CN110960429A - High-stability tooth whitening adhesive film - Google Patents
High-stability tooth whitening adhesive film Download PDFInfo
- Publication number
- CN110960429A CN110960429A CN201911052114.XA CN201911052114A CN110960429A CN 110960429 A CN110960429 A CN 110960429A CN 201911052114 A CN201911052114 A CN 201911052114A CN 110960429 A CN110960429 A CN 110960429A
- Authority
- CN
- China
- Prior art keywords
- layer
- whitening
- gel
- stability
- peroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 148
- 239000002313 adhesive film Substances 0.000 title claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000002978 peroxides Chemical class 0.000 claims abstract description 16
- 230000009467 reduction Effects 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000012377 drug delivery Methods 0.000 claims description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 13
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 13
- 239000003906 humectant Substances 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 229920005989 resin Polymers 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
- 239000003349 gelling agent Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- 229960001631 carbomer Drugs 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 7
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 7
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000022 bacteriostatic agent Substances 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 claims description 5
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 4
- 229950010221 alexidine Drugs 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 229920001206 natural gum Polymers 0.000 claims description 3
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 3
- 229920001281 polyalkylene Polymers 0.000 claims description 3
- 229920000768 polyamine Polymers 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 claims description 2
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 2
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 2
- 239000013522 chelant Substances 0.000 claims description 2
- 229960001859 domiphen bromide Drugs 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 108010025899 gelatin film Proteins 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229940084560 sanguinarine Drugs 0.000 claims description 2
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 claims description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 2
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 claims description 2
- 229910001488 sodium perchlorate Inorganic materials 0.000 claims description 2
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000012780 transparent material Substances 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 abstract description 11
- 229940034610 toothpaste Drugs 0.000 abstract description 10
- 210000000214 mouth Anatomy 0.000 abstract description 7
- 241001391944 Commicarpus scandens Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 2
- 239000013543 active substance Substances 0.000 abstract description 2
- 230000003266 anti-allergic effect Effects 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000009036 growth inhibition Effects 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 54
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 6
- 229940041616 menthol Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 2
- 229940078916 carbamide peroxide Drugs 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229920006187 aquazol Polymers 0.000 description 1
- 239000012861 aquazol Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0233—Distinct layers, e.g. core/shell sticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/10—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of paper or cardboard
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/06—Interconnection of layers permitting easy separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/06—Coating on the layer surface on metal layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/10—Coating on the layer surface on synthetic resin layer or on natural or synthetic rubber layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/12—Coating on the layer surface on paper layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/24—Organic non-macromolecular coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/28—Multiple coating on one surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
- B32B2307/7145—Rot proof, resistant to bacteria, mildew, mould, fungi
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2555/00—Personal care
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a high-stability tooth whitening adhesive film which comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer, the second layer is a high-stability whitening gel layer, the third layer is an auxiliary administration layer, and the fourth layer is a film stripping back lining layer and is formed by sequentially stacking and connecting the four layers. The tooth paste is convenient to use and carry, has high whitening effect and high speed, is relatively elastic, is not easy to break when being worn in the oral cavity, is easy to be attached to teeth, and is easy to fall off from the teeth along with the reduction of the viscosity of an active substance consumption system after being used; the tooth paste reduces the water content of the whitening gel layer, and is added with PVP and other substances which can form conjugated peroxide bonds with active peroxide components, so that the stability of active components of the tooth paste can be greatly improved, and the effective time of the tooth paste is prolonged; the antibacterial and antiallergic components are added, so that the oral cavity irritation is small, and the oral cavity bacteria growth inhibition effect can be achieved.
Description
Technical Field
The invention belongs to the technical field of human tooth care, relates to a film for whitening human teeth, and particularly relates to a high-stability tooth whitening film.
