CN110982655A - Preparation method of astragalus membranaceus health-care wine and astragalus membranaceus health-care wine prepared by same - Google Patents
Preparation method of astragalus membranaceus health-care wine and astragalus membranaceus health-care wine prepared by same Download PDFInfo
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Abstract
The invention relates to the technical field of wine making, in particular to a preparation method of astragalus membranaceus health-care wine and the astragalus membranaceus health-care wine prepared by the same. The preparation method of the astragalus membranaceus health-care wine provided by the invention comprises the following steps: the following raw materials are respectively weighed: mixing radix astragali, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, and radix Ophiopogonis, and pulverizing; adding ethanol water solution for leaching to obtain a leaching product; dissolving the extract with water, adding glycosidase, esterase and pectinase for enzymolysis; adding the corn tassel extract, the corn root extract and the white spirit into the enzymolysis product, standing, aging and filtering to obtain the astragalus membranaceus health-care wine. The preparation method of the astragalus membranaceus health-care wine provided by the invention can be used for effectively reducing the bitter taste of the health-care wine while greatly enhancing the effect of the health-care wine on regulating lipid metabolism.
Description
Technical Field
The invention relates to the technical field of wine making, in particular to a preparation method of astragalus membranaceus health-care wine and the astragalus membranaceus health-care wine prepared by the same.
Background
Lipodystrophy, also known as lipodystrophy, is one of the metabolic diseases, and is the abnormality of the quality and quantity of lipids (lipids) and their metabolites in blood and other tissues and organs caused by primary or acquired factors. Causes of lipid metabolism disorder are classified into primary and secondary. Primary is related to both congenital and genetic origin, either due to monogenic or polygenic defects, abnormalities in receptors involved in lipoprotein transport and metabolism or apolipoproteins, or due to environmental factors (diet, nutrition, drugs) and by unknown mechanisms. The secondary diseases are mainly caused by metabolic disorder diseases (diabetes, hypertension, hypothyroidism, obesity, liver diseases, etc.) or other factors (age, sex, season, drinking, smoking, diet, physical activity). Genetic factors: heredity can cause hyperlipidemia through a variety of mechanisms, mainly manifested by defects in cell surface lipoprotein receptors and defects in certain acids within the cell (e.g., defects or deficiencies in lipoprotein lipase). Dietary factors: a significant proportion of hyperlipoproteinemia patients are closely related to dietary factors. The lipid metabolism disorder is also the main inducing factor of diseases such as atherosclerosis, fatty liver, coronary heart disease, pancreatitis, diabetes, nephropathy, hypertension, etc. Lipid metabolism disorder is mainly manifested by increased blood cholesterol (TC), glycerol Triacetate (TG) and low-density lipoprotein (LDL-C) level or low-density lipoprotein (HDL) level.
At present, western medicines are mostly adopted to treat lipid metabolism disorder symptoms, such as lovastatin, simvastatin, pravastatin and other statins, which have the effects of quick response and strong action, the statins are used as common medicines for clinically treating hypercholesterolemia, and the statins achieve the purpose of reducing blood fat by inhibiting the activity of HMG-CoA, are rate-limiting enzymes for in-vivo cholesterol synthesis, but are usually accompanied by the following common adverse reactions, mainly manifested by gastrointestinal tract malaise reactions such as muscle adverse reactions, hepatotoxicity, nausea, vomiting, abdominal pain, abdominal thirst, constipation and the like. However, the traditional Chinese medicine composition for regulating lipid metabolism disorder has complex medicine components and poor product stability, and in view of the defects of the western medicines and the traditional Chinese medicines, the search for a new health drink which has simple components and can effectively regulate lipid metabolism becomes a hot spot at present.
