CN110960347A - Preparation method of hot compress patch - Google Patents
Preparation method of hot compress patch Download PDFInfo
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- CN110960347A CN110960347A CN201911238393.9A CN201911238393A CN110960347A CN 110960347 A CN110960347 A CN 110960347A CN 201911238393 A CN201911238393 A CN 201911238393A CN 110960347 A CN110960347 A CN 110960347A
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- temperature
- isobutylene
- maleic anhydride
- anhydride copolymer
- film bag
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
- A61F7/034—Flameless
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
- C09K5/16—Materials undergoing chemical reactions when used
- C09K5/18—Non-reversible chemical reactions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0098—Heating or cooling appliances for medical or therapeutic treatment of the human body ways of manufacturing heating or cooling devices for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
- A61F7/034—Flameless
- A61F2007/036—Fuels
- A61F2007/038—Carbon or charcoal, e.g. active
Abstract
The invention discloses a preparation method of hot compress paste, which comprises the following steps: 1) and preparing the temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; 2) preparing a heating element: uniformly mixing iron powder, activated carbon, sodium chloride, water and temperature-sensitive hydrogel to obtain a heating element; 3) filling the heating element into a porous film bag filled with the porous film bag, sealing, soaking the film bag in an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, cleaning in clear water, and vacuum drying; 4) fixing the non-woven fabric bag with the adhesive layer in the porous film bag with the temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the non-woven fabric bag into an isolation bag for vacuum pumping and sealing.
Description
Technical Field
The invention belongs to the field of hot compress application, and particularly relates to a preparation method of hot compress application.
Background
The hot compress paste is introduced to China from Japan in the last 90 th century, the working principle of the hot compress paste is that chemical energy is converted into heat energy to continuously release heat, the hot compress paste generally comprises a raw material layer, a gelatin layer and a non-woven fabric bag, the raw material layer is arranged in the non-woven fabric bag, the non-woven fabric bag is arranged in an airtight outer bag, the outer bag is removed when the hot compress paste is used, oxygen in air enters the bag through the air-permeable membrane, the heat release time and temperature are controlled by the oxygen permeation rate of the air-permeable membrane, if the oxygen permeation is too fast, the heat accumulation can scald the skin, and if the oxygen permeation is too slow. Therefore, a heat application which stably emits heat for a long period of time is required.
Disclosure of Invention
The invention aims to provide a preparation method of a hot-compress patch, which is more stable in heat release speed and longer in heat release time.
A preparation method of hot compress patch comprises the following steps:
1) and preparing the temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel;
2) preparing a heating element: uniformly mixing iron powder, activated carbon, sodium chloride, water and temperature-sensitive hydrogel to obtain a heating element;
3) filling the heating element into a porous film bag filled with the porous film bag, wherein the porous film bag is cylindrical, performing hot-press sealing on the porous film bag filled with the heating element to isolate the porous film bag, soaking the film bag in an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, cleaning the solution in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface;
4) fixing the non-woven fabric bag with the adhesive layer in the porous film bag with the temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the non-woven fabric bag into an isolation bag for vacuum pumping and sealing.
A preparation method of hot compress patch comprises the following steps:
1) and preparing the temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel;
2) preparing a heating element: uniformly mixing 30-80 parts by weight of iron powder, 3-25 parts by weight of activated carbon, 0.5-10 parts by weight of sodium chloride, 1-20 parts by weight of water and 10-30 parts by weight of temperature-sensitive hydrogel to obtain a heating element;
3) filling the heating element into a porous film bag which is filled with the porous film bag, wherein the porous film bag is cylindrical, and the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1 (10-20), performing hot-pressing sealing on the porous film bag filled with the heating element, isolating the porous film bag, soaking the film bag in an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface;
in the step 3), the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 2-4% of that of water, and the mass of the added aluminum sulfate octadecahydrate is 4-6% of that of the water in the isobutylene-maleic anhydride copolymer solution; specifically, 2-4 parts by weight of isobutylene-maleic anhydride copolymer and 100 parts by weight of water are mixed to obtain isobutylene-maleic anhydride copolymer solution, and 4-6 parts by weight of aluminum sulfate octadecahydrate are added to react with the isobutylene-maleic anhydride copolymer solution;
4) fixing the non-woven fabric bag with the adhesive layer in the porous film bag with the temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the non-woven fabric bag into an isolation bag for vacuum pumping and sealing.