Technical Field
The people always pursue a fashion to whiten and beautify the teeth. Hundreds of millions of people smoking, drinking tea and drinking coffee in China have different degrees of yellow, yellow or tawny pigment spots adhered to the surfaces of teeth due to long-term action, and the attractiveness of the teeth is seriously influenced. The requirements for whitening and beautifying teeth are increasing day by day, and the requirements for the mode, method and effect of whitening and beautifying teeth are higher and higher, so that the dentin is not damaged in the process of whitening and beautifying teeth, the requirements are time-saving and convenient, and the whitening and beautifying tooth paste is simple, practical and obvious in effect.
Tooth whitening can be classified into office whitening and home whitening. The family whitening refers to that a patient takes the whitening agent home to use alone under the guidance of a doctor, so that the treatment cost can be reduced. At present, there is no reliable evidence that the indoor whitening effect is better than the household whitening effect.
In the household tooth whitening process, the whitening agent is coated on the patch material by the tooth patch whitening, and the patch material covers the teeth to be whitened, so that the purpose of whitening the teeth is achieved. The tooth paste whitening is relatively lower in price and simple to operate than the denture base whitening, and is the most common household whitening method at present. The current tooth whitening films, while having the advantages of simplicity, convenience and practicality and certain results, have some, even prominent major disadvantages as noted.
CN 103735419A provides a hydrated gel whitening tooth adhesive film which is composed of a plastic film layer, a hydrogel whitening component and an easy-to-tear cover, but the tooth adhesive with the structure has relatively low elasticity and is easy to break when worn on the tooth surface; some tooth pastes are too hard and are not easy to stick to teeth; some whitening agents are too thin and tend to stick to the lips or tongue during wear.
CN 102961261a provides a formulation of a whitening strip, which reduces the discomfort of whitening agent to oral cavity by adding gel, but the water content in the formulation is high, the water content in the formulation is a key factor influencing the stability of peroxide, and the higher the water content in the formulation is, the worse the stability of peroxide is.
In view of the above, the present invention is to solve the problems of the whitening strip that it is easy to break and fall off during the trial process, and the problems of the whitening strip that the whitening active ingredient is unstable and the whitening effect is poor during the trial process.
Disclosure of Invention
In order to solve the problems, the invention provides a high-stability tooth whitening adhesive film, wherein an auxiliary drug delivery layer which is high in viscosity when being heated and water is extracted is added above a whitening gel layer, so that the adhesiveness of the adhesive film to teeth is improved, the problems that the adhesive film is small in relative elasticity, easy to break and not easy to attach to the teeth are solved, and meanwhile, the stability of whitening active ingredients is improved by stably adding and reducing the water content in the whitening layer.
The technical scheme adopted by the invention is that the high-stability tooth whitening adhesive film is characterized in that: the whitening gel carrier film comprises a four-layer structure, wherein a first layer is a whitening gel carrier film layer, a second layer is a high-stability whitening gel layer, a third layer is an auxiliary administration layer, and a fourth layer is a film stripping back lining layer and is formed by sequentially stacking and connecting the four layers.
The whitening gel carrier film layer is used for carrying the whitening gel layer on the second layer, the thickness of the whitening gel carrier film layer is less than 0.1 mm, and the whitening gel carrier film layer, the second layer and the third layer are attached to teeth together when the whitening gel carrier film layer is used.
The high-stability whitening gel layer is coated on one surface of the whitening gel carrier film layer, is a high-stability gel whitening layer composed of peroxide capable of whitening teeth and high molecular substances capable of forming a gel film, and is directly attached to the teeth when in use.
The auxiliary drug delivery layer is coated on the high-stability whitening gel layer and is made of a patch material with obviously increased viscosity after being heated or watered, so that the whitening agent can be adhered on the patch material, and the usability of the tooth patch material is improved. And the viscosity of the patch material is gradually reduced along with the reduction of the whitening concentration of the whitening agent, so that the dental patch is convenient to remove after the treatment is finished.
The film release backing layer is adhered to the auxiliary drug delivery layer and can be easily peeled off from the second layer during use, and the third layer is discarded after peeling.
Further, the high-stability tooth whitening adhesive film is characterized in that: the whitening gel carrier film layer is made of transparent material film, foil or paper.
