CN111035413A - Digestive tract sampling capsule and sampling system - Google Patents
Digestive tract sampling capsule and sampling system Download PDFInfo
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- CN111035413A CN111035413A CN201911299847.3A CN201911299847A CN111035413A CN 111035413 A CN111035413 A CN 111035413A CN 201911299847 A CN201911299847 A CN 201911299847A CN 111035413 A CN111035413 A CN 111035413A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- Medical Informatics (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a digestive tract sampling capsule, which comprises a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling cabin, and the other side of the partition plate is a control cabin; the control cabin comprises a micro motor, a control circuit board, a magnet, a micro battery and a signal transceiving component; the control circuit board is connected with the micro motor and the signal transceiving component; a circular ring is arranged at the position of the sampling cabin close to the partition plate, the circular ring is coaxial with the sampling capsule, and the outer surface of the circular ring is attached to the inner surface of the capsule shell; the micro motor drives the ring to rotate; be equipped with N sample inlet on the ring, be equipped with N sampling hole on the capsule casing with the ring laminating, sample inlet and sampling hole are sampled in order to counterpoint the intercommunication through the rotation of ring, perhaps dislocation shutoff. According to the invention, the external magnetic field detection device is used for accurately tracking the position of the sampling capsule, so that the accurate collection of the microorganisms in the target digestive tract area is realized.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a digestive tract sampling capsule and a sampling system.
Background
The large number of microorganisms inhabit the digestive tract, and the number of microorganisms in the human intestinal tract is 10 times of the number of human cells, and the microorganisms are various. These microorganisms constitute a large and complex ecosystem that establishes a symbiotic relationship with the host. Recent researches gradually reveal that the intestinal flora is closely related to human health, and the intestinal flora is attached to a mucous membrane layer on the inner wall surface of an intestinal tract, so that pathogenic bacteria can be prevented from invading a human body by shielding and influencing the immune system of the body. The intestinal flora influences the digestion capability of human and provides nutrition for human body. Can also control the reaction of human body to cancer treatment medicine. The intestinal dysbacteriosis is closely related to malnutrition, obesity, diabetes and other diseases. The microorganisms are not evenly distributed within the digestive tract. Due to the physiological state between different individuals and at different parts of the gastrointestinal tract of the same individual: such as different pH values, oxygen contents, antibacterial peptides, short-chain fatty acid levels and intestinal peristalsis strength, and interaction among floras, the types, distribution and quantity of the floras also have certain differences. Therefore, how to accurately collect microorganism samples in different areas of the digestive tract has a very important significance for accurately researching the action rule between microorganisms and human health.
CN201910087145.2 discloses a method and a system for detecting intestinal microbial flora, which is characterized in that a microbial sample is collected from excrement, the collected microbial sample is the microbe at the tail end of an intestinal tract, and the microbial sample in other digestive tracts can not be obtained; CN201710049217.5 discloses an intestinal microorganism collection capsule, which is provided with two groups of enteric-coated components, and the dissolution of the enteric-coated components in the intestinal tract triggers the capsule to sample in the gastrointestinal tract; the thickness of the enteric material is designed by estimating the time required for the capsule to reach each part of the intestinal tract; because different individuals have different physiological conditions of the digestive tract in different periods, the thickness of the enteric-coated material cannot be accurately designed, and accurate collection of a microorganism sample is realized.
Therefore, there is an increasing need for sample collection devices that can achieve precise control of the microorganism collection area.
Disclosure of Invention
The invention provides a digestive tract sampling capsule and a sampling system, which are used for solving or partially solving the technical problem that the sampling area cannot be accurately controlled by the conventional digestive tract sampling device or means.
In order to solve the technical problem, the invention provides a digestive tract sampling capsule, which comprises a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling cabin, and the other side of the partition plate is a control cabin;
the control cabin comprises a micro motor, a control circuit board, a magnet, a micro battery and a signal transceiving component; the control circuit board is connected with the micro motor and the signal transceiving component, and the micro battery supplies power to the micro motor, the control circuit board and the signal transceiving component; the magnet is fixed on the inner surface of the capsule shell;
a circular ring is arranged at the position of the sampling cabin close to the partition plate, the circular ring is coaxial with the sampling capsule, and the outer surface of the circular ring is attached to the inner surface of the capsule shell; the load end of the micro motor penetrates through the partition plate to be connected with the circular ring so as to drive the circular ring to rotate;
the ring is provided with N sampling holes, and the capsule shell attached to the ring is provided with N sampling holes; the signal receiving and transmitting component is used for receiving a sampling signal or a stop signal; the N sampling holes and the N sampling holes are communicated in an alignment mode through rotation of the circular ring for sampling or are blocked in a staggered mode, and N is larger than or equal to 1 and is a positive integer.