Wherein, the reaction time is controlled in the step 3), the temperature-sensitive hydrogel reacts with the film so as to be grafted to the surface of the film, the film is in a liquid state at the temperature of 10-40 ℃, the pore channel is opened, and when the temperature is raised to 50-60 ℃, crosslinking is carried out so as to seal the pore channel.
Wherein, in the step 4), the fixed film bag is placed in a woven fabric bag which is slightly larger than the fixed film bag in size, the opening is sealed so that the film bag is in an extension state in the non-woven fabric bag, the heating elements in the film bag can not be agglomerated, and then the non-woven fabric bag is put into an isolation bag for vacuum sealing.
Wherein the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution for preparing the temperature-sensitive hydrogel in the step 1) is 2-4% of that of water; the mass of the added aluminum sulfate octadecahydrate is 4-6% of that of the isobutylene-maleic anhydride copolymer solution; specifically, 2-4 parts by weight of isobutylene-maleic anhydride copolymer and 100 parts by weight of water are mixed to obtain isobutylene-maleic anhydride copolymer solution, and 4-6 parts by weight of aluminum sulfate octadecahydrate are added to react with the isobutylene-maleic anhydride copolymer solution to obtain the temperature-sensitive hydrogel.
Wherein the number average molecular weight of the isobutylene-maleic anhydride copolymer is 5500 to 30000, and more preferably, the number average molecular weight of the isobutylene-maleic anhydride copolymer is 16000.
The temperature sensitive hydrogel attached to the porous film bag is in liquid state at 10-40 deg.C, and can be reversibly changed into gel when the temperature is raised to 50-60 deg.C and is reduced to 35-40 deg.C.
Wherein, the film bag material can be acetate fiber, polypropylene film, polyethylene film.
Compared with the background technology, the hot-compress patch provided by the invention has the advantages that the surface of the temperature-sensitive hydrogel coated film bag prepared by the method is coated with the crosslinked hydrogel, when the temperature is reduced to 35-40 ℃, the hydrogel is changed into the liquid state, the hydrogel on the film bag is changed into the liquid state, the porosity is increased, and air enters the hot-compress patch, so that the temperature is rapidly increased.
In the invention, the temperature-sensitive hydrogel is added into the heating element and reacts and grafted with the temperature-sensitive hydrogel under the wrapping of the porous film bag, so that the temperature release can be better controlled. When the temperature is raised to 50-60 ℃, the temperature-sensitive hydrogel on the film bag is converted into a gel state, so that the porosity of the surface is reduced, the air is reduced, the temperature is lowered, the temperature is kept constant, and the iron powder in the hot compress patch can be completely reacted.
The heating body is arranged in the film bag and coated with the temperature-sensitive hydrogel, and when the hot compress patch is used, the heating body is arranged in the porous film and coated with the temperature-sensitive hydrogel, so that the heating body cannot be contacted with the skin of a human body to block a channel, the hot compress patch can completely release heat when in use, and the problem of incomplete heat release of the existing hot compress patch is solved.
Detailed Description
The core of the invention is to provide a preparation method of the hot compress patch. The present invention will be described in further detail with reference to specific embodiments in order to make the technical field better understand the scheme of the present invention.
Description of the raw materials
Porous acetate fiber film bag: shanghai Yiji industries Ltd, the film bag has a specification of 2cm by 12cm and a porosity of 20%.
Isobutylene-maleic anhydride copolymer: japanese Coli, ISOBAM-600(5500 molecular weight), ISOBAM-10(16000 molecular weight), ISOBAM-18(30000 molecular weight), ISOBAM-4(55500 molecular weight), ISOBAM-400(3000 molecular weight)
Example 1
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 2% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 4 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 5500; the temperature sensitive hydrogel is in liquid state at 10-40 deg.C, and can be reversibly converted into gel when the temperature is raised to 50 deg.C and is reduced to 35 deg.C;
2) preparing a heating element: uniformly mixing 30 parts by weight of iron powder, 3 parts by weight of activated carbon, 0.5 part by weight of sodium chloride, 1 part by weight of water and 10 parts by weight of temperature-sensitive hydrogel to obtain a heating element;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 20%, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:10, performing hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 2 percent of the mass of water, the mass of the aluminum sulfate octadecahydrate is 4 percent of the mass of the water in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 5500, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained;
4) fixing a 15 cm-15 cm non-woven fabric bag with an adhesive layer and a porous film bag with temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the extended non-woven fabric bag into an isolation bag for vacuum sealing.
