CN110996957A - 用于治疗子宫肌瘤并减少月经失血的促性腺激素释放激素拮抗剂给药方案 - Google Patents

用于治疗子宫肌瘤并减少月经失血的促性腺激素释放激素拮抗剂给药方案 Download PDF

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Publication number
CN110996957A
CN110996957A CN201880050807.2A CN201880050807A CN110996957A CN 110996957 A CN110996957 A CN 110996957A CN 201880050807 A CN201880050807 A CN 201880050807A CN 110996957 A CN110996957 A CN 110996957A
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China
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patient
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weeks
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Pending
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CN201880050807.2A
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English (en)
Chinese (zh)
Inventor
E·卢马耶
J-P·戈特兰德
O·波尔
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Kissei Pharmaceutical Co Ltd
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Obseva SA
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Publication of CN110996957A publication Critical patent/CN110996957A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201880050807.2A 2017-06-05 2018-06-05 用于治疗子宫肌瘤并减少月经失血的促性腺激素释放激素拮抗剂给药方案 Pending CN110996957A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762515232P 2017-06-05 2017-06-05
US62/515,232 2017-06-05
PCT/EP2018/064767 WO2018224497A1 (en) 2017-06-05 2018-06-05 Gonadotropin-releasing hormone antagonist dosing regimens for treating uterine fibroids and reducing menstrual blood loss

Publications (1)

Publication Number Publication Date
CN110996957A true CN110996957A (zh) 2020-04-10

Family

ID=62636157

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880050807.2A Pending CN110996957A (zh) 2017-06-05 2018-06-05 用于治疗子宫肌瘤并减少月经失血的促性腺激素释放激素拮抗剂给药方案

Country Status (18)

