CN110974881A

CN110974881A - Pure plant buccal tablet for stopping smoking and its preparation method

Info

Publication number: CN110974881A
Application number: CN202010012816.1A
Authority: CN
Inventors: 戴德凤
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-01-07
Filing date: 2020-01-07
Publication date: 2020-04-10

Abstract

The invention provides a pure plant buccal tablet for stopping smoking and a preparation method thereof, belonging to the field of health care products for stopping smoking, comprising the following raw materials in parts by weight: 5-20 parts of mint, 5-20 parts of dandelion, 5-20 parts of dried orange peel and 60-90 parts of pumpkin vine. The preparation method comprises the following steps: drying the raw materials, pulverizing, mixing, grinding, sieving to obtain mixed powder, homogenizing, and tabletting to obtain the final product. The pure plant smoking-quitting buccal tablet can be used before and after smoking or replace tobacco, and a user can feel the odor of nicotine at the mouth and the nose, so that the interest of the user in smoking can be eliminated, and meanwhile, nicotine toxin in the body can be gradually reduced until the nicotine toxin disappears under the action of the smoking-quitting buccal tablet, so that the purpose of smoking quitting is achieved, and the smoking quitting is avoided.

Description

Pure plant buccal tablet for stopping smoking and its preparation method

Technical Field

The invention belongs to the field of smoking cessation health products, and particularly relates to a pure plant smoking cessation buccal tablet and a preparation method thereof.

Background

Smoking brings many health hazards to human bodies, when cigarettes are burnt, more than 4000 chemical substances are generated, smoke carries a large amount of toxic substances to be deposited in a respiratory system, bronchitis, tracheitis, pneumonia and the like can be caused, and lung cancer can be caused seriously.

Therefore, more and more people are aware of the harm of smoking and also start smoking cessation, thus prompting the emergence of various smoking cessation products. For example, nicotine is generally added to a smoking-cessation chewing gum, and discomfort caused by nicotine withdrawal is relieved by nicotine chewing gum.

However, this smoking-cessation chewing gum only alleviates discomfort by chewing the gum containing a small amount of nicotine, which is equivalent to gradually reducing nicotine intake, resulting in an extended smoking-cessation period, and also failing to lessen the user's interest in cigarettes, which is prone to relapse.

Disclosure of Invention

Based on the background problems, the invention aims to provide the pure plant buccal tablets for quitting smoking, which can gradually eliminate the interest of a user in smoking so as to achieve the aim of quitting smoking without relapse. The invention also provides a preparation method of the pure plant buccal tablet for stopping smoking.

In order to achieve the purpose, the technical scheme provided by the invention is as follows:

the pure plant buccal tablet for stopping smoking comprises the following raw materials in parts by weight: 5-20 parts of mint, 5-20 parts of dandelion, 5-20 parts of dried orange peel and 60-90 parts of pumpkin vine.

Preferably, the smoking-quitting buccal tablets comprise the following raw materials in parts by weight: 10-15 parts of mint, 10-15 parts of dandelion, 10-15 parts of dried orange peel and 70-75 parts of pumpkin vine.

In one embodiment, the smoking-quitting buccal tablets further comprise 5-15 parts of brown sugar.

Mint: pungent and cool, and has effects of dispelling pathogenic wind, clearing heat, refreshing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing.

Dandelion: sweet in nature and taste, slightly bitter and cold in nature, entering liver and stomach meridians, and has the effects of promoting urination, relieving diarrhea, eliminating jaundice, and promoting bile flow.

Dried orange peel: bitter and pungent in flavor and warm in nature, enter lung and spleen meridians, regulate qi-flowing for strengthening spleen, dry dampness and resolve phlegm.

Pumpkin vine: calming the liver and harmonizing the stomach, dredging the meridian, promoting blood circulation, nourishing kidney water, treating liver wind, regulating menstruation and regulating qi, removing all wind and clearing heat.

The invention selects the four traditional Chinese medicine compositions, takes pumpkin vine as monarch drug, dandelion as ministerial drug and mint and dried orange peel as assistants, not only can eliminate interest and craving of users to cigarettes, but also can metabolize nicotine in vivo, and has the functions of clearing away the lung-heat and protecting the liver.

