CN110935494A - Micro-fluidic chip for analyzing coalescence effect of micro-bubbles - Google Patents
Micro-fluidic chip for analyzing coalescence effect of micro-bubbles Download PDFInfo
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- CN110935494A CN110935494A CN201911197772.8A CN201911197772A CN110935494A CN 110935494 A CN110935494 A CN 110935494A CN 201911197772 A CN201911197772 A CN 201911197772A CN 110935494 A CN110935494 A CN 110935494A
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- 238000004581 coalescence Methods 0.000 title claims abstract description 43
- 230000000694 effects Effects 0.000 title claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 77
- 239000000758 substrate Substances 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 5
- 239000012530 fluid Substances 0.000 abstract description 4
- 230000003993 interaction Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 32
- 238000000034 method Methods 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229940068984 polyvinyl alcohol Drugs 0.000 description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 5
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000010865 sewage Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000012482 interaction analysis Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0007—Investigating dispersion of gas
- G01N2015/0011—Investigating dispersion of gas in liquids, e.g. bubbles
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Abstract
A micro-fluidic chip for analyzing a coalescence effect of micro-bubbles belongs to the field of micro-bubble preparation and analysis of interaction of gas-liquid two-phase fluid in a micro-channel and aims to solve the problem that the real phenomenon cannot be accurately reflected in the prior art. The invention comprises a cover plate and a substrate, wherein the two surfaces of the cover plate and the substrate are mutually attached and bonded; two parallel liquid channels, a gas channel connected between the two liquid channels and a micro-bubble coalescence cavity communicated with one end of the two liquid channels are arranged on the surface, which is attached to the substrate, of the cover plate, and the communicated part of the liquid channels and the micro-bubble coalescence cavity is used as a micro-bubble outlet; the other ends of the two liquid channels are communicated; the liquid channel is provided with a liquid inlet which is vertical and penetrates through the cover plate, the gas channel is provided with a gas inlet which is vertical and penetrates through the cover plate, and one side of the micro-bubble coalescence cavity, which is opposite to the micro-bubble outlet, is provided with a gas-liquid mixture outlet which is vertical and penetrates through the cover plate.
Description
Technical Field
The invention belongs to the field of micro-bubble preparation and gas-liquid two-phase fluid interaction analysis in a micro-channel, and particularly relates to a micro-fluidic chip for analyzing a micro-bubble coalescence effect.
Background
With the increasing importance of the country on sewage treatment, it is essential to establish a complete high-efficiency sewage treatment system. In the field of sewage treatment, ozone has the characteristics of strong oxidizing property, strong organic matter decomposition, sterilization, disinfection, decoloration and the like, so that the application prospect is very wide. However, the technology of treating sewage with ozone has not been widely popularized, mainly because of the low utilization rate of ozone. The research and popularization of a high-efficiency and high-tech water treatment technology with additional value, which can meet the actual application requirements, is particularly urgent, and the combination of ozone and micro-bubble generation technology brings a new opportunity for further improvement of the current water treatment capacity. Based on a microfluidic control method, the micro-bubble preparation by utilizing a microfluidic chip has become the current mainstream technology, the method can generate the micro-bubbles with the diameter less than 100 microns, and a degassing source and liquid source equipment have no other energy consumption devices, so that the energy consumption is low. In addition, the micro-fluidic chip is easy to integrate, can realize the preparation of a large amount of micro-bubbles, and has a good development prospect in the field of engineering application.
At present, in the prior art, a micro-fluidic chip for preparing micro-bubbles mostly adopts a single-channel structure, that is, a single liquid micro-channel and a single gas micro-channel are adopted to generate micro-bubbles through a flow shearing action, and the main purpose of the micro-fluidic chip is to explore the characteristics of the generation size, the generation frequency and the like of the micro-bubbles. However, a large amount of fine bubbles may be aggregated in the liquid space after being generated, and the size and characteristics of the aggregated bubbles may be changed, thereby failing to accurately reflect the real phenomenon.