Optionally, a connecting sleeve is arranged at the center of the circular ring, the inner surface of the circular ring is fixedly connected with the connecting sleeve through a metal wire, the load end of the micro motor is connected with the input shaft of the reduction gear train, and the output shaft of the reduction gear train is connected with the connecting sleeve.
According to the technical scheme, the internal initial state of the sampling cabin is vacuum.
The invention also provides a digestive tract sampling system, which comprises an in-vitro control device and the digestive tract sampling capsule in the embodiment, wherein the in-vitro control device comprises a magnetic sensor array, a control module and a radio frequency transceiving module, and the control module is connected with the magnetic sensor array and the radio frequency transceiving module;
the magnetic sensor array detects and sends a magnetic induction intensity signal of the permanent magnet to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
when the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stop signal to the digestive tract sampling capsule through the radio frequency transceiving module;
the control circuit board in the alimentary canal sampling capsule controls the micro motor to drive the ring to rotate according to the sampling signal or the stop signal received by the signal receiving and sending component, so that the N sampling holes and the N sampling holes are communicated in an alignment mode to be sampled, or the sampling is stopped by dislocation plugging.
Optionally, external control device is wearable vest, sets up the mounting hole on the vest in order to install the magnetic sensor array, and control module group and radio frequency transceiver module are fixed to the vest.
Furthermore, more than one control switch is arranged on the waistcoat, each control switch corresponds to one preset digestive tract area, and the control switches are connected between the magnetic sensors of the preset digestive tract areas and the control module.
When one control switch is closed, the preset digestive tract area corresponding to the control switch is the target digestive tract area.
According to the technical scheme, the vest further comprises a wireless communication component connected with the control module, and the wireless communication component is in communication connection with the intelligent electronic equipment;
the control module sends the position information of the digestive tract sampling capsule to the intelligent electronic equipment in real time through the wireless communication module;
the intelligent electronic equipment is used for sending a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule
The intelligent electronic equipment sends a sampling signal or a stopping signal to the digestive tract sampling capsule through the control module so that the digestive tract sampling capsule performs sampling or stops sampling. Optionally, the wireless communication module comprises at least one of a Wifi module, a bluetooth module, a ZigBee module, and a cellular module.
The invention also provides a digestive tract sampling method, which uses the digestive tract sampling system in the technical scheme and specifically comprises the following steps:
determining a target digestive tract area for sampling, and closing a control switch on the waistcoat corresponding to the target digestive tract area;
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
after the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stop signal to the digestive tract sampling capsule through the radio frequency transceiving module;
the digestive tract sampling capsule controls the micro motor to drive the ring to rotate according to the sampling signal or the stop signal so as to ensure that the N sampling holes and the N sampling holes are communicated in an alignment mode for sampling or the sampling is stopped by dislocation plugging.
The invention also provides a digestive tract sampling method, which uses the digestive tract sampling system in the technical scheme and specifically comprises the following steps:
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
determining a target digestive tract area for sampling, and sending the position information of a digestive tract sampling capsule to intelligent electronic equipment in real time through a control module and a wireless communication component; the intelligent electronic equipment monitors the position information of the digestive tract sampling capsule;
when the digestive tract sampling capsule enters a target digestive tract area, the intelligent electronic equipment sends a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule;
when the fact that the digestive tract sampling capsule leaves a target digestive tract area is monitored, or after the sampling is carried out for a preset time length, the intelligent electronic equipment sends a stopping instruction to the control module, so that the control module sends a stopping signal to the digestive tract sampling capsule;
the digestive tract sampling capsule controls the micro motor to drive the ring to rotate according to the sampling signal or the stop signal so as to ensure that the N sampling holes and the N sampling holes are communicated in an alignment mode for sampling or the sampling is stopped by dislocation plugging.