The surface cross-linked hydrogel coated with the temperature-sensitive hydrogel film bag prepared by the method is changed into liquid when the temperature is reduced to 35-40 ℃, the hydrogel on the film bag is changed into liquid, so that the porosity is increased, and air enters the hot-compress patch, thereby rapidly heating. When the temperature is raised to 50-60 ℃, the temperature-sensitive hydrogel on the film bag is converted into a gel state, so that the porosity of the surface is reduced, the air is reduced, the temperature is lowered, the temperature is kept constant, and the iron powder in the hot compress patch can be completely reacted.
Example 2
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 4% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 6 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 30000; the temperature sensitive hydrogel is in liquid state at 10-40 ℃, and is reversibly converted into liquid state when the temperature is increased to 60 ℃ and is reduced to 40 ℃;
2) preparing a heating element: uniformly mixing 80 parts by weight of iron powder, 25 parts by weight of activated carbon, 10 parts by weight of sodium chloride, 20 parts by weight of water and 30 parts by weight of temperature-sensitive hydrogel to obtain a heating body;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 20%, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:20, performing hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 4% of that of water, the mass of the aluminum sulfate octadecahydrate is 6% of that in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 30000, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained; 4) placing the porous film bags with the temperature-sensitive hydrogel adhered on the surfaces side by side on parallel adhesive tapes for fixing, placing the fixed film bags in 15 cm-15 cm non-woven fabric bags to be in an extended state, and vacuumizing and sealing by using an isolation bag to obtain the hot compress patch.
Example 3
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 3% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 16000; the temperature sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃ and is changed into gel, and when the temperature is reduced to 37 ℃, the gel is reversibly changed into a liquid state;
2) preparing a heating element: uniformly mixing 50 parts by weight of iron powder, 15 parts by weight of activated carbon, 5 parts by weight of sodium chloride, 10 parts by weight of water and 20 parts by weight of temperature-sensitive hydrogel to obtain a heating body;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 20%, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:15, performing hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 3 percent of that of water, the mass of the aluminum sulfate octadecahydrate is 5 percent of that in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 16000, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained; 4) placing the porous film bags with the temperature-sensitive hydrogel adhered on the surfaces side by side on parallel adhesive tapes for fixing, placing the fixed film bags in 15 cm-15 cm non-woven fabric bags to be in an extended state, and vacuumizing and sealing by using an isolation bag to obtain the hot compress patch.
Example 4
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 3% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 55000; the temperature sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃ and is changed into gel, and when the temperature is reduced to 37 ℃, the gel is reversibly changed into a liquid state;
2) preparing a heating element: uniformly mixing 50 parts by weight of iron powder, 15 parts by weight of activated carbon, 5 parts by weight of sodium chloride, 10 parts by weight of water and 20 parts by weight of temperature-sensitive hydrogel to obtain a heating body;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 20%, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:15, performing hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 3 percent of that of water, the mass of the aluminum sulfate octadecahydrate is 5 percent of that in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 55000, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained;
4) placing the porous film bags with the temperature-sensitive hydrogel adhered on the surfaces side by side on parallel adhesive tapes for fixing, placing the fixed film bags in 15 cm-15 cm non-woven fabric bags to be in an extended state, and vacuumizing and sealing by using an isolation bag to obtain the hot compress patch.
Example 5
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 3% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 3000; the temperature sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃ and is changed into gel, and when the temperature is reduced to 37 ℃, the gel is reversibly changed into a liquid state;
2) preparing a heating element: uniformly mixing 50 parts by weight of iron powder, 15 parts by weight of activated carbon, 5 parts by weight of sodium chloride, 10 parts by weight of water and 20 parts by weight of temperature-sensitive hydrogel to obtain a heating body;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 20%, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:15, performing hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 3 percent of that of water, the mass of the aluminum sulfate octadecahydrate is 5 percent of that in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 3000, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained;
4) placing the porous film bags with the temperature-sensitive hydrogel adhered on the surfaces side by side on parallel adhesive tapes for fixing, placing the fixed film bags in 15 cm-15 cm non-woven fabric bags to be in an extended state, and vacuumizing and sealing by using an isolation bag to obtain the hot compress patch.
