CN110960581A

CN110960581A - Pain-relieving pill

Info

Publication number: CN110960581A
Application number: CN201911257967.7A
Authority: CN
Inventors: 朱洪英; 邵海燕; 于红霞; 颜晶; 朱凤祥; 赵红君; 周玥彤
Original assignee: WENDENG OSTEOPATH HOSPITAL
Current assignee: WENDENG OSTEOPATH HOSPITAL
Priority date: 2019-12-10
Filing date: 2019-12-10
Publication date: 2020-04-07

Abstract

The invention provides a pain-relieving pill which is prepared from the following raw materials in parts by weight: 2-10 parts of cassia twig; 2-10 parts of salvia miltiorrhiza; 2-10 parts of red peony root; 4-12 parts of fried white peony root; 2-8 parts of achyranthes bidentata; 2-8 parts of ephedra; 1-8 parts of prepared radix aconiti; 0.2-1 part of nux vomica and 1-7 parts of liquorice. The preparation method of the pain-relieving pill comprises the following steps: weighing the above materials, washing with water, drying at 60-80 deg.C, mixing, pulverizing, sieving with No. 6 sieve to obtain fine powder, adding Mel, and making into honeyed pill. The pain-relieving pill disclosed by the invention has the effects of clearing away heat and toxic materials, inducing sweat, expelling muscles, warming and activating meridians, removing blood stasis and relieving pain, can effectively treat diseases such as rheumatoid arthritis, gout, cervical spondylosis, lumbar disc herniation, sciatica, lumbago and skelalgia and the like, and particularly has an obvious effect on sciatica.

Description

Pain-relieving pill

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pain-relieving pill.

Background

The traditional Chinese medicine composition has the characteristics of long treatment course and easy recurrence for treating rheumatoid diseases, gout, cervical spondylosis, lumbar disc herniation, sciatica and lumbocrural pain, the pain can be paroxysmal or persistent, the acute onset pain is severe, and the quality of work and life is seriously affected. At present, various methods are used for treating rheumatoid arthritis, gout, cervical spondylosis, lumbar disc herniation, sciatica and lumbocrural pain, such as surgical treatment, physical treatment including massage, acupuncture, physical therapy and the like, medication treatment including western medicines, traditional Chinese medicines and the like is high in surgical treatment cost, economic burden is brought to patients, physical treatment can relieve symptoms but cannot radically cure the symptoms, western medicine treatment can relieve pain in a short time, only temporary treatment and permanent treatment are needed, long-term medicine taking is needed, stopping medicine taking is needed, pain is caused, the traditional Chinese medicine plaster is only suitable for light patients, severe patients cannot completely cure the sciatica well, and traditional Chinese medicine oral medicines are used for treating the lumbocrural pain so as to treat the sciatica fundamentally. The traditional Chinese medicine has long source, and the traditional Chinese medicine and food are from natural minerals, plants and animal medicines, and have no toxic or side effect. The traditional Chinese medicine has no drug resistance, can be continuously applied until diseases are radically treated, and has unique advantages.

The Chinese patent application with the application number of 201110327189.1 discloses a traditional Chinese medicine for treating sciatica, which is prepared from the following components in parts by weight: 20-30g of astragalus membranaceus, 10-15g of cassia twig, 20-30g of salvia miltiorrhiza, 15-20g of safflower, 15-20g of red paeony root, 10-15g of ligusticum wallichii, 10-15g of achyranthes bidentata, 15-20g of herba epimedii, 10-15g of radix angelicae pubescentis, 9-12g of monkshood, 10-15g of gardenia, 20-30g of coix seed, 10-15g of pawpaw, 15-20g of stiff silkworm and 15-20g of lycopodium clavatum. It is applicable to acute attack of sciatica and attack of wind-cold.

