CN111035689A

CN111035689A - Formula for treating systemic degenerative arthritis pain and preparation method thereof

Info

Publication number: CN111035689A
Application number: CN201911414411.4A
Authority: CN
Inventors: 李志强; 陈磊; 徐弘洲; 荆亚飞; 徐道志; 朱奎; 张甜甜; 王帅; 李艳玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2020-04-21

Abstract

The invention relates to a formula for treating systemic degenerative arthritis pain, which comprises the following components in parts by weight: 3-5 parts of prepared common monkshood mother root, 3-5 parts of fried white mustard seed, 3-5 parts of clematis root, 3-5 parts of cassia twig, 3-5 parts of pearl lopseed, 1-3 parts of szechuan lovage rhizome, 1-3 parts of rhubarb, 1-3 parts of Chinese taxillus twig, 1-3 parts of salvia miltiorrhiza, 1-3 parts of pepper, 1-3 parts of angelica dahurica, 1-3 parts of tree peony bark, 1-3 parts of medicinal cyathula root, 1-3 parts of teasel root, 1-3 parts of white paeony root and 1-3 parts of liquorice. The invention also relates to a preparation method of the formula. The medicinal powder prepared by the invention has reasonable composition, small dosage and environmental protection; the medicine materials are mixed, humidified, heated and steamed, so that the medicine effect is easy to leach, and the use amount is reduced; the mature vinegar is mixed and applied, so that the osteoarthritis symptom can be relieved, bony spur can be softened, local inflammation can be reduced, and the strength of dispelling wind-cold-dampness evil is enhanced; the operation is simple in the using process, the curative effect is obvious, the side effect is less, and therefore, the traditional Chinese medicine composition can be widely applied to the technical field of traditional Chinese medicines.

Description

Formula for treating systemic degenerative arthritis pain and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a formula for treating systemic degenerative arthritis pain and a preparation method thereof.

Background

The systemic degenerative arthritis is a clinically very common disease, also called osteoarthritis and proliferative osteoarthritis, which are mostly seen in the elderly and are now collectively called neck, shoulder, waist and leg pain diseases, and different names are from the pathological manifestations of joint diseases, namely cartilage degeneration accompanied with the formation of new bones. With the increasing aging degree of China, the incidence of the disease increases with the increasing age, and is one of the important disease causes of the life disorder and the life quality decline of the elderly.

Degenerative osteoarthritis is a chronic joint disease whose major changes are degeneration of the articular cartilage surface and secondary hyperosteogeny. The main manifestations are arthralgia and inflexibility, the X-ray shows that the joint space becomes narrow, the subchondral bone is compact, the trabecular bone is broken, and there are sclerosis and cystic changes. There was labial hyperplasia at the joint margins. Later, the bone end is deformed and the articular surface is uneven. This disease usually occurs in joints with more movement and heavy burden, such as knee joint, ankle joint, lumbar vertebra, cervical vertebra, sacroiliac joint, hip joint, shoulder joint, elbow joint, and wrist joint.

The "Nei Jing" has cloud: the disease is manifested as wind in yang and arthralgia in yin. So arthralgia is also marked by wind-cold-dampness affecting yin of meridians. Arthralgia is also called arthralgia because qi in three meridians and collaterals are blocked and blood and qi are obstructed. The formation of arthralgia is mostly caused by the deficiency of the healthy qi in the interior, the deficiency of the ying-wei in the meridians, the wind-evil attacking the body by means of the killing force of the wind-evil and the dampness of the wind-evil by means of the dispersing and draining energy of the wind-evil. When it first invades the meridians, it enters the muscles and bones, involving the blood vessels and flowing into the joints. Unsmooth menstruation, obstructed collateral and blood flow, and insufficient yang qi, which cause frequent and painful pathogenic qi.

