CN111041089A - Covid-19感染的宿主标志物的应用 - Google Patents
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Abstract
Description
ID | P-Value | FDR | log2(foldchange) | 方向 |
IL7R | 0.00081 | 0.07736 | -2.03342 | 下调 |
CD6 | 0.00094 | 0.07736 | -1.94928 | 下调 |
BCL2 | 0.00040 | 0.06780 | -1.86851 | 下调 |
SYNE3 | 0.00107 | 0.07736 | -1.84775 | 下调 |
ZC3H12D | 0.00215 | 0.09847 | -1.82164 | 下调 |
NUP210 | 0.00050 | 0.07133 | -1.81585 | 下调 |
SPOCK2 | 0.00166 | 0.09318 | -1.74198 | 下调 |
ETS1 | 0.00089 | 0.07736 | -1.68552 | 下调 |
B3GAT3 | 0.00030 | 0.06279 | -1.58194 | 下调 |
TMC6 | 0.00014 | 0.05316 | -1.57536 | 下调 |
HLA-DPB1 | 0.00128 | 0.08298 | -1.47970 | 下调 |
CIITA | 0.00105 | 0.07736 | -1.45844 | 下调 |
TUBGCP6 | 0.00058 | 0.07338 | -1.43074 | 下调 |
SIDT2 | 0.00199 | 0.09697 | -1.42095 | 下调 |
MOB3B | 0.00178 | 0.09513 | -1.38904 | 下调 |
BRAT1 | 0.00043 | 0.06968 | -1.28266 | 下调 |
SH3TC1 | 0.00061 | 0.07460 | -1.26360 | 下调 |
NKTR | 0.00131 | 0.08320 | -1.22115 | 下调 |
CITED2 | 0.00095 | 0.07736 | -1.18496 | 下调 |
MYO15B | 0.00098 | 0.07736 | -1.17774 | 下调 |
INF2 | 0.00034 | 0.06404 | -1.11141 | 下调 |
AP1B1 | 0.00015 | 0.05483 | -1.03972 | 下调 |
SLC10A3 | 0.00201 | 0.09697 | -1.03427 | 下调 |
DPH1 | 0.00110 | 0.07846 | -0.99796 | 下调 |
DYNC1H1 | 0.00207 | 0.09697 | -0.96452 | 下调 |
CDK13 | 0.00168 | 0.09318 | -0.94359 | 下调 |
HUWE1 | 0.00046 | 0.07133 | -0.89748 | 下调 |
RAPGEF1 | 0.00065 | 0.07475 | -0.87745 | 下调 |
MFSD11 | 0.00052 | 0.07133 | -0.84530 | 下调 |
VCP | 0.00204 | 0.09697 | -0.77699 | 下调 |
TRNG | 0.00003 | 0.01783 | 2.25573 | 上调 |
HMGB3 | 0.00003 | 0.01783 | 2.28739 | 上调 |
BCLAF3 | 0.00000 | 0.00002 | 3.00612 | 上调 |
EMX1 | 0.00000 | 0.00000 | 3.97603 | 上调 |
RNR1 | 0.00000 | 0.00000 | 4.86827 | 上调 |
CNTN3 | 0.00001 | 0.01065 | 6.25195 | 上调 |
基因ID | DYNC1H1、VCP、AP1B1、CDK13、TRNG、INF2、ETS1、HUWE1、CITED2、MFSD11、RNR1、SYNE3、SLC10A3 |
基因集合 | AUC |
SLC10A3 | 0.904761905 |
SYNE3 | 0.910256410 |
RNR1 | 0.921245421 |
MFSD11 | 0.936813187 |
SLC10A3 + RNR1 | 0.915750916 |
SYNE3 + SLC10A3 | 0.935897436 |
MFSD11 + SLC10A3 | 0.936813187 |
SYNE3 + RNR1 | 0.937728938 |
MFSD11 + SYNE3 | 0.954212454 |
MFSD11 + RNR1 | 0.965201465 |
MFSD11 + SYNE3 + SLC10A3 | 0.957875458 |
SYNE3 + SLC10A3 + RNR1 | 0.957875458 |
MFSD11 + SYNE3 + RNR1 | 0.970695971 |
MFSD11 + SLC10A3 + RNR1 | 0.970695971 |
MFSD11 + SYNE3 + SLC10A3 + RNR1 | 0.985347985 |
Sample | 差异基因 | Log2(Fold change) | 宿主标志物 | RT-PCR | mNGS |
样本21 | RNR1 | 5.39 | 阳 | 阴 | 阳 |
样本22 | RNR1 | 9.73 | 阳 | 阳 | 阳 |
样本23 | RNR1+MFSD11 | 10.63、-7.63 | 阳 | 阴 | 阳 |
样本24 | RNR1 | 8.52 | 阳 | 阳 | 阳 |
Sample | 差异基因 | Log2(Fold change) | 宿主标志物 | RT-PCR | mNGS |
样本25 | SYNE3 | -1.8 | 阳 | 阴 | 阴 |
样本26 | SYNE3+SLC10A3 | -3.36、-2.99 | 阳 | 阴 | 阳 |
样本27 | RNR1+SYNE3 | 2.84、-2.81 | 阳 | 阴 | 阳 |
样本28 | RNR1+MFSD11+SYNE3 | 3.80、-1.84、-3.50 | 阳 | 阳 | 阳 |
样本29 | SYNE3 | -3.45 | 阳 | 阳 | 阳 |
样本30 | RNR1+MFSD11+SYNE3 | 3.31、-2.11、-12.31 | 阳 | 阳 | 阳 |
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Cited By (10)
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CN111521818A (zh) * | 2020-04-27 | 2020-08-11 | 深圳海博生物技术有限公司 | 特异性IgA在评价COVID-19患病风险、患病严重程度以及预后评估中的应用 |
CN111796097A (zh) * | 2020-05-29 | 2020-10-20 | 武汉市金银潭医院 | 诊断新冠肺炎由轻症转重症的血浆蛋白标志物、检测试剂或试剂工具 |
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WO2021219029A1 (en) * | 2020-04-28 | 2021-11-04 | Versitech Limited | Sars-cov-2 viral proteins and use thereof |
WO2021231274A1 (en) * | 2020-05-11 | 2021-11-18 | Ampel Biosolutions, Llc | Methods and systems for analyzing targetable pathologic processes in covid-19 via gene expression analysis |
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CN112609024A (zh) * | 2020-12-31 | 2021-04-06 | 郑州大学第一附属医院 | 一种用于新型冠状病毒感染患者无创诊断的肠道微生物基因标志物及其应用 |
CN112609024B (zh) * | 2020-12-31 | 2023-08-15 | 郑州大学第一附属医院 | 一种用于新型冠状病毒感染患者无创诊断的肠道微生物基因标志物及其应用 |
CN113362901A (zh) * | 2021-05-14 | 2021-09-07 | 海南大学 | 快速进行全基因组注释区间比较的方法及系统 |
CN113362901B (zh) * | 2021-05-14 | 2023-09-01 | 海南大学 | 快速进行全基因组注释区间比较的方法及系统 |
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