Through one or more technical schemes of the invention, the invention has the following beneficial effects or advantages:
the invention discloses a digestive tract sampling capsule, which is internally provided with a sampling cabin and a control cabin; the control cabin is internally provided with a micro motor, a control circuit board, a magnet and a signal transceiving component; the invention accurately tracks the position of the sampling capsule through the external magnetic field detection device and then sends a sampling instruction to the sampling capsule; the micro motor drives the circular ring positioned in the sampling cabin to rotate, so that the sampling hole on the circular ring and the sampling hole on the capsule shell are in counterpoint communication for sampling, and the accurate collection of the microorganisms in the target digestive tract area is realized.
The foregoing description is only an overview of the technical solutions of the present invention, and the embodiments of the present invention are described below in order to make the technical means of the present invention more clearly understood and to make the above and other objects, features, and advantages of the present invention more clearly understandable.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
FIG. 1 shows a schematic structural view of an alimentary tract sampling capsule according to one embodiment of the present invention;
FIG. 2 shows a cross-sectional view A-A of an alimentary tract sampling capsule according to one embodiment of the present invention;
FIG. 3 shows a schematic view of a vest according to one embodiment of the invention;
description of reference numerals:
1. a capsule housing; 2. a sampling cabin; 3. a control cabin; 4. a partition plate; 5. a circular ring; 6. a micro motor; 7. a control circuit board; 8. a micro battery; 9. a magnet; 10. a signal transceiving component; 11. a sampling hole; 12. a sample inlet hole; 13. connecting sleeves; 14. a metal wire.
Detailed Description
In order to make the present application more clearly understood by those skilled in the art to which the present application pertains, the following detailed description of the present application is made with reference to the accompanying drawings by way of specific embodiments.
To achieve accurate sampling in different regions of the alimentary tract, the inventors propose in some alternative embodiments a method for positioning and sampling a sampling device using a magnet, as shown in fig. 1, in particular as follows:
a digestive tract sampling capsule comprises a hollow capsule shell 1, a partition plate 4 is arranged in the capsule shell 1, one side of the partition plate 4 is a sampling cabin 2, and the other side is a control cabin 3;
the control cabin 3 comprises a micro motor 6, a control circuit board 7, a magnet 9, a micro battery 8 and a signal transceiving component 10; the control circuit board 7 is connected with the micro motor 6 and the signal transceiving component 10, and the micro battery 8 supplies power to the micro motor 6, the control circuit board 7 and the signal transceiving component 10; the magnet 9 is fixed on the inner surface of the capsule shell 1;
a circular ring 5 is arranged at the position of the sampling cabin 2 close to the partition plate 4, the circular ring 5 is coaxial with the sampling capsule, and the outer surface of the circular ring 5 is attached to the inner surface of the capsule shell 1; the load end of the micro motor 6 penetrates through the partition plate 4 to be connected with the circular ring 5 so as to drive the circular ring 5 to rotate;
the ring 5 is provided with N sampling holes 12, and the capsule shell 1 attached to the ring 5 is provided with N sampling holes 11; the signal transceiving component 10 is used for receiving a sampling signal or a stop signal; the N sampling holes 12 and the N sampling holes 11 are communicated in an alignment mode through rotation of the circular ring 5 to perform sampling, or sampling is stopped by dislocation plugging, and N is not less than 1 and is a positive integer.
Specifically, the embodiment provides a sampling capsule robot, the size of the sampling capsule is similar to that of a common capsule, a subject to be sampled swallows the sampling capsule, and the capsule robot continuously advances along the directions of the stomach, duodenum, jejunum, ileum and rectum under the peristalsis of the intestines and stomach of a human body. Since the sampling capsule needs to enter the alimentary tract, the capsule housing 1 is made of a biomedical material that is biocompatible and not corroded by digestive fluids. For ease of manufacture, the capsule housing 1 may be a split-split structure. According to the function, can divide into sampling cabin 2 and control cabin 3 with the capsule that samples, in order to prevent that the sample of gathering from getting into control cabin 3, cut apart through baffle 4 between sampling cabin 2 and the control cabin 3, baffle 4 can be the plastics material. The load end of the micro-motor 6 is treated for anti-infiltration at the position where it passes through the partition 4.
