CN111084382A - Instant plant-based emulsion special for inflammatory bowel diseases and preparation method thereof - Google Patents
Instant plant-based emulsion special for inflammatory bowel diseases and preparation method thereof Download PDFInfo
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- CN111084382A CN111084382A CN202010040183.5A CN202010040183A CN111084382A CN 111084382 A CN111084382 A CN 111084382A CN 202010040183 A CN202010040183 A CN 202010040183A CN 111084382 A CN111084382 A CN 111084382A
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- grain
- inflammatory bowel
- oil
- parts
- based emulsion
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/20—Malt products
- A23L7/25—Fermentation of cereal malt or of cereal by malting
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a special instant plant-based emulsion for inflammatory bowel diseases and a preparation method thereof, which comprises the steps of germinating and fermenting whole grains, concentrating, drying, grinding, crushing to prepare germinated and fermented grain superfine powder, mixing with spirulina polysaccharide, aureobasidium polysaccharide and soybean protein peptide, adding water, and carrying out colloid milling to obtain grain mixed slurry; adding emulsifier into the compound vegetable oil to obtain emulsion oil phase component; mixing the grain mixed pulp with the emulsion oil phase components, adding compound mineral, compound vitamin, and pericarpium Granati extract, stirring, grinding with colloid mill, homogenizing under high pressure, sterilizing, and packaging. The invention combines N-3 with N-6 unsaturated fatty acid to enhance the immunity of the organism and has anti-inflammatory effect, the whole grain food is germinated and fermented, the nutrition is easy to absorb, the quantity of beneficial bacteria in intestinal flora is increased, the proportion of pathogenic bacteria is reduced, the level of intestinal tract and systemic inflammatory factors is reduced, the invention is an ideal substitute of animal-derived food, and the special nutritional requirement of patients with inflammatory bowel disease is met.
Description
Technical Field
The invention belongs to the technical field of food processing, and particularly relates to a special instant plant-based emulsion for inflammatory bowel diseases and a preparation method thereof.
Background
Inflammatory Bowel Disease (IBD) is enteritis and colitis caused by bacteria, viruses, fungi, and parasites. Is a serious gastrointestinal disease, is difficult to cure and easy to relapse, and has the conditions of continuously rising morbidity, gradually aging onset age and the like. The main pathological mechanism of inflammatory bowel disease is not well defined, and the pathogenesis of inflammatory bowel disease is multifaceted, such as genetic factors and environmental factors, which can cause intestinal innate and adaptive mucosal immune response.
In recent years, plant-based products have become increasingly popular with consumers. Especially whole grain food, its probiotic effect is more and more appreciated. Although the pathogenesis of IBD is still unclear, in recent years, as related studies are continuously carried out, intestinal flora imbalance is prevalent among IBD patients and is considered to be a main cause of IBD. Researches show that intestinal bacteria disorder can cause abnormal immune response to cause inflammatory mucosal injury of colon tissues; and improving intestinal flora can effectively regulate the intestinal mucosa immune system, relieve intestinal inflammatory injury and enhance the intestinal barrier function. Therefore, by ingesting prebiotics, the symptoms of IBD patients are improved, and this can be an important means for the adjuvant dietary therapy of inflammatory bowel diseases.
Although the whole grain contains a large amount of prebiotics, which is beneficial to adjusting and optimizing the intestinal flora structure of animals and human bodies, the bran of the whole grain contains anti-nutrient substances such as phytic acid, which can increase the intestinal burden of IBD patients and aggravate diarrhea. Although our country has achieved some achievements in the research of whole grains, on the whole, there are relatively few varieties, and there are not many products that can really reach the production scale. Therefore, the development of medical products related to inflammatory bowel disease by using whole grains needs to reasonably optimize the formula and the preparation process.
Compared with the traditional powder product-shaped instant food, the emulsion product has the characteristic of instant uncovering and is more convenient to use. Based on the whole grain rich in prebiotics, the emulsion product with stable quality and meeting the special nutritional requirements of inflammatory bowel disease is developed, can fill the blank of the current domestic related product forms, and meets the nutritional support requirements of a large number of patients with inflammatory bowel disease.
