CN111019763A - Artemisia argyi extraction method without toxic and side effects - Google Patents
Artemisia argyi extraction method without toxic and side effects Download PDFInfo
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- CN111019763A CN111019763A CN201911382966.5A CN201911382966A CN111019763A CN 111019763 A CN111019763 A CN 111019763A CN 201911382966 A CN201911382966 A CN 201911382966A CN 111019763 A CN111019763 A CN 111019763A
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- China
- Prior art keywords
- wormwood
- folium artemisiae
- artemisiae argyi
- side effects
- toxic
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
Abstract
The invention discloses a wormwood extraction method without toxic and side effects, belonging to the technical field of traditional Chinese medicine processing, and comprising the following steps: s1: pretreatment of raw materials: soaking fresh wormwood in liquid nitrogen for 30-40 min; s2: dehydrating the wormwood soaked in the liquid nitrogen until the water content in the wormwood is 1.3-4.8%; s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 40-50 deg.C under 20-25 MPa with CO2The feeding rate of (2) is 50-70 g/min; by using supercritical CO2The volatile oil in the wormwood after extraction and drying is easier to be CO due to certain moisture in the wormwood2The folium Artemisiae Argyi is not easy to be broken, and the integrity of folium Artemisiae Argyi can be maintained.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine herb processing, and particularly relates to a wormwood extraction method without toxic and side effects.
Background
The mugwort is a perennial herb or slightly semi-shrub, and the plant has strong fragrance. Stem simple or few, brown or sallowly brown, slightly lignified at the base, with few short branches at the upper part, thick paper of leaves, grayish white short, soft hair at the upper part, usually without or with very small pseudoleaves at the base; the upper leaves and bracts have half-feathered and half-split shape, head-shaped inflorescence is elliptical, the corolla is tubular or high-foot cup-shaped, the exterior has glandular spots, the anther is narrow-line-shaped, and the style is nearly equal to or slightly longer than the corolla. The slim fruit is oblong. Research shows that the chemical components of the mugwort are all from roots, stems and leaves, while the main chemical components are from the mugwort leaves, including volatile oil, flavone, trace elements, phenylpropanoids, triterpenoids and the like. The folium Artemisiae Argyi has high medicinal value, and has effects of warming channels, eliminating dampness, dispelling cold, stopping bleeding, relieving inflammation, relieving asthma, relieving cough, preventing miscarriage, and resisting allergy.
At present, the moxa has been developed in the aspects of daily necessities, health care, beauty treatment and medical treatment, such as moxa toothpaste, health care waistbands, moxa sticks, skin-attached moxa bags, moxa essence, moxa aerosol and the like, for the use of the skin-attached moxa bags, the moxa sticks are directly attached to the skin, the smoke is directly burnt into smoke and directly contacts with the skin, and certain volatile oil in the moxa leaves has certain side effects on skin mucous membranes, central nerves and gastrointestinal tracts due to the overhigh content of the volatile oil, so that the moxa cannot be blindly used.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a wormwood extraction method without toxic and side effects.
The technical scheme adopted by the invention is as follows: a folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh wormwood in liquid nitrogen for 30-40 min;
s2: dehydrating the wormwood soaked in the liquid nitrogen until the water content in the wormwood is 1.3-4.8%;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 40-50 deg.C under 20-25 MPa with CO2The feeding rate of (2) is 50-70 g/min.
Further limiting, after the soaking in the step S1 is completed, the wormwood is placed at room temperature for 3-5 min.
Further limiting, the extraction temperature in step S3 is 45 ℃.
Further limiting, the extraction pressure in step S3 is 22 MPa.
Further limiting, CO in step S32The throughput rate of (2) was 64 g/min.
Further, in step S2, the soaked wormwood is dehydrated in an oxygen-free environment.
Further, the temperature of the dehydration treatment in step S2 is 150 to 200 ℃.
Compared with the prior art, the invention has the beneficial effects that: fresh wormwood is soaked by adopting a liquid nitrogen method, so that the bioactivity of the wormwood can be kept, the wormwood is dehydrated, the moisture content in the wormwood is controlled to be 1.3-4.8%, and the wormwood has certain flexibility and is not easy to break; by using supercritical CO2The volatile oil in the wormwood after extraction and drying is easier to be CO due to certain moisture in the wormwood2The folium Artemisiae Argyi is not easy to be broken, and the integrity of folium Artemisiae Argyi can be maintained.
