CN110916040A - Sleep-aiding solid beverage - Google Patents
Sleep-aiding solid beverage Download PDFInfo
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- CN110916040A CN110916040A CN201911211357.3A CN201911211357A CN110916040A CN 110916040 A CN110916040 A CN 110916040A CN 201911211357 A CN201911211357 A CN 201911211357A CN 110916040 A CN110916040 A CN 110916040A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a sleep-aiding solid beverage which comprises roxburgh rose powder, blood orange powder, yeast β -glucan, gamma-aminobutyric acid and xanthan gum.
Description
Technical Field
The invention relates to the field of formula foods with special medical application, in particular to a sleep-aiding solid beverage.
Background
Sleep is a big thing in life. Good sleep is very important because the quality of sleep directly affects the next day's mental quality and work and learning efficiency. The sleep is good, people feel refreshing and full of vitality, and the learning, the work and the life are full of vitality; the user feels no sleep well, and the user can feel that the user has no essence to collect, does not eat sweet taste and is not conscious. The sleep quality can be reduced due to the fast pace of life and the high working pressure.
The traditional Chinese medicine calls insomnia as insomnia, insomnia and the like, and takes liver depression transforming into fire, phlegm heat internally winding, stasis disturbing the heart spirit, yin deficiency and fire hyperactivity, deficiency of both heart and spleen, deficiency of heart and gallbladder qi and the like as basic pathogenesis of insomnia. Insomnia usually refers to the condition that a patient is not easy to fall asleep, or has short and light sleep and is easy to wake up, or even cannot fall asleep all night, and is often difficult to fall asleep or easy to wake up at night. Light people have difficulty falling asleep, wake up when sleeping, and cannot sleep again after waking up, and heavy people can not sleep all night.
Patent CN107319525A discloses a special clinical nutritional formula for weight and fat reduction, comprising 20-38 parts of protein, 8-12 parts of fat, 40-50 parts of carbohydrate, 5-8 parts of dietary fiber, 0.3-1.5 parts of macroelements, 0.01-0.04 part of trace elements, 0.005-0.015 part of fat-soluble vitamins, 0.01-0.3 part of water-soluble vitamins, 0.05-1 part of dietary essence, 0.1-2 parts of homologous plant food ingredients, 0.1-3 parts of natural plant compounds and 0.005-2 parts of new resource food, wherein the new resource food is selected from at least one of colostrum basic protein, assai fruit powder, barley seedling, gamma-aminobutyric acid, chitosan oligosaccharide, eucommia male flower, bamboo leaf flavone, casein phosphopeptide, oat β -glucan, yeast β -glucan, milk mineral salt, maca powder, pear and xylo oligosaccharide, and the new resource food disclosed in patent CN107319525A is only used as a special nutritional formula for weight reduction and has no clinical effect related to the whole clinical nutritional formula.
Therefore, the development of the solid beverage which is safe, effective, low in cost and capable of helping sleep has important practical significance and wide market prospect.
Disclosure of Invention
In view of the above, the present invention aims to provide a solid beverage which is safe, effective, low in cost and helpful for sleep.
Therefore, the invention provides the following technical scheme.
In a first aspect, the invention provides a sleep-aiding solid beverage, wherein the beverage comprises roxburgh rose powder, blood orange powder, yeast β -glucan, gamma-aminobutyric acid and xanthan gum.
In a preferred embodiment, the roxburgh rose powder is 7-9 parts by mass; for example, the roxburgh rose powder can be 7, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9 or 9 in parts by mass.
In a preferred embodiment, the blood orange powder is 0.25-0.35 part by mass; for example, the blood orange powder may be 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34 or 0.35 in parts by mass.
In a preferred embodiment, the yeast β -glucan is present in an amount of 0.48 to 0.53 parts by weight, for example, the yeast β -glucan may be present in an amount of 0.48, 0.49, 0.5, 0.51, 0.52 or 0.53 parts by weight.
In a preferred embodiment, the mass portion of the gamma-aminobutyric acid is 0.18 to 0.22; for example, the gamma-aminobutyric acid may be present in a mass fraction of 0.18, 0.19, 0.2, 0.21 or 0.22.
In a preferred embodiment, the xanthan gum is 0.2-0.3 parts by mass; for example, the mass fraction of xanthan gum may be 0.2, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29 or 0.3.