Disclosure of Invention
Aiming at the problem of the prior art that special food and related emulsifier products specially for patients with inflammatory bowel diseases are deficient, the invention provides the special instant plant-based emulsion for the inflammatory bowel diseases and the preparation method thereof.
The invention is realized by the following technical scheme:
the instant plant-based emulsion special for inflammatory bowel diseases is characterized by comprising the following raw materials in parts by weight: 20-50 parts of whole grain germinated fermentation superfine powder, 10-30 parts of compound vegetable oil and 0.5-5 parts of emulsifier.
Furthermore, the raw materials also comprise 10-30 parts of soybean protein peptide, 10-30 parts of spirulina polysaccharide, 5-20 parts of pomegranate peel polyphenol extract, 1-10 parts of aureobasidium polysaccharide and 0.5-1 part of stabilizer.
Furthermore, the raw materials also comprise more than one of compound minerals, compound vitamins and flavoring agents.
Further, the whole grain is more than one of quinoa, millet and rice.
Furthermore, the grain diameter of the whole grain submicron powder is 18-20 μm.
Further, the compound vegetable oil is formed by mixing A, B groups according to the mass ratio of 1: 1; the group A vegetable oil is more than one of soybean oil, peanut oil and rapeseed oil; the B group vegetable oil is more than one of chia seed oil, linseed oil, olive oil and walnut oil.
Among unsaturated fatty acids (PUFA), N-3 unsaturated fatty acids and N-6 unsaturated fatty acids play an important role in human bodies, wherein the N-6 unsaturated fatty acids are rich in sources (soybean oil, peanut oil and rapeseed oil) and low in price, but have a certain promotion effect on body immunity and enhance inflammatory reaction, the N-3 unsaturated fatty acids (chia seed oil, linseed oil, olive oil and walnut oil) have an immunosuppressive effect and reduce inflammatory reaction, and the two unsaturated fatty acids can act together to regulate the viscosity of blood and prevent bleeding or blood coagulation at inflammatory parts.
Further, the emulsifier is at least two of lecithin, sucrose fatty acid ester, monoglyceride and capric triglyceride; the plant-based emulsion is a natural cereal raw material, belongs to a complex food system, is compounded by adopting a plurality of emulsifiers, can adjust the HLB of the composite emulsifier, and can better match various emulsifying objects in the system.
Further, the stabilizer is at least one of xanthan gum, konjac gum and guar gum.
In the invention, the preparation method of the special instant plant-based emulsion for the inflammatory bowel disease comprises the following steps:
(1) soaking and cleaning whole grains, spreading on a soaked cotton cloth, germinating for 12-24 hours at 20-28 ℃, drying for 12-24 hours at 40-55 ℃, grinding to obtain germinated whole grain powder, and adding a mixture of the germinated whole grain powder and grain raw materials in a weight ratio of 1: steaming 1-3 parts of water for 5-15 minutes, cooling to room temperature, adding a leavening agent, uniformly stirring, fermenting at 37 ℃ for 24-48 hours to obtain germinated fermented grain pulp, concentrating, drying, grinding, and performing superfine grinding to prepare germinated fermented grain superfine powder with the grain size of 18-20 microns;
(2) mixing the germinated fermented grain superfine powder with spirulina polysaccharide, aureobasidium polysaccharide and soybean protein peptide, adding water according to the material-liquid ratio of 1: 3-6, stirring for 10-15min, and colloid milling to obtain grain mixed slurry;
(3) keeping the temperature of the compound vegetable oil at 55-65 ℃ for half an hour, adding the water-soluble emulsifier, continuously stirring for 10-20min to obtain an emulsion oil phase component, and keeping the temperature at 55-65 ℃ for later use;
(4) heating the grain mixed slurry prepared in the step (2) to 55-65 ℃, adding 3-6 times of volume of water and a stabilizer, stirring for 15-20min, adding the emulsion oil phase component prepared in the step (3), keeping the temperature at 55-65 ℃, stirring for 3-5 min, adding the compound mineral, the compound vitamin and the pomegranate peel extract, continuously stirring and uniformly mixing for 5-10min at 55-65 ℃, grinding for 2-3 times by using a colloid mill, homogenizing for 2-3 times under 25-35MPa by using a high-pressure homogenizer, sterilizing and packaging uniformly to obtain the instant plant-based emulsion special for the inflammatory bowel disease.