Further, the high-stability tooth whitening adhesive film is characterized in that: the high-stability gel whitening layer is a hydrated gel whitening layer and mainly comprises a whitening agent, a gelling agent, a humectant, a stabilizer, a bacteriostatic agent, a pH regulator, a surfactant, an antiallergic agent and essence.
Wherein the whitening agent is prepared by mixing one or more of carbamide peroxide, hydrogen peroxide, sodium hypochlorite, sodium perchlorate, alkaline perborate, percarbonate and other oxidants. The gel is prepared from one or more of carbomer resin, carboxymethylcellulose sodium, hydroxyethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol resin, xanthan gum, natural gum, and acrylate copolymer. The humectant is prepared by mixing one or more of glycerol, ethanol, propylene glycol, polyethylene glycol, sorbitol, xylitol, and water. The stabilizer is composed of N-hydroxyethyl ethylenediamine triacetic acid, ethylene diamine tetraacetic acid disodium, polyethylene polyamine polyalkylene phosphonate (DTPMP-NaPA), sodium citrate, and metal chelate ions. The pH regulator is one or more of phosphoric acid, citric acid, triethanolamine and sodium hydroxide solution. The surfactant is one or more of polyoxyethylene ether hydrogenated castor oil, Tween-20 and the like. The bacteriostatic agent comprises one or more of phthalic acid and its salt, bischlorobenzene dimyohexane, alexidine, sanguinarine, benzalkonium chloride, domiphen bromide, and terephthalein chloride.
According to the weight percentage, the whitening agent content is 3-40%, the gel content is 0.5-10%, the humectant content is 10-70%, the stabilizer content is 1-3%, the bacteriostatic agent content is 0.1-0.5%, the pH regulator content is 0.2-3%, and the surfactant content is 1-10%.
When the whitening agent formula contains peroxide, the water content in the high-stability gel whitening layer is lower than 5% in order to ensure the stability of the peroxide.
In the high-stability gel whitening layer, in order to ensure the stability of peroxide under the condition that the formula of the whitening agent contains the peroxide, 0.5 to 3 percent of polyvinylpyrrolidone (PVP) is added into the high-stability gel whitening layer to form a conjugated peroxide bond so as to improve the stability of the peroxide.
Further, the high-stability tooth whitening adhesive film is characterized in that: the auxiliary administration layer is a mixture of high molecular polymer and whitening gel, the viscosity of the auxiliary administration layer is remarkably increased after the auxiliary administration layer is heated or water is added, wherein the high molecular polymer is one or more of poly (2-ethyl-2-oxazoline), polyvinyl butyral, polyvinyl alcohol and the like, the whitening gel is hydrated gel of a high-stability gel whitening layer, and the proportion of the high molecular polymer is 0.5-10% by weight.
The invention has the beneficial effects that:
1. the tooth paste is convenient to use and carry, has high whitening effect and high speed, has relatively high elasticity, is not easy to break when being worn in the oral cavity, is easy to adhere to teeth, and is easy to fall off from the teeth along with the reduction of the viscosity of an active substance consumption system after being used.
2. The tooth paste reduces the water content of the whitening gel layer, and is added with PVP and other substances which can form conjugated peroxide bonds with the active peroxide component, so that the stability of the active components of the tooth paste can be greatly improved, and the effective time of the tooth paste is prolonged.
3. The antibacterial and antiallergic components are added, so that the oral cavity irritation is small, and the oral cavity bacteria growth inhibition effect can be achieved.
Drawings
FIG. 1 is a schematic front view of the present invention;
in the figure, 1, a whitening gel carrier film layer, 2, a high-stability whitening gel layer, 3, an auxiliary drug administration layer and 4, and a film stripping back lining layer.
Detailed Description
The highly stable tooth whitening film of the present invention will be described with reference to the following examples, but the scope of the present invention is not limited to the following examples.
Example 1: as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer 1 is 0.05 mm, and the raw material is polyethylene.
