension, which has quick drug effect and shortens the medicine taking time of patients, and the preparation method thereof.
The technical scheme of the invention is realized as follows: a traditional Chinese medicine preparation for treating hypertension is prepared from the following raw materials: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts, 10-20 parts, 3-5 parts, 3-4 parts, 5-8 parts, 6-8 parts, 5-6 parts, 10-12 parts and 10-12 parts.
A preparation method of a traditional Chinese medicine preparation for treating hypertension comprises the following steps: soaking Spica Prunellae, radix Puerariae, rhizoma Gastrodiae, cortex Eucommiae, rhizoma Coptidis, radix astragali, fructus crataegi, radix Salviae Miltiorrhizae, and semen Cassiae in water for 30 min, ultrasonic extracting at 55 deg.C twice, wherein the water content is 10 times that of water for 40 min, and the water content is 8 times that of water for 40 min, filtering, mixing filtrates, concentrating at 55-60 deg.C under reduced pressure to 60 deg.C extract with density of 1.15, adding 95% ethanol to make alcohol content reach 70%, standing overnight, collecting supernatant at 55-60 deg.C, recovering ethanol under reduced pressure, concentrating to 60 deg.C extract with relative density of 1.3, adding microcrystalline cellulose, stirring, mixing, vacuum drying at 55-60 deg.C, taking out, pulverizing, and sieving with 20 mesh sieve to obtain powder; and (4) selecting an enteric capsule shell, and powdering to prepare the enteric capsule.
The technical scheme of the invention has the following positive effects: the traditional Chinese medicine composition has the advantages of excellent raw material formula, low cost and no toxic or side effect, and has the best effect on the existing hypertension patients with headache, dizziness, bitter taste, insomnia, vexation, numbness of hands and feet, deafness, tinnitus and the like.
Detailed Description
Example 1
A traditional Chinese medicine for treating hypertension is prepared from the following raw materials: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 grams, 3 grams, 5 grams, 6 grams, 5 grams, 10 grams.
The preparation method of the traditional Chinese medicine preparation comprises the following steps: soaking Spica Prunellae, radix Puerariae, rhizoma Gastrodiae, cortex Eucommiae, rhizoma Coptidis, radix astragali, fructus crataegi, radix Salviae Miltiorrhizae, and semen Cassiae in water for 30 min, ultrasonic extracting at 55 deg.C twice, wherein the water content is 10 times that of water for 40 min, and the water content is 8 times that of water for 40 min, filtering, mixing filtrates, concentrating at 55-60 deg.C under reduced pressure to obtain 60 deg.C extract with density of 1.15, adding 95% ethanol to make alcohol content reach 70%, standing overnight, collecting supernatant at 55-60 deg.C, recovering ethanol under reduced pressure, concentrating to obtain 60 deg.C extract with relative density of 1.3, adding appropriate amount of microcrystalline cellulose, stirring, mixing well, vacuum drying at 55-60 deg.C, taking out, pulverizing, and sieving with 20 mesh sieve to obtain; and (3) selecting an enteric capsule shell, and powdering to prepare the enteric capsule, wherein each capsule is 0.6 g.
Example 2
A traditional Chinese medicine for treating hypertension is prepared from the following raw materials: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 grams, 20 grams, 5 grams, 4 grams, 8 grams, 6 grams, 12 grams.
The preparation method of the traditional Chinese medicine preparation comprises the following steps: soaking Spica Prunellae, radix Puerariae, rhizoma Gastrodiae, cortex Eucommiae, rhizoma Coptidis, radix astragali, fructus crataegi, radix Salviae Miltiorrhizae, and semen Cassiae in water for 30 min, ultrasonic extracting at 55 deg.C twice, wherein the water content is 10 times that of water for 40 min, and the water content is 8 times that of water for 40 min, filtering, mixing filtrates, concentrating at 55-60 deg.C under reduced pressure to obtain 60 deg.C extract with density of 1.15, adding 95% ethanol to make alcohol content reach 70%, standing overnight, collecting supernatant at 55-60 deg.C, recovering ethanol under reduced pressure, concentrating to obtain 60 deg.C extract with relative density of 1.3, adding appropriate amount of microcrystalline cellulose, stirring, mixing, vacuum drying at 55-60 deg.C, taking out, pulverizing, and sieving with 20 mesh sieve to; and (3) selecting an enteric capsule shell, and powdering to prepare the enteric capsule, wherein each capsule is 0.6 g.
Example 3
The traditional Chinese medicine for treating hypertension is prepared from the following raw materials: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12.5 g, 15 g, 4 g, 3.5 g, 6.5 g, 7 g, 5-6 parts, 11 g and 11 g.
The preparation method of the traditional Chinese medicine preparation comprises the following steps: soaking Spica Prunellae, radix Puerariae, rhizoma Gastrodiae, cortex Eucommiae, rhizoma Coptidis, radix astragali, fructus crataegi, radix Salviae Miltiorrhizae, and semen Cassiae in water for 30 min, ultrasonic extracting at 55 deg.C twice, wherein the water content is 10 times that of water for 40 min, and the water content is 8 times that of water for 40 min, filtering, mixing filtrates, concentrating at 55-60 deg.C under reduced pressure to obtain 60 deg.C extract with density of 1.15, adding 95% ethanol to make alcohol content reach 70%, standing overnight, collecting supernatant at 55-60 deg.C, recovering ethanol under reduced pressure, concentrating to obtain 60 deg.C extract with relative density of 1.3, adding appropriate amount of microcrystalline cellulose, stirring, mixing, vacuum drying at 55-60 deg.C, taking out, pulverizing, and sieving with 20 mesh sieve to obtain; and (3) selecting an enteric capsule shell, and powdering to prepare the enteric capsule, wherein each capsule is 0.6 g.

