CN103143116B - Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa - Google Patents
Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa Download PDFInfo
- Publication number
- CN103143116B CN103143116B CN201310053465.9A CN201310053465A CN103143116B CN 103143116 B CN103143116 B CN 103143116B CN 201310053465 A CN201310053465 A CN 201310053465A CN 103143116 B CN103143116 B CN 103143116B
- Authority
- CN
- China
- Prior art keywords
- system controller
- electrode
- digestive tract
- implant system
- implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Under a kind of mucosa, implant electrode automatic sensing digestive tract order pacing therapy instrument, comprises an implant system controller, multiple sensor for detecting digestive tract activity, multiple implanted electrode and vitro system controller; The input signal end of implant system controller is connected with the sensor that can detect digestive tract activity; The output signal end of implant system controller is connected with implanted electrode.Therapeutic instrument of the present invention can receive one or more groups signal that multiple sensor inputs, and analyzes this one or more groups signal by implant system controller and identify a gastral specific state.Implant system controller can export many groups of stimulus signals to one or more implanted electrode by one or more signal generator and complete contraction movement for stimulating the muscle around each implanted electrode.For a long time in patients with implantation body, automatically can produce one or more groups order stimulus signal according to people digest road kinestate, stimulate digestion and recover normal physiological condition.
Description
Technical field
The invention belongs to medical electronic Instrument technology field, particularly relate to a kind of by the automatic sensing that implants, automatically startup, by sequencing multi-point sequent electricity irritation facilitating digestion road motion normalization, the therapy equipment for the treatment of upper digestive tract dyskinesis disease.
Background technology
Digestive tract power obstacle disease is the common class disease of Digestive, common are digestive tract power obstacle disease, peptic digestion reflux disease, gastroparesis etc.The effective Drug therapy of current shortage.Stimulus of direct current gastrointestinal smooth muscle cell can produce blockage effect.In theory, electricity irritation also can affect and even control gastrointestinal motor.But at present, the application of electricity irritation in digestive tract disease is also more preliminary: electricity irritation (frequency: 5. 5 cpm, ripple is wide: 550 ms, wave amplitude: 2 mA) rat stomach serosal surface can correct Gastric gysrhythmia and promote gastric emptying [Liu Jingsong, Qiao Xian, Hou Xiaohua, etc. the Gastric dysrhythmias therapeutical effect to diabetic gastroparesis rat gastric dysrhythmias and delayed gastric emptying. China's digestion magazine. and 2004 (24) 10:615-616.], multiple spot electricity irritation (50 Hz rectangular voltage having 20 V (peak to peak) amplitude, 18 second stimulus duration, and a nine second phase lag between stimulation trains in sequential electrode sets.) dog Isolated colon intestinal tube can promote its wriggle [M A Amaris, P Z Rashev, M P Mintchev, et al. Microprocessor controlled movement of solid colonic content using sequential neural electrical stimulation. Gut 2002, 50:475 – 479].
Although the corresponding research of this respect is fewer, all show that by electronic stimulation digestive tract power obstacle disease be feasible.There is no this type of instrument application both at home and abroad in clinical now.
Summary of the invention
The object of the invention is to develop a kind of automatic sensing that implants, automatically start, by implant electrode automatic sensing digestive tract order pacing therapy instrument under the mucosa of sequencing multi-point sequent electricity irritation promotion upper digestive tract motion normalization.
The present invention for addressing this problem taked technical scheme is:
Under mucosa of the present invention, implant electrode automatic sensing digestive tract order pacing therapy instrument, comprises an implant system controller, multiple sensor for detecting digestive tract activity, multiple implanted electrode and vitro system controller; The input signal end of implant system controller is connected with the sensor that can detect digestive tract activity; The output signal end of implant system controller is connected with implanted electrode.
One in described sensor is pH value change sensor in gastronintestinal system.One is gastronintestinal system built-in potential value change sensor; One is pressure change sensor in gastronintestinal system; One is variations in temperature sensor in gastronintestinal system; One is gastronintestinal system inner volume change sensor.
