CN111069212A - Cleaning machine for cleaning liquid phase sample injection bottle and 96-hole plate - Google Patents
Cleaning machine for cleaning liquid phase sample injection bottle and 96-hole plate Download PDFInfo
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- CN111069212A CN111069212A CN201911282839.8A CN201911282839A CN111069212A CN 111069212 A CN111069212 A CN 111069212A CN 201911282839 A CN201911282839 A CN 201911282839A CN 111069212 A CN111069212 A CN 111069212A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/36—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by using brushes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
- B08B9/30—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking and having conveyors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
- B08B9/34—Arrangements of conduits or nozzles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/42—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus being characterised by means for conveying or carrying containers therethrough
Abstract
The invention discloses a cleaning machine for cleaning a liquid phase sampling bottle and a 96-hole plate, which relates to the technical field of liquid chromatography and experimental instruments and comprises a numerical control system, a waste liquid collecting and treating system, a drying system and a cleaning system; the waste liquid collecting and treating system comprises a collector, a water pipeline, a treating part and a discharge interface; the cleaning system comprises a pressurizing and washing system, a rotary brushing system and a bottle cap screwing-out system. The invention can select the content of cleaning and whether to use drying or not through the control panel, namely whether to adopt rotary brushing or pressurized washing or not, select the cycle number of the circulating washing, can control the use proportion of the cleaning solution and the distilled water, and can select different cleaning modes for cleaning the 96-pore plate or the liquid-phase sample inlet bottle.
Description
Technical Field
The invention belongs to the technical field of liquid chromatogram and experimental instruments, relates to an automatic cleaning device for a 96-pore plate and a cleaning device for a liquid phase sample injection bottle, and particularly relates to a cleaning machine for cleaning the liquid phase sample injection bottle and the 96-pore plate.
Background
The high performance liquid chromatograph consists of liquid storage, pump, sample injector, chromatographic column, detector, recorder, etc. The mobile phase in the liquid storage device is pumped into the system by a high-pressure pump, the sample solution enters the mobile phase through the sample injector and is loaded into the chromatographic column by the mobile phase, and because each component in the sample solution has different distribution coefficients in two phases, when the two phases move relatively, the moving speed of each component generates large difference through repeated adsorption-desorption processes, the components are separated into single components and flow out of the column in sequence, and when the components pass through the detector, the concentration of the sample is converted into an electric signal and is transmitted to a recorder to output data in a map form. In the experimental process, the high-efficiency liquid phase sampling bottle has the advantages of high use frequency, large using amount, small size, difficulty in grasping, complex cleaning process, difficulty in water injection, time and labor consuming in one-by-one cleaning and inconvenience in cleaning.
The 96-well plate is mainly used in biomolecular experiments and medical experiments, and the cleaning of the 96-well plate after the experiment is used is necessary work. And some experimental residues, such as bacteria remains, medicament residues and the like, are difficult to remove, repeated brushing is needed, or long-time detergent soaking operation is needed, so that not only are various cleaning tools used, but also a large amount of detergent is consumed, and the working time of experimenters is greatly wasted.
In addition, a sample injection bottle cleaning device with application number of CN201720310609.8 is available in the prior patent; the existing products comprise a Sapriri SPR-BW200 liquid chromatography sampling bottle cleaning machine of Tianjin Sapriri experiment equipment Limited and a special cleaning machine for a chromatography sampling bottle of Beijing Dirong science and technology Limited, which can well clean the liquid chromatography sampling bottle, but have high price and single function; further, there are available a 96-well plate washing apparatus of CN201721710362.5 application number and a medical automatic 96-well plate washing apparatus of CN201621279099.4 application number, such as an ELISA Washer semi-automatic microplate Washer of Rocker of roche, taiwan, which can wash 96-well plates. Many designs of the devices are different, but the general design idea is that stains and residues are removed by constant-temperature vibration soaking, pressure washing, ultrasonic cavitation and the like. If two such instruments are prepared in a laboratory, not only is the capital wasted, but also a large space is occupied. And because the difference between the size of the small hole of the 96-pore plate and the size of the liquid phase sample injection bottle is not large, the sizes and the depths of the small hole and the liquid phase sample injection bottle are standard, and the cleaning modes are relatively close, the cleaning systems of the small hole and the liquid phase sample injection bottle can be shared in some modes.