In order to realize accurate positioning of the capsule robot in the body, a magnetic field is used for positioning and tracking. The magnet 9 in the capsule is used as a magnetic source and a tracking target, magnetic induction intensity of a space designated position can be measured by using a magnetic sensor outside the capsule, and position information and direction information of the magnet 9 can be calculated by using the data. In order to provide sufficient magnetic induction with a minimum volume, the magnet 9 in the present embodiment may use a set of neodymium-iron-boron permanent magnets, and the shape of the magnet 9 may be processed into a hollow cylindrical shape, which facilitates the fixed connection to the inner surface of the capsule housing 1.
When the sampling capsule reaches a target sampling area, a sampling instruction is sent to the sampling capsule through an external control device, and after the signal receiving and transmitting assembly 10 of the sampling capsule receives the sampling instruction, the control circuit board 7 controls the micro motor 6 to drive the circular ring 5 to rotate for sampling. The ring 5 is arranged in the capsule, the outer surface of the ring 5 is tightly attached to the inner surface of the capsule shell 1, and the ring can rotate around the axis of the capsule under the action of the motor. N sampling hole 11 on the capsule casing 1 and N on the ring 5 advance appearance hole 12 be in with capsule axis vertical concentric circles, through the rotation of ring 5, can make sampling hole 11 and advance appearance hole 12 counterpoint, make inside and the outside intercommunication of capsule, form sampling passage and take a sample. After the sampling is finished, the outside sends a stop instruction, the control circuit board 7 of the sampling capsule controls the micro motor 6 to drive the circular ring 5 to rotate, so that the N sampling holes 11 and the N sampling holes 12 are staggered, and the plugging and the stopping of the sampling are realized. The sampling capsule can be discharged out of the body along with excrement after being swallowed for 8-72 hours. The sampling of the microorganisms in the digestive tract can be realized by recovering the samples in the capsules.
The sampling capsule robot provided in this embodiment accurately tracks the position of the sampling capsule through the external magnetic field detection device, and then controls the sampling capsule robot to sample, thereby realizing accurate collection of microorganisms in the target digestive tract region. The sampling capsule robot can be applied to normal people without special requirements on magnetic fields, and can not be applied to people with special requirements on magnetic field strength similar to those who are provided with cardiac pacemakers.
In some optional embodiments, a specific scheme that the micro motor 6 drives the circular ring 5 to rotate is given, as shown in fig. 2, a connecting sleeve 13 is arranged at the center of the circular ring 5, the inner surface of the circular ring 5 is fixedly connected with the connecting sleeve 13 through a metal wire 14, the load end of the micro motor 6 is connected with the input shaft of the reduction gear train, and the output shaft of the reduction gear train is connected with the connecting sleeve 13. The output of the micro motor 6 is decelerated through the reduction gear train, and then the metal wire drives the circular ring 5 to rotate through the connecting shaft, so that the accurate alignment sampling or dislocation plugging of the sampling hole 11 and the sampling hole 12 is realized.
In order to effectively perform sampling and reduce the sampling time, in some alternative embodiments, the internal initial state of the sampling chamber 2 is vacuum, and when the sampling hole 11 and the sampling hole 12 are aligned, the digestive tract liquid will be automatically sucked into the sampling chamber 2, so as to realize rapid collection of the microorganism sample.
Since the sampling capsule is located in the alimentary tract of the body, the signal transceiving assembly 10 includes a signal receiver and a signal antenna in order to enhance the signal reception capability.
The foregoing embodiments provide a capsule for sampling a digestive tract, and in the following embodiments, a system for sampling a digestive tract is provided, including an extracorporeal control device and a capsule for sampling a digestive tract as in any of the foregoing embodiments, the extracorporeal control device includes a magnetic sensor array, a control module and a radio frequency transceiver module, the control module connects the magnetic sensor array and the radio frequency transceiver module;
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
after the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stop signal to the digestive tract sampling capsule through the radio frequency transceiving module;
the digestive tract sampling capsule controls the micro motor 6 to drive the circular ring 5 to rotate according to the sampling signal or the stop signal, so that the N sampling holes 12 and the N sampling holes 11 are communicated in a contraposition mode to carry out sampling, or the sampling is stopped by dislocation plugging.