Described implant system controller comprises a center of inside processor, an internal storage, an event detector, and one or more signal generator; These signal generators export many group stimulus signals to one or more implanted electrode and complete contraction movement for stimulating the muscle around each implanted electrode; One or more groups signal that event detector inputs for receiving multiple sensor, and identify a gastral specific state by analyzing this one or more groups signal; Center of inside processor receives the signal of the specific digestive tract activity of representative one inputted by event detector, store this signal in internal storage, control by signal generator discharge many groups stimulus signal between interval, thus coordinate the time sequencing of the muscle contraction activity around each implanted electrode.
Described implant system controller also comprises an internal communication device, internal communication device wirelessly by people digest road state, implant system controller work process, implant system controller working procedure information transmission to vitro system controller, and receiving body external system controller sends to implant system director demon regulation and control instruction.
Described implant system controller also comprises a startup/X button, when this startup/X button is triggered by patient, starts or shutdown system controller, sensor and implanted electrode, with solution of emergent event.
Described vitro system controller external central processing unit, an individual external memory and an external communicator; External communicator employing wireless working method realizes the communication for information of vitro system controller and implant system controller; The communication channels realization that external central processing unit passes through to be made up of internal communication device and external communicator, to the regulation and control of implant system controller and communication for information, stores these information to external memorizer, and completes display and the output of these information.
Each implanted electrode comprises Scolopendra electrode, after a sleeve pipe and an electrode discharge, electrode is fixed on the fixture of the electrode end on esophageal muscularis propria; Scolopendra electrode is bound in sleeve pipe; Often pair of corresponding Scolopendra electrode will fixedly be wound in a cable by fixed interval, around esophageal lumen half cycle, can form unique galvanism loop, cause esophagus ring muscle to shrink during often pair of Scolopendra electrode release.
The advantage that the present invention has and good effect are:
Therapeutic instrument of the present invention can receive one or more groups signal that multiple sensor inputs, and analyzes this one or more groups signal by implant system controller and identify a gastral specific state.Then, implant system controller can export many groups of stimulus signals to one or more implanted electrode by one or more signal generator and complete contraction movement for stimulating the muscle around each implanted electrode.
The present invention has following advantage: the first, selects the implantation of different sensors and different sensors and electrode, implantation position and fixed form according to the dissection of various disease and digestive tract different parts and physiological characteristics; The second, real-time digestive tract condition conversion is the signal of telecommunication by sensor, and nurses one's health the signal of telecommunication, converts digital signal to and stores, and is transferred to implant system controller; 3rd, implant system controller is the control core of this device, and sensor data acquisition, storage and transmission are all completed by implant system controller, and stimulus signal also has implant system controller to produce; 4th, external controller can receive by communicator the data stored in implant system controller, and carries out finishing analysis to data, generates report by man-machine interaction mode, and implant system director demon can be adjusted, thus reach best therapeutic effect; 5th, under mucosa of the present invention, implant electrode automatic sensing digestive tract order pacing therapy instrument can for a long time in patients with implantation body, and automatically produce one or more groups order stimulus signal according to people digest road kinestate, stimulate digestion recovery normal physiological condition.
Accompanying drawing explanation
Fig. 1 is the general structure frame figure of therapeutic instrument of the present invention;
Fig. 2 is an application example figure of therapeutic instrument of the present invention;
Fig. 3 is the structural representation of implanted electrode of the present invention.
Critical piece symbol description in accompanying drawing:
1: implant system controller 2: sensor
3: implanted electrode 4: vitro system controller
101: event detector 102: signal generator
103: internal storage 104: center of inside processor
105: internal communication device 106: startup/X button
301: Scolopendra electrode 302: sleeve pipe
303: fixture 403: external memorizer
404: external central processing unit 405: external communicator.
Detailed description of the invention
Referring to drawings and Examples, the present invention will be described in detail.