The main causes of the disease are wind, cold and damp invasion, which cause local muscle spasm, changes of bone joint positions, contracture of muscle ligament fascia, muscle adhesion, limited activity of local bone joints, gradual abrasion of joint cartilages and degeneration to form the disease. The disease is mainly the elderly, the people are weak in constitution, pathogenic wind, cold and dampness invade the human body due to deficiency, qi and blood are blocked, qi and blood are the disease, the pathogenic factors close channels and collaterals, the channels and collaterals are blocked, repeated attack and gradual development are realized, the channels and collaterals are blocked, phlegm and blood stasis are combined, and the disease is mostly caused by deficiency of healthy qi and excess of pathogenic factors; the deep invasion of pathogenic factors, the deficiency of qi and blood, the deficiency of liver and kidney, the malnutrition of muscles and bones, and severe systemic degenerative arthritis. The diseased part of the disease is in the joints of bones and muscles, the bones and muscles depend on the nourishment of essence and blood in liver and kidney and the warm-up of yang-qi in governor kidney, the kidney deficiency is inherent and unconsolidated, the diseases are all bred, the original yang in kidney is the origin of all yang of human body, and the arthralgia due to wind-cold-dampness is mostly manifested as pain, aching and serious, and can be dissolved when the yang-qi is excited, so the disease is related to the factors of liver and kidney deficiency, muscles and bones malnutrition, wind-cold-dampness pathogen invasion, phlegm stasis and stagnation, and the like, and belongs to the syndrome of deficiency of the origin and excess of the index.

The aim of treating osteoarthritis is currently to relieve pain, relieve symptoms, arrest and delay the progression of the disease, protect joint function from disability. At present, the following treatment methods are commonly used, including operation and non-operation treatment, and the non-operation treatment aims at eliminating aseptic inflammation and restoring the internal and external balance of bones and muscles of the spine. The non-operative treatment methods are various, but not limited to oral non-steroidal anti-inflammatory and analgesic drugs, manipulations, physical therapy, traditional Chinese medicine iontophoresis, traditional Chinese medicine fumigation, acupuncture, water injection, closure, functional exercise and the like. The non-operative methods mainly include: the cognition and prevention consciousness of the patient to the risk factors is improved, local relevant muscle group exercise is properly carried out, and the joint movement can be maintained and improved so as to enhance the stability of the joint; the sun is mostly sunned, and the people pay attention to cold and dampness prevention and warm keeping; the local treatment is carried out by infrared ray, traction, ultrashort wave, acupuncture, wax therapy, massage, traction and the like to relax muscles and improve local blood circulation; the non-steroid medicine and glucosamine chondroitin can repair local cartilage and eliminate local inflammation.

Currently, most of the doctors in clinic use multi-method combination, mainly hospitalization, wherein traditional Chinese medicine fumigation, traditional Chinese medicine oral administration, medicine hot compress, acupuncture and moxibustion, and manual therapy are the most commonly used. The traditional Chinese medicine external application method mainly comprises plaster, thin plaster, traditional Chinese medicine fumigation and hot compress, the traditional Chinese medicine external application plaster comprises black plaster, rubber plaster, cataplasm, coating agent and the like, individual components of the traditional Chinese medicine are extracted through high-temperature oil refining paste boiling processing or simply in the manufacturing process, the effective components of the medicine are destroyed completely, the medicine effect is greatly reduced, the traditional Chinese medicine external application method is not beneficial to treatment of lumbar disc herniation, and a large amount of precious medicinal material resources are wasted. The effects of the traditional Chinese medicine fumigation and washing medicines can not be completely acted on the skin, and only part of the medicines can be acted on the local part of the skin by hot steam; the existing hot compress traditional Chinese medicine particles are large, cannot fully exert the drug effect, have high hospitalization cost and cannot bring convenience.

Disclosure of Invention

In order to solve the technical problems, the technical scheme provided by the invention is as follows:

a formula for treating systemic degenerative arthritis pain comprises the following components in parts by weight: 3-5 parts of prepared common monkshood mother root, 3-5 parts of fried white mustard seed, 3-5 parts of clematis root, 3-5 parts of cassia twig, 3-5 parts of pearl lopseed, 1-3 parts of szechuan lovage rhizome, 1-3 parts of rhubarb, 1-3 parts of Chinese taxillus twig, 1-3 parts of salvia miltiorrhiza, 1-3 parts of pepper, 1-3 parts of angelica dahurica, 1-3 parts of tree peony bark, 1-3 parts of medicinal cyathula root, 1-3 parts of teasel root, 1-3 parts of white paeony root and 1-3 parts of liquorice.