Therefore, the instrument capable of cleaning the 96-pore plate and the liquid-phase sampling bottle by using the same cleaning system is developed, the problem that the two devices are inconvenient to clean and the problem that the laboratory space is tight can be solved, and the efficiency of experimental work can be improved.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is the connection between the conventional liquid-phase sampling bottle cleaning device and the conventional 96-well plate cleaning device, and the present invention aims to design a cleaning device which can be used by both devices, and is convenient to use and ensures the cleaning quality.
In order to achieve the aim, the invention provides a cleaning machine for cleaning liquid phase sample bottles and 96 pore plates, which is characterized by comprising a numerical control system, a waste liquid collecting and treating system, a drying system and a cleaning system;
the waste liquid collecting and treating system comprises a collector, a water pipeline, a treating part and a discharge interface;
the cleaning system comprises a pressurizing and washing system, a rotary brushing system and a bottle cap screwing-out system.
Furthermore, the pressurized flushing system comprises a high-pressure spray head, a deformation device, a liquid suction device, a mixing cavity, a high-pressure water pump and 1 feeding motor; the high-pressure sprayer is controlled by the deformation device and is connected with the high-pressure water pump, the liquid suction device is arranged beside the high-pressure sprayer, and the feeding motor controls the feeding motion of all the high-pressure sprayer, the deformation device and the liquid suction device in three directions.
Furthermore, the pressurized cleaning system comprises 8 identical high-pressure nozzles, and the liquid sprayed by the high-pressure nozzles is firstly mixed in the mixing cavity and then respectively sent to the high-pressure nozzles to be sprayed.
Further, the rotary scrubbing system comprises a dual-purpose soft brush, the deformation device, a spray head, a water pump, 1 feeding motor and 1 rotating motor; the dual-purpose soft brush is connected with the deformation device and the rotating motor, the spray head is connected with the water pump, and the feeding motor controls the feeding motion of all the spray head, the deformation device and the dual-purpose soft brush in three directions.
Further, the rotary brushing system has a function of spraying the cleaning solution while brushing; the length of the bristles of the dual-purpose soft brush is consistent with the inner height of the liquid phase sampling bottle, and the diameter of the bristles of the dual-purpose soft brush is consistent with the diameter of the small hole of the 96-hole plate.
Furthermore, the deformation device controls the distance between the two parts by a mechanical rod, controls the included angle between the three adjacent parts by the rotation of the two arc-shaped shell pieces on the mechanical rotating shaft, or limits the movement range of the parts by a slide rail; the two end points of the slide rail are respectively suitable for cleaning a 96-hole plate and cleaning the liquid-phase sample injection bottle, and the motor control part moves on the slide rail to complete the conversion between the cleaning of the 96-hole plate and the cleaning of the liquid-phase sample injection bottle.
Further, the bottle cap screwing-out system comprises a rotary claw, a bottle clamp, a thimble, a telescopic motor, 1 feeding motor and 1 rotating motor; the rotary claw is used for unscrewing a bottle cap of the liquid-phase sampling bottle, the thimble is used for taking down the bottle cap on the rotary claw, the feeding motor controls the whole movement, and the rotating motor controls the rotation of the rotary claw.
Further, the rotating motor comprises a revolution motor and a rotation motor; the rotation motor can control the brush hair to spin, the revolution motor is only opened when brushing the liquid phase sample injection bottle, and the revolution motor can control the dual-purpose soft brush to rotate along the inner wall of the liquid phase sample injection bottle so as to ensure that the whole inner wall can be cleaned.
Further, the bottle cap screwing-out system comprises 24 rotating claws, 24 bottle clamps and 24 thimbles; each rotary claw is assembled with one thimble and used for unscrewing the bottle cap of the liquid-phase sampling bottle.
Furthermore, the bottle in the bottle cap unscrewing system is provided with an arc-shaped rough surface which can prop against the liquid phase sampling bottle from the side surface, so that the liquid phase sampling bottle is prevented from rotating when the bottle cap is unscrewed.