Further, the fermentation inoculum in step (1) is lactobacillus plantarum powder, and the inoculation concentration is 10 per 1L of grain pulp5-107cfu。
Whole grain refers to whole, crushed or tabletted grain, which basically comprises starchy endosperm, germ and cortex, and not only contains abundant B vitamins, magnesium, iron and dietary fiber, but also contains common antioxidant ingredients such as polyphenol, vitamin E, tannin, carotenoid, phytic acid, lignin and lignan, and also contains antioxidant ingredients which are rare in some fruit and vegetable foods but have high nutritional values, such as gamma-oryzanol, alkylresorcinol, avenanthramide and the like. The sprouted grain is a novel functional food, which not only contains various bioactive components such as gamma-aminobutyric acid and glutathione, but also is easy to digest and absorb by human bodies after the sprouted grain, and not only generates a plurality of physiological metabolic changes such as activation and generation of enzyme and recovery of cell physiological activity in the process of the sprouted grain, but also can improve the nutritional quality of the grain, such as improving the composition of amino acid, improving the utilization rate of protein, increasing the content of B vitamins, reducing anti-nutritional factors and the like. A large amount of beneficial secondary metabolites are generated in the later lactobacillus plantarum fermentation process, and the flora regulating function of the whole grain food is further enhanced. Compared with non-whole grain or non-germinated and fermented whole grain food, the germinated and fermented specific grain food can effectively increase the number of beneficial bacteria in intestinal flora and reduce the proportion of conditional pathogenic bacteria in the flora, so that the levels of intestinal tract and systemic inflammatory factors are reduced, and the effect of preventing or assisting in treating inflammatory bowel diseases is achieved. Although China has achieved some achievements in the research of the sprouted grains, on the whole, the varieties are relatively few, and few products which can really reach the production scale are obtained.
Advantageous effects
(1) According to the plant-based raw materials adopted in the invention, the N-3 unsaturated fatty acid and the N-6 unsaturated fatty acid are used in a matching manner, so that the immunity of the organism is enhanced, the anti-inflammatory effect is enhanced, the viscosity of blood in an intestinal tract is adjusted, and bleeding or blood coagulation at an inflammation part is prevented;
(2) the invention carries out germination and fermentation treatment on the full-grain food with rich nutrition, the nutrient components are easy to be digested and absorbed by human bodies, the specific grain food subjected to germination and fermentation can effectively increase the number of beneficial bacteria in intestinal flora and reduce the proportion of conditional pathogenic bacteria in the flora, thereby reducing the level of intestinal tract and systemic inflammatory factors, playing a role in preventing or assisting in treating inflammatory bowel diseases, maintaining the epithelial structure of small intestine, being an ideal substitute for animal-derived food, and completely meeting the special nutritional requirements of patients with inflammatory bowel diseases.
Drawings
FIG. 1 shows the body weight change of mice during induction;
FIG. 2 is the change in Disease Activity Index (DAI) in mice during induction;
FIG. 3 is a graph showing the pathological staining results of the colon tissue of the mouse in example 1;
FIG. 4 is a graph showing the result of pathological staining of colon tissue in a mouse of comparative example 1;
FIG. 5 is a graph showing the result of pathological staining of colon tissue in a mouse of comparative example 2;
FIG. 6 is a graph showing the result of pathological staining of colon tissue in a mouse of comparative example 3;
FIG. 7 is a graph showing the result of pathological staining of colon tissue in a mouse of comparative example 4;
FIG. 8 is a graph showing the result of pathological staining of colon tissue in a mouse according to comparative example 5;
FIG. 9 is a graph showing the change in the phylum Proteobacteria (Proteobacteria) in the mouse gut during induction;
FIG. 10 shows the variation of the pathogenic bacterium Shigella coli (Escherichia-Shigella) in the mouse gut during induction;
FIG. 11 shows the variation of beneficial lactic acid bacteria (Lactobacillus) in the mouse intestinal tract during induction;
FIG. 12 shows the change of Bifidobacterium (beneficial bacterium) in the mouse intestinal tract during induction.