In this embodiment, the sampling capsule entering the alimentary tract is positioned and controlled for sampling by an extracorporeal control device. The magnetic sensor array comprises a group of magnetic sensors which can be arranged outside the body and correspond to different preset digestive tract regions. The predetermined alimentary canal region may be modified as desired, including at least one of the stomach, duodenum, ileum, jejunum, and colon. The magnetic sensor array sends magnetic induction intensity signals to the control circuit board 7 in real time, the control circuit board 7 comprises an operational amplifier and an A/D converter, analog signals transmitted by the magnetic sensors are converted into digital signals, and then a processor in the control circuit board 7 calculates position information and direction information of the magnet 9 in real time according to the magnetic induction intensity signals, so that the specific position of a sampling capsule entering the alimentary canal is determined. When the sampling capsule enters a certain preset digestive tract area, the magnetic induction intensity signal value measured by the magnetic sensor in the area is strongest, when the preset digestive tract area is a target digestive tract area to be sampled, the processor sends a sampling signal to the sampling capsule, and at the moment, the micro motor 6 in the sampling capsule drives the circular ring 5 to rotate, so that the sampling hole 11 and the sampling hole 12 are in contraposition sampling; after sampling is finished, the processor sends a stop signal to the sampling capsule, and the micro motor 6 drives the circular ring 5 to rotate again, so that the sampling hole 11 and the sampling hole 12 are plugged in a staggered mode to stop sampling. The processor in the control module can select a Programmable Logic Controller (PLC), and the target digestive tract area to be sampled is set in advance in a PLC programming mode.
Monitoring whether the sampling capsule reaches the target digestive tract area is a long time-consuming process, and in order to provide a convenient and comfortable monitoring environment for the sampling object, based on the same inventive concept of the previous embodiment, in some alternative embodiments, as shown in fig. 3, the extracorporeal control device is a wearable vest, the vest is provided with a mounting hole for mounting the magnetic sensor array, and the control module and the radio frequency transceiver module are fixed to the vest.
The material of the waistcoat depends on the actual situation, such as a cotton waistcoat. The size of the vest can be customized to different body types. The collected object can wear the vest to lie in a bed to wait for the swallowed sampling capsule to enter the target alimentary canal area for sampling. The waistcoat is provided with a mounting hole corresponding to the magnetic sensor according to the preset alimentary canal area, the magnetic sensor array is mounted on the mounting hole, and the control module and the radio frequency transceiving module can be fixedly mounted on the waistcoat. The control module of the waistcoat determines the specific position of the sampling capsule in the alimentary canal according to the magnetic induction intensity signal calculated in real time. For example, when the magnetic induction intensity measured by the magnetic sensor at a certain position exceeds a certain threshold, it indicates that the sampling capsule is located in the digestive tract near the magnetic sensor.
In order to facilitate and automatically control the sampling capsule to perform sampling in the target digestive tract region, based on the same inventive concept of the previous embodiment, in some optional embodiments, more than one control switch is arranged on the waistcoat, each control switch corresponds to one preset digestive tract region, and the control switches are connected between the magnetic sensors and the control module of the preset digestive tract region.
When one control switch is closed, the preset digestive tract area corresponding to the control switch is the target digestive tract area.
In this embodiment, the control switch corresponds to a predetermined digestive tract region, and the waistcoat may be provided with a plurality of control switches corresponding to positions to be observed: at least one of the stomach, duodenum, ileum, jejunum, and colon. When a certain control switch is closed, for example, the control switch corresponding to the stomach is closed, the switch indicator lamp is turned on at the moment, the stomach is the target digestive tract area to be sampled at the time, and the magnetic sensor corresponding to the stomach on the waistcoat is communicated with the control module at the moment. When the control module determines that the sampling capsule reaches the stomach through calculation, a sampling signal is automatically sent to the sampling capsule. When the control module confirms that the sampling capsule leaves the stomach through calculation, or after sampling is carried out for a preset time (such as 1 minute and 5 minutes), a stop signal is automatically sent to the sampling capsule. Before the sampling capsule enters the target digestive tract area, the control switch can be changed, so that the target digestive tract area to be sampled is changed, for example, the control switch corresponding to the stomach is switched off, and the control switch positioned in the duodenum is switched on. The control switch may be a mechanical switch or a solid-state switch as needed, and is not limited in particular.