Further, the feed comprises the following components in parts by weight: 3 parts of prepared common monkshood mother root, 3 parts of fried white mustard seed, 3 parts of clematis root, 3 parts of cassia twig, 3 parts of pearl lopseed, 1 part of szechuan lovage rhizome, 1 part of rhubarb, 1 part of parasitic loranthus, 1 part of salvia miltiorrhiza, 1 part of pepper, 1 part of angelica dahurica, 1 part of tree peony bark, 1 part of medicinal cyathula root, 1 part of teasel root, 1 part of white paeony root and 1 part of liquorice.

Further, the feed comprises the following components in parts by weight: 5 parts of prepared common monkshood mother root, 5 parts of fried white mustard seed, 5 parts of clematis root, 5 parts of cassia twig, 5 parts of pearl lopseed, 3 parts of szechuan lovage rhizome, 3 parts of rhubarb, 3 parts of Chinese taxillus twig, 3 parts of salvia miltiorrhiza, 3 parts of pepper, 3 parts of angelica dahurica, 3 parts of tree peony bark, 3 parts of medicinal cyathula root, 3 parts of himalayan teasel root, 3 parts of white paeony root and 3 parts of liquorice.

Further, the feed comprises the following components in parts by weight: 4 parts of prepared common monkshood mother root, 4 parts of fried white mustard seed, 4 parts of clematis root, 4 parts of cassia twig, 4 parts of pearl lopseed, 2 parts of szechuan lovage rhizome, 2 parts of rhubarb, 2 parts of Chinese taxillus twig, 2 parts of salvia miltiorrhiza, 2 parts of pepper, 2 parts of angelica dahurica, 2 parts of tree peony bark, 2 parts of medicinal cyathula root, 2 parts of himalayan teasel root, 2 parts of white paeony root and 2 parts of liquorice.

The invention also provides a technical scheme that:

a preparation method of the formula for treating the general degenerative arthritis pain comprises the following preparation steps:

s1, respectively mixing a certain amount of radix Aconiti Preparata, semen Sinapis Albae preparata, radix Clematidis, ramulus Cinnamomi, herba speranskiae tuberculatae, rhizoma Chuanxiong, radix Et rhizoma Rhei, herba Taxilli, radix Salviae Miltiorrhizae, pericarpium Zanthoxyli, radix Angelicae Dahuricae, cortex moutan, radix Cyathulae, radix Dipsaci, radix Paeoniae alba, and radix Glycyrrhizae, heating, and steaming to ensure the medicinal effect to be easily leached;

s2, drying the cooked medicinal powder obtained in the step S1, crushing the dried medicinal powder into fine powder, and sieving the fine powder by a 100-mesh sieve for later use;

s3, sealing the sieved medicine powder obtained in the step S2 by using a sealing bag according to the amount of one part per 50 g for later use.

Further, when in use, warm water and mature vinegar are firstly used for soaking the formula, the formula is mixed into paste, the pure cotton cloth bag is wrapped, the cloth bag is heated to a proper temperature and is externally applied to the corresponding part of a pathological change, the preservative film is externally used for covering, and the cotton quilt is kept warm.

Further, the application time is 40-45 min per time.

Furthermore, when the medicinal powder is blended by using warm water and mature vinegar, the weight ratio of the warm water to the mature vinegar to the medicinal powder is 3:1:1-4:2: 1.

Further, the temperature of the warm water is 45-50 ℃.

After the method is adopted, the invention has the following advantages:

① the powder prepared by the invention has reasonable composition, small dosage and environmental protection;

② the medicine materials are mixed, humidified, heated and steamed, so that the medicine effect is easy to leach out, and the use amount is reduced;

③ the mature vinegar can be mixed with the powder to relieve osteoarthritis, soften spur, reduce local inflammation, dispel wind-cold-dampness;

④ has simple operation, good therapeutic effect, and low adverse side effect.

Detailed Description

The present invention is described in further detail below.

With the gradual improvement of treatment technology, the search for simple, safe and effective non-operative treatment means for treating the disease aims at effectively relieving acute and chronic pain of the disease and recovering the living ability of the disease is a great difficulty in treatment. Through years of clinical experience summarization, a fine powder external application technology mainly aiming at eliminating local inflammatory edema and dispelling local wind-cold-dampness arthralgia is formed, and the external application technology is favored by more and more doctors due to the advantages of simple and convenient operation, exact curative effect, safety, low price, easy acceptance by patients and the like, and is one of the main treatment methods for treating systemic osteoarthritis pain at present.

