CN111035416A - Digestive tract sampling device and sampling system - Google Patents
Digestive tract sampling device and sampling system Download PDFInfo
- Publication number
- CN111035416A CN111035416A CN201911299824.2A CN201911299824A CN111035416A CN 111035416 A CN111035416 A CN 111035416A CN 201911299824 A CN201911299824 A CN 201911299824A CN 111035416 A CN111035416 A CN 111035416A
- Authority
- CN
- China
- Prior art keywords
- digestive tract
- sampling
- equal
- control module
- physiological parameters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005070 sampling Methods 0.000 title claims abstract description 231
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 229
- 239000002775 capsule Substances 0.000 claims abstract description 33
- 238000005192 partition Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 27
- 238000012806 monitoring device Methods 0.000 claims description 23
- 238000000338 in vitro Methods 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims description 15
- 238000003860 storage Methods 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 5
- 244000005700 microbiome Species 0.000 abstract description 12
- 230000008569 process Effects 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000001198 duodenum Anatomy 0.000 description 4
- 210000003405 ileum Anatomy 0.000 description 4
- 210000001630 jejunum Anatomy 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 210000002255 anal canal Anatomy 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 241000203069 Archaea Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/065—Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Human Computer Interaction (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a digestive tract sampling device, which comprises a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling area, and the other side of the partition plate is a control area; the control area comprises a first control module, a microsensor module, a switch controller and a micro battery; the first control module is connected with the micro sensor module and the switch controller; the sampling area is provided with a collection cabin and a control switch, the control switch controls the collection cabin to be opened or closed, and the control switch is connected with a switch controller; the micro sensor module comprises a pH value sensor, a temperature sensor and a humidity sensor and sends digestive tract physiological parameters to the first control module; the first control module is used for starting the acquisition cabin to sample when the digestive tract physiological parameters meet first preset conditions; the digestive tract sampling device provided by the invention realizes accurate collection of the microorganism sample by utilizing the difference of physiological parameters of different digestive tract regions.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a digestive tract sampling device and a sampling system.
Background
The digestive tract microorganisms are a general term for all microorganisms inhabiting the digestive tract of humans or animals, including bacteria, archaea, eukaryotes, etc., of which about 80% to 85% cannot be cultured by a conventional method, and thus a sample must be taken from the digestive tract. The distribution of the microorganisms in the digestive tract is very complex, the distribution of the microorganisms in the digestive tract or the dominant flora is different at different ages (day ages), and the distribution of the microorganisms at different parts of a specific growth and development stage is also different. The microorganisms in the digestive tract have a wide range of influences on the animal body, wherein certain diseases of the animal body are directly or indirectly related to the quantity of the microorganisms in the digestive tract and the change of the flora structure, such as the diseases of the digestive tract and the like.
In order to explore the microbial flora structures of different digestive tract areas and further explore the relationship between digestive tract microbes and body diseases, accurate collection of samples in different areas of the digestive tract is required, and the collection of samples in the digestive tract directly is most effective. Among the many sampling methods, the oral capsule-shaped sampling device can sample without causing discomfort to the sampling body, but the problem to be solved is how to control the sampling device in the digestive tract to accurately sample the target area. CN201710049217.5 discloses an intestinal microorganism collection capsule, which is provided with two groups of enteric-coated components, and the dissolution of the enteric-coated components in the intestinal tract triggers the capsule to sample in the gastrointestinal tract; the thickness of the enteric material is designed by estimating the time required for the capsule to reach each part of the intestinal tract; because different individuals have different physiological conditions of the digestive tract in different periods, the thickness of the enteric-coated material cannot be accurately designed, and accurate collection of a microorganism sample is realized.
Therefore, there is a need for a device for collecting digestive tract samples that can control the collection area more precisely.
Disclosure of Invention
The invention provides a digestive tract sampling device, which aims to solve the technical problem that a partial digestive tract sampling device cannot accurately sample a target area.
In order to solve the technical problem, the invention provides a digestive tract sampling device which comprises a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling area, and the other side of the partition plate is a control area;
the control area comprises a first control module, a microsensor module, a switch controller and a micro battery; the first control module is connected with the micro sensor module and the switch controller; the micro battery is connected with the first control module;
the sampling area is provided with a collection cabin and a control switch, the control switch controls the collection cabin to be opened or closed, and the control switch is connected with a switch controller;
the micro sensor module comprises a pH value sensor, a temperature sensor and a humidity sensor; the micro-sensor module sends the digestive tract physiological parameters to the first control module;
the first control module is used for controlling the control switch to start the acquisition cabin for sampling when the digestive tract physiological parameters meet a first preset condition.
Optionally, the number of the collection cabins is N, N is greater than or equal to 2 and is a positive integer, each collection cabin is provided with a control switch, the collection cabin is opened or closed, and the control switches are respectively connected with a switch controller.
Furthermore, a capacity detection sensor is arranged at the top end inside each acquisition cabin and is connected with the first control module;
the capacity detection sensor is used for sending a signal to the first control module when the capacity of the sample contained in the collection cabin reaches a preset capacity;
the first control module controls the switch controller to close the collection cabin according to the signal to stop sampling.
According to the technical scheme, the first control module comprises an operational amplifier, an A/D converter and a microprocessor, the operational amplifier is connected with the microsensor module, the A/D converter is connected between the operational amplifier and the microprocessor, and the microprocessor is connected with the switch controller.
Optionally, the microprocessor comprises a timing component, a storage component and a comparison component;
the comparison component is used for judging whether the physiological parameters of the digestive tract meet a second preset condition or a first preset condition;
when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition;
the storage component is used for storing digestive tract physiological parameters.
