CN111068045A - 一种重组胶原蛋白私密抑菌凝胶及其制备方法 - Google Patents
一种重组胶原蛋白私密抑菌凝胶及其制备方法 Download PDFInfo
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Abstract
本发明属于凝胶制备技术领域，特别是涉及一种重组胶原蛋白私密抑菌凝胶及其制备方法。由以下质量份数的原料组成，重组人源胶原蛋白0.1‑0.3份、水解胶原蛋白0.1‑0.5份、白芨2‑6份、积雪草3‑9份、茺蔚子6‑12份、黄柏5‑8份、红花7‑12份、苦参3‑6份、透明质酸钠0.05‑0.2份、冰片0.1‑0.3份、薄荷脑0.01‑0.5份和聚六亚甲基双胍0.01‑0.03份。渗透效果，及杀菌协同抗炎性更强。
Description
技术领域
本发明属于凝胶制备技术领域，特别是涉及一种重组胶原蛋白私密抑菌凝胶及其制备方法。
背景技术
樱花B-熊果苷,又名熊果甙、熊果素、熊果叶甙、熊果酚甙或杨梅甙，因其最早来源于天然绿色植物，是一个集"绿色"、"安全"和"高效"概念于一体的皮肤美白活性物质。它能够迅速渗入肌肤，在不影响皮肤细胞增殖浓度的同时，有效地抑制皮肤中酪氨酸酶的活性，阻断黑色素的形成，通过自身与酪氨酸酶的结合，加速黑色素的分解与排泄，从而减少皮肤色素沉积，祛除色斑和雀斑。它对黑色素细胞却不产生毒害性、刺激性、致敏性等副作用，同时还有润肤、愈创、杀菌和协同抗炎等作用。
发明内容
本发明提供了一种重组胶原蛋白私密抑菌凝胶及其制备方法。
为了实现上述目的，本发明实施例提供了一种重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.1-0.3份、水解胶原蛋白0.1-0.5份、白芨2-6份、积雪草3-9份、茺蔚子6-12份、黄柏5-8份、红花7-12份、苦参3-6份、透明质酸钠0.05-0.2份、冰片0.1-0.3份、薄荷脑0.01-0.5份和聚六亚甲基双胍0.01-0.03份。
进一步的，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.1份、水解胶原蛋白0.1份、白芨2份、积雪草3份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.05份、冰片0.1份、薄荷脑0.01份和聚六亚甲基双胍0.02份。
进一步的，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.15份、水解胶原蛋白0.5份、白芨5、积雪草3、茺蔚子8、黄柏6、红花11、苦参5、透明质酸钠0.1％、冰片0.2％、薄荷脑0.2％和聚六亚甲基双胍0.02份。
进一步的，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.3份、水解胶原蛋白0.5份、白芨6份、积雪草9份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.2份、冰片0.3份、薄荷脑0.2份和聚六亚甲基双胍0.02份。
一种重组胶原蛋白私密抑菌凝胶的制备方法，包括以下步骤，(1)将白芨、积雪草、茺蔚子、黄柏、红花、苦参六味中药分别用8倍量、6倍量的蒸馏水煎煮两次，第一次2小时，第二次1.5小时，分别过滤，合并滤液；(2)将上述合并后的滤液真空浓缩成相对密度为1.05的清膏，备用；(3)在上述清膏中加入凝胶赋形剂，在均质机中制成凝胶剂；最后依次加入重组人源胶原蛋白、水解胶原蛋白、透明质酸钠、冰片、薄荷脑、聚六亚甲基双胍，继续均质半小时，抽真空，将配制好的凝胶用全自动凝胶灌装机灌装，3.5g/支包装。
本发明相比现有技术的有益效果是：能够迅速渗入肌肤，有效地抑制皮肤中酪氨酸酶的活性，阻断黑色素的形成，通过自身与酪氨酸酶的结合，加速黑色素的分解与排泄；具有高效的杀菌和协同抗炎症作用。
具体实施方式
在本发明实施例的描述中，除非另有说明，“多个”的含义是指两个或两个以上。例如，多个元件是指两个元件或两个以上元件。
本文中术语“和/或”，是一种描述关联对象的关联关系，表示可以存在三种关系，例如，显示面板和/或背光，可以表示：单独存在显示面板，同时存在显示面板和背光，单独存在背光这三种情况。本文中符号“/”表示关联对象是或者的关系，例如输入/输出表示输入或者输出。
在本发明实施例中，“示例性的”或者“例如”等词用于表示作例子、例证或说明。本发明实施例中被描述为“示例性的”或者“例如”的任何实施例或设计方案不应被解释为比其它实施例或设计方案更优选或更具优势。确切而言，使用“示例性的”或者“例如”等词旨在以具体方式呈现相关概念。
