CN110927299A - Sample injection valve - Google Patents
Sample injection valve Download PDFInfo
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- CN110927299A CN110927299A CN201911171442.1A CN201911171442A CN110927299A CN 110927299 A CN110927299 A CN 110927299A CN 201911171442 A CN201911171442 A CN 201911171442A CN 110927299 A CN110927299 A CN 110927299A
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- China
- Prior art keywords
- port
- sample
- rotor
- stator
- pump
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
Abstract
The invention discloses a sample injection valve, which comprises a stator and a rotor, wherein the stator is rotationally connected with the rotor, the stator is provided with a plurality of interfaces, at least two interfaces in the plurality of interfaces are respectively connected with a quantitative ring, and at least one interface in the plurality of interfaces is connected with a chromatographic column; the rotor is provided with a plurality of guide grooves, and at least one guide groove in the guide grooves is connected with at least two interfaces in the plurality of interfaces. The sample injection valve is simultaneously connected with the quantitative ring and the chromatographic column, and the guide groove is connected with different interfaces on the stator by rotating the rotor to different angles so as to achieve the specific communication purpose.
Description
Technical Field
The invention relates to the technical field of structures, in particular to a sample injection valve.
Background
The liquid phase chromatographic instrument is one instrument for separating and analyzing mixture in liquid-solid or immiscible liquid. When analyzing or preparing a sample by a liquid chromatography apparatus, it is necessary to design a flow path so as to realize the following functions: 1. sampling, 2, injecting the sample in the sample ring into an analysis instrument or a preparation instrument, 3, flushing a system flow path, and 4, directly injecting the sample into the analysis instrument or the preparation instrument by a sample pump.
In the prior art, due to incomplete valve function of the liquid chromatography instrument, technicians are troublesome in cleaning process when continuously performing a plurality of experiments, and sometimes need to manually replace pipelines, so that the operation is complicated, and the working efficiency is low.
Disclosure of Invention
The invention provides a sample injection valve, which aims to solve the defect of troublesome cleaning caused by incomplete valve functions in the prior art.
The invention provides a sample injection valve, which comprises a stator and a rotor, wherein the stator is rotationally connected with the rotor, the stator is provided with a plurality of interfaces, at least two interfaces in the plurality of interfaces are respectively connected with a quantitative ring, and at least one interface in the plurality of interfaces is connected with a chromatographic column; the rotor is provided with a plurality of guide grooves, and at least one guide groove in the guide grooves is connected with at least two interfaces in the plurality of interfaces.
Optionally, the stator is provided with a receiving quantity ring left port 1, a receiving quantity ring right port 4 and a sample receiving needle port 8, the receiving quantity ring left port 1 and the receiving quantity ring right port 4 are respectively connected with the quantifying ring, the sample receiving needle port 8 is connected with a sample needle, and the rotor is provided with a first diversion trench C1; when the stator and the rotor are in a first position relation, the sample receiving needle port 8 is connected with the right receiving quantitative ring port 4 through the first diversion trench C1.
Optionally, the stator is provided with a chromatography column connecting port 3 and a system connecting pump port 7, the chromatography column connecting port 3 is connected with the chromatography column, the system connecting pump port 7 is connected with the system pump, and the rotor is provided with a second guide groove C2; when the stator and the rotor are in a first position relation, the system connection pump port 7 is connected with the column connection port 3 through the second guide groove C2.
Optionally, the stator is provided with a system pump port 7 and a system receiving amount ring left port 1, the system pump port 7 is connected with a system pump, the system receiving amount ring left port 1 is connected with the amount ring, and the rotor is provided with a second guide groove C2; when the stator and the rotor are in a second position relation, the system connection pump opening 7 is connected with the left opening 1 of the quantitative connection ring through the second guide groove C2.
Optionally, the stator is provided with a chromatography column connection port 3 and a sample connection pump port 5, the chromatography column connection port 3 is connected with the chromatography column, the sample connection pump port 5 is connected with the sample pump, and the rotor is provided with a first diversion trench C1; when the stator and the rotor are in a third positional relationship, the sample receiving pump port 5 is connected to the chromatography column port 3 through the first guide groove C1.