The invention also provides a digestive tract sampling method, which uses the digestive tract sampling device in the technical scheme and comprises the following steps:
when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition;
when the physiological parameters of the digestive tract meet a first preset condition, the first control module controls the control switch to start the first acquisition cabin for sampling; the memory stores the digestive tract physiological parameters at the current moment;
when the physiological parameters of the digestive tract at the next moment are changed compared with the physiological parameters of the digestive tract at the current moment, the first control module controls the control switch to start the second acquisition cabin for sampling; the memory stores the digestive tract physiological parameters at the next moment; so as to circulate;
after the N collection chambers have been sampled, the timing component stops timing.
The invention also provides a digestive tract sampling method, which uses the digestive tract sampling device in the technical scheme and comprises the following steps:
when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition;
the first preset condition comprises N preset sub-conditions, when the physiological parameter of the digestive tract at the current moment meets the ith preset sub-condition, the first control module controls the control switch to start the ith acquisition cabin for sampling, and i is greater than or equal to 1 and less than or equal to N and is a positive integer.
Further, when the physiological parameter of the alimentary canal at the present moment satisfies the ith preset sub-condition, the first control module controls the control switch to open the ith collection chamber for sampling, and the method specifically comprises the following steps:
when the pH value is less than or equal to 2.0, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the first collection chamber;
when the pH value is more than or equal to 4.0 and less than or equal to 6.0, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the second collection chamber;
when the pH value is more than or equal to 6.2 and less than or equal to 6.9, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the third collection chamber;
when the pH value is more than or equal to 7.0 and less than or equal to 7.8, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the fourth collection chamber;
when the pH value is more than or equal to 8.0 and less than or equal to 8.4, the humidity is more than or equal to 80 percent, and the temperature is more than or equal to 36.9 ℃ and less than or equal to 37.7 ℃, the first control module controls the control switch to open the fifth collection chamber.
The invention also provides a digestive tract sampling system, which comprises an in-vitro monitoring device and the digestive tract sampling device in any one of the technical schemes;
the digestive tract sampling device comprises a first radio frequency transceiving module;
the in-vitro monitoring device comprises a second radio frequency transceiving module and a second control module;
the first radio frequency transceiving module is used for transmitting the digestive tract physiological parameters to the second radio frequency transceiving module in real time;
the second control module is used for determining the position of the digestive tract sampling device in the digestive tract in real time according to the physiological parameters of the digestive tract;
when the digestive tract sampling device is positioned in the target digestive tract area, the second control module sends a sampling instruction to the digestive tract sampling device through the second radio frequency transceiving module;
the digestive tract sampling device controls the acquisition cabin to sample according to the sampling instruction.
The invention also provides a digestive tract sampling method, which applies the digestive tract sampling system in the technical scheme and specifically comprises the following steps:
the digestive tract sampling device sends the digestive tract physiological parameters to the in-vitro monitoring device in real time;
the in-vitro monitoring device confirms the position of the digestive tract sampling device in the digestive tract in real time according to the physiological parameters of the digestive tract;
when the digestive tract sampling device is positioned in a target digestive tract area, the in-vitro monitoring device sends a sampling instruction to the digestive tract sampling device;
the digestive tract sampling device controls the acquisition cabin to sample according to the sampling instruction.
Through one or more technical schemes of the invention, the invention has the following beneficial effects or advantages:
the invention provides a sampling device which determines whether a sampling device is positioned in a target digestive tract area according to detected digestive tract physiological parameters, and automatically opens a cabin door to sample when the detected digestive tract physiological parameters meet a first preset condition; the difference of physiological parameters of different digestive tract areas is utilized to realize accurate sampling.
The foregoing description is only an overview of the technical solutions of the present invention, and the embodiments of the present invention are described below in order to make the technical means of the present invention more clearly understood and to make the above and other objects, features, and advantages of the present invention more clearly understandable.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
FIG. 1 shows a block diagram of an alimentary tract sampling apparatus according to one embodiment of the present invention;
FIG. 2 illustrates a block diagram of an alimentary tract sampling apparatus having a plurality of collection pods, according to one embodiment of the present invention;
FIG. 3 illustrates a schematic component diagram of a digestive tract sampling apparatus according to one embodiment of the present invention;
FIG. 4 illustrates a block diagram of an alimentary tract sampling apparatus including a radio frequency transceiver module, according to one embodiment of the present invention;
FIG. 5 illustrates a component schematic of a digestive tract sampling system according to one embodiment of the present invention;
description of reference numerals:
1. a capsule housing; 2. a partition plate; 3. a collection chamber; 4. a cabin door; 5. a pH value sensor; 6. a temperature sensor; 7. a humidity sensor; 8. a first control module; 9. a switch controller; 10. a micro battery; 11. an operational amplifier; 12. an A/D converter; 13. a microprocessor; 14. a first radio frequency transceiver module; 15. an extracorporeal monitoring device; 16. a second radio frequency transceiver module; 17. a second control module.
Detailed Description
In order to make the present application more clearly understood by those skilled in the art to which the present application pertains, the following detailed description of the present application is made with reference to the accompanying drawings by way of specific embodiments.