In a second aspect, the invention provides a sleep-aiding solid beverage, wherein the beverage comprises, by mass, 7-9 parts of roxburgh rose powder, 0.25-0.35 part of blood orange powder, 0.48-0.53 part of yeast β -glucan, 0.18-0.22 part of gamma-aminobutyric acid and 0.2-0.3 part of xanthan gum.
In a third aspect, the invention provides a sleep-aiding solid beverage, wherein the beverage comprises 8 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum according to the fourth aspect by mass, and the food comprises the beverage.
In a fifth aspect, a method for preparing a sleep-aiding solid beverage is provided, the method comprising the following steps:
s1, weighing roxburgh rose powder, blood orange powder, yeast β -glucan, gamma-aminobutyric acid and xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing;
and S3, quantitatively subpackaging 10g each bag.
In a preferred embodiment, the time for blending in step S1 is 0.5 to 1 hour.
In a preferred embodiment, the time for blending in step S2 is 0.5 to 1 hour.
In addition, the invention provides the application of the beverage in preparing sleep-aiding food.
And, a pharmaceutical composition comprising a safe and effective amount of the beverage according to the present invention is provided.
In the invention, the pharmaceutical composition comprises the beverage and pharmaceutically acceptable auxiliary materials.
In the present invention, a safe and effective amount refers to an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive sleep aid benefit, including the benefits disclosed herein, either individually or in combination, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
The taking method of the sleep-aiding solid beverage comprises the following steps: each bag is 10g, and is taken with about 200mL warm water (suitable water temperature is 40-50 deg.C), 1 bag can be taken in one day, and is suitable for 1-2 hr before sleep at night.
Compared with the prior art, the invention has the beneficial effects that:
vitamin C and superoxide dismutase contained in the roxburgh rose powder can penetrate into cells and enter cerebral cortex to maintain the normal function of brain tissues, can keep the brain awake for a long time, and can achieve a good effect on sleep quality.
The gamma-aminobutyric acid has the effects of resisting anxiety, activating the brain and regulating emotion, the accumulation of the gamma-aminobutyric acid in the brain is abnormally difficult due to mental stress, and symptoms such as anxiety, fatigue and insomnia can be caused when the gamma-aminobutyric acid is deficient.
The invention unexpectedly discovers that the blood orange powder and the yeast β -glucan can well help sleep together with the roxburgh rose powder and the gamma-aminobutyric acid, the cooperation of the blood orange powder, the yeast β -glucan, the roxburgh rose powder and the gamma-aminobutyric acid can help people to quickly enter a sleep state, and the sleep quality is remarkably improved.
The sleep-aiding solid beverage is convenient to produce, low in cost and high in application value.
In addition, the xanthan gum used in the invention can ensure that the stability of the sleep-aiding solid beverage is better, and the sleep-aiding solid beverage can keep excellent stability from low temperature (about minus 10 ℃) to high temperature (about 45 ℃).
Moreover, the sleep-aiding solid beverage is safe and non-toxic through safety verification.
On the other hand, the sleep-aiding solid beverage has better sleep-improving effect by screening the types of the components in the sleep-aiding solid beverage and adjusting the mass parts of the components in the sleep-aiding solid beverage.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments and examples, and the advantages and various effects of the present invention will be more clearly apparent therefrom. It will be understood by those skilled in the art that these specific embodiments and examples are for the purpose of illustrating the invention and are not to be construed as limiting the invention.
The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.
Example 1
The embodiment provides a sleep-aiding solid beverage, which comprises the following components in parts by weight:
7 parts of roxburgh rose powder, 0.25 part of blood orange powder, 0.48 part of yeast β -glucan, 0.18 part of gamma-aminobutyric acid and 0.2 part of xanthan gum.
The preparation method of the sleep-aiding solid beverage comprises the following steps:
s1, weighing 7 parts of roxburgh rose powder, 0.25 part of blood orange powder, 0.48 part of yeast β -glucan, 0.18 part of gamma-aminobutyric acid and 0.2 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 0.5 h;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 0.5 h;
and S3, quantitatively subpackaging 10g each bag.
Example 2
The embodiment provides a sleep-aiding solid beverage, wherein the beverage comprises the following components in parts by weight:
9 parts of roxburgh rose powder, 0.35 part of blood orange powder, 0.53 part of yeast β -glucan, 0.22 part of gamma-aminobutyric acid and 0.3 part of xanthan gum.
The preparation method of the sleep-aiding solid beverage comprises the following steps:
s1, weighing 9 parts of roxburgh rose powder, 0.35 part of blood orange powder, 0.53 part of yeast β -glucan, 0.22 part of gamma-aminobutyric acid and 0.3 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Example 3
The embodiment provides a sleep-aiding solid beverage, wherein the beverage comprises the following components in parts by weight:
8 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum.