The second highly stable whitening gel layer 2 comprises the following structural components: 40% of carbamide peroxide, 3% of gelling agent sodium carboxymethylcellulose, 1% of carbomer resin, 1% of polyvinylpyrrolidone and a humectant: 20% of glycerin, 28% of propylene glycol, 0.5% of disodium EDTA, 0.5% of sodium citrate, 0.5% of triethanolamine, 0.2% of menthol, and a surfactant: polyoxyethylene ether hydrogenated castor oil 3%; 2% of water and 0.3% of phthalic acid; the proportion of the structural components is in weight percent.
The third auxiliary drug delivery layer 3 uses polyvinyl butyral as the high molecular polymer in the auxiliary drug delivery layer, the weight percentage ratio is 10%, the other components are the same as the second layer, and the thickness is 0.02 mm.
The formula can be kept stable for 30 days at the temperature of 60 ℃.
Example 2:
as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer is 0.08 mm, and the raw material is polypropylene.
The structural components of the second gel whitening layer 2 comprise 8 percent of hydrogen peroxide as an active component, a gelling agent: 5% of sodium hydroxyethyl cellulose, 2% of carbomer resin, 3% of polyvinylpyrrolidone, and a humectant: 38% of glycerol, 28% of propylene glycol, 8% of polyethylene glycol, 0.5% of EDTA disodium, 0.5% of polyethylene polyamine polyalkylene phosphonate, 0.5% of triethanolamine, 0.2% of menthol, and a surfactant: tween-203%; 5% of water and 0.3% of alexidine; the proportion of the structural components is in weight percent.
The third layer is an auxiliary drug delivery layer, wherein polyvinyl butyral is used as a high molecular polymer, the weight percentage ratio is 0.5%, and the other components are the same as the components of the second layer, and the thickness is 0.02 mm.
The formula can be kept stable for 30 days at the temperature of 60 ℃.
Example 3:
as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer is 0.05 mm, and the raw material is PVA.
The structural components of the second gel whitening layer 2 comprise 5 percent of hydrogen peroxide as an active component, a gelling agent: 1% of sodium carboxymethylcellulose, 2% of carbomer resin, 1% of polyvinylpyrrolidone, and a humectant: 38% of glycerol, 28% of propylene glycol, 10% of polyethylene glycol, 2% of xylitol, 0.5% of EDTA disodium, 0.5% of N-hydroxyethyl ethylenediamine triacetic acid, 1.5% of triethanolamine, 0.2% of menthol, and a surfactant: 5% of polyoxyethylene ether hydrogenated castor oil; 5% of water and 0.3% of alexidine; the proportion of the structural components is in weight percent.
The third layer is an auxiliary drug delivery layer, wherein the high molecular polymer in the auxiliary drug delivery layer is polyvinyl butyral, the weight percentage is 2%, and the other components are the same as the components in the second layer, and the thickness is 0.02 mm.
The formula can be kept stable for 20 days at the temperature of 60 ℃.
Example 4:
as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer is 0.05 mm, and the raw material is PVA.
The structural components of the second gel whitening layer 2 comprise 20 percent of urea peroxide as an active component, a gelling agent: 1% of carbomer resin, 1% of polyvinylpyrrolidone, and 1% of humectant: 34% of glycerin, 29% of propylene glycol, 3% of polyethylene glycol, 0.5% of EDTA disodium, 0.5% of N-hydroxyethyl ethylenediamine triacetic acid, 0.5% of sodium hydroxide, 0.2% of menthol, and a surfactant: 5% of polyoxyethylene ether hydrogenated castor oil; 5% of water and 0.3% of N-hydroxyethyl ethylene diamine triacetic acid; the proportion of the structural components is in weight percent.
The third layer is a high molecular polymer in the auxiliary drug delivery layer, poly 2-ethyl-2-oxazoline is used, the weight percentage is 2 percent, and the rest components are the same as the components of the second layer, and the thickness is 0.03 mm.