In order to achieve the purpose, the invention also provides a preparation method of the pure plant buccal tablet for quitting smoking, which comprises the steps of drying the raw materials, crushing, uniformly mixing, grinding and sieving the raw materials to obtain mixed powder, homogenizing the mixed powder, and pressing the homogenized mixed powder into tablets to obtain the buccal tablet for quitting smoking.

Preferably, the particle size of the mixed powder is 100-160 meshes.

Compared with the prior art, the invention has the following effects:

the pure plant smoking-quitting buccal tablet is taken during smoking or is taken instead of tobacco, so that a user can feel the odor of nicotine at the mouth and nose, the interest of the user in smoking can be eliminated, and meanwhile, nicotine toxin in the body can be gradually reduced until the nicotine toxin disappears under the action of the smoking-quitting buccal tablet, so that the purpose of smoking quitting is achieved, and the nicotine toxin cannot be repeatedly sucked.

Detailed Description

The invention relates to the field of smoking cessation health products, mainly aims to solve the defects of long smoking cessation period and easy relapse of the existing smoking cessation chewing gum, and provides a pure plant smoking cessation buccal tablet which comprises the following components: 5-20 parts of mint, 5-20 parts of dandelion, 5-20 parts of dried orange peel and 60-90 parts of pumpkin vine. The pure plant smoking-quitting buccal tablet is taken during smoking or is taken instead of tobacco, namely one or more tablets can be contained before and after smoking, or one or more tablets can be contained during smoking (namely smoking is not allowed), a user can feel the nicotine odor at the mouth and nose, so that the interest of the user in smoking can be eliminated, and meanwhile, nicotine toxin in vivo can be gradually reduced until the nicotine toxin disappears under the action of the smoking-quitting buccal tablet, so that the aim of smoking quitting is fulfilled, and the repeated smoking is avoided.

The present invention will next be described in detail by way of specific examples.

Example 1

The pure plant buccal tablet for stopping smoking comprises the following raw materials in parts by weight: 10 parts of mint, 20 parts of dandelion, 10 parts of dried orange peel and 60 parts of pumpkin vine.

The preparation method comprises the following steps:

(1) and (3) screening clean and intact mint, dandelion, dried orange peel and pumpkin vine, and cleaning and removing impurities from the screened austral.

(2) Dehydrating and drying the cleaned raw materials until the water content of the traditional Chinese medicinal materials is less than or equal to 5%;

(3) taking 10 parts of mint, 20 parts of dandelion, 10 parts of dried orange peel and 60 parts of pumpkin vine, adding the components into a pulverizer to be pulverized and uniformly mixed, grinding the pulverized and uniformly mixed traditional Chinese medicinal materials, sieving the powder by a 100-mesh sieve to obtain mixed powder, adding starch into the mixed powder, homogenizing the powder, and pressing the powder into sheets to obtain the smoking-quitting buccal tablets, wherein the weight of each smoking-quitting buccal tablet is 0.35 +/-0.02 g.

Example 2

The pure plant buccal tablet for stopping smoking comprises the following raw materials in parts by weight: 5 parts of mint, 5 parts of dandelion, 5 parts of dried orange peel, 90 parts of pumpkin vine and 5 parts of brown sugar. The preparation method of the pure plant buccal tablet for stopping smoking in example 2 is the same as that of example 1.

Example 3

The pure plant buccal tablet for stopping smoking comprises the following raw materials in parts by weight: 15 parts of mint, 15 parts of dandelion, 15 parts of dried orange peel, 70 parts of pumpkin vine and 10 parts of brown sugar. The preparation method of the pure plant buccal tablet for stopping smoking in example 3 is the same as that of example 1.

Example 4

The pure plant buccal tablet for stopping smoking comprises the following raw materials in parts by weight: 20 parts of mint, 10 parts of dandelion, 20 parts of dried orange peel, 75 parts of pumpkin vine and 15 parts of brown sugar. The preparation method of the pure plant buccal tablet for stopping smoking of example 4 is the same as that of example 1.