The preparation method of the sleep-aiding solid beverage comprises the following steps:
s1, weighing 8 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Example 4
The application method of the sleep-aiding solid beverage comprises the following steps:
each bag is 10g, and is taken with about 200mL warm water (suitable water temperature is 40-50 deg.C), 1 bag is taken one day, and 1.5 hours before sleep.
Comparative example 1
To further illustrate the beneficial effects of the present invention, comparative example 1 is provided, which is different from example 3 in that: the roxburgh rose powder is replaced by acerola cherry fruit powder.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 8 parts of acerola cherry fruit powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 2
To further illustrate the beneficial effects of the present invention, comparative example 2 is provided, which comparative example 2 differs from example 3 in that: the roxburgh rose powder is replaced by acerola cherry fruit powder, and the gamma-aminobutyric acid is replaced by wild jujube kernel powder.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 8 parts of acerola cherry fruit powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of wild jujube kernel powder and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 3
To further illustrate the beneficial effects of the present invention, comparative example 3 is provided, which comparative example 3 differs from example 3 in that: the roxburgh rose powder is replaced by acerola cherry fruit powder, the gamma-aminobutyric acid is replaced by wild jujube kernel powder, and the blood orange powder is replaced by a black ginger extract.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 8 parts of acerola cherry fruit powder, 0.3 part of black ginger extract, 0.5 part of yeast β -glucan, 0.2 part of wild jujube kernel powder and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 h;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 4
To further illustrate the advantageous effects of the present invention, comparative example 4 is provided, which is different from example 3 in that the Rosa roxburghii powder of the present invention is replaced with acerola powder, gamma-aminobutyric acid is replaced with spina date seed powder, blood orange powder is replaced with black ginger extract, and yeast β -glucan is replaced with chitosan oligosaccharide.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 8 parts of acerola cherry fruit powder, 0.3 part of black ginger extract, 0.5 part of chitosan oligosaccharide, 0.2 part of wild jujube kernel powder and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 h;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 5
To further illustrate the advantageous effects of the present invention, comparative example 5 is provided, which is different from example 3 in that the mass part of the roxburgh rose powder is adjusted to 6 parts, the mass part of the blood orange powder is adjusted to 0.2 part, the mass part of the yeast β -glucan is adjusted to 0.4 part, the mass part of the gamma-aminobutyric acid is adjusted to 0.15 part, and the mass part of the xanthan gum is adjusted to 0.1 part.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 6 parts of roxburgh rose powder, 0.2 part of blood orange powder, 0.4 part of yeast β -glucan, 0.15 part of gamma-aminobutyric acid and 0.1 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 6
To further illustrate the advantageous effects of the present invention, comparative example 6 is provided, which is different from example 3 in that the mass part of the roxburgh rose powder is adjusted to 10 parts, the mass part of the blood orange powder is adjusted to 0.4 part, the mass part of the yeast β -glucan is adjusted to 0.6 part, the mass part of the gamma-aminobutyric acid is adjusted to 0.3 part, and the mass part of the xanthan gum is adjusted to 0.4 part.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 10 parts of roxburgh rose powder, 0.4 part of blood orange powder, 0.6 part of yeast β -glucan, 0.3 part of gamma-aminobutyric acid and 0.4 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 h;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 7
To further illustrate the beneficial effects of the present invention, comparative example 7 is provided, which comparative example 7 differs from example 3 in that: the mass portion of the roxburgh rose powder is adjusted to 6 portions.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 6 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 8
To further illustrate the beneficial effects of the present invention, comparative example 8 is provided, which comparative example 8 differs from example 3 in that: regulating the mass part of the roxburgh rose powder to 10 parts.
The preparation method of the comparative example sleep-aiding solid beverage comprises the following steps:
s1, weighing 10 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum, adding into a container according to an equivalent incremental method, and uniformly mixing for 1 hour;
s2, placing the mixture obtained in the step S1 in a mixer, and uniformly mixing for 1 h;
and S3, quantitatively subpackaging 10g each bag.
Comparative example 9
In order to further illustrate the beneficial effects of the invention, the special clinical nutrition formula for weight reduction is provided, and is prepared by adopting the method in CN 107319525A.