Detailed Description
For better understanding of the present invention, the technical solution of the present invention will be described in detail with specific examples, but the present invention is not limited thereto.
The compound vitamin used in the embodiment of the invention is compound vitamin powder, comprising vitamin C, vitamin A, vitamin D2, vitamin B11, riboflavin, vitamin B6, nicotinamide, dexpanthenol, vitamin E, folic acid, biotin and vitamin B12; the compound mineral comprises calcium, potassium, magnesium, ferrum, copper, zinc, manganese, iodine, selenium, nickel, etc.
The parts in the examples of the present invention are parts by weight.
Example 1
The raw materials of the instant plant-based emulsion special for inflammatory bowel diseases comprise: 30 parts of whole-grain superfine powder, 10 parts of compound vegetable oil (soybean oil and 10 parts of linseed oil), 20 parts of soybean protein peptide, 20 parts of spirulina polysaccharide, 10 parts of pomegranate bark polyphenol extract, 8 parts of aureobasidium polysaccharide, 2 parts of emulsifier (lecithin and 1 part of sucrose fatty acid ester), 0.4 part of stabilizer (xanthan gum and 0.4 part of konjac glucomannan), 3 parts of compound vitamin, 10 parts of compound mineral substance and 0.5 part of essence.
A preparation method of a special instant plant-based emulsion for inflammatory bowel diseases comprises the following steps:
(1) soaking and cleaning millet, spreading on soaked cotton cloth, germinating for 20 hours at 25 ℃, drying for 20 hours at 50 ℃, grinding to obtain germinated whole millet powder, and adding the components in an amount which is 1:3, steaming for 10 minutes, cooling to room temperature, and adding 5 × 106Uniformly stirring cfu lactobacillus plantarum powder, fermenting for 36 hours at 37 ℃ to obtain germinated fermented millet pulp, concentrating, drying, grinding, and carrying out superfine grinding treatment on the germinated fermented millet powder by using a superfine grinder to prepare germinated fermented millet superfine powder with the particle size of 18-20 microns;
(2) mixing germinated and fermented millet superfine powder with spirulina polysaccharide, aureobasidium polysaccharide and soybean protein peptide, adding water according to the material-liquid ratio of 1:5, stirring for 12min, and colloid milling to obtain millet mixed slurry;
(3) keeping the temperature of the compound vegetable oil at 60 ℃ for half an hour, adding a water-soluble emulsifier (the emulsifier can be dissolved just by adding water), continuously stirring for 10-20min to obtain an emulsion oil phase component, and keeping the temperature at 60 ℃ for later use;
(4) adding 3 times of water into the millet mixed slurry prepared in the step (2), heating to 60 ℃, adding a stabilizer, stirring for 15min, adding the emulsion oil phase component prepared in the step (3), keeping the temperature at 60 ℃ and stirring for 5min, adding a mineral mixture, a vitamin mixture and a pomegranate peel extract, continuously stirring and uniformly mixing for 8min at 60 ℃, passing through a colloid mill for 2 times, homogenizing for 2 times under high pressure of a high-pressure homogenizer at 35MPa, sterilizing and packaging to obtain the instant plant-based emulsion special for the inflammatory bowel disease.