Disclosure of Invention
The invention aims to provide a micro-fluidic chip for analyzing a micro-bubble coalescence effect, which solves the problem that the real phenomenon cannot be accurately reflected in the prior art.
In order to achieve the above object, the microfluidic chip for analyzing the coalescence effect of micro-bubbles according to the present invention comprises a cover plate and a substrate, wherein the two surfaces of the cover plate and the substrate are bonded and attached to each other;
two parallel liquid channels, a gas channel connected between the two liquid channels and a micro-bubble coalescence cavity communicated with one end of the two liquid channels are arranged on the surface, which is attached to the substrate, of the cover plate, and the communicated part of the liquid channels and the micro-bubble coalescence cavity is used as a micro-bubble outlet; the other ends of the two liquid channels are communicated; the liquid channel is provided with a liquid inlet which is vertical and penetrates through the cover plate, the gas channel is provided with a gas inlet which is vertical and penetrates through the cover plate, and one side of the micro-bubble coalescence cavity, which is opposite to the micro-bubble outlet, is provided with a gas-liquid mixture outlet which is vertical and penetrates through the cover plate.
The gas inlet is positioned at the middle position of the gas channel; the liquid inlet is positioned at the middle position of the communication position of the two liquid channels.
The liquid channel and the gas channel are both of a groove structure.
The cross sections of the liquid channel and the gas channel are rectangular, the depth is 0.1mm, the groove width of the liquid channel is 0.5mm, and the groove width of the gas channel is 0.25 mm.
The substrate is a transparent structure.
The substrate is a glass material.
The cover sheet is made of polydimethylsiloxane.
The invention has the beneficial effects that: the microfluidic chip for analyzing the coalescence effect of the micro-bubbles is formed by bonding a Polydimethylsiloxane (PDMS) material with a glass substrate through a series of processes such as gluing, photoetching, mask plate processing and the like, so that the chip can be divided into a PDMS cover plate and a glass substrate. The surface of the PDMS cover plate is provided with a liquid channel and a gas channel for the flow of the liquid-liquid two-phase fluid. The gas channel is respectively connected with the liquid channels at the two end sides to form a double-T-shaped micro-channel structure, liquid and gas with certain flow rates respectively enter the liquid channel and the gas channel from the corresponding liquid inlet and gas inlet and are gathered at the intersection of the double-T-shaped structure, and according to the flow focusing principle, the gas at the intersection of the T-shaped structure can form micro bubbles under the shearing action of the liquid. The uniformly generated micro bubbles form micro bubble flow, flow along the liquid channels on two sides, enter the micro bubble coalescence area cavity through the micro bubble flow outlet and are subjected to coalescence phenomena in the area. And finally, enabling the coalesced bubbles to flow out of the chip through a gas-liquid mixture outlet.
In the test process of observing the coalescence phenomenon of the micro-bubbles by using the micro-fluidic chip, the volume and the generation frequency of the micro-bubbles during generation can be changed by controlling the liquid flow in the liquid channel and the gas pressure in the gas channel, and the adhesive force among the micro-bubbles can be changed by changing the concentration of the liquid. Therefore, the micro-fluidic chip is used for researching the influence of environmental factors such as different liquid flow rates, gas pressure, solution concentration and the like on the coalescence position and the coalescence quantity of the micro-bubbles.
Drawings
FIG. 1 is a perspective view of the whole structure of a microfluidic chip for analyzing the coalescence effect of micro-bubbles according to the present invention;
FIG. 2 is an exploded view of a microfluidic chip for analyzing the coalescence effect of microbubbles according to the present invention;
FIG. 3 is a schematic diagram of a cover sheet structure in a microfluidic chip for analyzing a microbubble coalescence effect according to the present invention;
wherein: 1. the cover plate 101, the liquid channel 102, the gas channel 103, the liquid inlet 104, the gas inlet 105, the micro-bubble coalescence cavity 106, the micro-bubble outlet 107, the gas-liquid mixture outlet 2 and the substrate.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings.