Experiment 1: safety verification test sample: examples 1-3 the experimental methods for the samples prepared were:
10 male and female mice are screened, the male and female mice are raised in cages with the weight of 18-22g, and the sleep-aiding solid beverage is used for gastric lavage of the mice according to the weight of 5g/kg (the mice are fasted for 8h before gastric lavage). After administration, the mice were observed for behavioral activity, mental state, appetite, fur, weight change, and death status on days 0, 7, and 14, respectively.
Through an acute oral toxicity experiment on mice, the mice are divided into two groups of experiments of a high dose group and a normal group, 14 days are observed, relevant data are recorded on 0 day, 7 days and 14 days respectively, and the experimental data are shown in the following table 1 and the following table 2.
TABLE 1 test results of normal acute oral toxicity group
TABLE 2 Experimental results for acute oral toxicity high dose group
From the above results, it can be seen that:
the sleep-aiding solid beverage prepared by the invention is administrated to experimental animals by gavage at normal dose or high dose, the experimental animals have good mental state, normal behaviors, normal weight increase, no adverse reaction and 0 death number after gavage, so that the sleep-aiding solid beverage is non-toxic and safe, belongs to a non-toxic result, and meets the requirement of acute toxicity experimental results of biological safety evaluation.
Experiment 2: stability test
And (3) testing a sample: the samples prepared in inventive examples 1-3 and comparative examples 1-9.
The experimental method comprises the following steps:
testing each sample under four test conditions of-10 ℃, room temperature, 45 ℃ and-10-45 ℃ for 15 days, 30 days and 40 days respectively, and observing whether the shape of each sample is obviously changed, wherein the change is qualified and the change is unqualified; testing each test sample for 15 days (days), 30 days (days) and 40 days (days) under four test conditions of-10 ℃, room temperature, 45 ℃ and-10-45 ℃ alternately, and detecting whether the total microbial count of each test sample is qualified according to the standards of GB4789.1, GB4789.2 and GB4789.3, wherein the qualified conditions are as follows: the total number of colonies is less than or equal to 1000, the number of mould and yeast is less than or equal to 20 respectively, the number of escherichia coli is less than or equal to 10, and staphylococcus aureus and salmonella are not detected;
the test results are shown in table 3 below.
Table 3 stability test results
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 1.1 is provided, which is distinguished from example 3 by the following: replacing the blood orange powder with a black ginger extract;
comparative example 1.2 is provided, which is distinguished from example 3 in that the yeast β -glucan of the invention is replaced by chitosan oligosaccharide;
comparative example 1.3 is provided, which is distinguished from example 3 by the following: replacing the gamma-aminobutyric acid of the invention with wild jujube kernel powder;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 2. The stability of the sleep-aiding solid beverages prepared in comparative example 1.1, comparative example 1.2 and comparative example 1.3 was observed. The results were similar to those in comparative example 1 described above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 2.1 is provided, which is distinguished from example 3 in that the blood orange powder of the invention is replaced by a Hejiang extract, the yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 2.2 is provided, which is distinguished from example 3 by the following: the roxburgh rose powder is replaced by acerola cherry fruit powder, and the blood orange powder is replaced by a black ginger extract;
comparative example 2.3 is provided, which is distinguished from example 3 in that the roxburgh rose powder of the invention is replaced by acerola powder, yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 2.4 is provided, which comparative example 2.4 differs from example 3 in that: the gamma-aminobutyric acid is replaced by wild jujube kernel powder, and the blood orange powder is replaced by a black ginger extract;
comparative example 2.5 is provided, which is distinguished from example 3 in that gamma-aminobutyric acid according to the present invention is replaced with spina date seed powder, yeast β -glucan is replaced with chitosan oligosaccharide;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 2. The stability of the sleep-aiding solid beverages prepared in comparative example 2.1, comparative example 2.2, comparative example 2.3, comparative example 2.4, and comparative example 2.5 was observed. The results were similar to those in comparative example 2 described above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 3.1 is provided, which is distinguished from example 3 in that the Rosa roxburghii powder of the invention is replaced by acerola powder, gamma-aminobutyric acid is replaced by spina date seed powder, yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 3.2 is provided, which is distinguished from example 3 in that the roxburgh rose powder of the invention is replaced by acerola powder, the blood orange powder by a black ginger extract, the yeast β -glucan by chitosan oligosaccharide;