Optionally, the stator has a sample connection pump port 5 and a right sample connection ring port 4, the sample connection pump port 5 is connected with a sample pump, the right sample connection ring port 4 is connected with the dosing ring, and the rotor has a fifth guide groove C5; when the stator and the rotor are in a fourth positional relationship, the sample receiving pump port is connected with the right port 4 of the sample receiving quantitative ring through the fifth guide groove C5.
Optionally, the second guiding channel C2 includes a first section and a second section, the first section is a linear structure, the second section is an arc structure, and the first section is connected to the second section.
Optionally, the first guiding channel C1 is an arc-shaped structure.
Optionally, the rotor further has third and fourth channels C3 and C4, the third and fourth channels C3 and C4 being arc-shaped structures.
Optionally, the rotor has a second guiding groove C2, a third guiding groove C3, a fourth guiding groove C4 and a fifth guiding groove C5, one end of a first section of the second guiding groove C1 is a rotation center of the rotor, and a second section of the second guiding groove C1 is distributed on the same circumference as the third guiding groove C3, the fourth guiding groove C4 and the fifth guiding groove C5.
The sample injection valve is simultaneously connected with the quantitative ring and the chromatographic column, and the guide groove is connected with different interfaces on the stator by rotating the rotor to different angles so as to achieve the specific communication purpose.
Drawings
FIG. 1 is a schematic structural diagram of a stator of a sample injection valve according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a rotor of the sample injection valve in an embodiment of the present invention;
FIG. 3 is a schematic diagram showing a combined shape of a rotor and a stator of the sample injection valve according to an embodiment of the present invention;
FIG. 4 is a schematic view of a connection relationship of the sample injection valve according to the embodiment of the present invention;
FIG. 5 is a schematic view of a connection relationship of the sample injection valve according to the embodiment of the present invention;
FIG. 6 is a schematic view of a connection relationship of the sample injection valve according to the embodiment of the present invention;
FIG. 7 is a schematic diagram of a connection relationship of the sample injection valve in the embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides a sample injection valve, which comprises a stator and a rotor, wherein the stator is rotationally connected with the rotor, the stator is provided with a plurality of interfaces, at least two interfaces in the plurality of interfaces are respectively connected with a quantitative ring, and at least one interface in the plurality of interfaces is connected with a chromatographic column; the rotor is provided with a plurality of guide grooves, and at least one guide groove in the guide grooves is connected with at least two interfaces in the plurality of interfaces.
The sample injection valve in the embodiment of the invention is simultaneously connected with the quantitative ring and the chromatographic column, and the guide groove is connected with different interfaces on the stator by rotating the rotor to different angles so as to achieve the specific communication purpose.
As shown in fig. 1, which is a schematic structural diagram of a stator of a sample injection valve in an embodiment of the present invention, the stator has 8 interfaces with unchanged positions, that is, a left interface 1 for receiving a quantitative ring, a waste interface 2, a chromatography column interface 3, a right interface 4 for receiving a quantitative ring, a pump interface 5 for receiving a sample, a waste interface 6, a pump interface 7 for receiving a system, and a needle interface 8 for receiving a sample.
As shown in fig. 2, which is a schematic structural diagram of a rotor of a sample injection valve in an embodiment of the present invention, the rotor has 4 flow guide grooves, that is, a first flow guide groove C1, a second flow guide groove C2, a third flow guide groove C3, a fourth flow guide groove C4, and a fifth flow guide groove C5. The second guiding groove C2 includes a first section and a second section, the first section is a linear structure, the second section is an arc structure, and the first section is connected to the second section. The first guide groove C1, the third guide groove C3, the fourth guide groove C4 and the fifth guide groove C5 are all arc-shaped structures.
One end of the first section of the second guide groove C1 is the rotation center of the rotor, and the second section of the second guide groove C1, the third guide groove C3, the fourth guide groove C4 and the fifth guide groove C5 are distributed on the same circumference.