Based on the same inventive concept of the previous embodiment, in order to facilitate sampling, in other optional embodiments, the vest further comprises a wireless communication component connected with the control module, and the wireless communication component is in communication connection with the intelligent electronic device; the control module sends the position information of the digestive tract sampling capsule to the intelligent electronic equipment in real time through the wireless communication module; the intelligent electronic equipment is used for sending a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule.
In this embodiment, the vest does not adopt a control switch to sample, but tracks the specific position of the sampling capsule in real time through monitoring software on the intelligent electronic device, and can send a sampling instruction or a stop instruction at any time as required.
Optionally, the wireless communication component comprises at least one of a Wifi module, a bluetooth module, a ZigBee module and a cellular module, and the intelligent electronic device can be a smart phone, a tablet computer, a notebook computer, a desktop computer and the like with the signal receiving and sending module.
Based on the same inventive concept of the foregoing embodiments, in other alternative embodiments, there is provided a method for sampling using the digestive tract sampling system of the foregoing embodiments, which specifically includes the following steps:
s1: determining a target digestive tract area for sampling, and closing a control switch on the waistcoat corresponding to the target digestive tract area;
s2: the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
s3: the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
s4: when the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stop signal to the digestive tract sampling capsule through the radio frequency transceiving module;
s5: the digestive tract sampling capsule controls the micro motor 6 to drive the circular ring 5 to rotate according to the sampling signal or the stop signal, so that the N sampling holes 12 and the N sampling holes 11 are communicated in a contraposition mode to carry out sampling, or the sampling is stopped by dislocation plugging.
In S4, the stop signal may be issued after the sampling has been performed for a preset period of time, or may be issued when the sampling capsule has left the target alimentary tract area.
Based on the same inventive concept of the foregoing embodiments, in other alternative embodiments, there is provided a method for sampling using the digestive tract sampling system of the foregoing embodiments, which specifically includes the following steps:
the method specifically comprises the following steps:
s1: the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
s2: the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
s3: the control module sends the position information of the digestive tract sampling capsule to the intelligent electronic equipment in real time through the wireless communication module;
s4: when the digestive tract sampling capsule enters a target digestive tract area, the intelligent electronic equipment sends a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule;
s5: the digestive tract sampling capsule controls the micro motor 6 to drive the circular ring 5 to rotate according to the sampling signal or the stop signal, so that the N sampling holes 12 and the N sampling holes 11 are communicated in a contraposition mode to carry out sampling, or the sampling is stopped by dislocation plugging. Similarly, the sampling command or stop command may be issued by the intelligent electronic device after the sampling has been performed for a predetermined period of time, or may be issued when the sampling capsule has left the target alimentary tract area.
Through one or more embodiments of the present invention, the present invention has the following advantageous effects or advantages:
the invention discloses a digestive tract sampling capsule, which is internally provided with a sampling cabin and a control cabin; the control cabin is internally provided with a micro motor, a control circuit board, a magnet and a signal transceiving component; the invention accurately tracks the position of the sampling capsule through the external magnetic field detection device and then sends a sampling instruction to the sampling capsule; the micro motor drives the circular ring positioned in the sampling cabin to rotate, so that the sampling hole on the circular ring and the sampling hole on the capsule shell are in counterpoint communication for sampling, and the accurate collection of the microorganisms in the target digestive tract area is realized.
Furthermore, the invention discloses a control waistcoat matched with the sampling capsule for use, magnetic induction intensity signals are acquired in real time through a magnetic sensor array on the waistcoat, the real-time position of the sampling capsule in the digestive tract is obtained through calculation of a control module, and when the sampling capsule enters a target digestive tract region, the control module sends a sampling instruction or a stopping instruction, so that accurate acquisition of microorganisms in different target digestive tract regions is conveniently and quickly realized.
While the preferred embodiments of the present application have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all alterations and modifications as fall within the scope of the application.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present application without departing from the spirit and scope of the application. Thus, if such modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application is intended to include such modifications and variations as well.