comparative example 3.3 is provided, which is distinguished from example 3 in that gamma-aminobutyric acid according to the present invention is replaced with spine date seed powder, blood orange powder is replaced with black ginger extract, yeast β -glucan is replaced with chitosan oligosaccharide;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 2. The stability of the sleep-aiding solid beverages prepared in comparative example 3.1, comparative example 3.2, and comparative example 3.3 was observed. The results were similar to those in comparative example 3 above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 7.1 is provided, which is distinguished from example 3 by the following: adjusting the mass part of the blood orange powder to 0.2 part;
comparative example 7.2 is provided, which is different from example 3 in that the mass part of yeast β -glucan is adjusted to 0.4 part;
comparative example 7.3 is provided, which comparative example 7.3 differs from example 3 in that: adjusting the mass part of the gamma-aminobutyric acid to 0.1 part;
comparative example 7.4 is provided, which is distinguished from example 3 by the following: adjusting the mass part of xanthan gum to 0.1 part;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 2. The stability of the sleep-aiding solid beverages prepared in comparative example 7.1, comparative example 7.2, comparative example 7.3, and comparative example 7.4 was observed. The results were similar to those in comparative example 7 described above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 8.1 is provided, which comparative example 8.1 differs from example 3 in that: adjusting the mass part of the blood orange powder to 0.5 part;
comparative example 8.2 is provided, which is different from example 3 in that the mass part of yeast β -glucan is adjusted to 0.6 part;
comparative example 8.3 is provided, which comparative example 8.3 differs from example 3 in that: adjusting the mass part of the gamma-aminobutyric acid to 0.3 part;
comparative example 8.4 is provided, which comparative example 8.4 differs from example 3 in that: adjusting the mass part of xanthan gum to 0.4 part;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 2. The stability of the sleep-aiding solid beverages prepared in comparative example 8.1, comparative example 8.2, comparative example 8.3, and comparative example 8.4 was observed. The results were similar to those in comparative example 8 described above.
From the above results, it can be seen that:
after the sleep-aiding solid beverage is tested for 15 days, 30 days and 40 days under four test conditions of-10 ℃, room temperature, 45 ℃ and-10-45 ℃ alternately, the sample forms of the sleep-aiding solid beverage are not changed obviously, and the detection results of the total number of microorganisms are qualified, so that the sleep-aiding solid beverage has good cold resistance and heat resistance, and can meet the use requirements under the condition of extreme temperature change. The sleep-aiding solid beverage without the formula system has poor cold resistance and heat resistance under the condition of long-time storage, and cannot meet the use requirement under the condition of extreme temperature change.
Experiment 3: sleep aid verification
And (3) testing a sample: the samples prepared in inventive examples 1-3 and comparative examples 1-9.
The experimental method comprises the following steps:
the experiment was carried out according to the method of example 4, and the application was continued for 1 month, during which the application of other Chinese and western medicines and health products was stopped.
Effect verification:
for patients with insomnia, 360 patients with age of 18-55 years can be randomly divided into A, B, C, D, E, F, G, H, I, J, K, L twelve groups of 30 patients. Wherein the content of the first and second substances,
group a using the sleep-aiding solid beverage prepared in the above example 1 of the present invention,
group B using the sleep-aiding solid beverage prepared in the above example 2 of the present invention,
group C using the sleep-aiding solid beverage prepared in the above example 3 of the present invention,
group D used the sleep-aiding solid beverage prepared in comparative example 1,
group E used the sleep-aid solid beverage prepared from comparative example 2,
group F used the sleep-aid solid beverage prepared in comparative example 3,
group G used the sleep-aid solid beverage prepared in comparative example 4,
group H used the sleep-aiding solid beverage prepared in comparative example 5,
group I used the sleep-aid solid beverage prepared by comparative example 6,
group J used the sleep-aid solid beverage prepared in comparative example 7,
group K used the sleep-aid solid beverage prepared in comparative example 8,
group L used the diet and fat reduction specialized clinical nutritional formula prepared from comparative example 9,
the experimental results are as follows:
the group A treats 30 cases of insomnia patients, and the cure rate is 86.7 percent, wherein 26 cases are cured; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate accounts for 93.4 percent; the efficiency of the sample is 2 invalid, and the inefficiency accounts for 6.7%.
The group B treats 30 cases of insomnia patients, and the cure rate is 86.7 percent, wherein 26 cases are cured; the improvement is improved by 3 cases, and the significant efficiency accounts for 10 percent; the total effective rate accounts for 96.7 percent; the efficiency is 3.3% in the case of 1 invalid case.
Group C treats 30 cases of insomnia patients, 28 cases are cured, and the cure rate accounts for 93.3%; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate is 100%; the case of no efficiency is 0%, and the failure rate is 0%.