Example 2
The raw materials of the instant plant-based emulsion special for inflammatory bowel diseases comprise: 40 parts of white chenopodium quinoa, 12.5 parts of compound vegetable oil (peanut oil and 12.5 parts of olive oil), 10 parts of soybean protein peptide, 20 parts of spirulina polysaccharide, 10 parts of pomegranate peel polyphenol extract, 5 parts of aureobasidium polysaccharide, 3 parts of emulsifier (lecithin and 2 parts of capric triglyceride), 3 parts of compound vitamin, 10 parts of compound mineral substance and 0.5 part of essence.
A preparation method of a special instant plant-based emulsion for inflammatory bowel diseases comprises the following steps:
(1) mixing fructus Chenopodii Trifoliatae and semen Tritici AestiviSoaking, cleaning, spreading on soaked cotton cloth, germinating at 25 deg.C for 20 hr, oven drying at 50 deg.C for 20 hr, grinding to obtain germinated quinoa wheat flour, adding the above materials in a weight ratio of 1: 2, steaming for 10 minutes, cooling to room temperature, and adding 107Uniformly stirring cfu lactobacillus plantarum powder, fermenting for 36 hours at 37 ℃ to obtain germinated fermented quinoa wheat pulp, concentrating, drying, grinding, and carrying out superfine grinding treatment on the germinated fermented quinoa wheat powder by using a superfine grinder to prepare germinated fermented quinoa superfine powder with the particle size of 18-20 microns;
(2) mixing the germinated and fermented quinoa micropowder with spirulina polysaccharide, aureobasidium pullulans polysaccharide and soybean protein peptide, adding water according to the material-liquid ratio of 1: 6, stirring for 10-15min, and colloid milling to obtain quinoa mixed slurry;
(3) keeping the temperature of the compound vegetable oil at 60 ℃ for half an hour, adding a water-soluble emulsifier (the emulsifier can be dissolved just by adding water), continuously stirring for 15min to obtain an emulsion oil phase component, and keeping the temperature at 60 ℃ for later use;
(4) adding 3 times of water into the quinoa mixed slurry prepared in the step (2), heating to 60 ℃, adding a stabilizer, stirring for 18min, adding the emulsion oil phase component prepared in the step (3), keeping the temperature at 60 ℃, stirring for 5min, adding a mineral mixture, a vitamin mixture and a pomegranate peel extract, continuously stirring and uniformly mixing for 8min at 60 ℃, passing through a colloid mill for 2 times, homogenizing for 3 times under 30MPa by a high-pressure homogenizer, sterilizing and packaging to obtain the instant plant-based emulsion special for the inflammatory bowel disease.
Example 3
The raw materials of the instant plant-based emulsion special for inflammatory bowel diseases comprise: 20 parts of rice, 5 parts of compound vegetable oil (soybean oil and 5 parts of walnut oil), 20 parts of soybean protein peptide, 15 parts of spirulina polysaccharide, 10 parts of pomegranate bark polyphenol extract, 5 parts of aureobasidium polysaccharide, 1 part of emulsifier (sucrose fatty acid ester and 1 part of capric triglyceride), 0.6 part of stabilizer (xanthan gum), 3 parts of vitamin complex, 10 parts of compound mineral substance and 0.5 part of essence.