The digestive tract is a long muscular tube which extends from the oral cavity to the pharynx, the esophagus, the stomach, the small intestine, the large intestine and the anal canal, and comprises the oral cavity, the pharynx, the esophagus, the stomach, the small intestine (duodenum, jejunum and ileum), the large intestine (cecum, appendix, colon and rectum), the anal canal and the like. There are large differences in physiological parameters (e.g., pH, temperature, humidity, etc.) of different regions of the digestive tract. Therefore, the inventor determines a specific area of the sampling device in the digestive tract by detecting the physiological parameter according to the characteristic of the difference of the physiological parameters of the digestive tract, so as to achieve the purpose of accurate sampling, which is specifically as follows:
in some alternative embodiments, as shown in fig. 1, a digestive tract sampling device is provided, which comprises a hollow capsule shell 1, a partition plate 2 is arranged in the capsule shell 1, one side of the partition plate 2 is a sampling area, and the other side is a control area;
the control area comprises a first control module 8, a microsensor module, a switch controller 9 and a micro battery 10; the first control module 8 is connected with the micro-sensor module and the switch controller 9; the micro battery 10 is connected with the first control module 8;
the sampling area is provided with a collection cabin 3 and a control switch, the control switch controls the collection cabin 3 to be opened or closed, and the control switch is connected with a switch controller 9;
the micro sensor module comprises a pH value sensor 5, a temperature sensor 6 and a humidity sensor 7; the micro sensor module sends the physiological parameters of the digestive tract to the first control module 8;
the first control module 8 is used for controlling the control switch to start the acquisition cabin 3 for sampling when the digestive tract physiological parameters meet the first preset conditions.
Specifically, the present embodiment provides a sampling capsule, which has a size similar to that of a common capsule and is convenient to swallow, and a subject to be sampled can continuously advance along the directions of the stomach, duodenum, jejunum, ileum and rectum by swallowing the sampling capsule. Since the sampling capsule needs to enter the alimentary tract, the capsule housing 1 is made of a biomedical material that is biocompatible and not corroded by digestive fluids. For ease of manufacture, the capsule housing 1 may be a split-split structure. According to the function, can divide into sampling district and control area with the sampling capsule, in order to prevent that the sample of gathering from getting into the control cabin, divide through baffle 2 between sampling district and the control area, baffle 2 can be the plastics material.
The sampling capsule confirms whether the sampling capsule is in a target digestive tract area to be sampled or not by detecting physiological parameters of the digestive tract, when the detected physiological parameters indicate that the sampling capsule is in the target area to be sampled, the first control module 8 sends an instruction to the switch controller 9, and the switch controller 9 controls the switch of the cabin door 4 of the acquisition cabin 3 to open the cabin door 4 for sampling. The hatch door 4 can be controlled by magnetic force, when the switch controller 9 inputs an electric signal, the hatch door 4 is popped up and kept to be opened, and when the switch controller 9 cuts off the electric signal, the magnetic force disappears, and the hatch door 4 is automatically closed.
The microsensor module in this embodiment includes pH sensor, temperature sensor 6 and humidity transducer 7, and microsensor module fixed connection is at the internal surface of the capsule casing 1 in control area to conveniently detect physiological parameters. In order to reduce the volume of the sampling capsule, the temperature sensor 6 can use an NTC thermistor, the pH sensor can use a hydrogen ion sensitive field effect tube as a sensitive element, and a working electrode is formed on the basis of the NTC thermistor and the pH sensor, and a miniature reference electrode is designed to form a miniature composite electrode. For the pH sensor, a sealed space can be independently arranged at the inner side of the capsule shell 1 for installation, a window is arranged at the upper part of the capsule shell 1, and when the pH value needs to be detected, the window of the capsule shell 1 is opened, so that the composite electrode is contacted with the digestive tract medium.
The sampling capsule in the embodiment takes the detected pH value of the digestive tract as a main criterion, and takes the temperature range and the humidity range as an auxiliary criterion to jointly judge whether the current physiological parameters of the digestive tract meet the first preset condition preset in the first control module 8, when the current physiological parameters meet the first preset condition, the sampling capsule enters a target sampling area at the moment, and the switch controller controls the switch to be turned on, and opens the capsule door for sampling.
For effective sampling and reduced sampling time, optionally, the initial state inside the collection chamber 3 is vacuum, and when the chamber door 4 of the collection chamber 3 is opened, the liquid in the digestive tract is automatically sucked into the collection chamber 3, so as to realize rapid collection of the sample in the digestive tract.
The embodiment provides a sampling device which determines whether the sampling device is in a target digestive tract area according to detected physiological parameters of the digestive tract and then automatically opens a hatch door 4 for sampling; accurate sampling is achieved through the difference of physiological parameters of different digestive tract regions.
In a sampling process, if microorganism samples of different digestive tract regions can be collected at the same time, it is very important to research the relationship between digestive tract microorganisms and body diseases, because the influence of other factors can be reduced to the minimum level by obtaining different digestive tract regions in a similar time, therefore, based on the same inventive concept of the above embodiments, in other alternative embodiments, as shown in fig. 2, the number of the collection chambers 3 is N, N is greater than or equal to 2 and is a positive integer, each collection chamber 3 is provided with a control switch, the collection chambers 3 are opened or closed, and the control switches are respectively connected with the switch controller 9.
That is, a plurality of acquisition cabins 3 exist in the sampling area, and different acquisition areas are judged according to different physiological parameters of the digestive tract, so that samples in a plurality of target digestive tract areas are acquired; it can also be arranged that: when the physiological parameters of the digestive tract change, an empty sampling cabin which is not sampled yet is opened for sampling. It is noted that the sampling chamber which has already been sampled cannot be opened again, so as to avoid the samples in different digestive tract regions from contaminating each other and affecting the sampling accuracy. The specific number of the collection chambers can be flexibly adjusted according to the area to be sampled in one sampling process, such as 3, 4, and 5, which is not specifically limited herein.
In the above embodiment, the hatch 4 of the sampling chamber is opened for sampling, and the hatch 4 is closed after sampling is completed. The judgment that the sampling is completed can be estimated by the opening time of the door 4, for example, the door 4 is closed after the door 4 is opened for a preset time (e.g. 1 minute, 5 minutes, etc.), which is suitable for the case that the sampling chamber is initially in a vacuum state and the sampling process is fast, and the essence is to estimate the sampling time. In some cases, however, the estimated sampling time is not necessarily accurate, and the amount of sample entering the sampling chamber during the predetermined time may be insufficient. For more precise control of the sampling amount, based on the same inventive concept of the previous embodiment, in some alternative embodiments, a capacity detection sensor is arranged at the top end of the interior of each collecting chamber 3, and the capacity detection sensor is connected with the first control module 8; the capacity detection sensor is used for sending a signal to the first control module 8 when the capacity of the sample contained in the collection cabin 3 reaches a preset capacity; the first control module 8 controls the switch controller 9 to close the collection chamber 3 to stop sampling according to the signal.