Referring to fig. 1-3, a microfluidic chip for analyzing the coalescence effect of micro-bubbles according to the present invention comprises a cover plate 1 and a substrate 2, the surfaces of which are bonded and connected to each other;
the surface of the cover plate 1, which is attached to the substrate 2, is provided with two mutually parallel liquid channels 101, a gas channel 102 connected between the two liquid channels 101, and a micro-bubble coalescence cavity 105 communicated with one ends of the two liquid channels 101, and the communication part of the liquid channels 101 and the micro-bubble coalescence cavity 105 is used as a micro-bubble outlet 106; the other ends of the two liquid channels 101 are communicated; the liquid channel 101 is provided with a liquid inlet 103 which is vertical and penetrates through the cover plate 1, the gas channel 102 is provided with a gas inlet 104 which is vertical and penetrates through the cover plate 1, and the side of the micro bubble coalescence cavity 105, which is opposite to the micro bubble outlet 106, is provided with a gas-liquid mixture outlet 107 which is vertical and penetrates through the cover plate 1.
The gas inlet 104 is located at the middle position of the gas channel 102; the liquid inlet 103 is located at an intermediate position where the two liquid passages 101 communicate.
The liquid channel 101 and the gas channel 102 are both of a groove structure.
The cross sections of the liquid channel 101 and the gas channel 102 are rectangular, the depth is 0.1mm, the groove width of the liquid channel 101 is 0.5mm, and the groove width of the gas channel 102 is 0.25 mm.
The substrate 2 is a transparent structure.
The substrate 2 is a glass material.
The cover sheet 1 is made of polydimethylsiloxane.
In the test process of using the chip to perform the observation of the coalescence phenomenon of the micro-bubbles, a micro-syringe pump (704500 Harvard Apparatus) is used to introduce Poly Vinyl Alcohol (PVA) solution with certain concentration and flow rate into the liquid channel 101 through the liquid inlet 103, and the flow rate of the liquid is continuously adjusted through the micro-syringe pump; a common nitrogen cylinder is connected with a secondary air pressure adjusting device, air is introduced into the air channel 102 through the air inlet 104, and the air pressure is adjusted through the air pressure adjusting device. When the liquid flow and the gas pressure reach a certain proportion range, micro-bubbles can be generated at the intersection of the double-T-shaped structure due to the flow focusing effect of the gas-liquid two-phase fluid flowing along the vertical direction. The uniformly generated fine bubbles form a fine bubble flow and enter the fine bubble coalescence chamber 105 along the two-side liquid channel 101. The entire bubble preparation and coalescence process can be observed by a microscopic observation system consisting of a microscope (CKX41 Olympus) and a high-speed camera (Phantom v 12.1).
The volume and the generation frequency of the micro-bubbles can be changed by controlling the liquid flow and the gas pressure value; by changing the concentration of the PVA solution, the adhesion force between the fine bubbles can be changed. The micro-fluidic chip can be used for observing the coalescence position and the coalescence number of the micro-bubbles under the conditions of different liquid flow rates, gas pressure and PVA solution concentration. The data measured in the above test can be processed by MATLAB numerical analysis software to obtain the corresponding micro-bubble coalescence effect change rule curve.
The adjusting range of the test parameters is as follows: the liquid flow is 30-50 mlh < -1 >, the gas pressure is 55-75 kPa, and the concentration of the PVA solution is 2%.