Disclosure of Invention
The invention aims to overcome the defects that the adverse reaction is easily caused by using western medicines to regulate lipid metabolism, and the traditional Chinese medicine composition has complex components and poor product stability in the prior art, and further provides the health-care wine which has simple components, is safe and harmless to a human body and has the outstanding effect of regulating lipid metabolism and the method for preparing the health-care wine.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 15-20 parts of astragalus membranaceus, 8-15 parts of ligusticum wallichii, 10-15 parts of angelica sinensis and 7-10 parts of radix ophiopogonis, and then the astragalus membranaceus, the ligusticum wallichii, the angelica sinensis and the radix ophiopogonis are mixed and crushed to obtain mixed powder;
2) adding 30-60% ethanol water solution into the mixture powder, leaching for 24-72 hr, collecting supernatant, filtering, concentrating, and drying to obtain extract;
3) dissolving the leaching product with water, and adding glycosidase, esterase and pectinase for enzymolysis to obtain an enzymatic hydrolysate;
4) filtering the enzymolysis liquid, concentrating and drying the filtrate to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing, aging and filtering to obtain the astragalus membranaceus health-care wine.
Preferably, the addition amount of the corn tassel extract is 0.2-1% of the weight of the extraction product;
the addition amount of the corn root extract is 0.2-1% of the weight of the extract.
Preferably, the preparation method of the corn tassel extract comprises the following steps:
taking the dried corn tassel, crushing, adding 30-60% ethanol water solution by volume fraction, leaching for 24-48 hours, taking supernatant, filtering the supernatant, concentrating and drying to obtain a corn tassel extract;
the preparation method of the corn root extract comprises the following steps:
pulverizing dried corn root, adding 30-60% ethanol water solution, leaching for 24-48 hr, collecting supernatant, filtering, concentrating, and drying to obtain corn root extract.
Preferably, in the preparation method of the corn tassel extract, the adding amount of the ethanol water solution is 5-10 times of the weight of the dried corn tassel, and the leaching temperature is 50-60 ℃;
in the preparation method of the corn root extract, the adding amount of the ethanol water solution is 5-10 times of the weight of the dried corn root, and the extraction temperature is 50-60 ℃.
Preferably, in the step 2), the adding amount of the ethanol water solution is 4-8 times of the total weight of the mixture powder, and the leaching temperature is 40-60 ℃.
Preferably, in the step 3), the addition amount of the glycosidase is 0.2-0.5% of the weight of the leaching product; the addition amount of the esterase is 0.3 to 0.6 percent of the weight of the leaching product; the addition amount of the pectinase is 0.2-0.5% of the weight of the leaching product.
Preferably, in the step 3), the enzymolysis temperature is 40-50 ℃, and the enzymolysis time is 100-120 min.
Preferably, the adding amount of the white spirit is 30-50 times of the weight of the leaching product;
the volume fraction of ethanol in the white spirit is 30-60%.
Preferably, in the step 4), the standing and aging temperature is 30-40 ℃, and the standing and aging time is 48-72 hours.
In the present invention, the ethanol aqueous solution with a volume fraction of 30-60% means that the volume content of ethanol in the ethanol aqueous solution is 30-60%; the corn root is corn node root.
The invention provides astragalus membranaceus health-care wine which is prepared by the preparation method of the astragalus membranaceus health-care wine.
The invention has the beneficial effects that:
1. the preparation method of the astragalus membranaceus health-care wine provided by the invention comprises the steps of carrying out alcohol extraction on specific amounts of astragalus membranaceus, ligusticum wallichii, angelica sinensis and radix ophiopogonis to obtain an extraction product, then carrying out enzymolysis on the extraction product, concentrating and drying the enzymolysis liquid, adding the corn tassel extract, the corn root extract and white spirit, standing, aging and filtering to obtain the astragalus membranaceus health-care wine, which is simple in component, safe and harmless to a human body and has an outstanding effect of regulating lipid metabolism. The corn tassel extract and the corn root extract are matched with the astragalus root, the ligusticum wallichii, the angelica sinensis and the radix ophiopogonis, so that the bitter taste of the health-care wine can be effectively reduced while the effect of regulating lipid metabolism of the health-care wine is greatly enhanced. Researches show that the health care wine prepared by the preparation method has better effect of regulating the lipid metabolism of women.
2. The preparation method of the astragalus membranaceus health-care wine provided by the invention further comprises the step of adding the corn tassel extract in an amount which is 0.2-1% of the weight of the extraction product; the addition amount of the corn root extract is 0.2-1% of the weight of the extract. According to the invention, the effect of the health care wine is effectively ensured and the effect of regulating lipid metabolism of the health care wine can be further improved by controlling the adding amount of the corn tassel extract and the corn root extract.