The capacity detection sensor can use a miniature limit switch, when the sample height touches the miniature limit switch, the miniature limit switch sends a signal representing that the sample chamber sample is full, the first control module 8 sends a chamber door 4 closing signal to the switch controller 9 according to the signal, and the switch controller 9 feeds back a sampling completion signal after the chamber door 4 is closed.
In the above embodiment, it is the first control module 8 that determines whether the digestive tract physiological parameter satisfies the first preset condition and sends the sampling command to the switch controller 9, in some optional embodiments, the first control module 8 includes an operational amplifier 11, an a/D converter 12 and a microprocessor 13, the operational amplifier 11 is connected to the microsensor module, the a/D converter 12 is connected between the operational amplifier 11 and the microprocessor 13, and the microprocessor 13 is connected to the switch controller 9.
The physiological parameters of the digestive tract sent by the microsensor module are analog signals, the analog signals are firstly amplified through the operational amplifier 11 and then pass through the A/D converter 12, namely, the ADC circuit is converted into digital signals and then transmitted to the microprocessor 13, the microprocessor 13 judges whether the physiological parameters meet a first preset condition, if so, sampling signals are sent to the switch controller 9, the sampling signals comprise sampling instructions and information about the collection cabin 3 to be started, and the switch controller 9 controls the corresponding collection cabin 3 to open the cabin door 4 according to the sampling signals, as shown in figure 3.
In still other alternative embodiments, further, as shown in fig. 1 or fig. 2, the microprocessor 13 includes a timing component, a storage component and a comparison component; the comparison component is used for judging whether the physiological parameters of the digestive tract meet a second preset condition or a first preset condition; when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition; the storage component is used for storing digestive tract physiological parameters.
In this embodiment, the second preset condition is used to determine whether the sampling device is in the digestive tract of the living body, and the second preset condition may be set as required, for example, when the sampling device enters the digestive tract, the humidity sensor 7 and the pH sensor 5 obtain a humidity signal and a pH signal, at this time, the timing component may be activated, and after the timing component is activated, the comparison component starts to determine whether the physiological parameter of the digestive tract at the current time meets the first preset condition, that is, whether the capsule of the digestive tract sampling capsule reaches the target digestive tract area, and after the physiological parameter of the digestive tract at the current time reaches the target digestive tract area, the microprocessor 13 controls the switch controller 9 to turn on the control switch to sample. When the timing assembly is in a closed state, the comparison assembly only judges whether the signal sent by the micro sensor module meets a first preset condition.
Based on the same inventive concept of the foregoing embodiments, in some alternative embodiments, there is provided a method for sampling a digestive tract, using the digestive tract sampling apparatus of the foregoing embodiments, including the steps of:
when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition;
when the physiological parameters of the digestive tract meet a first preset condition, the first control module 8 controls the control switch to start the first acquisition cabin 3 for sampling; the memory stores the digestive tract physiological parameters at the current moment;
when the physiological parameters of the digestive tract at the next moment are changed compared with the physiological parameters of the digestive tract at the current moment, the first control module 8 controls the control switch to start the second acquisition cabin 3 for sampling; the memory stores the digestive tract physiological parameters at the next moment; so as to circulate;
after the N collection pods 3 have been sampled, the timing assembly stops timing.
In this embodiment, an automatic sampling method is provided, and the sampling logic is as follows: firstly, setting a second preset condition and a first preset condition, wherein the second preset condition is used for representing that the digestive tract sampling device enters the digestive tract, the first preset condition is used for judging whether the sampling device reaches a target digestive tract area to be sampled, such as a digestive tract physiological parameter range of the stomach, and when the physiological parameter measured by a sensor meets the first preset condition, the sampling device reaches the stomach, and the first control module 8 automatically opens the hatch door 4 of one acquisition cabin 3 for sampling; when the physiological parameter changes, the sampling device enters another digestive tract area, and at the moment, the first control module 8 automatically opens the door 4 of another collection chamber 3 which is not sampled yet for sampling.
The complete process is described as follows:
(1) presetting a second preset condition and a first preset condition, monitoring humidity according to the second preset condition that saliva is stained on a shell of the device when the acquisition device is swallowed from the oral cavity, immediately activating a timing assembly, and starting to judge whether the physiological parameters meet the first preset condition or not;
(2) monitoring the pH value, temperature and humidity of the digestive tract environment in real time or at regular intervals, converting a pH value signal, a temperature signal and a humidity signal into corresponding analog electric signals by the micro-sensor module, buffering and amplifying the electric signals, and obtaining digital signals by an ADC (analog-to-digital converter) circuit;
(3) the automatic control collection cabin 3 carries out sampling: when the first control module 8 judges that the physiological parameters at the current moment meet the first preset condition, the first control module 8 determines the acquisition cabin 3 to be opened, sends a sampling signal carrying the opening information of the acquisition cabin 3 to the switch controller 9, the switch controller 9 sends an opening signal to a control switch of the corresponding acquisition cabin 3, and after receiving the signal, the control switch pops open the cabin door 4 and activates the capacity detection sensor; meanwhile, the storage component stores the current physiological parameters;
(4) after the cabin door 4 is opened, the capacity detection sensor monitors the sample capacity in the collection cabin 3, when the sample capacity reaches the preset capacity, the capacity detection sensor sends a signal that the collection cabin 3 is full to the first control module 8, the first control module 8 sends a sampling stop signal to the switch controller 9, the switch controller 9 closes the cabin door 4 to stop sampling, and after the cabin door 4 is closed, a signal of completing the sampling is fed back to the first control module 8;
(5) at the next moment, because the pH value, the temperature and the humidity of different parts of the alimentary canal are different, the digital signals are different, if the digital signals are the same, the acquisition device is still positioned at the same alimentary canal part at the next moment, and in order to not repeatedly acquire samples, the switch controller 9 is not required to be activated, and the physiological parameters at the next moment are not stored; if the digital signals are different, the situation that the digital signals are possibly positioned at different alimentary canal parts is indicated, and samples are required to be collected, so that the switch controller 9 is activated, the collection cabin 3 which is not sampled is started for sampling, and meanwhile, the alimentary canal physiological parameters at the current moment are stored;
(6) and repeating the steps until all the sampling chambers are sampled, and closing the timing assembly at the moment.