A preparation method of a special instant plant-based emulsion for inflammatory bowel diseases comprises the following steps:
(1) soaking rice, cleaning, spreading on soaked cotton cloth, 2Germinating at 5 ℃ for 18 hours, drying at 50 ℃ for 15 hours, grinding to obtain germinated rice flour, adding the germinated rice flour and the cereal raw materials in a weight ratio of 1:3, steaming for 8 minutes, cooling to room temperature, and adding 106Uniformly stirring cfu lactobacillus plantarum powder, fermenting for 30 hours at 37 ℃ to obtain germinated fermented rice slurry, concentrating, drying, grinding, and carrying out superfine grinding treatment on the germinated fermented rice by using a superfine grinder to prepare germinated fermented rice superfine powder with the particle size of 18-20 microns;
(2) mixing the germinated fermented rice superfine powder with spirulina polysaccharide, aureobasidium polysaccharide and soybean protein peptide, adding water according to the material-liquid ratio of 1:4, stirring for 12min, and carrying out colloid milling to obtain rice mixed slurry;
(3) keeping the temperature of the compound vegetable oil at 60 ℃ for half an hour, adding a water-soluble emulsifier (the emulsifier can be dissolved just by adding water), continuously stirring for 12min to obtain an emulsion oil phase component, and keeping the temperature at 60 ℃ for later use;
(4) adding 4 times of volume of water into the rice mixed pulp prepared in the step (2), heating to 60 ℃, adding a stabilizer, stirring for 15min, adding the emulsion oil phase component prepared in the step (3), keeping the temperature at 60 ℃ and stirring for 3 min, adding a mineral mixture, a vitamin mixture and a pomegranate peel extract, continuously stirring and uniformly mixing for 5min at 60 ℃, passing through a colloid mill for 2 times, homogenizing for 2 times at 30MPa by a high-pressure homogenizer, sterilizing and packaging to obtain the instant plant-based emulsion special for the inflammatory bowel disease.
Comparative example 1:
the procedure of example 1 was repeated except that the peeled foxtail millet was replaced with the foxtail millet in example 1, and the germination treatment was not performed.
Comparative example 2
The procedure of example 1 was repeated except that the millet in example 1 was not subjected to germination treatment.
Comparative example 3
The same procedure as in example 1 was repeated except that the millet in example 1 was not subjected to saccharification and fermentation treatment.
Comparative example 4
The compound oil in example 1 was replaced with one of soybean oil, peanut oil and rapeseed oil, and the rest was the same as in example 1.
Comparative example 5
The composite oil of example 1 was replaced with one of chia seed oil, linseed oil, olive oil and walnut oil, and the other operations were the same as example 1.
Animal experiments
60 7-week-old C57BL/6 male mice were randomized into 6 groups and adjusted twice for body weight to ensure that the average body weight of each group was close. After one week of adaptive standard feed feeding, the emulsion products described in example 1 and comparative examples 1 to 5 were changed to the standard feed, and the standard feed was fed for one week while the inflammatory bowel disease induction was performed for five days by adding 3% dextran sulfate to drinking water, and the body weight change tendency and disease activity index were recorded during the induction period. Dissecting a mouse at the end of the induction period, fixing colon tissues, carrying out H & E staining after paraffin embedding, and observing the damage degree of the colon epithelial structure by a microscope; five mice are randomly selected in each group, the whole cecum is taken, total DNA is extracted, a library is built after two rounds of PCR amplification, and the composition of the intestinal flora of the mice is identified by 16s rRNA sequencing.
1. Body weight changes during disease induction in mice
Weight change during the onset of enteritis is an important indicator of disease severity. The weight loss rate calculation method is as follows:
FIG. 1 shows the rate of weight loss of mice during induction, with higher rates of weight loss indicating more severe disease progression in the mice. FIG. 1 shows that the body weight of the mice in the group of example 1 is almost maintained unchanged by the fifth day of induction, which indicates that the emulsion product of the present invention has a significant effect of preventing enteritis; the mice in the comparative example 1 had the highest weight loss rate, indicating that the whole grain status is critical to preventing enteritis in the mice; the weight loss rates of the mice of comparative examples 2 and 3 were higher than example 1, but lower than comparative example 1, indicating that the pretreatment of whole grain had a great effect on the function of the emulsion of the present invention, wherein the weight loss rate of the comparative example 2 group was higher than that of the comparative example 3 group, indicating that the fermentative saccharification treatment was more critical for reducing the rapid weight loss during the onset of enteritis than the germination treatment; comparative example 4 the group of comparative example 5 had a lower rate of weight loss compared to comparative example 5, indicating that the intake of soybean oil, peanut oil and rapeseed oil was more beneficial for weight maintenance.