3. The preparation method of the astragalus membranaceus health-care wine provided by the invention further comprises the step of carrying out specific alcohol extraction on the dried corn tassel and corn root to obtain the corn tassel extract and corn root extract, wherein the corn tassel extract and the corn root extract are matched with astragalus membranaceus, ligusticum wallichii, angelica sinensis and radix ophiopogonis, and have a synergistic effect, so that the effect of the health-care wine on regulating lipid metabolism can be further improved.
Detailed Description
The following examples are provided to further understand the present invention, not to limit the scope of the present invention, but to provide the best mode, not to limit the content and the protection scope of the present invention, and any product similar or similar to the present invention, which is obtained by combining the present invention with other prior art features, falls within the protection scope of the present invention.
The examples do not show the specific experimental steps or conditions, and can be performed according to the conventional experimental steps described in the literature in the field. The reagents or instruments used are not indicated by manufacturers, and are all conventional reagent products which can be obtained commercially.
Example 1
A preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 15kg of astragalus membranaceus, 15kg of ligusticum wallichii, 10kg of angelica sinensis and 10kg of radix ophiopogonis, then mixing the materials, crushing the materials, and sieving the crushed materials by a 100-mesh sieve to obtain mixed material powder;
2) adding 30% ethanol aqueous solution into the mixture powder, leaching for 24 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, and drying at 60 ℃ for 2 hours to obtain a leaching product; the adding amount of the ethanol water solution is 4 times of the total weight of the mixture powder, and the leaching temperature is 40 ℃;
3) dissolving the leaching product with water, adding β -xylosidase, alkaline phosphatase and pectin methylesterase for enzymolysis to obtain an enzymolysis solution, wherein the addition amount of the water is 5 times of the weight of the leaching product, the addition amount of the β -xylosidase is 0.2 percent of the weight of the leaching product, the addition amount of the alkaline phosphatase is 0.6 percent of the weight of the leaching product, the addition amount of the pectin methylesterase is 0.2 percent of the weight of the leaching product, the enzymolysis temperature is 40 ℃, and the enzymolysis time is 120 min;
4) filtering the enzymolysis liquid, concentrating the filtrate into paste, drying at 30 ℃ for 1 hour to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing and aging at 30 ℃ for 72 hours, and filtering to remove insoluble substances to obtain the astragalus membranaceus health-care wine; the addition amount of the corn tassel extract is 0.2 percent of the weight of the extraction product; the addition amount of the corn root extract is 1 percent of the weight of the extract; the adding amount of the white spirit is 30 times of the weight of the leaching product; the volume fraction of ethanol in the white spirit is 30%.
The preparation method of the corn tassel extract comprises the following steps:
picking up the maize tassels 10-15 days after the maize plants extract the maize tassels, and drying the maize tassels for 6 hours at 50 ℃ to obtain dried maize tassels; crushing the dried corn tassels, sieving the crushed corn tassels with a 100-mesh sieve, adding an ethanol aqueous solution with the volume fraction of 30%, leaching the crushed corn tassels for 24 hours, taking supernatant, filtering the supernatant, concentrating the filtered supernatant into paste, drying the paste at 60 ℃ for 2 hours to obtain a corn tassels extract, wherein the adding amount of the ethanol aqueous solution is 5 times of the weight of the dried corn tassels, and the leaching temperature is 50 ℃.
The preparation method of the corn root extract comprises the following steps:
taking dried corn roots, crushing, sieving with a 100-mesh sieve, adding an ethanol aqueous solution with the volume fraction of 30%, leaching for 24 hours, taking a supernatant, filtering the supernatant, concentrating the filtrate into a paste, drying at 60 ℃ for 2 hours to obtain a corn root extract, wherein the addition amount of the ethanol aqueous solution is 5 times of the weight of the dried corn roots, and the leaching temperature is 50 ℃.