It is noted that the collecting chamber 3, which has already been sampled, will not be opened again in the subsequent process, so as to avoid contamination of the sampled sample.
The sampling method in the above embodiment is to determine whether the physiological parameters are the same to determine whether to sample. Based on the same inventive concept of the foregoing embodiments, in other alternative embodiments, another digestive tract sampling method is provided, which also uses the digestive tract sampling device of the foregoing embodiments, and comprises the following steps:
when the physiological parameters of the digestive tract meet the second preset condition, the timing component starts timing, and the comparison component starts to judge whether the physiological parameters of the digestive tract at the current moment meet the first preset condition;
the first preset condition comprises N preset sub-conditions, when the physiological parameter of the digestive tract at the current moment meets the ith preset sub-condition, the first control module 8 controls the control switch to start the ith acquisition cabin for sampling, and i is greater than or equal to 1 and less than or equal to N and is a positive integer.
In this embodiment, another automatic sampling method is provided, and the sampling logic is as follows: the method comprises the steps of firstly setting a second preset condition and a first preset condition, wherein the second preset condition is used for representing that a digestive tract sampling device enters a digestive tract, the first preset condition is used for judging whether the sampling device reaches a target digestive tract area to be sampled or not, the first preset condition comprises a plurality of preset sub-conditions, each preset sub-condition corresponds to a digestive tract area, such as a digestive tract physiological parameter range of a stomach, a duodenum, an ileum, a jejunum, a colon and the like, and when a physiological parameter measured by a sensor meets one preset sub-condition, a first control module 8 automatically opens a cabin door 4 of a collecting cabin 3 corresponding to the current preset sub-condition for sampling. The complete process is described as follows:
(1) presetting a second preset condition and a first preset condition, monitoring humidity according to the second preset condition that saliva is stained on a shell of the device when the acquisition device is swallowed from the oral cavity, immediately activating a timing assembly, and starting to judge whether the physiological parameters meet the first preset condition or not; the first preset condition comprises N preset sub-conditions, the ith preset sub-condition corresponds to the ith acquisition cabin, and when the physiological parameters detected by the sensor meet the ith preset sub-condition, the ith acquisition cabin is started for sampling;
(2) monitoring the pH value, temperature and humidity of the digestive tract environment in real time or at regular intervals, converting a pH value signal, a temperature signal and a humidity signal into corresponding analog electric signals by the micro-sensor module, buffering and amplifying the electric signals, and obtaining digital signals by an ADC (analog-to-digital converter) circuit;
(3) the automatic control collection cabin 3 carries out sampling: when the first control module 8 judges that the physiological parameter at the current moment meets the ith preset sub-condition, the first control module 8 sends a sampling signal for starting the ith acquisition cabin to the switch controller 9, the switch controller 9 sends a starting signal to a control switch of the ith acquisition cabin, and the control switch can flick the cabin door 4 and activate the capacity detection sensor after receiving the signal;
(4) after the cabin door 4 is opened, the capacity detection sensor monitors the sample capacity in the acquisition cabin 3, when the sample capacity reaches the preset capacity, the capacity detection sensor sends a signal that the ith acquisition cabin is full to the first control module 8, the first control module 8 sends a sampling stopping signal to the switch controller 9, the switch controller 9 closes the cabin door 4 to stop sampling, and after the cabin door 4 is closed, a signal of completing acquisition is fed back to the first control module 8;
(5) when passing through different alimentary canal regions, the sampling device automatically opens the corresponding collection cabin 3 according to the position to sample, and when all the sampling cabins finish sampling, the timing assembly is closed.
According to the automatic sampling method in the embodiment, through the plurality of preset physiological parameter sub-conditions, when the physiological parameters acquired by the sampling capsule meet one preset sub-condition, the corresponding acquisition cabin 3 is automatically opened for sampling, and samples in a plurality of digestive tract areas can be accurately acquired in the sequential sampling process.
In some alternative embodiments, 5 typical sampling processes according to preset sub-conditions are given, which are as follows: when the physiological parameter of the alimentary canal at the present moment satisfies the ith preset sub-condition, the first control module 8 controls the control switch to open the ith collection chamber for sampling, and the sampling method specifically comprises the following steps:
when the pH value is less than or equal to 2.0, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37 ℃ and less than or equal to 38 ℃, the first control module 8 controls the control switch to open the first collection chamber 3;
when the pH value is more than or equal to 4.0 and less than or equal to 6.0, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module 8 controls a control switch to open the second collection chamber 3;
when the pH value is more than or equal to 6.2 and less than or equal to 6.9, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module 8 controls a control switch to open the third collection chamber 3;
when the pH value is more than or equal to 7.0 and less than or equal to 7.8, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module 8 controls a control switch to open the fourth collecting cabin 3;
when the pH value is more than or equal to 8.0 and less than or equal to 8.4, the humidity is more than or equal to 80 percent, and the temperature is more than or equal to 36.9 ℃ and less than or equal to 37.7 ℃, the first control module 8 controls the control switch to open the fifth collection chamber 3.