2. Disease Activity index Change during disease Induction in mice
The disease activity index of the mouse during the induction period of the disease is obtained by respectively scoring and adding three indexes of the mouse fecal state, the mouse rectal bleeding state and the mouse weight loss state, and the scoring standards are as shown in the following table 1:
TABLE 1 mouse Disease Activity Index Scoring Standard Table (Disease activity Index, DAI)
According to the standard, the results of disease activity index in mice during induction of enteritis are shown in figure 1: the disease activity of the group of example 1 was lower than that of all the comparative groups, indicating that the emulsion of the present invention is effective in alleviating inflammatory bowel disease symptoms; the group of comparative example 1 exhibited the most severe symptoms, indicating that the effect of whole grain status on symptom relief was not negligible; the four remaining groups of comparative examples, which are evaluated as comparative example 2> comparative example 5> comparative example 4> comparative example 3 for the function of relieving enteritis symptoms, illustrate that the grain pretreatment and the oil-and-fat balance ratio bacteria in the examples have certain influence on the symptom relieving effect of the emulsion.
3. H & E staining results of mouse colonic epithelium
Pathological staining results of colon tissues of mice are shown in fig. 3-8, and in the mice fed with the diets of the example 1, the colon epithelial tissue structure is complete, goblet cells are intact, and no obvious colon injury is seen; in the comparative example 1, complete colon epithelial tissue structure is difficult to observe under a microscope, goblet cells are completely disappeared, inflammatory cells are infiltrated in a large area, and the fact that compared with whole grains, peeled refined grains cannot play a role in preventing colitis; compared example 2 and comparative example 3, the damage of colon epithelium of the mouse is serious, most goblet cells disappear, and inflammatory cell infiltration is obvious, which shows that the process of germination or fermentation saccharification is crucial to the efficacy of the emulsion; comparative example 4 and comparative example 5, the colonic status of the mice was significantly better than comparative examples 2 and 3, with comparative example 4 being slightly worse, indicating that chia, linseed, olive and walnut oils are superior to soybean, peanut and rapeseed oils for colonic lesions.
4. Changes in intestinal flora in mice
The composition of the mouse intestinal flora is identified, and the results are shown in fig. 9-12, and as can be seen from fig. 9-12, compared with the comparative example, the composition of the mouse intestinal flora in example 1 can effectively inhibit the growth of Proteobacteria (Proteobacteria) and Shigella coli (Escherichia-Shigella) related to enteritis, and simultaneously promote the growth of beneficial bacteria Lactobacillus (Lactobacillus) and Bifidobacterium (Bifidobacterium).
Claims (9)
1. The instant plant-based emulsion special for inflammatory bowel diseases is characterized by comprising the following raw materials in parts by weight: 20-50 parts of whole grain germinated fermentation superfine powder, 10-30 parts of compound vegetable oil and 0.5-5 parts of emulsifier.
2. The instant plant-based emulsion special for inflammatory bowel diseases according to claim 1, wherein the raw materials further comprise 10-30 parts of soybean protein peptide, 10-30 parts of spirulina polysaccharide, 5-20 parts of pomegranate peel polyphenol extract, 1-10 parts of aureobasidium polysaccharide and 0.5-1 part of stabilizer.
3. The instant plant-based emulsion for inflammatory bowel disease according to claim 1 or 2, wherein the raw material further comprises one or more of complex minerals, complex vitamins and flavoring agents.
4. The instant plant-based emulsion for inflammatory bowel disease according to claim 1, wherein the whole grain is one or more of quinoa, millet and rice.
5. The special instant plant-based emulsion for inflammatory bowel diseases according to claim 1, wherein the particle size of the whole grain submicron powder is 18-20 μm.
6. The instant plant-based emulsion special for inflammatory bowel diseases according to claim 1, wherein the compound plant oil is A, B mixture of two groups according to the mass ratio of 1: 1;
the group A vegetable oil is more than one of soybean oil, peanut oil and rapeseed oil;
the B group vegetable oil is more than one of chia seed oil, linseed oil, olive oil and walnut oil.