The Chinese invention patent application with the application number of 201410167311.7 discloses a medicine for treating rheumatism and gout, which is prepared from the following components in parts by weight: 50-72g of astragalus membranaceus, 12-18g of ligusticum wallichii, 16-23g of cassia twig, 8-12g of liquorice, 32-47g of codonopsis pilosula, 12-20g of angelica sinensis, 12-18g of eucommia ulmoides, 12-18g of pyrola, 12-18g of fried bighead atractylodes rhizome, 24-36g of prepared rehmannia rhizome, 12-20g of achyranthes root, 12-18g of poria cocos, 12-20g of parasitic loranthus, 12-20g of red paeony root, 12-20g of salvia miltiorrhiza, 12-20g of phellodendron amurense, 12-20g of radix angelicae pubescentis, 12-20g of gentiana macrophylla, 19-28g of caulis spatholobi, 12-20g of radix clematidis, 12-18g of divaricate saposhn.

The traditional Chinese medicine has better curative effect on rheumatoid, ventilation, lumbar disc herniation, sciatica, lumbocrural pain and other diseases, has more folk prescription, has slow effect on most of the traditional Chinese medicine prescriptions, and each prescription has the characteristic of specially treating certain diseases. Can be used for treating rheumatoid diseases, ventilation, lumbar intervertebral disc prolapse, sciatica, lumbago, skelalgia, etc. And the symptoms of the chronic diseases can be obviously relieved when the medicine is taken many times, the chronic diseases are easy to relapse once the medicine is stopped for a period of time, and the probability of relapse after healing is high.

Disclosure of Invention

The invention aims to overcome the defects, and provides a pain-relieving pill which has the effects of enriching blood, nourishing blood, promoting blood circulation to remove blood stasis, expelling wind and removing dampness, clearing and activating the channels and collaterals, powerfully relieving pain, relaxing muscles and tendons and strengthening bones, inducing diuresis and excreting dampness, tonifying qi and invigorating yang, benefiting wei and strengthening the exterior, and eliminating stagnation and reducing swelling, can effectively treat diseases such as rheumatoid diseases, gout, cervical spondylosis, lumbar disc herniation, sciatica, lumbago and skelalgia, and particularly has the advantages of quick response, no side effect and low recurrence rate after healing.

Sciatica is a muscle pain in arthralgia pain in traditional Chinese medicine, and is caused by invasion of exogenous pathogenic factors such as wind, cold, dampness, heat and the like to block meridians and collaterals, unsmooth circulation of qi and blood and pain caused by stagnation. Therefore, the therapeutic principle should be warming channels and dredging collaterals, dispelling wind and removing dampness, promoting blood circulation and relieving pain, strengthening tendons and bones, and invigorating qi and blood.

The pain-relieving pill of the invention adopts the following medicinal materials based on pharmacology: the ancient traditional Chinese medicine formula comprises: decocting 50 g of raw ephedra herb, cassia twig and siegesbeckia herb respectively, 15g of prepared common monkshood mother root and costustoot respectively, 100 g of incised notopterygium rhizome, clematis root and kadsura pepper stem respectively in 2000 ml of water for 20 minutes, wherein the prescription has the functions of dispelling wind and removing dampness, and activating blood and relieving pain; medicated wine for treating arthralgia syndrome by virtue of the following components: caulis Spatholobi, Carthami flos, radix Clematidis, Glycyrrhrizae radix, Poria, radix Paeoniae alba, radix Angelicae Pubescentis, fructus Chaenomelis, etc. [ usage and amount ]: twice a day, half two each time (one spoon); the people who drink the wine all the year round are two or one at a time. The medicinal liquor has the functions of removing blood stasis and relieving arthralgia, and has the defects of incapability of enriching blood, nourishing blood and activating blood circulation. If blood stasis is not activating the vessels, enriching blood and nourishing blood, blood and qi are consumed for a long time, six spirit is damaged, and the treatment is not prolonged and the body is injured after long-term use.