Under mucosa of the present invention, implant electrode automatic sensing digestive tract order pacing therapy instrument comprises an implant system controller 1, multiple sensor 2 for detecting digestive tract activity, multiple implanted electrode 3 and vitro system controller 4.Therapeutic instrument of the present invention for a long time in patients with implantation body, can produce one or more groups order stimulus signal according to people digest road kinestate, stimulates digestion and recover normal physiological condition automatically.Wherein:
The input signal end of implant system controller 1 is connected to multiple sensor 2 detecting digestive tract activity; The output signal end of implant system controller 1 is connected to multiple implanted electrode 3;
Sensor 2 can be implanted digestive tract and sensor 2 and digestive tract be fixed in one form, is applicable to detect one or more and occurs in activity in gastronintestinal system.Gastronintestinal system comprises the organ-tissue forming digestive tract stomach function regulating and the inner chamber formed by the organ-tissue forming digestive tract stomach function regulating.The formation that sensor 2 is fixed with digestive tract comprises: sensor is fixed on alimentary canal mucous membrane layer surface; Sensor is fixed on digestive tract placenta percreta surface; Sensor is fixed on any one deck between digestive tract placenta percreta and mucous layer; Between to be fixed on by sensor between digestive tract placenta percreta and mucous layer any two-layer.Can according to the different fixed forms needing selection different in practical operation.One in sensor 2 is the sensor being applicable to detect pH value change in gastronintestinal system.One is the sensor being applicable to detect the change of gastronintestinal system built-in potential value; One is the sensor being applicable to detect pressure change in gastronintestinal system; One is the sensor being applicable to detect variations in temperature in gastronintestinal system; One is the sensor being applicable to detect the change of gastronintestinal system inner volume.
Implant system controller 1 comprises an event detector 101, this event detector 101 can receive one or more groups signal that multiple sensor 2 inputs, and identifies a gastral specific state by analyzing this one or more groups signal and be stored in memorizer 103.
Implant system controller 1 also comprises one or more signal generator 102, and the one or more signal generator 102 can export many groups of stimulus signals to one or more implanted electrode 3 and complete contraction movement for stimulating the muscle around each implanted electrode 3.
Implant system controller 1 also comprises an internal storage 103, for storing the data of digestive tract state and output signal.
Implant system controller 1 also comprises a center of inside processor 104, this center of inside processor 104 can receive the signal of the specific digestive tract activity of representative one inputted by event detector 101, store this signal to internal storage 103, interval between many groups stimulus signal that control is discharged by signal generator 102, thus coordinate the time sequencing of the muscle contraction activity around each implanted electrode 3.
A gastral specific state refers in digestive tract the state that there is residual food stagnation.Whenever implant system controller 1, to identify a specific digestive tract movable, and the stimulus signal thus reach namely discharging at least one group at least one implanted electrode 3 controls muscle contraction around at least one implanted electrode 3 or diastole activity.
When implant system controller 1 None-identified goes out a specific digestive tract activity, namely stop discharging stimulus signal to all implanted electrodes 3 thus reaching stopping stimulating the muscle contraction activity around all implanted electrodes 3.
Implant system controller 1 also comprises an internal communication device 105, this internal communication device 105 can to wirelessly by information transmission such as people digest road state, implant system controller 1 work process, implant system controller 1 working procedures to vitro system controller 4, and the instruction of system controller 1 program calling and controlling can be sent to by receiving body external system controller 4.
Implant system controller 1 also comprises a startup/X button 106, when this startup/X button 106 is triggered by patient, can start or close implant system controller 1, sensor 2 and implanted electrode 3, in order to solution of emergent event.
Implanted electrode 3 by gastroscope guide indwelling in by gastroscope in the tunnel that upper alimentary tract mucosa lower floor sets up.Implanted electrode 3 comprises the Scolopendra electrode 301 arranged in pairs, and often pair of counter electrode will fixedly be wound in a cable by fixed interval, can be about half cycle, form unique galvanism loop, cause esophagus ring muscle to shrink during often pair of electrode release around esophageal lumen.
Implanted electrode 3 comprises a sleeve pipe 302, is strapped in sleeve pipe before Scolopendra electrode 301 is placed by electrode, conduit can be exited when being placed into ideal position, and Scolopendra electrode 301 can be released into functional status voluntarily.Electrode can be fixed on esophageal muscularis propria by the fixture 303 that implanted electrode 3 also comprises an electrode end.
Vitro system controller 4 comprises an individual external memory 403, external communicator 405, and this external communicator 405 employing wireless working method can realize the communication for information of vitro system controller 4 and system controller 1.
Vitro system controller 4 also comprises a central processing unit 404, this central processing unit 404 is for realizing regulation and control to implant system controller 1 and communication for information by the communication channels that is made up of internal communication device 105 and external communicator 405, store these information to external memorizer 403, and display and the output function of these information can be realized.