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, it is obvious that the described embodiments are a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
In order to solve the problem that the content of volatile oil in the wormwood is too high and certain side effects are generated on skin mucous membrane, central nerve and gastrointestinal tract of a human body after the wormwood is taken by the human body, the invention provides an extraction method of the volatile oil in the wormwood, which is characterized by comprising the following steps: s1: pretreatment of raw materials: soaking fresh wormwood in liquid nitrogen for 30-40 min; s2: dehydrating the wormwood soaked in the liquid nitrogen until the water content in the wormwood is 1.3-4.8%; s3: will be provided withSubjecting to supercritical CO treatment to obtain folium Artemisiae Argyi2Extracting at 40-50 deg.C under 20-25 MPa with CO2The feeding rate of (2) is 50-70 g/min.
The method comprises the steps of firstly keeping the biological activity of the wormwood through liquid nitrogen, then dehydrating the wormwood to control the moisture content in the wormwood to be within the range of 1.3-4.8%, so that the wormwood has certain flexibility, is not easy to break in the subsequent extraction process, retains partial volatile oil, is convenient for people to use, does not generate side effect on human bodies due to the reduction of the content of the volatile oil in the wormwood, and ensures that people can use the wormwood with confidence.
Wherein: the soaked wormwood is dehydrated in the step S2 in an oxygen-free environment, which is an environment with an oxygen content of less than 0.5%,
the temperature of the dehydration treatment in the step S2 is 150-200 ℃, and the water and a small part of volatile oil in the dehydration treatment are evaporated at the temperature, so that the subsequent processing is facilitated.
And (3) placing the soaked wormwood at room temperature for 3-5 min, so that the subsequent dehydration process can be smoothly carried out.
Example 1
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 30min, and standing at room temperature for 3 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in oxygen-free environment at 150 deg.C, wherein the oxygen content in oxygen-free environment is less than 0.5%, and dehydrating is stopped until the water content in folium Artemisiae Argyi is 1.3%, measuring the water content in folium Artemisiae Argyi every 2min during dehydrating process, and overturning continuously during dehydrating process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 40 deg.C under 20MPa with CO2The feed rate of (2) was 50 g/min.
Example 2
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 35min, and standing at room temperature for 5 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in an oxygen-free environment at 180 deg.C, wherein the oxygen content is less than 0.5% until the water content in folium Artemisiae Argyi is 3.4%, measuring the water content in folium Artemisiae Argyi every 2min during dehydration process, and continuously overturning during dehydration process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 45 deg.C under 22MPa with CO2The feed rate of (2) was 60 g/min.
Example 3
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 40min, and standing at room temperature for 4 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in an oxygen-free environment at 200 deg.C, wherein the oxygen content is less than 0.5% until the water content in folium Artemisiae Argyi is 4.8%, measuring the water content in folium Artemisiae Argyi every 2min during dehydration process, and continuously overturning during dehydration process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 50 deg.C under 25MPa with CO2The feed rate of (2) was 70 g/min.
Example 4
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 40min, and standing at room temperature for 4 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in oxygen-free environment at 200 deg.C until the water content in folium Artemisiae Argyi is 4.8%, measuring the water content in folium Artemisiae Argyi every 2min during dehydration process, and overturning continuously during dehydration process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 50 deg.C under 25MPa with CO2The feed rate of (2) was 70 g/min.
Example 5
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 35 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in an oxygen-free environment at 180 deg.C, wherein the oxygen content is less than 0.5% until the water content in folium Artemisiae Argyi is 3.4%, measuring the water content in folium Artemisiae Argyi every 2min during dehydration process, and continuously overturning during dehydration process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 45 deg.C under 22MPa with CO2The feed rate of (2) was 60 g/min.
Example 6
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 30 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in oxygen-free environment at 150 deg.C until the water content in folium Artemisiae Argyi is 1.3%, measuring the water content in folium Artemisiae Argyi every 2min during dehydration process, and overturning continuously during dehydration process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 40 deg.C under 20MPa with CO2The feed rate of (2) was 50 g/min.
