CN110944616A - 具有从血液中分离prp后再注入剩余元素的能力的prp生产工具包 - Google Patents

具有从血液中分离prp后再注入剩余元素的能力的prp生产工具包 Download PDF

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CN110944616A
CN110944616A CN201780093280.7A CN201780093280A CN110944616A CN 110944616 A CN110944616 A CN 110944616A CN 201780093280 A CN201780093280 A CN 201780093280A CN 110944616 A CN110944616 A CN 110944616A
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bag
blood
prp
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艾哈迈德·甘巴里
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Ai HamaideGanbali
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/105—Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
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  • Cardiology (AREA)
  • Pathology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

在本发明中，通过使用两个连接的聚合物袋和与抽血的连接，第一袋中的第一分离和血液成分的传输，例如RPP进入第二袋并将剩余的血液重新注射到所考虑的人是可能的。

Description

具有从血液中分离PRP后再注入剩余元素的能力的PRP生产工 具包
技术领域
本发明涉及一种从生物体内提取血液、提取血小板元素注射给抽血对象的工具和方法。
发明的背景
过去关于血小板聚集对生物体组织尤其是人类组织的影响的研究表明，血小板水平的升高会刺激活细胞自我重建并形成符合原始结构的组织。鉴于这一重要性，研究人员和医生一直试图解释从人体中提取血液并分离其成分的方法。从血液中分离血小板成分的常用方法之一是使用注射器进入患者血管，产生负压并随后抽取血液，抽取血液后，用离心法将材料倒入试管中，由于颗粒质量和血液成分的不同，形成了不同的几层，并有可能成为血液的多个阶段。现在，通过分离过程，可以提取PRP及其诱导物。在另一种方法中，使用标准血袋分离元素并提取血液成分。其次是国际领域的代表性发明。
发明的详细说明
如图1所示，使用针头(100)时，由于静脉内的高压，血液流过针道，血液流过针道，经过针头与PRP工具包管的连接后到达内锁(102)，在抽血时间中必须提及，通过打破上述锁，有可能使得血液进入血袋血液，由于外锁(103)的打开，血液可以通过与袋血液(105)相连的管进入上述血液，并通过所需的时间，积聚在所述袋中的血液体积积累。通过完成抽血量，可以锁定外锁(103)，并且通过切割PRP成套工具包的针头部分(100)和内锁(102)可以混合并放在一起，使得第一血袋(105)的输出面对离心机的旋转中心。通过结束离心过程，血液被分成三部分。下面有红细胞和较重的元素(elements)，在这部分形成了较大的血容量。在中间，离心机结束后，有相对较小的体积和较薄的一层血液，包括PRP部分及其下面，有非常薄的一层白细胞，在上面，有血浆和液体，如水。
现在，通过打破第二内锁(109)并挤压梭形血袋，分离的相进入第一袋的出口管(108)，并且在通过三通(109)和内锁(110)之后，由于外锁(112)的打开，在通过第二袋(113)的连接管后进入第二袋。根据第一袋的梭形，每相的高度在通过袋出口时加倍，层宽也变得很低。这使得操作员具有最大的精度和能力来发送自我要求的相。在传送血浆相，以及将分离的血小板相从第一袋转移到第二袋，通过锁定位于两袋之间的外锁(112)，消除了返回分离相和混合相的可能性。
现在，通过将本发明中的PRP工具包与第二袋再离心混合，以与第一袋相同的方式，可以分离血浆和血小板。由于现有的工具包空间总量可用于标准抗凝剂，因此不存在凝血或分离细胞的风险。现在，通过打开两个袋子之间的外锁并挤压第二个袋子，可以将血浆相(PPP)返回到第一个袋子，并且在锁定第一个袋子中两个袋子之间的外锁之后，我们就有了共同(common)的血液元素。如果需要，它可以通过解锁连接(111)和注射回到患者体内。另一方面，第二袋(113)中的剩余PRP通过解锁连接(116)提取，并且如果需要，可以将其注射到所需位置。刚性杆(114)位于袋的两侧，防止在离心过程中挤压袋。在制作本工具包中所用聚合物的柔性防止了血小板壳的破坏。
具体实施例的说明
本发明包括至少一根抽血针、血袋前后的多个锁、一梭形血袋、一个三通、两个取料连接、一梭形血袋，梭形血袋上设有竖直和强支撑的侧杆，该支撑杆由于缺少在抽血过程中负压的作用下，血小板的溶解和PPP效果的降低将是最小的，而且由于在第一袋纺锤形的情况下，有更好的控制血相分离的过程。由于抗凝剂的存在，在这个过程中凝血的可能性和它的元素被最小化，并且由于存在从第一个袋子中提取血液的连接，如有必要，血液元素可以再次注入病人的身体，并且第二个袋子的梭形可以提供高精度的将提取相分离并将这些相返回到第一袋中，其中在梭袋的侧面上存在刚性棒防止在离心第二袋时挤压袋，并且在袋的生产中使用的聚合物的柔韧性和柔软性最小化了血小板的损伤。

Claims (8)

1.本发明的具有将PRP与血液分离后再注入剩余元素的能力的PRP生产工具包，包括至少一个抽血针、血袋前后的数个锁、一个梭形血袋、一个三通、两个用于提取材料的连接，一个梭形血袋，配有竖直和坚固支撑的侧杆。
2.根据权利要求1所述的发明，其中由于抽血过程中没有负压，血小板溶解和PPP的有效性的降低是最小的。
3.根据权利要求1所述的发明，其中由于第一袋的纺锤形状，可以更好地控制分离血相的过程。
4.根据权利要求1所述的发明，其中由于抗凝剂的存在，在该过程中凝血的可能性及其元素被最小化。
5.根据权利要求1所述的发明，其中由于存在从第一袋中提取血液的连接，如有必要，可将血液元素再次注入患者体内。
6.根据权利要求1所述的发明，其中所述第二袋的梭形能够在分离所述提取相并将所述相返回至所述第一袋的过程中提供高精度。
7.根据权利要求1所述的发明，其中梭形袋侧面的刚性杆防止在离心第二个袋子时挤压袋子。
8.根据权利要求1所述的发明，其中用于生产袋的柔韧和柔软的聚合物最小化对血小板的损害。
CN201780093280.7A 2017-07-22 2017-07-22 具有从血液中分离prp后再注入剩余元素的能力的prp生产工具包 Pending CN110944616A (zh)

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PCT/IB2017/054453 WO2019021033A1 (en) 2017-07-22 2017-07-22 PRODUCTION KIT FOR PRP HAVING THE CAPACITY OF REINJECTING REMAINING ELEMENTS AFTER SEPARATION OF BLOOD PRP

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EP (1) EP3658102A4 (zh)
KR (1) KR20200031620A (zh)
CN (1) CN110944616A (zh)
AU (1) AU2017424896A1 (zh)
BR (1) BR112020001169A2 (zh)
CO (1) CO2020000506A2 (zh)
IL (1) IL272125A (zh)
MA (1) MA48227A1 (zh)
RU (1) RU2746589C1 (zh)
SG (1) SG11202000364VA (zh)
WO (1) WO2019021033A1 (zh)

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US5017338A (en) * 1986-04-11 1991-05-21 The Center For Blood Research, Inc. Platelet concentrates
EP0542221A1 (en) * 1991-11-11 1993-05-19 Terumo Kabushiki Kaisha Medical container device and method for manufacturing same
EP0420757B1 (en) * 1989-09-27 1994-07-20 Terumo Kabushiki Kaisha Multiple blood bag system
CN1300233A (zh) * 1999-04-12 2001-06-20 丰收技术股份有限公司 制造富含血小板的血浆和/或血小板浓缩液的方法和设备
CN102215885A (zh) * 2008-12-03 2011-10-12 泰尔茂株式会社 血袋系统及血液处理方法
US20160008223A1 (en) * 2014-07-08 2016-01-14 Fenwal, Inc. Minimization of air ingress in solution containers
SE1650038A1 (en) * 2016-01-14 2017-07-15 Ghanbari Ahmad Method, device and kit for the preparation of prp

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SU1556686A1 (ru) * 1987-08-14 1990-04-15 Харьковский научно-исследовательский институт дерматологии и венерологии Микроконтейнер дл лиофилизации и хранени реагентов дл иммуноферментного анализа
SE9001271D0 (sv) * 1990-04-06 1990-04-06 Eric Westberg Blodpaase foer anvaendning vid separation av blod i komponenter
US7169547B2 (en) * 1994-12-05 2007-01-30 New York Blood Center, Inc. High concentration white blood cells as a therapeutic product
FR2825261B1 (fr) * 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
WO2011095964A1 (en) * 2010-02-03 2011-08-11 Fuil Technologies Limited A method and apparatus for separating a liquid component from a liquid medium
EP3346968A4 (en) * 2015-09-10 2019-05-15 New Health Sciences, Inc. REINFORCED GAS-FLUID BLOOD STORAGE BAGS AND METHOD FOR THE PRODUCTION THEREOF

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017338A (en) * 1986-04-11 1991-05-21 The Center For Blood Research, Inc. Platelet concentrates
EP0420757B1 (en) * 1989-09-27 1994-07-20 Terumo Kabushiki Kaisha Multiple blood bag system
EP0542221A1 (en) * 1991-11-11 1993-05-19 Terumo Kabushiki Kaisha Medical container device and method for manufacturing same
CN1300233A (zh) * 1999-04-12 2001-06-20 丰收技术股份有限公司 制造富含血小板的血浆和/或血小板浓缩液的方法和设备
CN102215885A (zh) * 2008-12-03 2011-10-12 泰尔茂株式会社 血袋系统及血液处理方法
US20160008223A1 (en) * 2014-07-08 2016-01-14 Fenwal, Inc. Minimization of air ingress in solution containers
SE1650038A1 (en) * 2016-01-14 2017-07-15 Ghanbari Ahmad Method, device and kit for the preparation of prp

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MA48227A1 (fr) 2020-12-31
EP3658102A4 (en) 2021-03-17
CO2020000506A2 (es) 2020-01-31
BR112020001169A2 (pt) 2020-07-21
SG11202000364VA (en) 2020-02-27
WO2019021033A1 (en) 2019-01-31
IL272125A (en) 2020-03-31
AU2017424896A1 (en) 2020-01-16
EP3658102A1 (en) 2020-06-03
US20200230303A1 (en) 2020-07-23
RU2746589C1 (ru) 2021-04-16

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Application publication date: 20200331