Use the method for the method of implant electrode automatic sensing digestive tract order pacing therapy instrument treatment digestive tract power obstacle disease under mucosa of the present invention and work process of the present invention as follows:
Set up tunnel through Inner mirror in upper alimentary tract mucosa lower floor, under Inner mirror guides, implanted electrode is fixed on tunnel intracavity, and discharges Scolopendra electrode, the system controller that the end of Scolopendra electrode is subcutaneous with implantation connects.
Continued to detect the signal that one or more groups can represent the gastral activity of patient by sensor;
Residual food stagnation whether is there is in the digestive tract identifying patient by system controller continual analysis;
When there is food stagnation in the digestive tract that system controller identifies patient, system controller is to one or more groups electrode release stimulus signal, these signals have certain temporal aspect, when it stimulates the electrode of implanted digestive tract different parts according to this temporal aspect, the muscle of surrounding them can regular contraction be pushed downwards in press-in gastral cavity to make food stagnation residual in digestive tract;
When there is not food stagnation in the digestive tract that system controller identifies patient, system controller stops to all electrode release stimulus signals.
When occurring that special circumstances can discharge stimulus signal by patient temporarily.
Can by patient's emergency shutdown system controller, sensor and implant electrode when being in an emergency.
Doctor can read and store patient information, and according to individual patients feature adjustment system director demon.
Claims (4)
1. an implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa, comprises an implant system controller (1), multiple sensor (2) for detecting digestive tract activity, multiple implanted electrode (3) and vitro system controller (4); The input signal end of implant system controller (1) is connected with the sensor (2) that can detect digestive tract activity; The output signal end of implant system controller (1) is connected with implanted electrode (3); It is characterized in that: each implanted electrode (3) comprises the Scolopendra electrode (301) arranged in pairs, after a sleeve pipe (302) and an electrode discharge, electrode is fixed on the fixture (303) of the electrode end on esophageal muscularis propria; Scolopendra electrode (301) is placed in digestive tract by alimentary canal mucous membrane, and is bound in sleeve pipe (302); Often pair of corresponding Scolopendra electrode will fixedly be wound in a cable by fixed interval, around esophageal lumen half cycle, can form unique galvanism loop, cause esophagus ring muscle to shrink during often pair of Scolopendra electrode release; Implant system controller (1) comprises a center of inside processor (104), an internal storage (103), an event detector (101), and one or more signal generator (102); These signal generators (102) export many group stimulus signals to one or more implanted electrode (3) and complete contraction movement for stimulating each implanted electrode (3) muscle around; One or more groups signal that event detector (101) inputs for receiving multiple sensor (2), and identify a gastral specific state by analyzing this one or more groups signal; Center of inside processor (104) receives the signal of the specific digestive tract activity of representative one inputted by event detector (101), store this signal in internal storage (103), interval between the stimulus signal controlling to discharge many groups by signal generator (102) institute, thus coordinate the time sequencing of the muscle contraction activity of each implanted electrode (3) surrounding; Implant system controller (1) comprises an internal communication device (105), internal communication device (105) wirelessly by people digest road state, implant system controller (1) work process, implant system controller (1) working procedure information transmission to vitro system controller (4), and receiving body external system controller (4) sends to the program calling and controlling instruction of implant system controller (1).
2. implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa according to claim 1, it is characterized in that: implant system controller (1) comprises a startup/X button (106), when this startup/X button (106) is triggered by patient, start or close implant system controller (1), sensor (2) and implanted electrode (3), with solution of emergent event.
3. implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa according to claim 1, it is characterized in that: vitro system controller (4) comprises an external central processing unit (404), an individual external memory (403) and an external communicator (405); External communicator (405) employing wireless working method realizes the communication for information of vitro system controller (4) and implant system controller (1); The communication channels realization that external central processing unit (404) passes through to be made up of internal communication device and external communicator (405) is to the regulation and control of implant system controller (1) and communication for information, store these information to external memorizer (403), and complete display and the output of these information.
4. implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa according to claim 1, is characterized in that: described sensor to comprise in pH value change sensor in a gastronintestinal system, a gastronintestinal system built-in potential value change sensor, a gastronintestinal system variations in temperature sensor and a gastronintestinal system inner volume change sensor in pressure change sensor, a gastronintestinal system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310053465.9A CN103143116B (en) | 2013-02-20 | 2013-02-20 | Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310053465.9A CN103143116B (en) | 2013-02-20 | 2013-02-20 | Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103143116A CN103143116A (en) | 2013-06-12 |
| CN103143116B true CN103143116B (en) | 2015-07-29 |
Family
ID=48541602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310053465.9A Active CN103143116B (en) | 2013-02-20 | 2013-02-20 | Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103143116B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213066B (en) * | 2014-06-25 | 2017-04-19 | 中国人民解放军第二军医大学 | Synthesized patch with wireless stimulation function and used for resisting reflux esophagitis |
| CN105521561B (en) * | 2015-12-30 | 2018-06-12 | 宁波贝思转化医学研究中心有限公司 | A kind of closed circuit small intestine electrical stimulation device |
| CN105617530A (en) * | 2016-03-02 | 2016-06-01 | 西安交通大学第一附属医院 | Digital gastrointestinal pacemaker |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075658A (en) * | 1992-12-04 | 1993-09-01 | 中国原子能科学研究院 | Electrode for electrochemical therapy of esophageal cancer |
| CN102068240A (en) * | 2011-02-17 | 2011-05-25 | 上海交通大学 | Non-invasive detection system for multiple physiological parameters in whole digestive tract |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7702394B2 (en) * | 2001-05-01 | 2010-04-20 | Intrapace, Inc. | Responsive gastric stimulator |
-
2013
- 2013-02-20 CN CN201310053465.9A patent/CN103143116B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075658A (en) * | 1992-12-04 | 1993-09-01 | 中国原子能科学研究院 | Electrode for electrochemical therapy of esophageal cancer |
| CN102068240A (en) * | 2011-02-17 | 2011-05-25 | 上海交通大学 | Non-invasive detection system for multiple physiological parameters in whole digestive tract |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103143116A (en) | 2013-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102500057B (en) | Multifunctional implanted gastrointestinal electrical stimulation system | |
| US10471255B2 (en) | Systems and methods for patient-enabled bladder control | |
| CN201316482Y (en) | Ultra-thin micro multifunctional heart rate regulating device without electrode wire | |
| UA48221C2 (en) | Electrical gastro-intestinal tract stimulator | |
| CN107847731A (en) | Implantable nerve stimulator and application method with the internal electronic equipment without ASIC | |
| CN107427685A (en) | The attached peripheral device and associated method being used together with nerve stimulation charging equipment | |
| CN103282079A (en) | Medical system and methods for providing obesity therapy in response to a heart rate change | |
| CN103143116B (en) | Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa | |
| CN105431195A (en) | System and method for electrical stimulation of anorectal structures to treat anal dysfunction | |
| CN101896137A (en) | Apparatus for controlling flow in a bodily organ | |
| CN107398013A (en) | For arousing the device of continuous contraction of muscle in gastrointestinal organ | |
| CN105848710B (en) | Apparatus and method for stimulating nerves | |
| CN103949008B (en) | Intelligent electric based on the external magnetic control of video image navigation stimulates capsule system | |
| CN104411359B (en) | There is the neural stimulation system for enabling magnetic field sensing turning off Hall element | |
| JP7097888B2 (en) | Embeddable system | |
| CN112169171A (en) | Bionic anal sphincter system implanted in situ based on defecation function reconstruction | |
| CN106512218A (en) | Temperature-control charging implantable medical device cooperation work system | |
| CN112402793A (en) | Sacral nerve stimulation device | |
| IL267105B2 (en) | A device and method for administration of a substance | |
| CN208823794U (en) | A kind of implanted gastric stimulator | |
| CN107898439B (en) | Implanted diabetes monitoring and treatment device | |
| CN115500994A (en) | Shape memory alloy flexible ring type artificial bladder urination system | |
| CN110585597B (en) | Intestinal peristalsis intelligent regulation system | |
| CN113576921A (en) | Swallowing function rehabilitation treatment equipment | |
| CN206304225U (en) | Automatic sensing order electrical pacing device under implantation alimentary canal mucous membrane |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |