CN110960631A - External composition for treating acne, preparation method and application thereof - Google Patents
External composition for treating acne, preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to an external composition for treating acne, which is prepared from scutellaria root, phellodendron bark and coptis root for clearing heat and drying dampness, purging fire and removing toxicity, and dahurian angelica root and scutellaria root for dispelling wind and removing dampness, purging fire and reducing swelling; the angelica root is compatible with the bletilla striata to reduce swelling, expel pus and promote tissue regeneration; notoginseng radix and flos Magnoliae are combined to stop bleeding and relieve pain, warm middle energizer and relieve muscle. The traditional Chinese medicine composition has the effects of effectively treating skin problems such as acne, whelk and closed acne, and the like, and has no recurrence after healing and no stimulation and side effect on the skin. The preparation method of the external composition for treating acne adjusts the process steps according to the nature and taste functions of the components, does not damage the human body when quickly and completely treating acne, warms middle-jiao and relieves muscles, and expels toxin and reduces swelling. The application of the external composition for treating acne disclosed by the invention enables the external composition to be more convenient to use, and the external composition is uniformly mixed with the anhydrous honey, uniformly and comprehensively contacts the affected part, so that the treatment is more effective.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external composition for treating acne, and a preparation method and application thereof.
Background
Acne is a chronic inflammatory dermatosis of a pilosebaceous unit, is good for teenagers, has great influence on the psychology and the social interaction of the teenagers, and is characterized by polymorphic skin lesions such as acne, pimples, pustules, nodules and the like which are good for faces in clinical manifestation. Acne occurs in close relation to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammation. Acne is easy to occur, and because areas such as the face and the neck are very easy to contact bacteria in life and bacterial infection is not easy to stop, the acne is not easy to cure and long in course of disease, the acne is easy to cause more acne on the face of a human body for a long time, and deep-colored scars are left. Common western medicine methods for treating acne include: sulfur, local hormone injection, vitamin acid, benzoperoxide and other methods, but generally only treat the symptoms and not the root causes, once the medicine is stopped, the medicine is easy to repeat, and certain side effects exist, such as dry skin, pruritus, dry throat and other side effects frequently occur after long-term use of vitamin acid medicines; if hormone therapy is used for a long time, serious symptoms such as endocrine dyscrasia and the like can occur; however, the general daily skin care products can only relieve the conditions of water shortage and excessive grease secretion of the skin, and cannot fundamentally treat acne, whelk and the like.
Disclosure of Invention
Based on the above problems, it is an object of the present invention to provide a composition for external use for effectively treating acne, whelk, etc., which rapidly controls the development of acne, is not likely to recur after treatment, and does not injure the body of a human body during the treatment process, without significant side effects.
It is still another object of the present invention to provide a method for preparing the external composition and use of the external composition.
The technical scheme of the invention is as follows:
the invention provides an external composition for treating acne, which comprises the following components in parts by weight: 3-8 parts of biond magnolia flower, 1-4 parts of baical skullcap root, 0-7 parts of dahurian angelica root, 3-8 parts of bletilla striata, 1-4 parts of amur corktree bark, 1-5 parts of pseudo-ginseng and 1-5 parts of golden thread.
Preferably, the external composition for treating acne comprises the following components in parts by weight: 4-6 parts of biond magnolia flower, 2-3 parts of scutellaria baicalensis, 1-6 parts of angelica dahurica, 4-6 parts of bletilla striata, 2-3 parts of golden cypress, 2-4 parts of pseudo-ginseng and 2-3 parts of coptis chinensis.
Preferably, the external composition for treating acne comprises the following components in parts by weight: 5 parts of biond magnolia flower, 2 parts of baical skullcap root, 5 parts of dahurian angelica root, 5 parts of bletilla striata, 2 parts of amur corktree bark, 2 parts of pseudo-ginseng and 2 parts of golden thread.
The invention provides a preparation method of the external composition, which comprises the following steps:
(1) mixing three components of radix scutellariae, golden cypress and coptis chinensis, crushing to obtain first mixed powder, adding 70-80% of the total mass of the first mixed powder into water for extraction, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with the relative density of 1.2-1.25;
(2) mixing radix Angelicae Dahuricae and rhizoma Bletillae, pulverizing to obtain second mixed powder, adding 70-80% of the second mixed powder into 8-10 times of ethanol water solution, extracting, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with relative density of 1.1-1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 70-80% of the total mass of the second mixed powder into 8-10 times of ethanol water solution for extraction, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.05-1.1;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The preparation method of the external composition comprises the following specific preparation processes according to the compatibility of the components: the radix scutellariae, the phellodendron amurense and the coptis chinensis are extracted by water, the radix angelicae and the bletilla striata are extracted by an ethanol water solution, the pseudo-ginseng and the magnolia flower are extracted by an ethanol water solution, not only can the effect of effectively improving and treating acne be achieved, but also the human body can be prevented from being excessively invaded by the bitter and cold properties of the radix scutellariae, the phellodendron amurense and the coptis chinensis in treatment, and the mixture of the radix angelicae, the bletilla striata, the pseudo-ginseng and the magnolia flower is respectively extracted by the ethanol water solution, so that the.
According to the preparation method of the external composition, in the steps (2) and (3), the volume percentage of the ethanol in the ethanol water solution is 70-85%. The ethanol content in the ethanol water solution is not suitable to be too low, and the too low ethanol content cannot be fully combined with each component in the extraction process, so that the effect of the bitter and cold components on human bodies is alleviated.
According to the preparation method of the external composition, in the step (1), the extraction is carried out twice, the first time of extraction is carried out by adding 70-80% of the total mass of the first mixed powder into 8-10 times of water, then the filtration is carried out to obtain a first filtrate and filter residue, the second time of extraction is carried out by adding the filter residue obtained after the first extraction into 6-8 times of water for extraction, and the two extracted filtrates are combined and concentrated.
According to the preparation method of the external composition, the external composition is heated and concentrated at 80-90 ℃ in the step (1), and heated and concentrated at 60-70 ℃ in the steps (2) and (3), the concentration temperature is not too high, and the state and the efficacy of the extract are influenced.
According to the preparation method of the composition for external use of the present invention, in the step (1), the heating temperature at the time of extraction is 100-120 ℃, in the steps (2) and (3), the heating temperature at the time of extraction is 80-90 ℃, and the extraction heating temperature in each step is determined according to the extraction efficiency; the extraction time in steps (1), (2) and (3) is 2-3 hours. The extraction temperature and time ensure that all components are fully extracted, and a small part of ethanol is reserved in the filtrate extracted in the steps (2) and (3), and the ethanol can act together with the angelica dahurica, the bletilla striata, the pseudo-ginseng and the magnolia flower to relieve the effect of bitter and cold.
The invention provides application of the external composition for treating acne, the external composition is prepared into external application, and the preparation method of the external application comprises the following steps:
(1) pulverizing the components of the external composition, and mixing to obtain powdery components;
(2) uniformly mixing the powdery components and anhydrous honey according to the weight ratio of 1:1.8-2.3, and making into paste to obtain the external application agent.
The invention provides application of the external composition for treating acne, the external composition is prepared into external application, and the preparation method of the external application comprises the following steps:
(1) mixing three components of radix scutellariae, golden cypress and coptis chinensis, crushing to obtain first mixed powder, adding 70-80% of the total mass of the first mixed powder into water for extraction, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with the relative density of 1.2-1.25;
(2) mixing radix Angelicae Dahuricae and rhizoma Bletillae, pulverizing to obtain second mixed powder, adding 70-80% of the second mixed powder into 8-10 times of ethanol water solution, extracting, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with relative density of 1.1-1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 70-80% of the total mass of the second mixed powder into 8-10 times of ethanol water solution for extraction, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.05-1.1;
(4) and (3) adding the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder into anhydrous honey to prepare a paste, thus obtaining the external application agent.
In the step (4), the weight ratio of the total mass of the extract obtained in the steps (1), (2) and (3), the rest first mixed powder, the rest second mixed powder and the rest third mixed powder to the anhydrous honey is 1: 1.6-2.0.
The extractum obtained in the steps (1), (2) and (3), the first mixed powder, the second mixed powder and the third mixed powder are added into anhydrous honey to prepare a paste, and the external composition is dispersed in the honey in different forms to jointly act, so that the efficiency of contacting the skin and treating acne by the external application agent is improved.
The application method of the external composition or the external application comprises the steps of cleaning the skin and applying the composition or the external application to the affected part for one hour once a day.
The following is a brief description of the components of the composition for external use:
and (3) magnolia flower: pungent and warm in nature and flavor, enter lung and stomach meridians and warm middle energizer and release muscles.