Claims (10)
1. A digestive tract sampling capsule is characterized by comprising a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling cabin, and the other side of the partition plate is a control cabin;
the control cabin comprises a micro motor, a control circuit board, a magnet, a micro battery and a signal transceiving component; the control circuit board is connected with the micro motor and the signal transceiving component, and the micro battery supplies power to the micro motor, the control circuit board and the signal transceiving component; the magnet is fixed on the inner surface of the capsule shell;
a circular ring is arranged at the position of the sampling cabin close to the partition plate, the circular ring is coaxial with the sampling capsule, and the outer surface of the circular ring is attached to the inner surface of the capsule shell; the load end of the micro motor penetrates through the partition plate to be connected with the circular ring so as to drive the circular ring to rotate;
the ring is provided with N sampling holes, and the capsule shell attached to the ring is provided with N sampling holes; the signal transceiving component is used for receiving a sampling signal or a stop signal; the N sampling holes and the N sampling holes are communicated in an alignment mode through rotation of the circular ring for sampling, or the sampling is stopped through dislocation plugging, and N is not less than 1 and is a positive integer.
2. The digestive tract sampling capsule as claimed in claim 1, wherein the center of the circular ring is provided with a connecting sleeve, the inner surface of the circular ring is fixedly connected with the connecting sleeve through a metal wire, the load end of the micro motor is connected with the input shaft of a reduction gear train, and the output shaft of the reduction gear train is connected with the connecting sleeve.
3. The alimentary sampling capsule according to claim 1, wherein an initial state of the interior of said sampling capsule is a vacuum.
4. A digestive tract sampling system comprising an extracorporeal control device and a digestive tract sampling capsule as claimed in any one of claims 1 to 3, the extracorporeal control device comprising a magnetic sensor array, a control module and a radio frequency transceiver module, the control module connecting the magnetic sensor array and the radio frequency transceiver module;
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
after the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule through the radio frequency transceiving module;
the digestive tract sampling capsule controls the micro motor to drive the circular ring to rotate according to the sampling signal or the stop signal, so that the N sampling holes and the N sampling holes are communicated in an alignment mode to perform sampling, or the sampling is stopped by dislocation plugging.
5. The digestive tract sampling system of claim 4 wherein the extracorporeal control device is a wearable vest having mounting holes for mounting the array of magnetic sensors, the control module and the radio frequency transceiver module being secured to the vest.
6. The digestive tract sampling system according to claim 5, wherein the vest is provided with more than one control switch, each control switch corresponds to a preset digestive tract region, and the control switches are connected between the magnetic sensors of the preset digestive tract regions and the control module;
when one control switch is closed, the preset digestive tract area corresponding to the control switch is the target digestive tract area.
7. The digestive tract sampling system of claim 5 wherein the vest further comprises a wireless communication module connected to the control module, the wireless communication module establishing a communication link with intelligent electronic equipment;
the control module sends the position information of the digestive tract sampling capsule to the intelligent electronic equipment in real time through the wireless communication component;
the intelligent electronic equipment is used for sending a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule.
8. The digestive tract sampling system of claim 7, wherein the wireless communication component comprises at least one of a Wifi module, a bluetooth module, a ZigBee module, and a cellular module.
9. A method for sampling the digestive tract, wherein the method for sampling uses the digestive tract sampling system of claim 6, and comprises the following steps:
determining a target digestive tract area for sampling, and closing a control switch on the waistcoat corresponding to the target digestive tract area;
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
after the digestive tract sampling capsule enters a target digestive tract area, the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule through the radio frequency transceiving module;
the digestive tract sampling capsule controls the micro motor to drive the circular ring to rotate according to the sampling signal or the stop signal, so that the N sampling holes and the N sampling holes are communicated in an alignment mode to perform sampling, or the sampling is stopped by dislocation plugging.
10. A method for sampling the digestive tract, wherein the method for sampling uses the digestive tract sampling system according to claim 7 or 8, and comprises the following steps:
the magnetic sensor array detects and sends a magnetic induction intensity signal to the control module;
the control module determines the position information of the digestive tract sampling capsule according to the magnetic induction intensity signal;
the control module sends the position information of the digestive tract sampling capsule to the intelligent electronic equipment in real time through the wireless communication component;
after the digestive tract sampling capsule enters a target digestive tract area, the intelligent electronic equipment sends a sampling instruction or a stopping instruction to the control module so that the control module sends a sampling signal or a stopping signal to the digestive tract sampling capsule;
the digestive tract sampling capsule controls the micro motor to drive the circular ring to rotate according to the sampling signal or the stop signal, so that the N sampling holes and the N sampling holes are communicated in a contraposition mode to carry out sampling, or the sampling is stopped by dislocation plugging.
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Application publication date: 20200421 |