The traditional Chinese medicine formula is a new formula based on the two proved formulas, and the formula selects compatible combined traditional Chinese medicines according to the treatment essence for years, and has the effects of clearing and activating the channels and collaterals, powerfully relieving pain, relaxing muscles and tendons and strengthening bones, inducing diuresis and excreting dampness, tonifying qi and invigorating yang, tonifying the wei-defense and consolidating the exterior, and eliminating stagnation and reducing swelling; has effects in relieving inflammation, activating collaterals, relieving arthralgia, tonifying blood, strengthening tendons and bones, invigorating qi, and consolidating superficial resistance. The added fried white paeony root and the liquorice are matched, so that the pain relieving tea has obvious pain relieving effect on pain caused by acetic acid; the parched white peony root can protect the liver and reduce the damage of taking medicine to the liver; the product has effects of protecting intestine and stomach, and protecting people with gastrointestinal disorder; the parched radix Paeoniae alba has antiinflammatory and pathological cells phagocytizing effects, and has immunity effect.

The technical scheme of the invention is as follows: the pain-relieving pill is prepared from the following raw materials in parts by weight: 2-10 parts of cassia twig; 2-10 parts of salvia miltiorrhiza; 2-10 parts of red peony root; 4-12 parts of fried white peony root; 2-8 parts of achyranthes bidentata; 2-8 parts of ephedra; 1-8 parts of prepared radix aconiti; 0.2-1 part of nux vomica and 1-7 parts of liquorice.

Cassia twig: the traditional Chinese medicine has pungent and sweet taste, enters liver, kidney and spleen, is a commonly used interior warming medicine for mainly treating interior cold, has the effects of tonifying primordial yang, promoting blood circulation and warming spleen and stomach, is often combined with liver and kidney tonifying medicines and qi and blood tonifying medicines to treat kidney yang deficiency, decline of vital gate fire and cold limbs and slight pulse, is combined with other interior warming medicines to treat abdominal psychroalgia, cold arthralgia and lumbago, and has obvious effects of easing pain, resisting cancer and preventing cancers.

Red sage root: bitter and slightly cold. It enters heart and liver meridians. The functions and indications are as follows: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Red peony root: clear heat and cool blood, dissipate blood stasis and alleviate pain. Can be used for treating heat syndrome of nutrient-blood, macula due to toxic heat, hematemesis and epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and sore.

Parching radix Paeoniae alba: bitter and sour in taste, slightly cold in nature. It enters liver and spleen meridians. Nourish blood and astringe yin, soften liver and alleviate pain, pacify liver yang. Pacify liver and alleviate pain, nourish blood and regulate menstruation, astringe yin and check sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.

Achyranthes root: sweet, slightly bitter and neutral in nature. It enters liver and kidney meridians. Promoting blood circulation, dispelling blood stasis, dispelling pathogenic wind, and removing dampness.

Herba ephedrae: 2, pungent taste; slightly bitter; and (4) temperature. Entering the lung; the bladder channel. Sweating and relieving exterior syndrome; ventilating lung and relieving asthma; induce diuresis to alleviate edema. Mainly treats the exterior excess syndrome of wind-cold; aversion to cold and fever; no sweat exists; headache and body pain; pathogenic factors stagnated in the lung; lung qi failing to disperse; cough and asthma; edema due to wind; difficulty in urination; rheumatic arthralgia; dull skin and rubella itching; ma Huang is the first herb to release exterior syndrome because it can remove excess, and Ma Huang can excite central nerve, so Ma Huang is not used in many applications. The content of the Chinese ephedra in the invention is lower than that of other formulas.

Radix aconiti: pungent, bitter and warm in flavor. It enters heart, liver, kidney and spleen meridians. Dispel wind and dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, and cold hernia. Can be used for treating arthralgia due to wind-cold-dampness and arthralgia.

①, 8932, has the effects of promoting blood circulation, dispelling cold and dredging collaterals, has good curative effect on breast lumps, carbuncle-abscess swelling and pain, ② has the effects of diminishing inflammation and resisting bacteria, is suitable for nonspecific inflammation, carbuncle-abscess swelling and pain, ③ has the effect of relieving pain, wherein nux vomica is one of the most effective traditional Chinese medicine for relieving pain, particularly breast pain, rheumatism and bone pain, muscle injury and pain, ④ has the effects of removing blood stasis and promoting tissue regeneration, has certain effects on poliomyelitis, hand and foot numbness, cancer resistance and the like, is toxic, and has reduced toxicity after preparation.