Example 2
A preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 20kg of astragalus membranaceus, 8kg of ligusticum wallichii, 15kg of angelica sinensis and 7kg of radix ophiopogonis, then mixing the astragalus membranaceus, the ligusticum wallichii, the angelica sinensis and the radix ophiopogonis, crushing the mixture, and sieving the crushed mixture through a 100-mesh sieve to obtain mixed powder;
2) adding an ethanol water solution with the volume fraction of 60% into the mixed material powder, leaching for 72 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, and drying the paste at 60 ℃ for 2 hours to obtain a leaching product; the adding amount of the ethanol water solution is 8 times of the total weight of the mixture powder, and the leaching temperature is 60 ℃;
3) dissolving the leaching product with water, adding β -xylosidase, alkaline phosphatase and pectin methylesterase for enzymolysis to obtain an enzymolysis solution, wherein the addition amount of the water is 5 times of the weight of the leaching product, the addition amount of the β -xylosidase is 0.5 percent of the weight of the leaching product, the addition amount of the alkaline phosphatase is 0.3 percent of the weight of the leaching product, the addition amount of the pectin methylesterase is 0.5 percent of the weight of the leaching product, the enzymolysis temperature is 50 ℃, and the enzymolysis time is 100 min;
4) filtering the enzymolysis liquid, concentrating the filtrate into paste, drying at 30 ℃ for 1 hour to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing and aging at 40 ℃ for 48 hours, and filtering to remove insoluble substances to obtain the astragalus membranaceus health-care wine; the addition amount of the corn tassel extract is 1 percent of the weight of the extraction product; the addition amount of the corn root extract is 0.2 percent of the weight of the extract; the adding amount of the white spirit is 30 times of the weight of the leaching product; the volume fraction of ethanol in the white spirit is 30%.
The preparation method of the corn tassel extract comprises the following steps:
picking up the maize tassels 10-15 days after the maize plants extract the maize tassels, and drying the maize tassels for 6 hours at 50 ℃ to obtain dried maize tassels; crushing the dried corn tassels, sieving the crushed corn tassels with a 100-mesh sieve, adding 60% by volume of ethanol aqueous solution into the crushed corn tassels, leaching the crushed corn tassels for 48 hours, taking supernatant, filtering the supernatant, concentrating the filtered supernatant into paste, and drying the paste at 60 ℃ for 2 hours to obtain a corn tassels extract, wherein the adding amount of the ethanol aqueous solution is 10 times of the weight of the dried corn tassels, and the leaching temperature is 60 ℃.
The preparation method of the corn root extract comprises the following steps:
taking dried corn roots, crushing, sieving with a 100-mesh sieve, adding 60% by volume of ethanol aqueous solution, leaching for 48 hours, taking supernatant, filtering the supernatant, concentrating the filtrate into paste, drying at 60 ℃ for 2 hours to obtain a corn root extract, wherein the addition amount of the ethanol aqueous solution is 10 times of the weight of the dried corn roots, and the leaching temperature is 60 ℃.
Example 3
A preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 18kg of astragalus membranaceus, 12kg of ligusticum wallichii, 14kg of angelica sinensis and 9kg of radix ophiopogonis, then mixing the materials, crushing the materials, and sieving the crushed materials by a 100-mesh sieve to obtain mixed material powder;
2) adding 50% ethanol aqueous solution into the mixture powder, leaching for 50 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, and drying at 60 ℃ for 2 hours to obtain a leaching product; the adding amount of the ethanol water solution is 6 times of the total weight of the mixture powder, and the leaching temperature is 50 ℃;
3) dissolving the leaching product with water, adding β -xylosidase, alkaline phosphatase and pectin methylesterase for enzymolysis to obtain an enzymolysis solution, wherein the addition amount of the water is 5 times of the weight of the leaching product, the addition amount of the β -xylosidase is 0.3 percent of the weight of the leaching product, the addition amount of the alkaline phosphatase is 0.4 percent of the weight of the leaching product, the addition amount of the pectin methylesterase is 0.3 percent of the weight of the leaching product, the enzymolysis temperature is 45 ℃, and the enzymolysis time is 110 min;
4) filtering the enzymolysis liquid, concentrating the filtrate into paste, drying at 32 ℃ for 1.2 hours to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing and aging at 35 ℃ for 50 hours, and filtering to remove insoluble substances to obtain the astragalus membranaceus health-care wine; the addition amount of the corn tassel extract is 0.8 percent of the weight of the extraction product; the addition amount of the corn root extract is 0.4 percent of the weight of the extract; the adding amount of the white spirit is 30 times of the weight of the leaching product; the volume fraction of ethanol in the white spirit is 30%.