Scutellaria baicalensis: bitter in property and cold in nature, entering lung, gallbladder, spleen, large intestine and small intestine channels, clearing heat and drying dampness, purging fire and removing toxicity.
Radix angelicae: pungent and warm in nature and flavor, entering stomach, large intestine and lung meridians, dispelling wind and removing dampness, and relieving swelling and discharging pus.
Bletilla striata: bitter, sweet, astringent and slightly cold in nature; enter lung, liver and stomach meridians, astringe to stop bleeding, resolve swelling and promote granulation.
Phellodendron bark: bitter in property and cold in nature, entering kidney and bladder meridians, clearing heat and drying dampness, purging fire and removing steam, detoxifying and curing sores.
Pseudo-ginseng: sweet in nature and taste, slightly bitter and warm, and can dissipate blood stasis to stop bleeding, relieve swelling and alleviate pain.
Coptis chinensis: bitter in property and cold in nature, entering heart, spleen, stomach, liver, gallbladder and large intestine channels, clearing heat and drying dampness, purging fire and removing toxicity.
The invention has the technical effects that:
the external composition for treating acne disclosed by the invention has the effects of clearing heat and drying dampness, purging fire and removing toxicity by using the scutellaria baicalensis, the phellodendron amurense and the coptis chinensis, and dispelling wind and eliminating dampness, and purging fire and reducing swelling by matching the angelica dahurica and the scutellaria baicalensis; the angelica root is compatible with the bletilla striata to reduce swelling, expel pus and promote tissue regeneration; notoginseng radix and flos Magnoliae are combined to stop bleeding and relieve pain, warm middle energizer and relieve muscle. The traditional Chinese medicine composition has the effects of effectively treating skin problems such as acne, whelk and closed acne, and the like, and has no recurrence after healing and no stimulation and side effect on the skin.
The preparation method of the external composition for treating acne adjusts the process steps according to the nature and taste functions of the components, does not damage the human body when quickly and completely treating acne, warms middle-jiao and relieves muscles, and expels toxin and reduces swelling.
The application of the external composition for treating acne disclosed by the invention enables the external composition to be more convenient to use, and the external composition is uniformly mixed with the anhydrous honey, uniformly and comprehensively contacts the affected part, so that the treatment is more effective.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The following examples refer to 1 part as 1 g.
Example 1
The invention provides an external composition for treating acne, which comprises the following components in parts by weight: 3 parts of biond magnolia flower, 4 parts of baical skullcap root, 8 parts of bletilla striata, 1 part of amur corktree bark, 5 parts of pseudo-ginseng and 1 part of golden thread.
The preparation method of the external composition comprises the following steps:
(1) mixing three components of scutellaria baicalensis, phellodendron amurense and coptis chinensis, crushing to obtain first mixed powder, adding 80% of the total mass of the first mixed powder into water, extracting for 2 hours at 100 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 90 ℃ to obtain an extract with the relative density of 1.2;
(2) pulverizing rhizoma bletilla to obtain second mixed powder, adding 80% of the total weight of the second mixed powder into 8 times of 85% ethanol water solution by volume percentage, extracting at 80 deg.C for 2 hr, filtering, collecting filtrate, and heating and concentrating the filtrate at 70 deg.C to obtain extract with relative density of 1.1;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 80% of the total mass of the second mixed powder into 8 times of 85% ethanol aqueous solution by volume percentage, extracting for 3 hours at 800 ℃, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.05 at 0 ℃;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The application one is as follows: the application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application comprises the following steps:
adding the external composition obtained by the preparation method into 1.6 times of anhydrous honey by weight to prepare a paste, thus obtaining the external application agent.
The application II comprises the following steps: the application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application can be simply adjusted to comprise the following steps:
(1) crushing and mixing the components of the external composition to obtain powdery components;
(2) uniformly mixing the powdery components and anhydrous honey according to the weight ratio of 1:2, and preparing into paste, thus obtaining the external application agent.
Example 2
The invention provides an external composition for treating acne, which comprises the following components in parts by weight: 8 parts of biond magnolia flower, 1 part of baical skullcap root, 7 parts of dahurian angelica root, 3 parts of bletilla striata, 4 parts of amur corktree bark, 1 part of pseudo-ginseng and 5 parts of golden thread.