The humidity value is relative humidity, the preset sub-conditions are mainly pH value and are assisted by temperature and relative humidity to determine a specific area of the digestive tract. In order to ensure the sampling accuracy, the parameters are preset sub-conditions of the digestive tract of the human body in a normal, healthy and fasting state, wherein the target digestive tract area corresponding to the first acquisition cabin 3 is the stomach; the target digestive tract area corresponding to the second collection cabin 3 is duodenum; the target digestive tract area corresponding to the third acquisition cabin 3 is jejunum; the target digestive tract region corresponding to the fourth collecting cabin 3 is the ileum; the target digestive tract region corresponding to the fifth collection chamber 3 is the colon.
In the foregoing embodiment, the digestive tract sampling device automatically performs sampling according to the obtained physiological parameters of the digestive tract. In fact, in order to track the position of the sampling device in real time and to control the sampling flexibly, an extracorporeal monitoring device 15 can be added and manually control when the sampling is performed. Based on the same inventive concept of the previous embodiments, in some alternative embodiments, as shown in fig. 4 and 5, there is provided a digestive tract sampling system, comprising an extracorporeal monitoring device 15 and the digestive tract sampling device of the previous embodiments;
the digestive tract sampling device comprises a first radio frequency transceiving module 14; the in-vitro monitoring device 15 comprises a second radio frequency transceiver module 16 and a second control module 17;
the first radio frequency transceiving module 14 is configured to send the digestive tract physiological parameters to the second radio frequency transceiving module 16 in real time; the second control module 17 is used for determining the position of the digestive tract sampling device in the digestive tract in real time according to the physiological parameters of the digestive tract; when the digestive tract sampling device is in the target digestive tract area, the second control module 17 sends a sampling instruction to the digestive tract sampling device through the second radio frequency transceiving module 16; the digestive tract sampling device controls the acquisition cabin 3 to sample according to the sampling instruction.
In this embodiment, the position of the digestive tract sampling device can be tracked in real time by the in-vitro monitoring device 15, and when sampling is performed is manually controlled, when the in-vitro monitoring device 15 sends a sampling instruction, the digestive tract sampling device enters a manual control mode, the priority of the manual control mode is higher than that of the automatic sampling mode, and when the manual control mode is effective, the automatic sampling mode is shielded.
Optionally, the first and second rf transceiver components may each include an rf transceiver and an antenna. The first radio frequency transceiver component sends the digital signal of the physiological parameter to the in-vitro monitoring device 15, and the specific position of the acquisition device in the alimentary canal can be determined through the analysis and calculation of the in-vitro monitoring device 15, and the acquisition cabin 3 can be manually controlled to perform sampling at any time. The second radio frequency transceiving component can restore the digital signals into pH value, temperature and humidity signals, can convert sampling instructions of users into digital signals and send the digital signals to the first radio frequency transceiving component, and the first radio frequency transceiving component controls the acquisition cabin 3 to sample after receiving the sampling instructions.
The in-vitro monitoring device 15 may be an intelligent electronic device, on which sampling device position tracking software is installed, and the intelligent electronic device may be a smart phone, a tablet computer, a notebook computer, a desktop computer, or the like.
Based on the same inventive concept of the foregoing embodiment, the present invention provides a method for sampling a digestive tract, which applies the digestive tract sampling system of the foregoing embodiment, and specifically includes:
the digestive tract sampling device sends the physiological parameters of the digestive tract to the in-vitro monitoring device 15 in real time;
the in-vitro monitoring device 15 confirms the position of the digestive tract sampling device in the digestive tract in real time according to the physiological parameters of the digestive tract;
when the digestive tract sampling device is in the target digestive tract area, the in-vitro monitoring device 15 sends a sampling instruction to the digestive tract sampling device;
the digestive tract sampling device controls the acquisition cabin 3 to sample according to the sampling instruction.
Through one or more embodiments of the present invention, the present invention has the following advantageous effects or advantages:
the invention provides a sampling device which determines whether a sampling device is positioned in a target digestive tract area according to detected digestive tract physiological parameters, and automatically opens a cabin door to sample when the detected digestive tract physiological parameters meet a first preset condition; the difference of physiological parameters of different digestive tract areas is utilized to realize accurate sampling;
furthermore, the digestive tract sampling device provided by the invention is provided with a plurality of acquisition cabins, so that the accurate acquisition of microbial samples in a plurality of digestive tract areas can be realized according to physiological parameters of different digestive tract areas in one sampling process;
furthermore, the invention also provides a digestive tract sampling system, which comprises an in-vitro monitoring device and a digestive tract sampling device, wherein the in-vitro monitoring device can confirm the specific position of the digestive tract sampling device in real time through the physiological parameters of the digestive tract and then flexibly control the digestive tract sampling device to sample in different areas.
While the preferred embodiments of the present application have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all alterations and modifications as fall within the scope of the application.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present application without departing from the spirit and scope of the application. Thus, if such modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application is intended to include such modifications and variations as well.
Claims (10)
1. The digestive tract sampling device is characterized by comprising a hollow capsule shell, wherein a partition plate is arranged in the capsule shell, one side of the partition plate is a sampling area, and the other side of the partition plate is a control area;
the control area comprises a first control module, a microsensor module, a switch controller and a micro battery; the first control module is connected with the micro sensor module and the switch controller; the micro battery is connected with the first control module;
the sampling area is provided with a collection cabin and a control switch, the control switch controls the collection cabin to be opened or closed, and the control switch is connected with the switch controller;
the micro sensor module comprises a pH value sensor, a temperature sensor and a humidity sensor; the micro sensor module sends digestive tract physiological parameters to the first control module;
the first control module is used for controlling the control switch to start the acquisition cabin for sampling when the digestive tract physiological parameters meet first preset conditions.