The preparation method of the corn tassel extract comprises the following steps:
picking up the maize tassels 10-15 days after the maize plants extract the maize tassels, and drying the maize tassels for 6 hours at 50 ℃ to obtain dried maize tassels; crushing the dried corn tassels, sieving the crushed corn tassels with a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution into the crushed corn tassels, leaching the crushed corn tassels for 30 hours, taking supernate, filtering the supernate, concentrating the filtered supernate into paste, drying the paste at 60 ℃ for 2 hours to obtain a corn tassels extract, wherein the adding amount of the ethanol aqueous solution is 8 times of the weight of the dried corn tassels, and the leaching temperature is 55 ℃.
The preparation method of the corn root extract comprises the following steps:
taking dried corn roots, crushing, sieving with a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution, leaching for 30 hours, taking supernatant, filtering the supernatant, concentrating the filtrate into paste, drying at 60 ℃ for 2 hours to obtain a corn root extract, wherein the addition amount of the ethanol aqueous solution is 8 times of the weight of the dried corn roots, and the leaching temperature is 55 ℃.
Example 4
A preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 17kg of astragalus membranaceus, 10kg of ligusticum wallichii, 13kg of angelica sinensis and 8kg of radix ophiopogonis, mixing, crushing and sieving by using a 100-mesh sieve to obtain mixture powder;
2) adding 40% ethanol aqueous solution into the mixture powder, leaching for 48 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, and drying at 65 ℃ for 2 hours to obtain a leaching product; the adding amount of the ethanol water solution is 6 times of the total weight of the mixture powder, and the leaching temperature is 50 ℃;
3) dissolving the leaching product with water, adding β -xylosidase, alkaline phosphatase and pectin methylesterase for enzymolysis to obtain an enzymolysis solution, wherein the addition amount of the water is 6 times of the weight of the leaching product, the addition amount of the β -xylosidase is 0.4 percent of the weight of the leaching product, the addition amount of the alkaline phosphatase is 0.4 percent of the weight of the leaching product, the addition amount of the pectin methylesterase is 0.4 percent of the weight of the leaching product, the enzymolysis temperature is 45 ℃, and the enzymolysis time is 110 min;
4) filtering the enzymolysis liquid, concentrating the filtrate into paste, drying at 32 ℃ for 1.2 hours to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing and aging at 35 ℃ for 50 hours, and filtering to remove insoluble substances to obtain the astragalus membranaceus health-care wine; the addition amount of the corn tassel extract is 0.8 percent of the weight of the extraction product; the addition amount of the corn root extract is 0.4 percent of the weight of the extract; the adding amount of the white spirit is 50 times of the weight of the leaching product; the volume fraction of ethanol in the white spirit is 60%.
The preparation method of the corn tassel extract comprises the following steps:
picking up the maize tassels 10-15 days after the maize plants extract the maize tassels, and drying the maize tassels for 6 hours at 50 ℃ to obtain dried maize tassels; crushing the dried corn tassels, sieving the crushed corn tassels by a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution into the crushed corn tassels, leaching the crushed corn tassels for 35 hours, taking supernatant, filtering the supernatant, concentrating the filtered supernatant into paste, and drying the paste at 60 ℃ for 2 hours to obtain a corn tassels extract, wherein the adding amount of the ethanol aqueous solution is 8 times of the weight of the dried corn tassels, and the leaching temperature is 55 ℃.
The preparation method of the corn root extract comprises the following steps:
taking dried corn roots, crushing, sieving with a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution, leaching for 35 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, drying at 60 ℃ for 2 hours to obtain a corn root extract, wherein the addition amount of the ethanol aqueous solution is 8 times of the weight of the dried corn roots, and the leaching temperature is 55 ℃.