The preparation method of the external composition comprises the following steps:
(1) mixing three components of scutellaria baicalensis, phellodendron amurense and coptis chinensis, crushing to obtain first mixed powder, adding 70% of the total mass of the first mixed powder into water, extracting for 3 hours at 120 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 80 ℃ to obtain an extract with the relative density of 1.25;
(2) mixing and crushing angelica dahurica and bletilla striata to obtain second mixed powder, adding 70% of the total mass of the second mixed powder into 10 times of 70% ethanol water solution with volume percentage content, extracting for 3 hours at 90 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 60 ℃ to obtain extract with the relative density of 1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 70% of the total mass of the second mixed powder into 10 times of 70% ethanol aqueous solution by volume percentage, extracting for 2 hours at 90 ℃, filtering, collecting filtrate, and concentrating the filtrate at 60 ℃ to obtain an extract with the relative density of 1.1;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application comprises the following steps:
adding the external composition obtained by the preparation method into 2.0 times of anhydrous honey to prepare a paste, thus obtaining the external application agent.
Example 3
The invention provides an external composition for treating acne, which comprises the following components in parts by weight: 4 parts of biond magnolia flower, 3 parts of baical skullcap root, 1 part of dahurian angelica root, 6 parts of bletilla striata, 2 parts of amur corktree bark, 4 parts of pseudo-ginseng and 2 parts of golden thread.
The preparation method of the external composition comprises the following steps:
(1) mixing and crushing three components of scutellaria baicalensis, phellodendron amurense and coptis chinensis to obtain first mixed powder, adding 75% of the total mass of the first mixed powder into water, extracting at 110 ℃, performing extraction twice, adding 75% of the total mass of the first mixed powder into 8 times of the total mass of the first mixed powder for extraction for 1.5 hours for the first time, adding filter residues obtained after the first extraction into 8 times of the total mass of the second mixed powder for extraction for 1 hour, filtering, combining the two extracted filtrates, and heating and concentrating the filtrate at 85 ℃ to obtain an extract with the relative density of 1.22;
(2) mixing and crushing angelica dahurica and bletilla striata to obtain second mixed powder, adding 75% of the total mass of the second mixed powder into 9 times of 80% ethanol water solution by volume percentage, extracting for 2 hours at 85 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 65 ℃ to obtain extract with the relative density of 1.2;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 75% of the total mass of the second mixed powder into 9 times of 80% ethanol aqueous solution by volume percentage, extracting for 2 hours at 85 ℃, filtering, collecting filtrate, and concentrating the filtrate at 65 ℃ to obtain an extract with the relative density of 1.08;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application comprises the following steps:
adding the external composition obtained by the preparation method into 1.8 times of anhydrous honey by weight to prepare a paste, thus obtaining the external application agent.
Example 4
The invention provides an external composition for treating acne, which comprises the following components in parts by weight: 6 parts of biond magnolia flower, 2 parts of baical skullcap root, 6 parts of dahurian angelica root, 4 parts of bletilla striata, 3 parts of amur corktree bark, 2 parts of pseudo-ginseng and 3 parts of golden thread.
The preparation method of the external composition comprises the following steps:
(1) mixing and crushing three components of scutellaria baicalensis, phellodendron amurense and coptis chinensis to obtain first mixed powder, adding 70% of the total mass of the first mixed powder into water, extracting at 120 ℃, performing extraction twice, adding 75% of the total mass of the first mixed powder into 10 times of the total mass of the first mixed powder for extraction for 2 hours for the first time, adding filter residues obtained after the first extraction into 6 times of the total mass of the second mixed powder for extraction for 1 hour, filtering, combining the two extracted filtrates, and heating and concentrating the filtrate at 90 ℃ to obtain an extract with the relative density of 1.2-1.25;
(2) mixing and crushing angelica dahurica and bletilla striata to obtain second mixed powder, adding 80% of the total mass of the second mixed powder into 10 times of 70% ethanol water solution by volume percentage, extracting for 2 hours at 90 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 70 ℃ to obtain extract with the relative density of 1.15;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 75% of the total mass of the second mixed powder into 10 times of 80% ethanol aqueous solution by volume percentage, extracting for 2.5 hours at 80 ℃, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.1 at 70 ℃;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application comprises the following steps:
(1) crushing and mixing the components of the external composition to obtain powdery components;
(2) uniformly mixing the powdery components and anhydrous honey according to the weight ratio of 1:1.8, and preparing into paste to obtain the external application agent.