Example 6
The hot compress patch is prepared by the following method:
1) preparation of temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel; wherein the mass of the isobutylene-maleic anhydride copolymer is 3% of the mass of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of the water, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 16000; the temperature sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃ and is changed into gel, and when the temperature is reduced to 37 ℃, the gel is reversibly changed into a liquid state;
2) preparing a heating element: uniformly mixing 50 parts by weight of iron powder, 15 parts by weight of activated carbon, 5 parts by weight of sodium chloride, 10 parts by weight of water and 20 parts by weight of temperature-sensitive hydrogel to obtain a heating body;
3) putting a heating element into a porous film bag, wherein the porosity of a film used by the porous film bag is 30 percent, the porous film bag is cylindrical, the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1:15, carrying out hot-pressing sealing isolation on the porous film bag filled with the heating element, soaking the film bag into an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and carrying out vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface; in the step, the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 3 percent of that of water, the mass of the aluminum sulfate octadecahydrate is 5 percent of that in the isobutylene-maleic anhydride copolymer solution, and the number average molecular weight of the isobutylene-maleic anhydride copolymer is 16000, so that the porous film bag with the temperature-sensitive hydrogel attached to the surface is obtained;
4) placing the porous film bags with the temperature-sensitive hydrogel adhered on the surfaces side by side on parallel adhesive tapes for fixing, placing the fixed film bags in 15 cm-15 cm non-woven fabric bags to be in an extended state, and vacuumizing and sealing by using an isolation bag to obtain the hot compress patch.
Comparative example 1
The hot compress patch is prepared by the following method:
the heating element comprises the following components in parts by mass: 50 parts of iron powder, 15 parts of activated carbon, 5 parts of sodium chloride, 10 parts of water and 20 parts of temperature-sensitive hydrogel.
The preparation method of the temperature-sensitive hydrogel comprises the following steps: mixing isobutylene and maleic anhydride copolymer with water to obtain isobutylene and maleic anhydride copolymer solution; mixing aluminum sulfate octadecahydrate with isobutylene and maleic anhydride copolymer solution to obtain temperature sensitive hydrogel; the mass of the isobutylene-maleic anhydride copolymer is 3% of that of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of water, the number average molecular weight of the copolymer of the isobutene and the maleic anhydride is 16000, the temperature-sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃, the hydrogel becomes gel, and when the temperature is reduced to 37 ℃, the hydrogel reversibly changes into the liquid state.
The preparation method of the hot compress patch comprises the following steps: filling the heating element in a non-woven fabric bag of 15cm by 15cm, sealing the non-woven fabric bag by hot pressing, placing the non-woven fabric bag in an isolation bag, and sealing in vacuum.
Comparative example 2
The hot compress patch is prepared by the following method:
preparing a heating element: 50 parts of iron powder, 15 parts of activated carbon, 5 parts of sodium chloride and 10 parts of water are uniformly mixed to obtain the heating element.
The preparation method of the hot compress patch comprises the following steps: filling the heating element in a non-woven fabric bag of 15cm by 15cm, sealing the non-woven fabric bag by hot pressing, placing the non-woven fabric bag in an isolation bag, and sealing in vacuum.
Comparative example 3
The heat application includes: the heat application includes: the heating element is arranged in the film bag.
Preparing a heating element: uniformly mixing 50 parts by weight of iron powder, 15 parts by weight of activated carbon, 5 parts by weight of sodium chloride, 10 parts by weight of water and 20 parts by weight of temperature-sensitive hydrogel to obtain a heating element;
the preparation method of the temperature-sensitive hydrogel comprises the following steps: mixing isobutylene and maleic anhydride copolymer with water to obtain isobutylene and maleic anhydride copolymer solution; mixing aluminum sulfate octadecahydrate with isobutylene and maleic anhydride copolymer solution to obtain temperature sensitive hydrogel; the mass of the isobutylene-maleic anhydride copolymer is 3% of that of water; the mass of the aluminum sulfate octadecahydrate is 5 percent of that of water, the number average molecular weight of the copolymer of the isobutene and the maleic anhydride is 16000, the temperature-sensitive hydrogel is in a liquid state at 10-40 ℃, and when the temperature is increased to 55 ℃, the hydrogel becomes gel, and when the temperature is reduced to 37 ℃, the hydrogel reversibly changes into the liquid state.
Selecting an empty film bag with the porosity of 20%, wherein the film bag is in a strip shape, the film bag is in a cylindrical shape, the ratio of the diameter of the cylinder to the length of the cylinder is 1:15, putting a heating body into the film bag for hot-press sealing and isolation, putting the film bags side by side on parallel adhesive tapes for fixing, putting the fixed film bags into 15 cm-15 cm non-woven fabric bags to enable the fixed film bags to be in an extended state, and vacuumizing and sealing by using the isolation bags.
The heat patches prepared in examples 1 to 6 and comparative examples 1 to 3 were subjected to a test of heat releasing ability, and the heat patches were taken out from the sealed bags and subjected to a surface test for temperature at 0.5h, 2h,6h,10h and 16h, respectively. The test method comprises the following steps: the temperature of the heat applied surface was measured with a beckmann thermometer. The test results are listed in table 1.
TABLE 1 Heat Release Capacity test for Heat application
As can be seen from Table 1, the added temperature-sensitive hydrogel can adjust the heat release speed of the hot compress patch, so that the hot compress patch can keep a stable heat release speed, the structure arrangement of the film bag coated with the temperature-sensitive hydrogel can ensure that the hot compress patch can completely react, and the heat release time of the hot compress patch is prolonged and the reaction is complete through the combined action of the temperature-sensitive hydrogel in the heating body and the porous film bag coated with the temperature-sensitive hydrogel. By adding temperature-sensitive hydrogel into a hot-patch, placing a heating body into an empty film bag, and then crosslinking the temperature-sensitive hydrogel on the surface of the film bag, the heat release of examples 1-3 is stable, the heat release time can reach more than 20 hours, the molecular weight of the copolymer of isobutylene and maleic anhydride in example 4 is 55000, the molecular weight of the copolymer of isobutylene and maleic anhydride in example 5 is 3000, and the prepared hot-patch can not stably release heat, so the molecular weight of the copolymer of isobutylene and maleic anhydride can influence whether the temperature-sensitive hydrogel can form colloid, the porosity of the porous film in example 6 is 30%, the heat release temperature of the hot-patch is higher than that of example 3, compared with example 1 and example 3, the heating body is not placed in the porous film bag, because iron powder in the hot-patch does not completely react, the heat release time is 14 hours, compared with example 3, the conventional hot-patch setting is adopted in comparative example 2, the heat release is too fast, the heat release is stable and unstable, the heat release duration is short, the heat release time is only 8 hours, compared with the example 3, the temperature-sensitive hydrogel is not crosslinked on the film bag, holes on the film cannot be selectively closed or opened due to the change of temperature, the heat release temperature is higher than that of the example 3, and the heat release time is 16 hours.
The heat-not-released examples 1 to 3, comparative examples 1 to 3, the heat-applied sheets with the separator opened, poured out and laid in a petri dish, and left at room temperature to test whether the heat-applied sheets would continue to generate heat, examples 1 to 3, comparative example 3, the heat-applied sheets with the separator laid, did not release heat, and comparative examples 1 to 2, which remained exothermic after left at room temperature.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. A preparation method of hot compress patch is characterized by comprising the following steps:
1) and preparing the temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel;
2) preparing a heating element: uniformly mixing iron powder, activated carbon, sodium chloride, water and temperature-sensitive hydrogel to obtain a heating element;
3) filling the heating element into a porous film bag filled with the porous film bag, wherein the porous film bag is cylindrical, performing hot-press sealing on the porous film bag filled with the heating element to isolate the porous film bag, soaking the film bag in an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, cleaning the solution in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface;
4) fixing the non-woven fabric bag with the adhesive layer in the porous film bag with the temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the non-woven fabric bag into an isolation bag for vacuum pumping and sealing.