Based on the shape of the stator in fig. 1 and the shape of the rotor in fig. 2, the combined shape of the rotor and stator is shown in fig. 3, where the stator top thread interface is omitted.
As shown in fig. 4, which is a schematic connection diagram of a sample injection valve in an embodiment of the present invention, the stator has a left quantitative receiving ring port 1, a right quantitative receiving ring port 4, and a sample receiving needle port 8, the left quantitative receiving ring port 1 and the right quantitative receiving ring port 4 are respectively connected to the quantitative ring, the sample receiving needle port 8 is connected to the sample needle, and the rotor has a first guiding groove C1; when the stator and the rotor are in a first position relation, the sample receiving needle port 8 is connected with the right port 4 of the sample receiving quantitative ring through the first diversion groove C1.
Based on the above connection relationship, when the solvent is injected through the sample receiving needle port 8 on the stator by using the injector, the solvent flows to the first guiding groove C1 on the rotor and then is injected into the quantitative ring from the right port 4 of the quantitative ring, thereby realizing manual sample loading, wherein the quantitative ring has the function of storing the solvent.
In addition, the stator is also provided with a chromatography column connection port 3 and a system connection pump port 7, the chromatography column connection port 3 is connected with a chromatography column, the system connection pump port 7 is connected with a system pump, and the rotor is provided with a second guide groove C2; when the stator and the rotor are in the first position relation, the system connecting pump port 7 is connected with the column connecting port 3 through a second guide groove C2.
Based on the connection relation, when the solvent is injected through the system-connecting pump port 7 on the stator by using the system pump, the solvent flows through the second guide groove C2 and flows into the chromatographic column from the chromatographic column port 3, thereby realizing the sample loading of the system pump.
As shown in fig. 5, which is a schematic diagram of a connection relationship of the sample injection valve in the embodiment of the present invention, the stator has a system connection pump port 7 and a quantitative ring connection left port 1, the system connection pump port 7 is connected to the system pump, the quantitative ring connection left port 1 is connected to the quantitative ring, and the rotor has a second guiding groove C2; when the stator and the rotor are in a second position relation, the system-receiving pump opening 7 is connected with the left opening 1 of the quantitative receiving ring through a second diversion groove C2.
Based on the connection relation, when the solvent is injected by using the system pump through the system connecting pump port 7 on the stator, the solvent flows through the second diversion trench C2 and flows into the quantitative ring from the left port 1 of the quantitative ring, so that the system pump can sample through the quantitative ring, and the sample pump can be cleaned.
As shown in fig. 6, which is a schematic diagram of a connection relationship of the sample injection valve in the embodiment of the present invention, the stator has a chromatography column connection port 3 and a sample pump connection port 5, the chromatography column connection port 3 is connected with the chromatography column, the sample pump connection port 5 is connected with the sample pump, and the rotor has a first guiding gutter C1; when the stator and the rotor are in a third position relation, the sample connection pump port 5 is connected with the chromatography column port 3 through the first diversion groove C1.
Based on the above connection relationship, when the sample pump is used to inject the solvent through the sample-receiving pump port 5 on the stator, the solvent flows through the first guiding groove C1 and flows into the chromatographic column from the chromatographic column-receiving port 3, so as to realize the sample-pumping-receiving chromatographic column, and simultaneously, the system pump can be cleaned.
As shown in fig. 7, which is a schematic diagram of a connection relationship of the sample injection valve in the embodiment of the present invention, the stator has a sample connection pump port 5 and a dosing ring connection right port 4, the sample connection pump port 5 is connected to the sample pump, the dosing ring connection right port 4 is connected to the dosing ring, and the rotor has a fifth guiding groove C5; when the stator and the rotor are in a fourth position relation, the sample receiving pump port is connected with the right port 4 of the sample receiving quantitative ring through a fifth diversion trench C5.