Example 5
A preparation method of astragalus membranaceus health care wine comprises the following steps:
1) respectively weighing the following raw materials in parts by weight: 20kg of astragalus membranaceus, 11kg of ligusticum wallichii, 12kg of angelica sinensis and 10kg of radix ophiopogonis, then mixing the astragalus membranaceus, the ligusticum wallichii, the angelica sinensis and the radix ophiopogonis, crushing the mixture, and sieving the crushed mixture through a 100-mesh sieve to obtain mixed powder;
2) adding 40% ethanol aqueous solution into the mixture powder, leaching for 48 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, and drying at 65 ℃ for 2 hours to obtain a leaching product; the adding amount of the ethanol water solution is 6 times of the total weight of the mixture powder, and the leaching temperature is 50 ℃;
3) dissolving the leaching product with water, adding β -xylosidase, alkaline phosphatase and pectin methylesterase for enzymolysis to obtain an enzymolysis solution, wherein the addition amount of the water is 6 times of the weight of the leaching product, the addition amount of the β -xylosidase is 0.4 percent of the weight of the leaching product, the addition amount of the alkaline phosphatase is 0.4 percent of the weight of the leaching product, the addition amount of the pectin methylesterase is 0.4 percent of the weight of the leaching product, the enzymolysis temperature is 45 ℃, and the enzymolysis time is 110 min;
4) filtering the enzymolysis liquid, concentrating the filtrate into paste, drying at 32 ℃ for 1.2 hours to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing and aging at 35 ℃ for 50 hours, and filtering to remove insoluble substances to obtain the astragalus membranaceus health-care wine; the addition amount of the corn tassel extract is 0.8 percent of the weight of the extraction product; the addition amount of the corn root extract is 0.4 percent of the weight of the extract; the adding amount of the white spirit is 50 times of the weight of the leaching product; the volume fraction of ethanol in the white spirit is 60%.
The preparation method of the corn tassel extract comprises the following steps:
taking dried corn tassel, crushing, sieving with a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution, leaching for 35 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, drying at 60 ℃ for 2 hours to obtain a corn tassel extract, wherein the adding amount of the ethanol aqueous solution is 8 times of the weight of the dried corn tassel, and the leaching temperature is 55 ℃.
The preparation method of the corn root extract comprises the following steps:
taking dried corn roots, crushing, sieving with a 100-mesh sieve, adding 40% by volume of ethanol aqueous solution, leaching for 35 hours, taking supernatant, filtering the supernatant, concentrating the supernatant into paste, drying at 60 ℃ for 2 hours to obtain a corn root extract, wherein the addition amount of the ethanol aqueous solution is 8 times of the weight of the dried corn roots, and the leaching temperature is 55 ℃.
Comparative example 1
The comparative example provides a preparation method of astragalus membranaceus health care wine, which is different from example 3 only in that the corn tassel extract and the corn root extract are not added in step 4).
Comparative example 2
The comparative example provides a preparation method of astragalus membranaceus health care wine, which is different from example 3 only in that no corn root extract is added in step 4).
Comparative example 3
The comparative example provides a preparation method of astragalus membranaceus health care wine, which is different from example 3 only in that no corn tassel extract is added in step 4).
Application test example
Effect of health care wine on experimental rat hyperlipidemia
Experimental animals: SD rats, SPF grade, male, body weight 200 + -20 g.
The experimental method comprises the following steps: after adaptive feeding for one week, dividing the rats into a normal control group and a modeling group randomly according to the weight, wherein 10 normal control groups are fed with basic feed; and (4) building 80 modules, after feeding with high-fat feed for 2 weeks, taking blood from eye sockets to measure blood fat, and selecting rats with remarkably increased blood fat as successful modeling of the hyperlipidemia.
The patients with blood TC higher than 2.5mmol/L were taken into the experiment, and the hyperlipidemic rats were divided into a hyperlipidemic model group, a health wine drug group prepared in examples 1-3 and comparative examples 1-3, and a positive drug simvastatin (5mg/kg body weight) group according to the blood lipid level, each group containing 10 rats. Normal control group and hyperlipemia model group were given physiological saline of equal volume, and experimental treatment: the rats in the normal control group and the model group are respectively administrated with physiological saline according to the intragastric administration of 20ml/kg body weight, the simvastatin in the positive control drug is administrated according to 5mg/kg body weight, the health care wine drug groups prepared in examples 1-3 and comparative examples 1-3 are administrated according to 20mg/kg body weight, and the normal control group and the model group are prepared into appropriate concentrations with the administration volume of 20ml/kg body weight for administration. The administration is performed by intragastric administration 1 time per day for 14 days, and 60 minutes after the last administration, blood is taken from ocular venous plexus for measurement and blood fat. The results are shown in Table 1.