Comparative example 1

A smoking cessation buccal tablet comprises the following raw materials in parts by weight: 10 parts of mint, 20 parts of chrysanthemum, 10 parts of dried orange peel and 60 parts of pumpkin vine.

(I) Experimental method

In order to verify the efficacy of the pure plant smoking cessation buccal tablets, 45 mice with the weight of 18-20g are selected and fed under the SPF-level condition; preparing 2mg/mL nicotine solution, and during the feeding period, taking 1mL solution every day to perfuse the stomach of the mouse, and continuously perfusing the stomach for 30 days to establish a mouse nicotine dependence model.

45 of the mice were randomly divided into experimental and control groups, experimental: dissolving 3 tablets of the smoking-quitting buccal tablets prepared in example 1 into 50mL of liquid medicine by water every day, performing intragastric administration on experimental mice, and treating for 40 d;

control group: dissolving 3 pure plant buccal tablets prepared in comparative example 1 into 50mL of liquid medicine with water every day, performing intragastric administration on experimental mice, and treating for 40 d;

blank group: mice in the experimental group were gavaged daily with an equal amount of physiological saline.

During the experiment, 1mL of feed containing the nicotine solution and common feed are simultaneously placed in front of an experimental group, a control group and a blank group of mice every day, and the selection of the mice on the feed is observed; in addition, the urine content of cotinine (a nicotine metabolite) in the urine of the mice in the experimental group, the control group and the blank group was measured periodically.

(II) results of the experiment

The experimental group mice had 1 mouse selected to eat common feed from day 5, 10 mice had 10 mice selected to eat common feed at day 10, and all the experimental group mice had the common feed after day 28, which shows that the pure plant buccal tablet for stopping smoking of the invention can eliminate the dependence on nicotine.

Only 2 mice in the control group selected to eat the common feed from the 10 th day, 10 mice in the 18 th day selected to eat the common feed, and the experimental group mice all selected to eat the common feed after 35 days, which shows that the smoking-quitting buccal tablets have better smoking-quitting effect compared with the smoking-quitting buccal tablets in the comparative example, namely, although the chrysanthemum has the similar efficacy with the dandelion, the smoking-quitting effect is obviously reduced after the chrysanthemum is used for replacing the dandelion, and the relationship that the pumpkin vine and the dandelion supplement each other is verified.

The control mice had been fed the nicotine supplemented diet for 40 days.

The structure of the content of cotinine in urine of the mice of the experimental group and the control group is shown in table 1.

TABLE 1 cotinine content in mouse urine (μmol/L)

As can be seen from the table 1, the cotinine content in the urine of the experimental mice is reduced all the time, while the cotinine content in the urine of the control mice is unchanged or even increased, which is related to the fact that the control mice use the feed added with nicotine all the time, and the pure plant smoking-quitting buccal tablets can eliminate the interest of users in smoking, can metabolize nicotine in the body and have better smoking-quitting effect compared with the control mice.

It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the inventive concept of the present invention, and these changes and modifications belong to the protection scope of the present invention.

Claims

1. The pure plant buccal tablet for stopping smoking is characterized by comprising the following raw materials in parts by weight: 5-20 parts of mint, 5-20 parts of dandelion, 5-20 parts of dried orange peel and 60-90 parts of pumpkin vine.

2. The pure plant buccal tablet for stopping smoking as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-15 parts of mint, 10-15 parts of dandelion, 10-15 parts of dried orange peel and 70-75 parts of pumpkin vine.

3. The pure plant buccal tablet for stopping smoking of claim 1, wherein the buccal tablet for stopping smoking further comprises 5-15 parts of brown sugar.

4. A method for preparing the pure plant buccal tablet for stopping smoking according to any one of claims 1 to 3, wherein the pure plant buccal tablet for stopping smoking is prepared by drying the raw materials, crushing, uniformly mixing, grinding and sieving to obtain mixed powder, homogenizing the mixed powder, and pressing into tablets.

5. The method for preparing the plant buccal tablet for stopping smoking as claimed in claim 4, wherein the particle size of the mixed powder is 100-160 mesh.