Based on the connection relation, when the sample pump is used for injecting the solvent through the sample receiving pump port 5 on the stator, the solvent flows through the fifth guide groove C5 and flows into the quantitative ring from the right port 4 of the quantitative ring, so that sample loading of the sample pump is realized, and manual sample loading is replaced.
The embodiment of the invention is based on the shape and the position of the diversion trench on the rotor of the sample injection valve, the diversion trench is connected with the plurality of interfaces on the stator by rotating the rotor to different angles so as to achieve the specific communication purpose, and the work of manual sample injection, quantitative ring sample injection, sample pump sample injection, a large amount of sample injection of a system pump, sample pump sample injection to a quantitative ring, cleaning of all pipelines and the like can be completed without changing the connection of instrument and equipment and all pipelines, so that the working efficiency is improved.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A sample injection valve is characterized by comprising a stator and a rotor, wherein the stator is rotationally connected with the rotor, the stator is provided with a plurality of interfaces, at least two interfaces in the plurality of interfaces are respectively connected with a quantitative ring, and at least one interface in the plurality of interfaces is connected with a chromatographic column; the rotor is provided with a plurality of guide grooves, and at least one guide groove in the guide grooves is connected with at least two interfaces in the plurality of interfaces.
2. The sample injection valve as claimed in claim 1, wherein the stator has a receiving quantity ring left port 1, a receiving quantity ring right port 4 and a sample receiving needle port 8, the receiving quantity ring left port 1 and the receiving quantity ring right port 4 are respectively connected with the quantity ring, the sample receiving needle port 8 is connected with the sample needle, and the rotor has a first guiding groove C1; when the stator and the rotor are in a first position relation, the sample receiving needle port 8 is connected with the right receiving quantitative ring port 4 through the first diversion trench C1.
3. The sample injection valve as claimed in claim 1, wherein the stator has a column port 3 and a system pump port 7, the column port 3 is connected to the column, the system pump port 7 is connected to the system pump, and the rotor has a second guiding groove C2; when the stator and the rotor are in a first position relation, the system connection pump port 7 is connected with the column connection port 3 through the second guide groove C2.
4. The injection valve as claimed in claim 1, wherein the stator has a system pump port 7 and a dosing ring left port 1, the system pump port 7 is connected to a system pump, the dosing ring left port 1 is connected to the dosing ring, and the rotor has a second guiding groove C2; when the stator and the rotor are in a second position relation, the system connection pump opening 7 is connected with the left opening 1 of the quantitative connection ring through the second guide groove C2.
5. The sample injection valve as claimed in claim 1, wherein the stator has a column port 3 and a sample pump port 5, the column port 3 is connected to the chromatography column, the sample pump port 5 is connected to the sample pump, and the rotor has a first guiding groove C1; when the stator and the rotor are in a third positional relationship, the sample receiving pump port 5 is connected to the chromatography column port 3 through the first guide groove C1.
6. The sample injection valve as claimed in claim 1, wherein the stator has a sample connection pump port 5 and a right sample connection loop port 4, the sample connection pump port 5 is connected to a sample pump, the right sample connection loop port 4 is connected to the dosing loop, and the rotor has a fifth guiding groove C5; when the stator and the rotor are in a fourth positional relationship, the sample receiving pump port is connected with the right port 4 of the sample receiving quantitative ring through the fifth guide groove C5.
7. The sample injection valve as claimed in claim 3 or 4, wherein the second guiding channel C2 comprises a first section and a second section, the first section is a linear structure, the second section is an arc structure, and the first section is connected with the second section.
8. The sample injection valve as claimed in claim 2 or 5, wherein the first guiding channel C1 is of an arc-line structure.
9. The sample injection valve of claim 1, wherein the rotor further comprises a third channel C3 and a fourth channel C4, and wherein the third channel C3 and the fourth channel C4 are both arc-shaped structures.