2. The sampling device according to claim 1, wherein the number of the collection chambers is N, N is greater than or equal to 2 and is a positive integer, each collection chamber is provided with a control switch for turning on or off the collection chamber, and the control switches are respectively connected with the switch controller.
3. The sampling device according to claim 2, wherein a capacity detection sensor is arranged at the top end of the interior of each collection chamber, and the capacity detection sensor is connected with the first control module;
the capacity detection sensor is used for sending a signal to the first control module when the capacity of the sample contained in the collection cabin reaches a preset capacity;
the first control module controls the switch controller to close the collection cabin according to the signal so as to stop sampling.
4. The sampling device of claim 2, wherein the first control module comprises an operational amplifier, an a/D converter and a microprocessor, the operational amplifier is connected to the micro-sensor module, the a/D converter is connected between the operational amplifier and the microprocessor, and the microprocessor is connected to the switch controller.
5. The sampling device of claim 4, wherein the microprocessor comprises a timing component, a storage component, and a comparison component;
the comparison component is used for judging whether the digestive tract physiological parameters meet a second preset condition or a first preset condition;
when the digestive tract physiological parameters meet second preset conditions, the timing component starts timing, and the comparison component starts to judge whether the digestive tract physiological parameters at the current moment meet the first preset conditions;
the storage component is used for storing digestive tract physiological parameters.
6. A method of sampling the digestive tract using the digestive tract sampling apparatus according to claim 5, comprising the steps of:
when the digestive tract physiological parameters meet second preset conditions, the timing component starts timing, and the comparison component starts to judge whether the digestive tract physiological parameters at the current moment meet the first preset conditions;
when the digestive tract physiological parameters meet a first preset condition, the first control module controls the control switch to start a first acquisition cabin for sampling; the memory stores the digestive tract physiological parameters at the current moment;
when the digestive tract physiological parameter at the next moment is changed compared with the digestive tract physiological parameter at the current moment, the first control module controls the control switch to start a second acquisition cabin for sampling; the memory stores digestive tract physiological parameters at the next moment; so as to circulate;
after the N collection chambers have been sampled, the timing component stops timing.
7. A method of sampling the digestive tract using the digestive tract sampling apparatus according to claim 5, comprising the steps of:
when the digestive tract physiological parameters meet second preset conditions, the timing component starts timing, and the comparison component starts to judge whether the digestive tract physiological parameters at the current moment meet the first preset conditions;
the first preset condition comprises N preset sub-conditions, when the physiological parameter of the digestive tract at the current moment meets the ith preset sub-condition, the first control module controls the control switch to open the ith acquisition cabin for sampling, and i is more than or equal to 1 and less than or equal to N and is a positive integer.
8. The method for sampling a digestive tract according to claim 7, wherein when the physiological parameter of the digestive tract at the current moment meets an ith preset sub-condition, the first control module controls the control switch to open an ith collection chamber for sampling, specifically comprising:
when the pH value is less than or equal to 2.0, the humidity is more than or equal to 90%, and the temperature is more than or equal to 37 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to start the first collection chamber;
when the pH value is more than or equal to 4.0 and less than or equal to 6.0, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the second collection chamber;
when the pH value is more than or equal to 6.2 and less than or equal to 6.9, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the third collection chamber;
when the pH value is more than or equal to 7.0 and less than or equal to 7.8, the humidity is more than or equal to 90 percent, and the temperature is more than or equal to 37.5 ℃ and less than or equal to 38 ℃, the first control module controls the control switch to open the fourth collection chamber;
when the conditions that the pH value is more than or equal to 8.0 and less than or equal to 8.4, the humidity is more than or equal to 80 percent, and the temperature is more than or equal to 36.9 ℃ and less than or equal to 37.7 ℃ are met, the first control module controls the control switch to open the fifth collection chamber.
9. An alimentary canal sampling system comprising an extracorporeal monitoring apparatus and an alimentary canal sampling apparatus according to any one of claims 1 to 5;
the digestive tract sampling device comprises a first radio frequency transceiving module;
the in-vitro monitoring device comprises a second radio frequency transceiving module and a second control module;
the first radio frequency transceiving module is used for transmitting the digestive tract physiological parameters to the second radio frequency transceiving module in real time;
the second control module is used for determining the position of the digestive tract sampling device in the digestive tract in real time according to the digestive tract physiological parameters;
when the digestive tract sampling device is positioned in a target digestive tract area, the second control module sends a sampling instruction to the digestive tract sampling device through the second radio frequency transceiving module;
and the digestive tract sampling device controls the acquisition cabin to sample according to the sampling instruction.