Licorice root: has mild property and sweet taste, and has effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Preferably, the pain relieving pill is prepared from the following raw materials in parts by weight: 2-8 parts of cassia twig; 4-10 parts of salvia miltiorrhiza; 4-10 parts of red peony root; 6-10 parts of fried white peony root; 4-8 parts of achyranthes bidentata; 2-6 parts of ephedra; 1-6 parts of prepared radix aconiti; 0.2 to 0.8 portion of nux vomica and 1 to 6 portions of liquorice.

Preferably, the pain relieving pill is prepared from the following raw materials in parts by weight: 2-6 parts of cassia twig; 6-8 parts of salvia miltiorrhiza; 6-8 parts of red peony root; 8-10 parts of fried white peony root; 6-8 parts of achyranthes bidentata; 2-4 parts of ephedra; 1-4 parts of prepared radix aconiti; 0.2-0.6 part of nux vomica and 1-4 parts of liquorice.

More preferably, the pain relieving pill is prepared from the following raw materials in parts by weight: 4 parts of cassia twig; 8 parts of salvia miltiorrhiza; 8 parts of red peony root; 8 parts of fried white peony root; 8 parts of achyranthes bidentata; 2 parts of ephedra; 3 parts of prepared radix aconiti; 0.4 part of nux vomica and 2 parts of liquorice.

The preparation method of the pain relieving pill comprises the steps of weighing the above medicines, washing with water, drying at 60-80 ℃, mixing and crushing, sieving by a No. 6 sieve to obtain fine powder, adding refined honey to prepare large honeyed pills, and sealing and storing in a moisture-proof manner.

The pain-relieving pill has the beneficial effects that: the medicine combination is more reasonable, the disease causes can be conditioned, the medicine use and the dosage are reasonable, and the effects of clearing away heat and toxic materials, inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, removing blood stasis and relieving pain can be achieved; can treat rheumatoid, gout, cervical spondylosis, lumbar disc herniation, sciatica, lumbocrural pain and other diseases, takes effect in 3-7 days of treatment of sciatica, and has the effective rate of 100%.

Detailed Description

Example 1:

3 parts of cassia twig; 2 parts of salvia miltiorrhiza; 2 parts of red peony root; 4 parts of fried white peony root; 2.5 parts of achyranthes bidentata; 3 parts of ephedra; 1 part of prepared radix aconiti; 0.2 part of semen strychni preparata and 3 parts of liquorice are washed by water, dried at 60-80 ℃, mixed and crushed, sieved by a No. 6 sieve to obtain fine powder, and added with refined honey to prepare large honeyed pills, wherein each honeyed pill weighs 9g, and the patient takes the pills one time in the morning and at night each day.

Example 2:

4 parts of cassia twig; 7 parts of salvia miltiorrhiza; 8 parts of red peony root; 8 parts of fried white peony root; 8 parts of achyranthes bidentata; 2 parts of ephedra; 3 parts of prepared radix aconiti; 0.3 part of semen strychni preparata and 4 parts of liquorice are washed by water, dried at 60-80 ℃, mixed and crushed, sieved by a No. 6 sieve to obtain fine powder, and added with refined honey to prepare large honeyed pills, wherein each honeyed pill weighs 9g, and the patient takes the pills one time in the morning and at night each day.

Example 3:

9 parts of cassia twig; 9 parts of salvia miltiorrhiza; 10 parts of red peony root; 11 parts of fried white peony root; 7 parts of achyranthes bidentata; 3 parts of ephedra; 7 parts of prepared radix aconiti; 0.7 part of semen strychni preparata and 7 parts of liquorice are washed by water, dried at 60-80 ℃, mixed and crushed, sieved by a No. 6 sieve to obtain fine powder, and added with refined honey to prepare large honeyed pills, wherein each honeyed pill weighs 9g, and the patient takes the pills one time in the morning and at night each day.