10. The sample injection valve as claimed in claim 1, wherein the rotor has a second guiding groove C2, a third guiding groove C3, a fourth guiding groove C4 and a fifth guiding groove C5, one end of a first section of the second guiding groove C1 is a rotation center of the rotor, and a second section of the second guiding groove C1 is distributed on the same circumference as the third guiding groove C3, the fourth guiding groove C4 and the fifth guiding groove C5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911171442.1A CN110927299A (en) | 2019-11-26 | 2019-11-26 | Sample injection valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911171442.1A CN110927299A (en) | 2019-11-26 | 2019-11-26 | Sample injection valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110927299A true CN110927299A (en) | 2020-03-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911171442.1A Pending CN110927299A (en) | 2019-11-26 | 2019-11-26 | Sample injection valve |
Country Status (1)
| Country | Link |
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| CN (1) | CN110927299A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101617226A (en) * | 2007-02-22 | 2009-12-30 | 通用电气健康护理生物科学股份公司 | Be used for the rotating valve that sample injects |
| CN102460145A (en) * | 2009-06-03 | 2012-05-16 | 安捷伦科技有限公司 | Sample injector with metering device balancing pressure differences in an intermediate valve state |
| US20130068977A1 (en) * | 2011-09-21 | 2013-03-21 | Affluidx, Llc | Multi-Mode Injection Valve |
| CN104265952A (en) * | 2014-10-24 | 2015-01-07 | 北京佰纯润宇生物科技有限公司 | Eight-way valve and chromatographic system based on eight-way valve |
| CN105308448A (en) * | 2013-06-12 | 2016-02-03 | 安捷伦科技有限公司 | Flushing a metering device switchable between different fluidic paths by solvent from an analysis path of a fluid separation system |
| US20170336369A1 (en) * | 2014-12-01 | 2017-11-23 | Waters Technologies Corporation | System and method for performing a chromatography injection sequence using a single injection valve |
| US20180306758A1 (en) * | 2016-01-29 | 2018-10-25 | Dionex Softron Gmbh | Sample pre-compression valve for liquid chromatography |
| CN209432756U (en) * | 2018-12-11 | 2019-09-24 | 苏州英赛斯智能科技有限公司 | A kind of selector valve and liquid-chromatography apparatus |
-
2019
- 2019-11-26 CN CN201911171442.1A patent/CN110927299A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101617226A (en) * | 2007-02-22 | 2009-12-30 | 通用电气健康护理生物科学股份公司 | Be used for the rotating valve that sample injects |
| CN102460145A (en) * | 2009-06-03 | 2012-05-16 | 安捷伦科技有限公司 | Sample injector with metering device balancing pressure differences in an intermediate valve state |
| US20130068977A1 (en) * | 2011-09-21 | 2013-03-21 | Affluidx, Llc | Multi-Mode Injection Valve |
| CN105308448A (en) * | 2013-06-12 | 2016-02-03 | 安捷伦科技有限公司 | Flushing a metering device switchable between different fluidic paths by solvent from an analysis path of a fluid separation system |
| CN104265952A (en) * | 2014-10-24 | 2015-01-07 | 北京佰纯润宇生物科技有限公司 | Eight-way valve and chromatographic system based on eight-way valve |
| US20170336369A1 (en) * | 2014-12-01 | 2017-11-23 | Waters Technologies Corporation | System and method for performing a chromatography injection sequence using a single injection valve |
| US20180306758A1 (en) * | 2016-01-29 | 2018-10-25 | Dionex Softron Gmbh | Sample pre-compression valve for liquid chromatography |
| CN209432756U (en) * | 2018-12-11 | 2019-09-24 | 苏州英赛斯智能科技有限公司 | A kind of selector valve and liquid-chromatography apparatus |
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Effective date of registration: 20220302 Address after: 310053 room 10007, 1f, No. 6899, Wentao Road, Puyan street, Binjiang District, Hangzhou, Zhejiang Applicant after: Zhejiang Jinyi Shengshi Biological Engineering Co.,Ltd. Address before: 102208 room 1011, 10 / F, block a, Longyu center, building 1, yard 1, Longyu middle street, Huilongguan town, Changping District, Beijing Applicant before: BEIJING HUACHUANG JINGKE BIOTECHNOLOGY Co.,Ltd. |