7. The instant plant-based emulsion for inflammatory bowel disease of claim 1, wherein the emulsifier is at least two of lecithin, sucrose fatty acid ester, monoglyceride, and capric triglyceride; the stabilizer is at least one of xanthan gum, konjac gum and guar gum.
8. The preparation method of the instant plant-based emulsion special for inflammatory bowel diseases as claimed in any one of claims 1 to 7, characterized by comprising the following steps:
(1) soaking and cleaning whole grains, spreading on a soaked cotton cloth, germinating for 12-24 hours at 20-28 ℃, drying for 12-24 hours at 40-55 ℃, grinding to obtain germinated whole grain powder, and adding a mixture of the germinated whole grain powder and grain raw materials in a weight ratio of 1: steaming 1-3 parts of water for 5-15 minutes, cooling to room temperature, adding a leavening agent, uniformly stirring, fermenting at 37 ℃ for 24-48 hours to obtain germinated fermented grain pulp, concentrating, drying, grinding, and performing superfine grinding to prepare germinated fermented grain superfine powder with the grain size of 18-20 microns;
(2) mixing the germinated and fermented grain superfine powder with spirulina polysaccharide, aureobasidium polysaccharide and soybean protein peptide, adding water according to the material-liquid ratio of 1: 3-6, stirring for 10-15 minutes, and carrying out colloid milling to obtain grain mixed slurry;
(3) preserving the temperature of the compound vegetable oil at 55-65 ℃ for 20-40 minutes, adding a water-soluble emulsifier, continuously stirring for 10-20min to obtain an emulsion oil phase component, and preserving the temperature at 55-65 ℃ for later use;
(4) heating the grain mixed slurry prepared in the step (2) to 55-65 ℃, adding 3-6 times of volume of water and a stabilizer, stirring for 15-20 minutes, adding the emulsion oil phase component prepared in the step (3), keeping the temperature at 55-65 ℃, stirring for 3-5 minutes, adding the compound mineral, the compound vitamin and the pomegranate peel extract, continuously stirring and uniformly mixing for 5-10 minutes at 55-65 ℃, grinding for 2-3 times by using a colloid mill, homogenizing for 2-3 times under 25-35MPa by using a high-pressure homogenizer, sterilizing and packaging uniformly to obtain the instant plant-based emulsion special for the inflammatory bowel disease.
9. The method according to claim 8, wherein the fermentation inoculum in step (1) is Lactobacillus plantarum powder having an inoculation concentration of 10 per 1L of grain slurry5-107cfu。
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| CN103431276A (en) * | 2013-08-31 | 2013-12-11 | 山东卫康生物医药科技有限公司 | Mixed-grain total-nutrition formulation food for patients with inflammatory bowel diseases |
| CN105685826A (en) * | 2016-03-01 | 2016-06-22 | 武汉千汇德科技有限公司 | Probiotic grain powder and production method and application thereof |
| CN109730252A (en) * | 2019-01-31 | 2019-05-10 | 渤海大学 | A method of improving full cereal edible quality |
| CN109965031A (en) * | 2019-03-29 | 2019-07-05 | 江南大学 | A kind of special medicine purposes formula food fat component formula and preparation method for inflammatory bowel disease |
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| CN103431276A (en) * | 2013-08-31 | 2013-12-11 | 山东卫康生物医药科技有限公司 | Mixed-grain total-nutrition formulation food for patients with inflammatory bowel diseases |
| CN105685826A (en) * | 2016-03-01 | 2016-06-22 | 武汉千汇德科技有限公司 | Probiotic grain powder and production method and application thereof |
| CN109730252A (en) * | 2019-01-31 | 2019-05-10 | 渤海大学 | A method of improving full cereal edible quality |
| CN109965031A (en) * | 2019-03-29 | 2019-07-05 | 江南大学 | A kind of special medicine purposes formula food fat component formula and preparation method for inflammatory bowel disease |
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| CN113439839A (en) * | 2021-06-18 | 2021-09-28 | 华南理工大学 | Full-plant-based high-energy ready-to-drink nutrient and preparation method thereof |
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