Clinical curative effect

1. Sample information

The samples were screened for clinical treatment of typical sciatica cases for years, 152 in case of men and 120 in case of women, with an average age of 40.6 years. Patients were randomized into 2 groups, 70 men and 60 women in the treatment group, and 72 men and 60 women in the control group.

2. Basis of diagnosis

1) Spontaneous and radioactive pain along the route of the sciatic nerve, or pain spots on the buttocks, popliteal fossa, fibula, lateral malleolus, etc. can aggravate cough, sneeze, negative force, and stool;

2) the positive sign with the most diagnostic value is sciatic nerve traction pain, dry sciatica is mainly positive in a straight leg raising test, and radicular sciatica is mainly positive in a stooping (pick-up) test;

3) the achilles tendon reflex is weakened or disappeared, slight sensory disturbance of instep and outer leg, or the affected gluteus muscle is relaxed, the fold is low, and the leg muscle is slightly atrophied.

3. Criteria for therapeutic effect

According to the standard of curative effect of diagnosis of traditional Chinese medicine diseases issued by the State administration of traditional Chinese medicine.

And (3) curing: the symptom sign disappears completely, the original work can be recovered, and people who do not relapse after more than one year follow-up visit can be carried out;

the effect is shown: clinical symptoms disappear, the original work can be carried out, and the disease does not relapse after half a year of follow-up visit;

the method has the following advantages: pain is relieved, and symptoms relapse after the patients suffer from over-exertion, wind cold or withdrawal of the medicine;

and (4) invalidation: the clinical symptoms and physical signs are not obviously improved.

4. Method of treatment

Treatment groups: the pill is used for treatment, the pill is taken once a day in the morning and at night, 9g of the pill is taken, 1 pill is taken each time, the pill is taken according to the serious condition and the length of the course of disease, 10 days are taken as a treatment course for patients with mild condition, and 20 days are taken as a treatment course for patients with severe disease.

Control group: ibuprofen is taken orally, 0.6g each time, 3 times a day; dexamethasone injection 10mg is added into 5% glucose 100ml for intravenous drip, and 5 days is a treatment course.

4. Clinical results

Group of	Number of examples	Cure (%)	Significant effect (%)	Effective (%)	Null (%)	Effective rate (%)
							Treatment of male group	70	63(90)	7(10)	0(0)	0(0)	100
Treatment group woman	60	55(91.2)	5(8.8)	0(0)	0(0)	100
							Male in control group	72	33(45.8)	20(27.8)	9(12.5)	10(13.9)	73.6
Control group women	60	28(46.7)	8(13.3)	10(16.7)	14(23.3)	70.0

After the traditional Chinese medicine formula disclosed by the invention is used for treating patients with sciatica for years, most of the patients can be treated to greatly improve symptoms and recover to be normal. The above table shows that the average cure rate of the traditional Chinese medicine formula for the sciatica patients is up to more than 90%, the effective rate is 100%, and the traditional Chinese medicine formula has an obvious curative effect.

5. Typical cases

(1) Wendeng osteopathic hospital patient Wangzhi, women, age 55, had a history of sciatica and had a recent relapse. The patient takes the big honeyed pill prepared by the embodiment 2 of the invention once every morning and evening, one pill is taken every time, 20 days is a treatment course, the symptoms disappear after one treatment course, and the patient can completely recover after continuing to take the big honeyed pill for 2 treatment courses, which is not repeated at present.

(2) The Wendeng osteopathic hospital patient is Zhangzhi, male, 53 years old, and is initially diagnosed 7 months and 25 days in 2013. After the patients describe the sciatica for more than 3 years, the sciatica recurs frequently after tiredness or cold, sudden symptoms are aggravated due to climate change before one week, the right leg from the hip joint to the foot is radioactive, the pain is aggravated at night, the patients cannot squat, the patients are inconvenient to walk, and the treatment by Chinese and western medicines has poor effect. And (4) checking: the Plough muscle tenderness of the right hip is obvious, and the straight leg elevation test is positive. The tongue is pale with white coating and the pulse is wiry and thready. The western medicine diagnosis is sciatica. The Chinese medicine diagnosis is arthralgia syndrome (arthritis of cold), the big honeyed pills prepared by the embodiment 2 of the invention are taken once in the morning and evening every day, one pill is taken each time, 10 days are taken as a treatment course, the symptoms disappear after one treatment course, the symptoms and physical signs of a patient disappear completely after 2 treatment courses, the patient can walk and move freely, the treatment is continued for 1 treatment course according to the upper part, and the follow-up visit does not relapse after one year.