10. A method for sampling the digestive tract, which is characterized by applying the digestive tract sampling system according to claim 9, and comprises the following steps:
the digestive tract sampling device sends the digestive tract physiological parameters to the in-vitro monitoring device in real time;
the in-vitro monitoring device confirms the position of the digestive tract sampling device in the digestive tract in real time according to the physiological parameters of the digestive tract;
when the digestive tract sampling device is in a target digestive tract area, the in-vitro monitoring device sends a sampling instruction to the digestive tract sampling device;
and the digestive tract sampling device controls the acquisition cabin to sample according to the sampling instruction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911299824.2A CN111035416A (en) | 2019-12-17 | 2019-12-17 | Digestive tract sampling device and sampling system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911299824.2A CN111035416A (en) | 2019-12-17 | 2019-12-17 | Digestive tract sampling device and sampling system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111035416A true CN111035416A (en) | 2020-04-21 |
Family
ID=70235180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911299824.2A Pending CN111035416A (en) | 2019-12-17 | 2019-12-17 | Digestive tract sampling device and sampling system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111035416A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991034A (en) * | 2020-08-21 | 2020-11-27 | 天津大学 | Multiple biopsy device embedded in capsule endoscope |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1758873A (en) * | 2003-03-07 | 2006-04-12 | 新引导系统公司 | Method and apparatus for tracking insertion depth |
| CN101107038A (en) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | Electronically controlled capsule |
| CN101237903A (en) * | 2005-01-18 | 2008-08-06 | 皇家飞利浦电子股份有限公司 | System and method for controlling traversal of an ingested capsule |
| WO2008113697A1 (en) * | 2007-03-22 | 2008-09-25 | Siemens Aktiengesellschaft | Magnetically guiding system, particularly medical system, particularly capsule endoscope system with prediction |
| US20090209849A1 (en) * | 2007-05-02 | 2009-08-20 | Philip Stephen Rowe | Medical Device Placement and Monitoring System Utilizing Radio Frequency Identification |
| CN102176855A (en) * | 2008-10-24 | 2011-09-07 | 奥林巴斯医疗株式会社 | Capsular endoscopic system |
| US20130204085A1 (en) * | 2012-02-07 | 2013-08-08 | Ian J. Alexander | System and method for a magnetic endoscope |
| CN107307853A (en) * | 2017-06-02 | 2017-11-03 | 唐山金万众科技有限公司 | A kind of capsule monitoring device |
| CN109374150A (en) * | 2018-12-07 | 2019-02-22 | 苏州大学 | A kind of swallow type capsule monitoring device |
| CN109464742A (en) * | 2018-12-29 | 2019-03-15 | 上海安翰医疗技术有限公司 | Gastrointestinal tract position-sensing switch and preparation method thereof and alimentary canal site-specific drug release capsule |
-
2019
- 2019-12-17 CN CN201911299824.2A patent/CN111035416A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1758873A (en) * | 2003-03-07 | 2006-04-12 | 新引导系统公司 | Method and apparatus for tracking insertion depth |
| CN101107038A (en) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | Electronically controlled capsule |
| CN101237903A (en) * | 2005-01-18 | 2008-08-06 | 皇家飞利浦电子股份有限公司 | System and method for controlling traversal of an ingested capsule |
| US20090306633A1 (en) * | 2005-01-18 | 2009-12-10 | Koninklijke Philips Electronics, N.V. | Electronically controlled capsule |
| WO2008113697A1 (en) * | 2007-03-22 | 2008-09-25 | Siemens Aktiengesellschaft | Magnetically guiding system, particularly medical system, particularly capsule endoscope system with prediction |
| US20090209849A1 (en) * | 2007-05-02 | 2009-08-20 | Philip Stephen Rowe | Medical Device Placement and Monitoring System Utilizing Radio Frequency Identification |
| CN102176855A (en) * | 2008-10-24 | 2011-09-07 | 奥林巴斯医疗株式会社 | Capsular endoscopic system |
| US20130204085A1 (en) * | 2012-02-07 | 2013-08-08 | Ian J. Alexander | System and method for a magnetic endoscope |
| CN107307853A (en) * | 2017-06-02 | 2017-11-03 | 唐山金万众科技有限公司 | A kind of capsule monitoring device |
| CN109374150A (en) * | 2018-12-07 | 2019-02-22 | 苏州大学 | A kind of swallow type capsule monitoring device |
| CN109464742A (en) * | 2018-12-29 | 2019-03-15 | 上海安翰医疗技术有限公司 | Gastrointestinal tract position-sensing switch and preparation method thereof and alimentary canal site-specific drug release capsule |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991034A (en) * | 2020-08-21 | 2020-11-27 | 天津大学 | Multiple biopsy device embedded in capsule endoscope |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20020132226A1 (en) | Ingestible electronic capsule | |
| CN105050500B (en) | Sampling apparatus | |
| EP2489303B1 (en) | Positioning system and method for esophageal ph value wireless monitoring | |
| US7892179B2 (en) | Apparatus, method and system for determining a physiological condition within a mammal | |
| JP5987151B2 (en) | Small threshold sensor | |
| US8728289B2 (en) | Monolithic electrodes and pH transducers | |
| CN102006822A (en) | Endocapsule | |
| CN110996754B (en) | Swallowable capsules, systems and methods for determining gastric emptying parameters | |
| JP2013507203A5 (en) | ||
| Cheng et al. | A wireless, ingestible pH sensing capsule system based on iridium oxide for monitoring gastrointestinal health | |
| US8840551B2 (en) | Tethering capsule system | |
| CN111035416A (en) | Digestive tract sampling device and sampling system | |
| CN112472009A (en) | Detection system and method of capsule endoscope | |
| KR101659471B1 (en) | The underpants for urinary incontinence and remote-control medical treatment using it | |
| CN114554973A (en) | Sampling device | |
| JPH057573A (en) | Tablet type digestive organ diagnostic apparatus | |
| Gonzales et al. | A technical review on existing pH detection and monitoring technology for in-vivo diagnostic application | |
| US20230009747A1 (en) | System And Method For Monitoring A Bodily Substance In A Human Orifice With A Wearable Device | |
| CN103381282A (en) | Intelligent module for measuring pH value in drug release capsule | |
| Wrigglesworth et al. | Sampling device | |
| KR102595784B1 (en) | Magnetically controlled, ph sensor-assisted navigation capsule endoscopy and control method thereof | |
| CN116784806A (en) | ISFET-based single-chip integrated miniature wireless PH detection device and system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200421 |
|
| RJ01 | Rejection of invention patent application after publication |