TABLE 1 Effect of health wine on Experimental rat hyperlipidemia
Note: compared with the normal control group,#P<0.05，##P<0.01; compared with the hyperlipemia model group,**P<0.01、*P<0.05 Table 1 shows that the hyperlipidemia model group of the present invention has significant effect compared with the normal control groupSignificant difference (P)<0.01), indicating that the molding is successful. Compared with the comparative example, the health-care wine obtained by the embodiment of the invention has obviously enhanced lipid metabolism regulation effect on rats, which shows that the health-care wine has obvious regulation effect on lipid metabolism abnormality of experimental rats caused by high-fat feeding.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The preparation method of the astragalus membranaceus health-care wine is characterized by comprising the following steps of:
1) respectively weighing the following raw materials in parts by weight: 15-20 parts of astragalus membranaceus, 8-15 parts of ligusticum wallichii, 10-15 parts of angelica sinensis and 7-10 parts of radix ophiopogonis, and then the astragalus membranaceus, the ligusticum wallichii, the angelica sinensis and the radix ophiopogonis are mixed and crushed to obtain mixed powder;
2) adding 30-60% ethanol water solution into the mixture powder, leaching for 24-72 hr, collecting supernatant, filtering, concentrating, and drying to obtain extract;
3) dissolving the leaching product with water, and adding glycosidase, esterase and pectinase for enzymolysis to obtain an enzymatic hydrolysate;
4) filtering the enzymolysis liquid, concentrating and drying the filtrate to obtain an enzymolysis product, adding a corn tassel extract, a corn root extract and white spirit into the enzymolysis product, standing, aging and filtering to obtain the astragalus membranaceus health-care wine.
2. The preparation method of the astragalus membranaceus health-care wine as claimed in claim 1, wherein the corn tassel extract is added in an amount of 0.2-1% of the weight of the extracted product;
the addition amount of the corn root extract is 0.2-1% of the weight of the extract.
3. The preparation method of the astragalus membranaceus health-care wine as claimed in claim 2, wherein the preparation method of the corn tassel extract comprises the following steps:
taking the dried corn tassel, crushing, adding 30-60% ethanol water solution by volume fraction, leaching for 24-48 hours, taking supernatant, filtering the supernatant, concentrating and drying to obtain a corn tassel extract;
the preparation method of the corn root extract comprises the following steps:
pulverizing dried corn root, adding 30-60% ethanol water solution, leaching for 24-48 hr, collecting supernatant, filtering, concentrating, and drying to obtain corn root extract.
4. The preparation method of the astragalus membranaceus health-care wine as claimed in claim 3, wherein in the preparation method of the corn tassel extract, the adding amount of the ethanol water solution is 5-10 times of the weight of the dried corn tassel, and the extraction temperature is 50-60 ℃;
in the preparation method of the corn root extract, the adding amount of the ethanol water solution is 5-10 times of the weight of the dried corn root, and the extraction temperature is 50-60 ℃.
5. The preparation method of the astragalus membranaceus health-care wine according to any one of claims 1 to 4, wherein in the step 2), the adding amount of the ethanol aqueous solution is 4-8 times of the total weight of the mixture powder, and the extraction temperature is 40-60 ℃.
6. The preparation method of the astragalus membranaceus health-care wine as claimed in any one of claims 1 to 5, wherein in the step 3), the addition amount of the glycosidase is 0.2 to 0.5 percent of the weight of the extracted product; the addition amount of the esterase is 0.3 to 0.6 percent of the weight of the leaching product; the addition amount of the pectinase is 0.2-0.5% of the weight of the leaching product.
7. The method for preparing the astragalus membranaceus health-care wine as claimed in any one of claims 1 to 6, wherein in step 3), the enzymolysis temperature is 40-50 ℃, and the enzymolysis time is 100-120 min.
8. The preparation method of the astragalus membranaceus health-care wine according to any one of claims 1 to 7, wherein the adding amount of the white wine is 30-50 times of the weight of the extracted product;
the volume fraction of ethanol in the white spirit is 30-60%.
9. The method for preparing astragalus membranaceus health-care wine according to any one of claims 1 to 8, wherein in step 4), the standing and aging temperature is 30-40 ℃, and the standing and aging time is 48-72 hours.
10. An astragalus health wine, which is characterized by being prepared by the preparation method of the astragalus health wine of any one of claims 1 to 9.
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