Compared with the prior art, the invention has the beneficial effects that at least the following beneficial technical effects are achieved:
1. the invention can select the content of cleaning and whether to use drying or not through the control panel, namely whether to adopt rotary brushing or pressurized washing or not, select the cycle number of the circulating washing, can control the use ratio of the washing liquid and the distilled water, and can select different cleaning modes for cleaning a 96-pore plate or a liquid-phase sampling bottle;
2. when the liquid-phase sample injection bottle is cleaned, the liquid-phase sample injection tray is only required to be placed into an instrument, the sample injection bottles do not need to be taken down and then rearranged, and the liquid-phase sample injection tray can be directly placed into the device for cleaning;
3. the cleaning device can automatically take down the bottle cap of the sampling bottle for the next use after cleaning;
4. the cleaning device can clean dried stains at the bottom of the 96-well plate.
The conception, the specific structure and the technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, the features and the effects of the present invention. These descriptions are provided only to help explain the present invention and should not be used to limit the scope of the claims of the present invention.
Drawings
FIG. 1 is a schematic overall design of a preferred embodiment of the present invention;
FIG. 2 is a schematic diagram of the internal components of a preferred embodiment of the present invention (the power supply parts such as the motor, the water pump, the mechanical transmission device, etc. are hidden);
FIG. 3 is a top view of a deformation apparatus in a preferred embodiment of the invention;
fig. 4 is a top view of a deformation apparatus in a preferred embodiment of the invention.
Wherein, 1-a shell body, 2-an inlet and an outlet of a liquid phase sample injection tray, 3-an inlet and an outlet of a 96 pore plate, 4-a glass plate, 5-a display, 6-an operation panel, 7-a water pipe interface, 8-a liquid inlet pipe, 9-a bottle cap, 10-a washing liquid storage bottle, 11-a mixing cavity, 12-a rotary claw and a thimble, 13-an upper top plate, 14-a deformation device, 15-a water pipe, 16-an upper top plate, 17-a conveyor belt, 18-a dual-purpose soft brush, 19-a liquid phase sample injection tray, 20-a liquid phase sample injection tray chuck, 21-a 96 pore plate, 22-a 96 pore plate chuck, 23-a collector, 24-a processing part, 25-a discharge interface, 26-a high pressure spray head and a liquid suction device, 27-a slide rail and 28-, 29-bolt, 30-sliding housing.
Detailed Description
The invention is described in further detail below with reference to the figures and specific embodiments. It should be understood that the embodiments are illustrative of the invention and are not to be construed as limiting the scope of the invention in any way. The present invention may be embodied in many different forms of embodiments and the scope of the invention is not limited to the embodiments set forth herein.
In the drawings, structurally identical elements are represented by like reference numerals, and structurally or functionally similar elements are represented by like reference numerals throughout the several views. The size and thickness of each component shown in the drawings are arbitrarily illustrated, and the present invention is not limited to the size and thickness of each component. The thickness of the components may be exaggerated where appropriate in the figures to improve clarity.
Example one
Firstly, two automatic cleaning modes of the liquid-phase sampling bottle and the 96-pore plate which are commonly used by the device are determined to be cyclic pressurization washing and rotary scrubbing. The device adopts the two cleaning modes to clean the liquid phase sample bottle and the 96-hole plate. The device is divided into a numerical control system, a waste liquid collecting and treating system, a drying system and a cleaning system.
As shown in fig. 2, the waste liquid collecting system includes a collector 23, a water pipe 15, a processing portion 24 and a discharge port 25, the collector 23 is located at the bottom of the device, and the collected waste liquid is sent to the processing portion 24 through the water pipe 15 for processing and then discharged from the discharge port 25 through the water pipe 15, a water pump is installed on the water pipe 15 to pump the waste water in the device, and water processing fillers such as activated carbon are filled in the processing portion 24.