The formula can be kept stable for 30 days at the temperature of 60 ℃.
Example 5:
as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer is 0.05 mm, and the raw material is PVA.
The structural components of the second gel whitening layer 2 comprise 10 percent of urea peroxide as an active component, a gelling agent: 1% of acrylate copolymer, 2% of natural gum, 2% of polyvinylpyrrolidone, and a humectant: 28% of glycerin, 39% of propylene glycol, 3% of polyethylene glycol, 0.5% of EDTA disodium, 0.5% of N-hydroxyethyl ethylenediamine triacetic acid, 0.5% of sodium hydroxide, 0.2% of menthol, and a surfactant: polyoxyethylene ether hydrogenated castor oil 2%; 2% of water and 0.3% of N-hydroxyethyl ethylene diamine triacetic acid; the proportion of the structural components is in weight percent.
The third layer is a high molecular polymer in the auxiliary drug delivery layer, poly 2-ethyl-2-oxazoline is used, the weight percentage ratio is 0.5 percent, and the other components are the same as the components of the second layer, and the thickness is 0.01 mm.
The formula can be kept stable for 30 days at the temperature of 60 ℃.
Example 6:
as shown in fig. 1, a high-stability adhesive film for whitening teeth comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer 1, the second layer is a high-stability whitening gel layer 2, the third layer is an auxiliary administration layer 3, and the fourth layer is a film stripping backing layer 4, and the four layers are sequentially stacked and connected.
The thickness of the first whitening gel carrier film layer is 0.05 mm, and the raw material is PVA.
The structural components of the second gel whitening layer 2 comprise 20 percent of urea peroxide as an active component, a gelling agent: 1% of carbomer resin, 1% of polyvinylpyrrolidone, and 1% of humectant: 34% of glycerol, 27% of propylene glycol, 3% of polyethylene glycol, 5% of xylitol, 0.5% of EDTA disodium, 0.5% of N-hydroxyethyl ethylenediamine triacetic acid, 0.5% of sodium hydroxide, 0.2% of menthol, and a surfactant: 5% of polyoxyethylene ether hydrogenated castor oil; 5% of water and 0.3% of N-hydroxyethyl ethylene diamine triacetic acid; the proportion of the structural components is in weight percent.
The third layer is a high molecular polymer in the auxiliary drug delivery layer, poly 2-ethyl-2-oxazoline is used, the weight percentage is 10 percent, and the rest components are the same as the components of the second layer, and the thickness is 0.02 mm.
The formula can be kept stable for 20 days at the temperature of 60 ℃.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (7)
1. A high-stability tooth whitening adhesive film is characterized in that: the whitening gel carrier film comprises a four-layer structure, wherein the first layer is a whitening gel carrier film layer, the second layer is a high-stability whitening gel layer, the third layer is an auxiliary administration layer, and the fourth layer is a film stripping back lining layer and is formed by sequentially stacking and connecting the four layers;
the whitening gel carrier film layer is used for carrying the whitening gel layer on the second layer, the thickness of the whitening gel carrier film layer is less than 0.1 mm, and the whitening gel carrier film layer, the second layer and the third layer are attached to teeth together when the whitening gel carrier film layer is used;
the high-stability whitening gel layer is coated on one surface of the whitening gel carrier film layer, is a high-stability gel whitening layer consisting of peroxide capable of whitening teeth and high molecular substances capable of forming a gel film, and is directly attached to the teeth when in use;
the auxiliary drug delivery layer is coated on the high-stability whitening gel layer and is made of a patch material with viscosity remarkably increased after being heated or watered, so that the whitening agent can be adhered on the patch material, and the viscosity of the patch material is gradually reduced along with the reduction of the whitening concentration of the whitening agent;
the film release backing layer is adhered to the auxiliary drug delivery layer and can be easily peeled off from the second layer during use, and the third layer is discarded after peeling.
2. The high stability tooth whitening patch according to claim 1, wherein: the whitening gel carrier film layer is made of transparent material film, foil or paper.