The traditional Chinese medicinal materials required by the invention comprise radix aconiti preparata, stir-fried semen brassicae, radix clematidis, cassia twig, pearl speranskia herb, ligusticum wallichii, rheum officinale, parasitic loranthus, the root of red-rooted salvia, pepper, radix angelicae, cortex moutan, medicinal cyathula root, teasel root, radix paeoniae alba and liquorice.

Example one

The components and the mixture ratio adopted in the specific implementation process of the invention are as follows:

a formula for treating systemic degenerative arthritis pain comprises the following components in parts by weight: 3 parts of prepared common monkshood mother root, 3 parts of fried white mustard seed, 3 parts of clematis root, 3 parts of cassia twig, 3 parts of pearl lopseed, 1 part of szechuan lovage rhizome, 1 part of rhubarb, 1 part of parasitic loranthus, 1 part of salvia miltiorrhiza, 1 part of pepper, 1 part of angelica dahurica, 1 part of tree peony bark, 1 part of medicinal cyathula root, 1 part of teasel root, 1 part of white paeony root and 1 part of liquorice.

The formula of the invention is prepared by using the components, and the specific steps are as follows:

In the process of treating patients by using the invention, the specific using method is as follows:

soaking the above prepared formula with warm water and old vinegar, concocting into paste, wrapping with pure cotton cloth bag, heating the cloth bag to appropriate temperature, applying on the corresponding part of pathological changes, covering with preservative film, and keeping the cotton quilt warm. In the process of treating patients by using the external application medicament, the time for each external application of the external application medicament is 40 minutes. Wherein the temperature of the warm water is 45 deg.C or above, and the weight ratio of the warm water, mature vinegar and the medicinal powder is 3:1: 1.

Example two

On the basis of not changing the preparation and use methods, the proportion of each component is changed, and the method specifically comprises the following steps:

a formula for treating systemic degenerative arthritis pain comprises the following components in parts by weight: 5 parts of prepared common monkshood mother root, 5 parts of fried white mustard seed, 5 parts of clematis root, 5 parts of cassia twig, 5 parts of pearl lopseed, 3 parts of szechuan lovage rhizome, 3 parts of rhubarb, 3 parts of Chinese taxillus twig, 3 parts of salvia miltiorrhiza, 3 parts of pepper, 3 parts of angelica dahurica, 3 parts of tree peony bark, 3 parts of medicinal cyathula root, 3 parts of himalayan teasel root, 3 parts of white paeony root and 3 parts of liquorice.

In the preparation process, the weight ratio of the warm water, the mature vinegar and the medicinal powder is 4:2: 1.

EXAMPLE III

A formula for treating systemic degenerative arthritis pain comprises the following components in parts by weight: 4 parts of prepared common monkshood mother root, 4 parts of fried white mustard seed, 4 parts of clematis root, 4 parts of cassia twig, 4 parts of pearl lopseed, 2 parts of szechuan lovage rhizome, 2 parts of rhubarb, 2 parts of Chinese taxillus twig, 2 parts of salvia miltiorrhiza, 2 parts of pepper, 2 parts of angelica dahurica, 2 parts of tree peony bark, 2 parts of medicinal cyathula root, 2 parts of himalayan teasel root, 2 parts of white paeony root and 2 parts of liquorice.

Example four

In this embodiment, the treatment effects of the first to third embodiments are verified.

According to the theory of traditional Chinese medicine and the characteristics of the material components, when the mature vinegar is used for mixing and applying, the relieving of osteoarthritis symptoms can be improved, bony spurs can be softened, and local inflammation can be reduced, so that the strength of dispelling wind-cold-dampness evil of the invention is enhanced.

The osteoarticular pain disease is more obvious particularly in cold seasons, and the pain of the affected part of the patient is increased when the weather changes, so that the disease is treated in spring seasons when the invention is used for experimental verification of the patient, and the situation that the local position of the patient is stuffy due to the attaching effect of the preservative film can be avoided.

In the process of clinical experiment, an experimental group, a control group and a blank group are respectively selected for verification, wherein: the experimental group selects 15 patients with the same age and different clinical bone and joint pain feelings, and is pasted with the formula provided by the invention on time, the control group selects the patients with the joint pain generally treated in the prior art, and the blank group is cleaned with warm water every day and is pasted with a preservative film for treatment.