The cleaning system comprises a pressurized flushing system, a rotary brushing system and a bottle cap screwing-out system. The pressurized flushing system comprises a high-pressure spray head and a liquid suction device 26, a deformation device 14, a mixing cavity 11, a high-pressure water pump and 1 feeding motor; a plurality of water pipe interfaces 7 are arranged in the machine body, the water pipe interfaces 7 are connected with a plurality of cleaning solution storage bottles 10 arranged outside, alcohol, distilled water, RBS cleaning agent and the like are respectively filled in the bottles, the water pipe interfaces 7 are connected to a high-pressure water pump, a water outlet of the high-pressure water pump is connected with a mixing cavity 11, liquid is pumped out according to a set flow proportion and is mixed in the mixing cavity 11 under the control of a numerical control system, and the mixing cavity 11 is connected with all high-pressure spray nozzles 26 and conveys the mixed cleaning solution; the liquid suction device and the high-pressure spray head are connected with and controlled by the deformation device 14 and can be switched between modes of cleaning a 96-pore plate and a cleaning liquid phase sampling bottle; the high-pressure nozzle is arranged on an upper top plate 16 and can spray high-pressure cleaning liquid or high-pressure water; the liquid absorbing device is additionally arranged with the high-pressure spray head 26, absorbs liquid by pressure and directly discharges the sucked waste liquid into the waste liquid collector; the feed motor controls 3 axial movements of the upper top plate 16 by mechanical transmission; the deforming device 14 is loaded in the upper top plate 16 or between the high-pressure nozzles, and can drive the nozzles densely arranged in a linear type to be changed into an arc-shaped arrangement suitable for the liquid phase sample injection tray 19 and can adjust the gap between the high-pressure nozzles.
As shown in fig. 3 and 4, the deforming means 14 has two alternatives: firstly, two movable cross rods 28 are used for connecting two adjacent high-pressure spray heads, the deformation device part of each spray head is divided into two halves, each half is provided with a slide rail 27, the two movable cross rods 28 are arranged on the slide rails 27, and when the movable cross rods 28 are stretched/compressed, the two half deformation devices 14 can rotate relatively, so that the high-pressure spray heads 26 which are arranged in a linear shape in a dense way are changed into an arc shape which is in accordance with the liquid phase sampling tray 19 and are arranged in a dispersed way; secondly, a plurality of slide rails 27 are arranged on the upper top plate 16, the dense ends of the distributed ends of the slide rails 27 are sparse, the sparse ends are arranged in an arc shape conforming to the liquid phase sample feeding tray 19, the high-pressure spray heads 26 are correspondingly arranged on the slide rails 27 one by one, and the high-pressure spray heads are driven by a motor to move on the slide rails 27, so that the linear high-pressure spray heads 26 which are densely arranged are changed into arc line type distributed arrangement.
As shown in fig. 2, the rotary scrubbing system includes a dual-purpose soft brush 18, a deforming device 14, a spray head, a water pump, 1 feeding motor, and 1 rotating motor; the configuration of the water pump, the spray head, the deformation device 14 and the feeding motor is consistent with that of corresponding components in the pressurizing and washing system, and the spray head can spray cleaning liquid with a set proportion during brushing; the brush handle of the dual-purpose soft brush 18 is connected with the upper top plate 16, the length of the brush hair part of the dual-purpose soft brush is matched with the liquid phase sample injection bottle, and the diameter of the brush hair part of the dual-purpose soft brush is matched with the small hole of the 96-hole plate; the rotating motor enables the dual-purpose soft brush to rotate at a controllable rotating speed.
The rotating motor comprises a revolution motor and a rotation motor; the self-rotating motor can control the brush hair to spin; the revolution motor is only started when the liquid phase sampling bottle is scrubbed, and the revolution motor can control the dual-purpose soft brush to rotate along the inner wall of the liquid phase sampling bottle so as to ensure that the whole inner wall can be cleaned.
The bottle cap screwing-out system comprises a rotary claw 12, a bottle clamp, a thimble, a telescopic motor, 1 feeding motor and 1 rotating motor; the configuration of the feeding motor is consistent with that of corresponding components in the rotary brushing system, and the configuration of the rotary motor is consistent with that of a self-rotation motor in the rotary brushing system; the rotary claw 12 is arranged on the upper top plate 16 and connected with a rotary motor, the claw can be clamped into a thin groove of the bottle cap of the liquid phase sample injection bottle, and the bottle cap 9 of the liquid phase sample injection bottle can be taken down in a rotary mode; the bottle clamp is provided with an arc-shaped rough surface which can prop against the liquid phase sampling bottle from the side surface to prevent the liquid phase sampling bottle from rotating when the bottle cap 9 is unscrewed; the thimble is arranged beside the rotary claw 12 and is connected with a telescopic motor, and the thimble can extend to push down the bottle cap 9 of the liquid-phase sampling bottle clamped on the rotary claw.