3. The high stability tooth whitening patch according to claim 1, wherein: the high-stability gel whitening layer is a hydrated gel whitening layer and mainly comprises a whitening agent, a gelling agent, a humectant, a stabilizer, a bacteriostatic agent, a pH regulator, a surfactant, an anti-allergic agent and essence;
wherein the whitening agent is prepared by mixing one or more of urea peroxide, hydrogen peroxide, sodium hypochlorite, sodium perchlorate, alkaline perborate and percarbonate; the gel is prepared from one or more of carbomer resin, carboxymethylcellulose sodium, hydroxyethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol resin, xanthan gum, natural gum, and acrylate copolymer; the humectant is prepared by mixing one or more of glycerol, ethanol, propylene glycol, polyethylene glycol, sorbitol, xylitol and water; the stabilizer is composed of N-hydroxyethyl ethylenediamine triacetic acid, ethylene diamine tetraacetic acid disodium, polyethylene polyamine polyalkylene phosphonate (DTPMP-NaPA), sodium citrate, and metal chelate ions; the pH regulator is one or more of phosphoric acid, citric acid, triethanolamine and sodium hydroxide solution; the surfactant is one or two of polyoxyethylene ether hydrogenated castor oil and Tween-20; the bacteriostatic agent comprises one or more of phthalic acid and its salt, bischlorobenzene dimyohexane, alexidine, sanguinarine, benzalkonium chloride, domiphen bromide, and terephthalein chloride.
4. The high stability tooth whitening patch according to claim 3, wherein: in the high-stability gel whitening layer, according to the weight percentage, the whitening agent content is 3% -40%, the gel content is 0.5% -10%, the humectant content is 10% -70%, the stabilizing agent content is 1% -3%, the bacteriostatic agent content is 0.1% -0.5%, the pH regulator content is 0.2% -3%, and the surfactant content is 1% -10%.
5. The high stability tooth whitening patch according to claim 3 or 4, wherein: in the high-stability gel whitening layer, when the whitening agent formula contains peroxide, in order to ensure the stability of the peroxide, the water content in the high-stability gel whitening layer is lower than 5 percent.
6. The patch for whitening teeth according to any one of claims 3 to 5, wherein: in the high-stability gel whitening layer, in order to ensure the stability of peroxide under the condition that the formula of the whitening agent contains the peroxide, 0.5 to 3 percent of polyvinylpyrrolidone (PVP) is added into the high-stability gel whitening layer to form a conjugated peroxide bond so as to improve the stability of the peroxide.
7. The high stability tooth whitening patch according to claim 1 or 3, wherein: the auxiliary administration layer is a mixture of high molecular polymer and whitening gel, the viscosity of the auxiliary administration layer is obviously increased after the auxiliary administration layer is heated or water is added, wherein the high molecular polymer is one or more of poly 2-ethyl-2-oxazoline, polyvinyl butyral, polyvinyl alcohol and the like, the whitening gel is hydrated gel of a high-stability gel whitening layer, and the proportion of the high molecular polymer is 0.5-10% by weight percent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911052114.XA CN110960429A (en) | 2019-10-31 | 2019-10-31 | High-stability tooth whitening adhesive film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911052114.XA CN110960429A (en) | 2019-10-31 | 2019-10-31 | High-stability tooth whitening adhesive film |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110960429A true CN110960429A (en) | 2020-04-07 |
Family
ID=70030214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911052114.XA Pending CN110960429A (en) | 2019-10-31 | 2019-10-31 | High-stability tooth whitening adhesive film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110960429A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107509A (en) * | 2020-09-25 | 2020-12-22 | 山东华熙海御生物医药有限公司 | Tooth whitening paste containing hyaluronic acid and preparation method thereof |