Country Link
US (2) US11759464B2 (OSRAM)
EP (2) EP4509173A3 (OSRAM)
JP (2) JP7292566B2 (OSRAM)
KR (1) KR102884301B1 (OSRAM)
CN (1) CN110996957A (OSRAM)
AU (2) AU2018280741B2 (OSRAM)
CA (1) CA3066188A1 (OSRAM)
DK (1) DK3634419T3 (OSRAM)
EA (1) EA201992812A1 (OSRAM)
ES (1) ES3018358T3 (OSRAM)
FI (1) FI3634419T3 (OSRAM)
HR (1) HRP20250390T1 (OSRAM)
HU (1) HUE070907T2 (OSRAM)
MX (2) MX2023013582A (OSRAM)
PL (1) PL3634419T3 (OSRAM)
PT (1) PT3634419T (OSRAM)
SG (1) SG11201911599XA (OSRAM)
WO (1) WO2018224497A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014143669A1 (en) 2013-03-15 2014-09-18 AbbVie Inc . Compositions for use in treating heavy menstrual bleeding and uterine fibroids
US11980621B2 (en) 2017-06-05 2024-05-14 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis
EP4509173A3 (en) 2017-06-05 2025-06-04 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for treating uterine fibroids and reducing menstrual blood loss
JP2021531236A (ja) 2018-04-19 2021-11-18 アッヴィ・インコーポレイテッド 重度の月経出血を治療する方法
JP2021532160A (ja) * 2018-08-01 2021-11-25 アッヴィ・インコーポレイテッド エラゴリックスに関する投与計画
MA54058A (fr) 2018-10-29 2021-09-08 ObsEva SA Compositions et méthodes de traitement de l'endométriose interne et de l'endométriose rectovaginale
US20230067378A1 (en) * 2018-11-07 2023-03-02 ObsEva S.A. Compositions and methods for the treatment of estrogen-dependent disorders
JP2022543757A (ja) * 2019-08-08 2022-10-14 オブセヴァ エス．エー． エストロゲン依存性障害の治療のためのｇｎｒｈアンタゴニスト
EP4009977A2 (en) * 2019-08-08 2022-06-15 ObsEva S.A. Compositions and methods for the treatment of estrogen-dependent disorders
KR20210155350A (ko) 2020-06-15 2021-12-22 한상왕 녹차 추출물 및 비타민 d3를 유효성분으로 포함하는 자궁근종 개선용 조성물
CN115232144B (zh) * 2021-04-22 2024-04-02 长春金赛药业有限责任公司 含氮稠环类衍生物、药物组合物及其制备方法和应用
KR102738115B1 (ko) 2024-03-25 2024-12-05 한상왕 자궁근종 예방, 개선 또는 치료용 약학 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753557A (zh) * 2010-02-10 2012-10-24 橘生药品工业株式会社 稠合杂环衍生物的盐及其晶体
JP2016513708A (ja) * 2013-03-15 2016-05-16 アッヴィ・インコーポレイテッド 月経出血過多および子宮類線維腫の処置に使用するための組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109171B2 (en) 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
RU2418803C2 (ru) * 2005-10-19 2011-05-20 Киссеи Фармасьютикал Ко., Лтд. Конденсированное гетероциклическое производное, содержащая его лечебная композиция и ее применение в медицине
WO2014042176A1 (ja) 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
BR112019002513A2 (pt) 2016-08-08 2019-05-14 Kissei Pharmaceutical Co., Ltd. uso e dosagem de agentes terapêuticos para endometriose
ES2912929T5 (en) 2016-09-30 2025-05-09 Sumitomo Pharma Switzerland Gmbh Methods of treating uterine fibroids and endometriosis
US11980621B2 (en) 2017-06-05 2024-05-14 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis
EP4509173A3 (en) 2017-06-05 2025-06-04 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for treating uterine fibroids and reducing menstrual blood loss
US20230067378A1 (en) 2018-11-07 2023-03-02 ObsEva S.A. Compositions and methods for the treatment of estrogen-dependent disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753557A (zh) * 2010-02-10 2012-10-24 橘生药品工业株式会社 稠合杂环衍生物的盐及其晶体
JP2016513708A (ja) * 2013-03-15 2016-05-16 アッヴィ・インコーポレイテッド 月経出血過多および子宮類線維腫の処置に使用するための組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAVID F. ARCHER, M.D.等: "Elagolix for the management of heavy", 《FERTILITY AND STERILITY》 *
OBSEVA: "Annual Report 2016", 《HTTP://INVESTORS.OBSEVA.COM/FINANCIAL-REPORTS》 *

Also Published As

Publication number Publication date
EP3634419A1 (en) 2020-04-15
AU2024201694A1 (en) 2024-04-04
JP2020522525A (ja) 2020-07-30
JP2023078315A (ja) 2023-06-06
EP4509173A3 (en) 2025-06-04
EP3634419B1 (en) 2025-01-29
US20200179390A1 (en) 2020-06-11
AU2018280741A1 (en) 2020-01-30
JP7292566B2 (ja) 2023-06-19
KR102884301B1 (ko) 2025-11-11
HUE070907T2 (hu) 2025-07-28
JP7485815B2 (ja) 2024-05-16
US11759464B2 (en) 2023-09-19
PT3634419T (pt) 2025-04-04
EA201992812A1 (ru) 2020-05-21
DK3634419T3 (da) 2025-03-31
PL3634419T3 (pl) 2025-06-09
US20240000785A1 (en) 2024-01-04
MX2019014482A (es) 2020-08-17
EP4509173A2 (en) 2025-02-19
SG11201911599XA (en) 2020-01-30
HRP20250390T1 (hr) 2025-05-23
AU2018280741B2 (en) 2023-12-21
WO2018224497A1 (en) 2018-12-13
MX2023013582A (es) 2024-04-16
KR20200024797A (ko) 2020-03-09
FI3634419T3 (fi) 2025-05-02
ES3018358T3 (es) 2025-05-16
CA3066188A1 (en) 2018-12-13

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Effective date of registration: 20221018

Address after: Nagano

Applicant after: KISSEI PHARMACEUTICAL Co.,Ltd.

Address before: Swiss Prang Eli Ute

Applicant before: ObsEva S.A.