2. A preparation method of hot compress patch is characterized by comprising the following steps:
1) and preparing the temperature-sensitive hydrogel: mixing the isobutylene-maleic anhydride copolymer with water to obtain an isobutylene-maleic anhydride copolymer solution; adding aluminum sulfate octadecahydrate into the isobutylene-maleic anhydride copolymer solution for mixing to obtain temperature-sensitive hydrogel;
2) preparing a heating element: uniformly mixing 30-80 parts by weight of iron powder, 3-25 parts by weight of activated carbon, 0.5-10 parts by weight of sodium chloride, 1-20 parts by weight of water and 10-30 parts by weight of temperature-sensitive hydrogel to obtain a heating element;
3) filling the heating element into a porous film bag which is filled with the porous film bag, wherein the porous film bag is cylindrical, and the ratio of the diameter of the cylindrical diameter to the length of the cylindrical diameter is 1 (10-20), performing hot-pressing sealing on the porous film bag filled with the heating element, isolating the porous film bag, soaking the film bag in an isobutylene-maleic anhydride copolymer solution, adding aluminum sulfate octadecahydrate into the solution, reacting for 30min-1h at the temperature of 10-35 ℃, cleaning in clear water, and performing vacuum drying to obtain the porous film bag with the temperature-sensitive hydrogel attached to the surface;
in the step 3), the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution is 2-4% of that of water, and the mass of the added aluminum sulfate octadecahydrate is 4-6% of that of the water in the isobutylene-maleic anhydride copolymer solution;
4) fixing the non-woven fabric bag with the adhesive layer in the porous film bag with the temperature-sensitive hydrogel attached to the surface to form an extended state, and then placing the non-woven fabric bag into an isolation bag for vacuum pumping and sealing.
3. A method of producing a hot compress patch according to claim 2, characterized in that:
the mass of the isobutylene-maleic anhydride copolymer in the isobutylene-maleic anhydride copolymer solution for preparing the temperature-sensitive hydrogel in the step 1) is 2-4% of that of water; the mass of the added aluminum sulfate octadecahydrate is 4-6% of the mass of water in the isobutylene-maleic anhydride copolymer solution.
4. A method of producing a hot compress patch according to claim 2, characterized in that:
the number average molecular weight of the isobutylene-maleic anhydride copolymer is 5500-30000.
5. A method of producing a hot compress patch according to claim 2, characterized in that:
the temperature sensitive hydrogel attached to the porous film bag is in liquid state at 10-40 deg.C, and can be reversibly changed into gel when the temperature is raised to 50-60 deg.C and is reduced to 35-40 deg.C.
6. A method of producing a hot compress patch according to claim 2, characterized in that:
the film bag material can be cellulose acetate, polypropylene film, polyethylene film.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268166A (en) * | 2005-09-23 | 2008-09-17 | 宝洁公司 | A method of making heat cells comprising exothermic compositions having absorbent gelling material |
| CN101437476A (en) * | 2005-09-23 | 2009-05-20 | 惠氏公司 | Heat cells comprising exothermic compositions having absorbent gelling material |
| CN109354700A (en) * | 2018-10-22 | 2019-02-19 | 中国科学院上海硅酸盐研究所 | A kind of temperature-sensitive hydrogel and preparation method thereof |
| CN109432511A (en) * | 2018-12-29 | 2019-03-08 | 常州乐奥医疗科技股份有限公司 | A kind of temperature-sensitive hydrogel and its preparation method and application |
| CN109512802A (en) * | 2018-12-13 | 2019-03-26 | 广州润虹医药科技股份有限公司 | It is a kind of defervescence plaster used and preparation method thereof |
| CN109692069A (en) * | 2018-12-25 | 2019-04-30 | 徐红花 | A kind of intelligent warming patch with overheating protection function |
-
2019
- 2019-12-06 CN CN201911238393.9A patent/CN110960347A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268166A (en) * | 2005-09-23 | 2008-09-17 | 宝洁公司 | A method of making heat cells comprising exothermic compositions having absorbent gelling material |
| CN101437476A (en) * | 2005-09-23 | 2009-05-20 | 惠氏公司 | Heat cells comprising exothermic compositions having absorbent gelling material |
| CN109354700A (en) * | 2018-10-22 | 2019-02-19 | 中国科学院上海硅酸盐研究所 | A kind of temperature-sensitive hydrogel and preparation method thereof |
| CN109512802A (en) * | 2018-12-13 | 2019-03-26 | 广州润虹医药科技股份有限公司 | It is a kind of defervescence plaster used and preparation method thereof |
| CN109692069A (en) * | 2018-12-25 | 2019-04-30 | 徐红花 | A kind of intelligent warming patch with overheating protection function |
| CN109432511A (en) * | 2018-12-29 | 2019-03-08 | 常州乐奥医疗科技股份有限公司 | A kind of temperature-sensitive hydrogel and its preparation method and application |
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