Claims (2)

1. A traditional Chinese medicine preparation for treating hypertension is prepared from the following raw materials: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: : 10-15 parts, 10-20 parts, 3-5 parts, 3-4 parts, 5-8 parts, 6-8 parts, 5-6 parts, 10-12 parts and 10-12 parts.
2. A method for preparing the traditional Chinese medicine preparation for treating hypertension according to claim 1, which is characterized by comprising the following steps: the preparation method comprises the following steps: soaking Spica Prunellae, radix Puerariae, rhizoma Gastrodiae, cortex Eucommiae, rhizoma Coptidis, radix astragali, fructus crataegi, radix Salviae Miltiorrhizae, and semen Cassiae in water for 30 min, ultrasonic extracting at 55 deg.C twice, wherein the water content is 10 times that of water for 40 min, and the water content is 8 times that of water for 40 min, filtering, mixing filtrates, concentrating at 55-60 deg.C under reduced pressure to 60 deg.C extract with density of 1.15, adding 95% ethanol to make alcohol content reach 70%, standing overnight, collecting supernatant at 55-60 deg.C, recovering ethanol under reduced pressure, concentrating to 60 deg.C extract with relative density of 1.3, adding microcrystalline cellulose, stirring, mixing, vacuum drying at 55-60 deg.C, taking out, pulverizing, and sieving with 20 mesh sieve to obtain powder; and (4) selecting an enteric capsule shell, and powdering to prepare the enteric capsule.
CN201811240945.5A 2018-10-24 2018-10-24 Traditional Chinese medicine preparation for treating hypertension and preparation method thereof Pending CN111084856A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663030A (en) * 2021-09-14 2021-11-19 威海德尚医中医药科技有限公司 Formula for purifying and reducing blood pressure of traditional Chinese medicine Baicao and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663030A (en) * 2021-09-14 2021-11-19 威海德尚医中医药科技有限公司 Formula for purifying and reducing blood pressure of traditional Chinese medicine Baicao and preparation method thereof

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Application publication date: 20200501