(3) The Wendeng osteopathic hospital patient is Liezhi, male, 57 years old, suffers from intervertebral disc herniation for 3 years, is treated in many ways, and has the disease condition of mild and severe, low back pain and severe pain of the hip of the left leg and the posterior tendon of the thigh, and the sciatica is diagnosed. The big honeyed pills prepared in the embodiment 1 of the invention are taken once every morning and evening, one pill is taken every time, 10 days are taken as a treatment course, pain is relieved in one treatment course, and the patient can be healed after taking for 4 treatment courses continuously, followed and relapsed.

(4) A patient in a Wendeng osteopathy hospital has a certain Liu, a woman in the Wendeng osteopathy, a 39-year-old patient and a diagnosis in 2013 in 9 months, has a history of sciatica, has hip pain recently and difficulty in sitting, and is diagnosed as sciatica after being diagnosed. The big honeyed pills prepared in the embodiment 1 of the invention are taken once every morning and evening, one pill is taken every time, 20 days are a treatment course, the hip pain is relieved after one treatment course, the symptom difficult to sit is relieved, after the big honeyed pills are continuously taken for 2 treatment courses, the clinical symptom disappears, the original work can be carried out, the patient can be cured after 2 treatment courses, and the patient can be followed up without relapse after one year.

Claims

1. The pain-relieving pill is characterized in that: the health-care food is prepared from the following raw materials in parts by weight: 2-10 parts of cassia twig; 2-10 parts of salvia miltiorrhiza; 2-10 parts of red peony root; 4-12 parts of fried white peony root; 2-8 parts of achyranthes bidentata; 2-8 parts of ephedra; 1-8 parts of prepared radix aconiti; 0.2-1 part of nux vomica and 1-7 parts of liquorice.

2. A pain-relieving pill according to claim 1, wherein: the health-care food is prepared from the following raw materials in parts by weight: 2-8 parts of cassia twig; 4-10 parts of salvia miltiorrhiza; 4-10 parts of red peony root; 6-10 parts of fried white peony root; 4-8 parts of achyranthes bidentata; 2-6 parts of ephedra; 1-6 parts of prepared radix aconiti; 0.2 to 0.8 portion of nux vomica and 1 to 6 portions of liquorice.

3. A pain-relieving pill according to claim 2, characterized in that: the health-care food is prepared from the following raw materials in parts by weight: 2-6 parts of cassia twig; 6-8 parts of salvia miltiorrhiza; 6-8 parts of red peony root; 8-10 parts of fried white peony root; 6-8 parts of achyranthes bidentata; 2-4 parts of ephedra; 1-4 parts of prepared radix aconiti; 0.2-0.6 part of nux vomica and 1-4 parts of liquorice.

4. A pain-relieving pill according to claim 3, wherein: the health-care food is prepared from the following raw materials in parts by weight: 4 parts of cassia twig; 8 parts of salvia miltiorrhiza; 8 parts of red peony root; 8 parts of fried white peony root; 8 parts of achyranthes bidentata; 2 parts of ephedra; 3 parts of prepared radix aconiti; 0.4 part of nux vomica and 2 parts of liquorice.

5. A pain-relieving pill according to any one of claims 1-4, wherein said medicament is in the form of a decoction, tablet, pill, capsule, soft capsule or ointment.

6. The method for preparing the pain-relieving pill according to any one of claims 1 to 4 is characterized in that: weighing the above materials, washing with water, drying at 60-80 deg.C, mixing, pulverizing, sieving with No. 6 sieve to obtain fine powder, adding Mel, and making into big honeyed pill; each pill weighed 9 g.