Claims (7)
1. A micro-fluidic chip for analyzing the coalescence effect of micro-bubbles is characterized by comprising a cover plate (1) and a substrate (2), wherein the two surfaces of the cover plate (1) and the substrate are mutually attached and bonded;
the surface of the cover plate (1) attached to the substrate (2) is provided with two mutually parallel liquid channels (101), a gas channel (102) connected between the two liquid channels (101) and a micro-bubble coalescence cavity (105) communicated with one end of the two liquid channels (101), and the communication part of the liquid channels (101) and the micro-bubble coalescence cavity (105) is used as a micro-bubble outlet (106); the other ends of the two liquid channels (101) are communicated; the liquid channel (101) is provided with a liquid inlet (103) which is vertical and penetrates through the cover plate (1), the gas channel (102) is provided with a gas inlet (104) which is vertical and penetrates through the cover plate (1), and the side, opposite to the micro-bubble coalescence cavity (105) and the micro-bubble outlet (106), of the micro-bubble coalescence cavity is provided with a gas-liquid mixture outlet (107) which is vertical and penetrates through the cover plate (1).
2. A microfluidic chip for analyzing the coalescence of micro-bubbles according to claim 1, wherein the gas inlet (104) is located in the middle of the gas channel (102); the liquid inlet (103) is located at an intermediate position where the two liquid channels (101) are communicated.
3. A microfluidic chip for analyzing the coalescence of micro-bubbles according to claim 1 or 2, wherein the liquid channel (101) and the gas channel (102) are both of a groove structure.
4. A microfluidic chip for analyzing the coalescence of fine bubbles according to claim 3, wherein the liquid channel (101) and the gas channel (102) have rectangular cross-sections and a depth of 0.1mm, the liquid channel (101) has a channel width of 0.5mm, and the gas channel (102) has a channel width of 0.25 mm.
5. A microfluidic chip for analyzing the coalescence of micro-bubbles according to claim 1 or 2, characterized in that the substrate (2) is a transparent structure.
6. A microfluidic chip for analyzing the coalescence of micro-bubbles according to claim 5, characterized in that the substrate (2) is a glass material.
7. A microfluidic chip for analyzing the coalescence of fine bubbles according to claim 1 or 2, wherein the cover plate (1) is made of polydimethylsiloxane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911197772.8A CN110935494A (en) | 2019-11-29 | 2019-11-29 | Micro-fluidic chip for analyzing coalescence effect of micro-bubbles |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911197772.8A CN110935494A (en) | 2019-11-29 | 2019-11-29 | Micro-fluidic chip for analyzing coalescence effect of micro-bubbles |
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| CN110935494A true CN110935494A (en) | 2020-03-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201911197772.8A Withdrawn CN110935494A (en) | 2019-11-29 | 2019-11-29 | Micro-fluidic chip for analyzing coalescence effect of micro-bubbles |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445681A (en) * | 2022-08-31 | 2022-12-09 | 南京理工大学 | Taylor flow and liquid drop preparation system based on pulse airflow |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030196714A1 (en) * | 2002-04-17 | 2003-10-23 | Coventor, Inc. | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
| CN108993622A (en) * | 2018-07-13 | 2018-12-14 | 北京工业大学 | It is a kind of to realize various combination drop to the micro-fluidic chip of collision |
-
2019
- 2019-11-29 CN CN201911197772.8A patent/CN110935494A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030196714A1 (en) * | 2002-04-17 | 2003-10-23 | Coventor, Inc. | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
| CN108993622A (en) * | 2018-07-13 | 2018-12-14 | 北京工业大学 | It is a kind of to realize various combination drop to the micro-fluidic chip of collision |
Non-Patent Citations (3)
| Title |
|---|
| 付涛涛: ""微通道内气液两相流及气泡行为研究"", 《中国博士学位论文全文数据库工程科技I辑》 * |
| 孙亚威: ""非牛顿流体中平行气泡聚并行为研究"", 《中国优秀硕士学位论文全文数据库工程科技I辑》 * |
| 张乐翔: ""平行微通道中两相流的随机模型和检测方法"", 《中国博士学位论文全文数据库工程科技I辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445681A (en) * | 2022-08-31 | 2022-12-09 | 南京理工大学 | Taylor flow and liquid drop preparation system based on pulse airflow |
| CN115445681B (en) * | 2022-08-31 | 2024-06-18 | 南京理工大学 | Taylor flow and liquid drop preparation system based on pulse air flow |
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