The drying system comprises an HEPA, a blower and an electric heating wire; the HEPA is arranged together with the blower to clean and dry the entering air; the electric heating wire can control the temperature in the instrument to rise and can maintain the temperature in the instrument; the blower blows dry air to carry away residual moisture.
The numerical control system comprises a processor, an operation panel and a control circuit, wherein the processor receives information transmitted by the control panel through the control circuit and controls each module.
Example two
The embodiment provides a cleaning machine for cleaning liquid phase sampling bottles and 96-well plates, which comprises a numerical control system, a waste liquid collecting and processing system, a drying system and a cleaning system, wherein the numerical control system comprises a processor, an operation panel 6 and a control circuit, and the processor receives information transmitted by the operation panel 6 through the control circuit and controls each module; as shown in fig. 2, the waste liquid collecting and treating system comprises a collector 23, a treating part 24, a water pipeline 15 and a discharge interface 25, wherein the collector 23 is positioned at the bottom of the device, and discharges the collected waste liquid through the discharge interface 25 after being treated by the treating part 24; the cleaning system comprises a high-pressure spray head and liquid suction device 26, a liquid inlet pipe 8, a water pipe connector 7, a cleaning liquid storage bottle 10, a deformation device 14, a mixing cavity 11, a dual-purpose soft brush 18, a feeding motor, a rotating motor, a high-pressure water pump, a rotary claw and thimble 12, a bottle clamp and a telescopic motor; the drying system mainly comprises an electric heating wire, an HEPA high-efficiency filter and a blower.
In practical application, the cleaning presetting is adjusted through the operation panel 6, a 96-pore plate or a liquid phase sample introduction bottle is selected as a corresponding cleaning mode, then the 96-pore plate or the liquid phase sample introduction tray is placed into the automatically ejected chuck, and the manual operation can be completed after the selection is started on the operation panel 6; when the clicking is started, the chuck can be automatically sent back to the interior of the machine, and then cleaning is carried out according to the preset cleaning steps; when the pressurized washing step is carried out, the deformation device is started to be changed into a form corresponding to a washing mode, the corresponding upper top plate 16 horizontally precesses and corresponds to the chuck and then descends to enable the high-pressure spray head and the liquid suction device 26 to just completely enter small holes of a 96-pore plate or a liquid-phase sample feeding bottle, liquid suction or high-pressure washing is carried out according to the preset washing step, and when the pressurized washing step is finished, the upper top plate 16 ascends and horizontally precesses to return to the initial position; when the rotary brushing step is carried out, the deformation device is started to be changed into a form corresponding to a cleaning mode, the corresponding upper top plate 16 horizontally precesses and corresponds to the chuck, then the deformation device descends to enable the dual-purpose soft brush 18 to enter small holes of the 96-hole plate 21 or a liquid-phase sample injection bottle exactly, the rotary brushing is carried out according to the preset cleaning step, and when the rotary brushing step is finished, the upper top plate 16 ascends and horizontally precesses to return to the initial position; when the bottle cap screwing-out step is carried out, the corresponding upper top plate 16 horizontally precesses and corresponds to the chuck and then descends to enable the rotating claw and the ejector pin 12 to be just clamped in the thin groove of the bottle cap, after the rotating claw rotates to take off the bottle cap, the upper top plate 16 moves, the ejector pin extends to push the bottle cap down to the liquid phase sample injection tray chuck 20, and when the bottle cap screwing-out step is finished, the upper top plate 16 ascends and horizontally precesses to return to the initial position; when the drying step is carried out, the electric heating wire is electrified to heat the interior of the device, and a blower works to blow clean and dry air to take away moisture; when the waste liquid is generated by cleaning, the waste liquid collecting and treating system works and sends the treated waste liquid out of the device; when the cleaning is finished, the corresponding chuck is popped out, and after the 96-pore plate or the liquid phase sample injection tray on the chuck is taken down, the chuck is automatically retracted into the device.
EXAMPLE III
This example provides the effect of reducing the time spent by experimenters after using the cleaning machine of the present invention to clean a liquid-phase sample injection vial and a 96-well plate. When the device is used for cleaning the liquid-phase sampling bottle, the continuous operation of experimenters is not needed, and the preset cleaning mode is generally not needed to be changed frequently, so that the time occupation of the experimenters can be almost ignored; when experimenters in laboratories without automatic cleaning devices wash liquid-phase small bottles, each small bottle needs to be unscrewed, filled with alcohol, washed with alcohol and the like, at least 3-5 seconds are needed for each small bottle on average, nearly hundreds of sampling bottles are needed for each liquid chromatogram, namely, more than 1 hour is needed for washing after each liquid phase on average; in contrast, the time of experimenters can be greatly saved if the cleaning device of the invention is used.
Example four
This example provides, by way of example, a comparison of the advantages of the present invention in terms of laboratory space savings. If the laboratory uses SPR-BW200 laboratory sample injection bottle cleaning machine of Tianjin Securio experimental facilities Limited and ELISA Washer semi-automatic micropore disk cleaning machine of Rocker of Taiwan Luo, the specifications are 668mm multiplied by 442mm multiplied by 399mm and 200mm multiplied by 240mm multiplied by 130mm respectively, the volumes are 0.1178 cubic meters and 0.00624 cubic meters respectively, the occupied areas are about 0.30 square meter and 0.05 square meter respectively, and the total occupied space is 0.35 square meter and 0.1242 cubic meter; if the invention is used, the machine size of the invention can be reduced to at least 600mm x 500mm x 400mm, i.e. occupying only 0.3 square meter and 0.12 cubic meter of space, by integrating the main functions of the two types of washing machines.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (10)
1. A cleaning machine for cleaning liquid phase sample injection bottles and 96-hole plates is characterized by comprising a numerical control system, a waste liquid collecting and treating system, a drying system and a cleaning system;
the waste liquid collecting and treating system comprises a collector, a water pipeline, a treating part and a discharge interface;
the cleaning system comprises a pressurizing and washing system, a rotary brushing system and a bottle cap screwing-out system.
2. The cleaning machine for cleaning solution phase sampling bottles and 96-well plates according to claim 1, characterized in that the pressurized flushing system comprises a high-pressure nozzle, a deforming device, a liquid absorbing device, a mixing chamber, a high-pressure water pump and 1 feeding motor; the high-pressure sprayer is controlled by the deformation device and is connected with the high-pressure water pump, the liquid suction device is arranged beside the high-pressure sprayer, and the feeding motor controls the feeding motion of all the high-pressure sprayer, the deformation device and the liquid suction device in three directions.
3. The cleaning machine for cleaning solution sample vials and 96-well plates as claimed in claim 2, wherein said pressurized cleaning system comprises 8 identical said high pressure nozzles, and the liquids sprayed from said high pressure nozzles are first mixed in said mixing chamber and then respectively fed to said high pressure nozzles for spraying.
4. The cleaning machine for cleaning solution-phase sampling bottles and 96-well plates according to claim 1, wherein the rotary scrubbing system comprises a dual-purpose soft brush, the deforming device, a spray head, a water pump, 1 feeding motor and 1 rotating motor; the dual-purpose soft brush is connected with the deformation device and the rotating motor, the spray head is connected with the water pump, and the feeding motor controls the feeding motion of all the spray head, the deformation device and the dual-purpose soft brush in three directions.
5. The cleaning machine for a cleaning solution-sampling bottle and a 96-well plate according to claim 4, wherein the rotary brush system has a function of ejecting the cleaning solution while brushing; the length of the bristles of the dual-purpose soft brush is consistent with the inner height of the liquid phase sampling bottle, and the diameter of the bristles of the dual-purpose soft brush is consistent with the diameter of the small hole of the 96-hole plate.
6. The cleaning machine for cleaning solution phase sampling bottles and 96-well plates as claimed in any one of claims 2 and 4, wherein the deformation device controls the distance between two parts by a mechanical rod, controls the included angle between three adjacent parts by the rotation of two arc-shaped shell sheets on a mechanical rotating shaft, or limits the movement range of the parts by a slide rail; the two end points of the slide rail are respectively suitable for cleaning a 96-hole plate and cleaning the liquid-phase sample injection bottle, and the motor control part moves on the slide rail to complete the conversion between the cleaning of the 96-hole plate and the cleaning of the liquid-phase sample injection bottle.
7. The cleaning machine for cleaning solution-phase sampling bottles and 96-well plates according to claim 1, wherein the bottle cap unscrewing system comprises a rotary claw, a bottle clamp, a thimble, a telescopic motor, 1 feeding motor and 1 rotating motor; the rotary claw is used for unscrewing a bottle cap of the liquid-phase sampling bottle, the thimble is used for taking down the bottle cap on the rotary claw, the feeding motor controls the whole movement, and the rotating motor controls the rotation of the rotary claw.
8. The cleaning machine for cleaning the cleaning liquid-phase sampling bottle and the 96-well plate according to any one of claims 4 and 7, wherein the rotating motor comprises a revolution motor and a rotation motor; the rotation motor can control the brush hair to spin, the revolution motor is only opened when brushing the liquid phase sample injection bottle, and the revolution motor can control the dual-purpose soft brush to rotate along the inner wall of the liquid phase sample injection bottle so as to ensure that the whole inner wall can be cleaned.
9. The cleaning machine for cleaning solution sample vials and 96-well plates according to claim 7, wherein the cap unscrewing system comprises 24 rotating jaws, 24 vial clamps and 24 ejector pins; each rotary claw is assembled with one thimble and used for unscrewing the bottle cap of the liquid-phase sampling bottle.
10. The cleaning solution sample inlet bottle and 96 well plate cleaning machine of claim 7 wherein said bottle in said cap unscrewing system has an arcuate roughened surface that laterally abuts said liquid phase inlet bottle to prevent rotation of said liquid phase inlet bottle when said cap is unscrewed.
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| CN201911282839.8A CN111069212B (en) | 2019-12-13 | 2019-12-13 | Cleaning machine for cleaning liquid phase sample injection bottle and 96-hole plate |
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| CN201911282839.8A CN111069212B (en) | 2019-12-13 | 2019-12-13 | Cleaning machine for cleaning liquid phase sample injection bottle and 96-hole plate |
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| CN111069212A true CN111069212A (en) | 2020-04-28 |
| CN111069212B CN111069212B (en) | 2021-08-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113406224A (en) * | 2021-06-10 | 2021-09-17 | 生态环境部固体废物与化学品管理技术中心 | Method and system for testing cleanliness of cleaned packaging container |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101138119B1 (en) * | 2011-09-16 | 2012-04-23 | 황지연 | Automatic cleaning device for medicines bottle |
| CN105436170A (en) * | 2015-12-08 | 2016-03-30 | 广东省肇庆市质量计量监督检测所 | Automatic rotating and washing device for gas-liquid chromatography-mass spectrography method |
| CN206951725U (en) * | 2017-07-14 | 2018-02-02 | 广东省保化检测中心有限公司 | Sample injection bottle takes lid, takes bottle |
-
2019
- 2019-12-13 CN CN201911282839.8A patent/CN111069212B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101138119B1 (en) * | 2011-09-16 | 2012-04-23 | 황지연 | Automatic cleaning device for medicines bottle |
| CN105436170A (en) * | 2015-12-08 | 2016-03-30 | 广东省肇庆市质量计量监督检测所 | Automatic rotating and washing device for gas-liquid chromatography-mass spectrography method |
| CN206951725U (en) * | 2017-07-14 | 2018-02-02 | 广东省保化检测中心有限公司 | Sample injection bottle takes lid, takes bottle |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406224A (en) * | 2021-06-10 | 2021-09-17 | 生态环境部固体废物与化学品管理技术中心 | Method and system for testing cleanliness of cleaned packaging container |
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| Publication number | Publication date |
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| CN111069212B (en) | 2021-08-24 |
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