Example 5
The invention provides an external composition for treating acne, which comprises the following components in parts by weight: 5 parts of biond magnolia flower, 2 parts of baical skullcap root, 5 parts of dahurian angelica root, 5 parts of bletilla striata, 2 parts of amur corktree bark, 2 parts of pseudo-ginseng and 2 parts of golden thread.
The preparation method of the external composition comprises the following steps:
(1) mixing and crushing three components of scutellaria baicalensis, phellodendron amurense and coptis chinensis to obtain first mixed powder, adding 70% of the total mass of the first mixed powder into water, extracting at 120 ℃, performing extraction twice, adding 75% of the total mass of the first mixed powder into 10 times of the total mass of the first mixed powder for extraction for 1.5 hours for the first time, adding filter residues obtained after the first extraction into 6 times of the total mass of the second mixed powder for extraction for 1.5 hours, filtering, combining two extracted filtrates, and heating and concentrating the filtrate at 80 ℃ to obtain an extract with the relative density of 1.2-1.25;
(2) mixing and crushing angelica dahurica and bletilla striata to obtain second mixed powder, adding 70% of the total mass of the second mixed powder into 10 times of 85% ethanol water solution by volume percentage, extracting for 2 hours at 90 ℃, filtering, collecting filtrate, and heating and concentrating the filtrate at 70 ℃ to obtain extract with the relative density of 1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 80% of the total mass of the second mixed powder into 8 times of 85% ethanol aqueous solution by volume percentage, extracting for 2.5 hours at 90 ℃, filtering, collecting filtrate, and concentrating the filtrate at 60 ℃ to obtain an extract with the relative density of 1.1;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
The application of the external composition for treating acne is to prepare the external composition into an external application, and the preparation method of the external application comprises the following steps:
(1) crushing and mixing the components of the external composition to obtain powdery components;
(2) uniformly mixing the powdery components and anhydrous honey according to the weight ratio of 1:2.3, and preparing into paste to obtain the external application agent.
Examples of the experiments
1. Case selection: the diagnostic criteria were customized with reference to clinical manifestations of acne in clinical dermatology: it is well developed on the face and upper trunk and in areas of profuse sebum secretion, and is manifested by polymorphic lesions such as acne, blackhead, cyst, inflammatory papule, pustule, and nodule.
2. Test object
50 volunteers with composite acne diagnosis standard and no other organ diseases were collected, wherein 28 men and 22 women were divided into 2 groups, and each group had 14 men and 11 women. One group of the applications of the first application of the invention in example 1 and two groups of the applications of the second application of the invention in example 1.
3. Criteria for therapeutic effect
And (3) curing: the skin damage basically disappears, and no subjective symptoms exist;
the effect is shown: the subjective symptoms are obviously relieved, and the skin damage is reduced by more than 50 percent;
the method has the following advantages: the subjective symptoms are relieved, and the skin damage is relieved by more than 30 percent;
and (4) invalidation: no obvious change in clinical symptoms.
4. Results of the experiment
Two weeks are taken as a treatment course, and after 5 treatment courses, the using curative effect of the volunteers is counted. The results are shown in table 1:
TABLE 1
| Group of | Cure/human | Show effect/human | Effective/human | Total effective/human | Invalid/human |
| A group of | 13 | 4 | 6 | 23 | 2 |
| Two groups are | 10 | 5 | 6 | 21 | 4 |
As can be seen from the results shown in table 1, after 5 treatment courses, the two groups of the external application of the present invention have significant efficacy, and the total effective rates of the one group and the two groups respectively reach 92% and 84%, which shows that the external application of the first application prepared by improving the preparation process of the external composition according to the compatibility of the components, the drug property and the like has better effect on the acne with the curative effect on the affected part compared with the external application of the second application prepared by directly crushing the components and adding honey into the paste.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The external composition for treating acne is characterized by comprising the following components in parts by weight: 3-8 parts of biond magnolia flower, 1-4 parts of baical skullcap root, 0-7 parts of dahurian angelica root, 3-8 parts of bletilla striata, 1-4 parts of amur corktree bark, 1-5 parts of pseudo-ginseng and 1-5 parts of golden thread.
2. The composition for external use for treating acne according to claim 1, characterized by comprising the following components in parts by weight: 4-6 parts of biond magnolia flower, 2-3 parts of scutellaria baicalensis, 1-6 parts of angelica dahurica, 4-6 parts of bletilla striata, 2-3 parts of golden cypress, 2-4 parts of pseudo-ginseng and 2-3 parts of coptis chinensis.