After three days of use of the present invention, symptoms were significantly improved, and after 30-45 days of control treatment, the pain sensation of the patients in the experimental group was significantly improved and gradually cured. The symptoms of the control group were relieved to some extent, but when it came to be rainy and the weather turned cold, there was still a recurrent pain. The blank group gave only slight relief and had no therapeutic effect.

Claims

1. The formula for treating the general degenerative arthritis pain is characterized by comprising the following components in parts by weight: 3-5 parts of prepared common monkshood mother root, 3-5 parts of fried white mustard seed, 3-5 parts of clematis root, 3-5 parts of cassia twig, 3-5 parts of pearl lopseed, 1-3 parts of szechuan lovage rhizome, 1-3 parts of rhubarb, 1-3 parts of Chinese taxillus twig, 1-3 parts of salvia miltiorrhiza, 1-3 parts of pepper, 1-3 parts of angelica dahurica, 1-3 parts of tree peony bark, 1-3 parts of medicinal cyathula root, 1-3 parts of teasel root, 1-3 parts of white paeony root and 1-3 parts of liquorice.

2. The formula for treating the systemic degenerative arthritis pain according to claim 1, which comprises the following components in parts by weight: 3 parts of prepared common monkshood mother root, 3 parts of fried white mustard seed, 3 parts of clematis root, 3 parts of cassia twig, 3 parts of pearl lopseed, 1 part of szechuan lovage rhizome, 1 part of rhubarb, 1 part of parasitic loranthus, 1 part of salvia miltiorrhiza, 1 part of pepper, 1 part of angelica dahurica, 1 part of tree peony bark, 1 part of medicinal cyathula root, 1 part of teasel root, 1 part of white paeony root and 1 part of liquorice.

3. The formula for treating the systemic degenerative arthritis pain according to claim 1, which comprises the following components in parts by weight: 5 parts of prepared common monkshood mother root, 5 parts of fried white mustard seed, 5 parts of clematis root, 5 parts of cassia twig, 5 parts of pearl lopseed, 3 parts of szechuan lovage rhizome, 3 parts of rhubarb, 3 parts of Chinese taxillus twig, 3 parts of salvia miltiorrhiza, 3 parts of pepper, 3 parts of angelica dahurica, 3 parts of tree peony bark, 3 parts of medicinal cyathula root, 3 parts of himalayan teasel root, 3 parts of white paeony root and 3 parts of liquorice.

4. The formula for treating the systemic degenerative arthritis pain according to claim 1, which comprises the following components in parts by weight: 4 parts of prepared common monkshood mother root, 4 parts of fried white mustard seed, 4 parts of clematis root, 4 parts of cassia twig, 4 parts of pearl lopseed, 2 parts of szechuan lovage rhizome, 2 parts of rhubarb, 2 parts of Chinese taxillus twig, 2 parts of salvia miltiorrhiza, 2 parts of pepper, 2 parts of angelica dahurica, 2 parts of tree peony bark, 2 parts of medicinal cyathula root, 2 parts of himalayan teasel root, 2 parts of white paeony root and 2 parts of liquorice.

5. The method of preparing a formulation for treating degenerative systemic arthritis pain according to claim 1, comprising the steps of:

6. The preparation method of the formula for treating the degenerative systemic arthritis pain according to claim 5, wherein in use, warm water and mature vinegar are firstly used for soaking the formula, the formula is mixed into paste, a pure cotton cloth bag is wrapped, the cloth bag is heated to a proper temperature and is externally applied to the corresponding part of the pathological change, a preservative film is externally used for covering, and a cotton quilt is used for keeping warm.

7. The method for preparing a formulation for the treatment of degenerative general arthritis pain according to claim 5, wherein the application is performed for 40-45 minutes each time on the lesion site.

8. The method for preparing a formulation for treating degenerative joint pain throughout the body according to claim 5, wherein the weight ratio of the warm water, the mature vinegar and the powder is 3:1:1-4:2:1 when the warm water and the mature vinegar are used to blend the powder.

9. The method for preparing a formulation for the treatment of degenerative systemic arthritis pain according to claim 8, wherein the temperature of the warm water is 45-50 ℃.