| CN112957280A (en) * | 2021-02-04 | 2021-06-15 | 南昌思麦科技有限公司 | Dry tooth whitening adhesive film |
| CN113621097A (en) * | 2021-07-30 | 2021-11-09 | 深圳爱尔创口腔技术有限公司 | Antibacterial alkalescent whitening tooth paste |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735419A (en) * | 2014-01-18 | 2014-04-23 | 阮仕星 | Hydrated gel tooth-whitening sticker |
| US20180289606A1 (en) * | 2017-04-09 | 2018-10-11 | Bo Tao | Multi-film delivery system for multi-component teeth whitening, desensitization and remineralization compositions |
| CN208448175U (en) * | 2018-01-30 | 2019-02-01 | 黄睿祥 | The white pad pasting of tooth |
-
2019
- 2019-10-31 CN CN201911052114.XA patent/CN110960429A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735419A (en) * | 2014-01-18 | 2014-04-23 | 阮仕星 | Hydrated gel tooth-whitening sticker |
| US20180289606A1 (en) * | 2017-04-09 | 2018-10-11 | Bo Tao | Multi-film delivery system for multi-component teeth whitening, desensitization and remineralization compositions |
| CN208448175U (en) * | 2018-01-30 | 2019-02-01 | 黄睿祥 | The white pad pasting of tooth |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107509A (en) * | 2020-09-25 | 2020-12-22 | 山东华熙海御生物医药有限公司 | Tooth whitening paste containing hyaluronic acid and preparation method thereof |
| CN112107509B (en) * | 2020-09-25 | 2022-11-15 | 山东华熙海御生物医药有限公司 | Tooth whitening paste containing hyaluronic acid and preparation method thereof |
| CN112957280A (en) * | 2021-02-04 | 2021-06-15 | 南昌思麦科技有限公司 | Dry tooth whitening adhesive film |
| CN113621097A (en) * | 2021-07-30 | 2021-11-09 | 深圳爱尔创口腔技术有限公司 | Antibacterial alkalescent whitening tooth paste |
| CN113621097B (en) * | 2021-07-30 | 2023-02-24 | 深圳爱尔创口腔技术有限公司 | Antibacterial alkalescent whitening tooth paste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110960429A (en) | High-stability tooth whitening adhesive film | |
| EP1267812B1 (en) | Patches for teeth whitening | |
| US4594240A (en) | Sheet-shape adhesive preparation | |
| JP5053091B2 (en) | Method for preparing polymeric adhesive composition using mechanism of interaction between polymers | |
| TWI484977B (en) | Oral care strip or tape and methods of use and manufacture thereof | |
| US20050196350A1 (en) | Stabilized peroxide compositions | |
| JPWO2003030851A1 (en) | Teeth whitening method, tooth whitening composition and tooth whitening set | |
| JP3997371B2 (en) | Teeth whitening set | |
| AU2004264812A1 (en) | Compositons and devices having a tray-like configuration | |
| CN101019812A (en) | Elastic gel tooth film for deep whitening | |
| TWI532504B (en) | Paraben-free preservative systems for oral care compositions | |
| CN112107509B (en) | Tooth whitening paste containing hyaluronic acid and preparation method thereof | |
| CN102579270B (en) | Water-free super-sticky type adhering film for whitening teeth | |
| CN102961261A (en) | Whitening strips | |
| WO2001054610A1 (en) | Compositions and methods for whitening and desensitizing teeth | |
| CN112957280A (en) | Dry tooth whitening adhesive film | |
| CN103735419B (en) | Hydrated gel whitening teeth pad pasting | |
| CN102626379B (en) | Anhydrous ultra-sticky type double-component tooth-whitening sticking film | |
| CN103599025A (en) | Phytochemical whitening tooth paste | |
| CN103585027A (en) | Dissolvable whitening tooth paster | |
| KR100796385B1 (en) | Thin-Film type Tooth Whitener | |
| JPS5993012A (en) | Base for pack | |
| CN113041168A (en) | Active whitening tooth paste and preparation method thereof | |
| KR102089536B1 (en) | Mouth band | |
| CN102631292A (en) | Elastic anhydrous high-thickness gel sticking film for whitening teeth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200407 |