Example 7
A folium Artemisiae Argyi extraction method without adverse side effects comprises the following steps:
s1: pretreatment of raw materials: soaking fresh folium Artemisiae Argyi in liquid nitrogen for 30min, and standing at room temperature for 3 min;
s2: dehydrating folium Artemisiae Argyi soaked in liquid nitrogen in oxygen-free environment at 150 deg.C, wherein the oxygen content in oxygen-free environment is less than 0.5%, and dehydrating is stopped until the water content in folium Artemisiae Argyi is 1.3%, measuring the water content in folium Artemisiae Argyi every 2min during dehydrating process, and overturning continuously during dehydrating process;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 45 deg.C under 22MPa with CO2The throughput rate of (2) was 64 g/min.
The invention is not limited to the above alternative embodiments, and any other various forms of products can be obtained by anyone in the light of the present invention, but any changes in shape or structure thereof, which fall within the scope of the present invention as defined in the claims, fall within the scope of the present invention.
Claims (7)
1. The wormwood extraction method without toxic and side effects is characterized by comprising the following steps:
s1: pretreatment of raw materials: soaking fresh wormwood in liquid nitrogen for 30-40 min;
s2: dehydrating the wormwood soaked in the liquid nitrogen until the water content in the wormwood is 1.3-4.8%;
s3: subjecting the dehydrated folium Artemisiae Argyi to supercritical CO treatment2Extracting at 40-50 deg.C under 20-25 MPa with CO2The feeding rate of (2) is 50-70 g/min.
2. The wormwood extraction method without toxic and side effects according to claim 1, wherein the wormwood is placed at room temperature for 3-5 min after completion of the soaking in the step S1.
3. The method for extracting moxa without toxic and side effects according to claim 2, wherein the extraction temperature in the step S3 is 45 ℃.
4. The folium artemisiae argyi extraction method without toxic or side effects of claim 2, wherein the extraction pressure in the step S3 is 22 MPa.
5. The folium Artemisiae Argyi extraction method of claim 3, wherein the CO in step S3 is added to the folium Artemisiae Argyi extraction solution without adverse side effects2The throughput rate of (2) was 64 g/min.
6. The method for extracting moxa without toxic and side effects as claimed in claim 3, wherein the soaked moxa is dehydrated in an oxygen-free environment at step S2.
7. The folium artemisiae argyi extraction method without toxic or side effects of claim 6, wherein the temperature of the dehydration treatment in the step S2 is 150-200 ℃.
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| CN201911382966.5A CN111019763A (en) | 2019-12-27 | 2019-12-27 | Artemisia argyi extraction method without toxic and side effects |
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| CN201911382966.5A CN111019763A (en) | 2019-12-27 | 2019-12-27 | Artemisia argyi extraction method without toxic and side effects |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398622A (en) * | 2021-05-14 | 2021-09-17 | 暨南大学 | Supercritical CO2Method for preparing wormwood raw pulp by extraction and molecular distillation processes |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716212A (en) * | 2009-12-25 | 2010-06-02 | 温州医学院附属第二医院 | Method for preparing special healthy old mugwort flosses and mugwort sticks by moxibustion method |
| CN107446702A (en) * | 2017-08-12 | 2017-12-08 | 安徽楚艾农业科技有限公司 | A kind of extracting method of wormwood essential oil |
| CN110540904A (en) * | 2018-05-29 | 2019-12-06 | 江苏芝能生物科技有限公司 | method for extracting wormwood essential oil |
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2019
- 2019-12-27 CN CN201911382966.5A patent/CN111019763A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716212A (en) * | 2009-12-25 | 2010-06-02 | 温州医学院附属第二医院 | Method for preparing special healthy old mugwort flosses and mugwort sticks by moxibustion method |
| CN107446702A (en) * | 2017-08-12 | 2017-12-08 | 安徽楚艾农业科技有限公司 | A kind of extracting method of wormwood essential oil |
| CN110540904A (en) * | 2018-05-29 | 2019-12-06 | 江苏芝能生物科技有限公司 | method for extracting wormwood essential oil |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398622A (en) * | 2021-05-14 | 2021-09-17 | 暨南大学 | Supercritical CO2Method for preparing wormwood raw pulp by extraction and molecular distillation processes |
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Application publication date: 20200417 |