本发明实施例提供了一种重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.1-0.3份、水解胶原蛋白0.1-0.5份、白芨2-6份、积雪草3-9份、茺蔚子6-12份、黄柏5-8份、红花7-12份、苦参3-6份、透明质酸钠0.05-0.2份、冰片0.1-0.3份、薄荷脑0.01-0.5份和聚六亚甲基双胍0.01-0.03份。
实施例1，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.1份、水解胶原蛋白0.1份、白芨2份、积雪草3份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.05份、冰片0.1份、薄荷脑0.01份和聚六亚甲基双胍0.02份。
实施例2，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.15份、水解胶原蛋白0.5份、白芨5、积雪草3、茺蔚子8、黄柏6、红花11、苦参5、透明质酸钠0.1％、冰片0.2％、薄荷脑0.2％和聚六亚甲基双胍0.02份。
实施例3，，重组胶原蛋白私密抑菌凝胶，由以下质量份数的原料组成，重组人源胶原蛋白0.3份、水解胶原蛋白0.5份、白芨6份、积雪草9份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.2份、冰片0.3份、薄荷脑0.2份和聚六亚甲基双胍0.02份。
一种重组胶原蛋白私密抑菌凝胶的制备方法，包括以下步骤，首先将白芨、积雪草、茺蔚子、黄柏、红花、苦参六味中药分别用8倍量、6倍量的蒸馏水煎煮两次，第一次2小时，第二次1.5小时，分别过滤，合并滤液；接下来，将上述合并后的滤液真空浓缩成相对密度为1.05的清膏，备用；然后在上述清膏中加入凝胶赋形剂，在均质机中制成凝胶剂；最后依次加入重组人源胶原蛋白、水解胶原蛋白、透明质酸钠、冰片、薄荷脑、聚六亚甲基双胍，继续均质半小时，抽真空，将配制好的凝胶用全自动凝胶灌装机灌装，3.5g/支包装。
通过本发明实施例的技术方案中的重组胶原蛋白私密抑菌凝胶能够迅速渗入肌肤，有效地抑制皮肤中酪氨酸酶的活性，阻断黑色素的形成，通过自身与酪氨酸酶的结合，加速黑色素的分解与排泄；具有高效的杀菌和协同抗炎症作用。用于女性生殖道的瘙痒、炎症、糜烂修复及滋养。
使用方法：用此配方制备的凝胶，每晚睡前，清洗双手后，平躺身体，取本品一支，去除辅助器前端的保护帽，将凝胶推至阴道深处，撤出辅助器，保持臀部向上静趟10-15分钟。
上面对本发明的实施例进行了描述，但是本发明并不局限于上述的具体实施方式，上述的具体实施方式仅仅是示意性的，而不是限制性的，本领域的普通技术人员在本发明的启示下，在不脱离本发明宗旨和权利要求所保护的范围情况下，还可做出很多形式，均属于本发明的保护之内。
Claims (5)
1.一种重组胶原蛋白私密抑菌凝胶，其特征在于：由以下质量份数的原料组成，重组人源胶原蛋白0.1-0.3份、水解胶原蛋白0.1-0.5份、白芨2-6份、积雪草3-9份、茺蔚子6-12份、黄柏5-8份、红花7-12份、苦参3-6份、透明质酸钠0.05-0.2份、冰片0.1-0.3份、薄荷脑0.01-0.5份和聚六亚甲基双胍0.01-0.03份。
2.根据权利要求1所述的重组胶原蛋白私密抑菌凝胶，其特征在于：重组人源胶原蛋白0.1份、水解胶原蛋白0.1份、白芨2份、积雪草3份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.05份、冰片0.1份、薄荷脑0.01份和聚六亚甲基双胍0.02份。
3.根据权利要求1所述的重组胶原蛋白私密抑菌凝胶，其特征在于：重组人源胶原蛋白0.15份、水解胶原蛋白0.5份、白芨5、积雪草3、茺蔚子8、黄柏6、红花11、苦参5、透明质酸钠0.1％、冰片0.2％、薄荷脑0.2％和聚六亚甲基双胍0.02份。
4.根据权利要求1所述的重组胶原蛋白私密抑菌凝胶，其特征在于：重组人源胶原蛋白0.3份、水解胶原蛋白0.5份、白芨6份、积雪草9份、茺蔚子6份、黄柏5份、红花7份、苦参3份、透明质酸钠0.2份、冰片0.3份、薄荷脑0.2份和聚六亚甲基双胍0.02份。
5.一种制备权利要求1至4中任一所述的重组胶原蛋白私密抑菌凝胶的方法，其特征在于：包括以下步骤，(1)将白芨、积雪草、茺蔚子、黄柏、红花、苦参六味中药分别用8倍量、6倍量的蒸馏水煎煮两次，第一次2小时，第二次1.5小时，分别过滤，合并滤液；(2)将上述合并后的滤液真空浓缩成相对密度为1.05的清膏，备用；(3)在上述清膏中加入凝胶赋形剂，在均质机中制成凝胶剂；最后依次加入重组人源胶原蛋白、水解胶原蛋白、透明质酸钠、冰片、薄荷脑、聚六亚甲基双胍，继续均质半小时，抽真空，将配制好的凝胶用全自动凝胶灌装机灌装，3.5g/支包装。
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