3. The composition for external use for treating acne according to claim 1, characterized by comprising the following components in parts by weight: 5 parts of biond magnolia flower, 2 parts of baical skullcap root, 5 parts of dahurian angelica root, 5 parts of bletilla striata, 2 parts of amur corktree bark, 2 parts of pseudo-ginseng and 2 parts of golden thread.
4. A method for preparing a composition for external use according to any one of claims 1 to 3, comprising the steps of:
(1) mixing three components of radix scutellariae, golden cypress and coptis chinensis, crushing to obtain first mixed powder, adding 70-80% of the total mass of the first mixed powder into water for extraction, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with the relative density of 1.2-1.25;
(2) mixing radix Angelicae Dahuricae and rhizoma Bletillae, pulverizing to obtain second mixed powder, adding 70-80% of the second mixed powder into 8-10 times of ethanol water solution, extracting, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with relative density of 1.1-1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 70-80% of the total mass of the second mixed powder into 8-10 times of ethanol water solution for extraction, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.05-1.1;
(4) and (3) uniformly mixing the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder to obtain the external composition.
5. The method according to claim 4, wherein the ethanol in the ethanol aqueous solution is 70 to 85% by volume in steps (2) and (3).
6. The preparation method according to claim 4, wherein in the step (1), the extraction is performed twice, the first extraction is performed by adding 70-80% of the total mass of the first mixed powder into 8-10 times of water for extraction, then the filtration is performed to obtain a first filtrate and a filter residue, the second extraction is performed by adding the filter residue obtained after the first extraction into 6-8 times of water for extraction, and the two extraction filtrates are combined and concentrated.
7. The method according to claim 4, wherein the concentration is carried out by heating at 80 to 90 ℃ in the step (1), and the concentration is carried out by heating at 60 to 70 ℃ in the steps (2) and (3).
8. The method according to claim 4, wherein the heating temperature for extraction in the step (1) is 100-120 ℃ and the heating temperature for extraction in the steps (2) and (3) is 80-90 ℃.
9. Use of a topical composition for the treatment of acne as claimed in any of claims 1 to 3 wherein said topical composition is formulated as a topical application, said topical application being prepared by a process comprising the steps of:
(1) pulverizing the components of the external composition, and mixing to obtain powdery components;
(2) uniformly mixing the powdery components and anhydrous honey according to the weight ratio of 1:1.8-2.3, and making into paste to obtain the external application agent.
10. Use of the topical composition for the treatment of acne according to any of claims 1 to 3, characterized in that the topical composition is prepared as a topical application, the process for the preparation of the topical application comprising the steps of:
(1) mixing three components of radix scutellariae, golden cypress and coptis chinensis, crushing to obtain first mixed powder, adding 70-80% of the total mass of the first mixed powder into water for extraction, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with the relative density of 1.2-1.25;
(2) mixing radix Angelicae Dahuricae and rhizoma Bletillae, pulverizing to obtain second mixed powder, adding 70-80% of the second mixed powder into 8-10 times of ethanol water solution, extracting, filtering, collecting filtrate, and concentrating the filtrate to obtain extract with relative density of 1.1-1.25;
(3) mixing pseudo-ginseng and magnolia flower, crushing to obtain third mixed powder, adding 70-80% of the total mass of the second mixed powder into 8-10 times of ethanol water solution for extraction, filtering, collecting filtrate, and concentrating the filtrate into an extract with the relative density of 1.05-1.1;
(4) and (3) adding the extractum obtained in the steps (1), (2) and (3) and the rest of the first mixed powder, the second mixed powder and the third mixed powder into anhydrous honey to prepare a paste, thus obtaining the external application agent.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279042A (en) * | 2008-05-23 | 2008-10-08 | 杨光忠 | Whelk-eliminating paste and method of preparing the same |
| CN103877455A (en) * | 2014-04-18 | 2014-06-25 | 山东省千佛山医院 | Chinese medicinal composition for treating acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279042A (en) * | 2008-05-23 | 2008-10-08 | 杨光忠 | Whelk-eliminating paste and method of preparing the same |
| CN103877455A (en) * | 2014-04-18 | 2014-06-25 | 山东省千佛山医院 | Chinese medicinal composition for treating acne |
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| 刘子君等: "治疗痤疮外用中药专利用药规律分析 ", 《新中医》 * |
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