Group D treats 30 cases of insomnia patients, 24 cases are cured, and the cure rate accounts for 80.0 percent; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate accounts for 86.7 percent; the efficiency of 4 cases is not high, and the inefficiency accounts for 13.3 percent.
The group E treats 30 cases of insomnia patients, 20 cases are cured, and the cure rate accounts for 66.7 percent; the improvement is improved by 3 cases, and the significant efficiency accounts for 10.0 percent; the total effective rate accounts for 76.6 percent; the number of the ineffective cases is 7, and the ineffective rate accounts for 23.4 percent.
The group F treats 30 cases of insomnia patients, 16 cases are cured, and the cure rate accounts for 53.3 percent; the improvement is improved by 3 cases, and the significant efficiency accounts for 10.0 percent; the total effective rate is 63.3%; the number of the ineffective cases is 11, and the ineffective rate is 36.7 percent.
Group G treats 30 cases of insomnia patients, 12 cases are cured, and the cure rate accounts for 40.0 percent; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate accounts for 46.7 percent; 16 cases were invalid, and the inefficiency was 53.3%.
Group H treats 30 cases of insomnia patients, 11 cases are cured, and the cure rate accounts for 36.7 percent; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate accounts for 43.4%; the number of the ineffective cases is 17.6 percent.
Group I treats 30 cases of insomnia patients, 12 cases are cured, and the cure rate accounts for 40.0 percent; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate is 46.7%; 16 cases were invalid, and the inefficiency was 53.3%.
J, 30 cases of insomnia patients are treated, 25 cases are cured, and the cure rate accounts for 83.3 percent; the improvement is 1 case, and the significant efficiency accounts for 3.3 percent; the total effective rate accounts for 86.6 percent; the efficiency of 4 cases is invalid, and the inefficiency accounts for 13.4%.
Group K treats 30 cases of insomnia patients, 24 cases are cured, and the cure rate accounts for 80.0 percent; the improvement is improved by 2 cases, and the significant efficiency accounts for 6.7 percent; the total effective rate accounts for 86.7 percent; the efficiency of 4 cases is not high, and the inefficiency accounts for 13.3 percent.
L group treats 30 cases of insomnia patients, 10 cases are cured, and the cure rate accounts for 33.3 percent; the improvement is improved by 3 cases, and the significant efficiency accounts for 10.0 percent; the total effective rate is 43.3%; the number of the ineffective cases is 17.7 percent.
Typical cases and efficacy:
the patient, female, 18 years old, has insomnia symptoms for a long time, difficulty in falling asleep, waking up when sleeping, incapability of sleeping after waking up, dysphoria, and serious influence on learning. When the solid sleep-aiding beverage prepared in the embodiment 1 of the invention is taken 1 bag a day and 1.5 hours before sleep, after the solid sleep-aiding beverage is continuously used for 1 month, the symptoms of a patient are relieved, the sleep is stable, and the normal learning is recovered.
The patients, male, are 40 years old, have great working pressure, gradually have insomnia symptoms, and are difficult to fall asleep or sleep and easy to wake up at night. By using the sleep-aiding solid beverage prepared in the embodiment 2 of the invention, 1 bag is taken in one day, 1.5 hours before sleep at night, and after 1 month of continuous use, the symptoms of a patient are relieved, the sleep is stable, dreams are less, and the work is recovered to be normal.
Patients, male, 55 years old, have high long-term stress, poor sleep and very poor sleep quality. By using the sleep-aiding solid beverage prepared in the embodiment 3 of the invention, 1 bag is taken one day, 1.5 hours before sleep at night, after 1 month of continuous use, insomnia symptoms are relieved, and sleep is stable.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 1.1 is provided, which is distinguished from example 3 by the following: replacing the blood orange powder with a black ginger extract;
comparative example 1.2 is provided, which is distinguished from example 3 in that the yeast β -glucan of the invention is replaced by chitosan oligosaccharide;
comparative example 1.3 is provided, which is distinguished from example 3 by the following: replacing the gamma-aminobutyric acid of the invention with wild jujube kernel powder;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The stability of the sleep-aiding solid beverages prepared in comparative example 1.1, comparative example 1.2 and comparative example 1.3 was observed. The results were similar to those in group D above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 2.1 is provided, which is distinguished from example 3 in that the blood orange powder of the invention is replaced by a Hejiang extract, the yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 2.2 is provided, which is distinguished from example 3 by the following: the roxburgh rose powder is replaced by acerola cherry fruit powder, and the blood orange powder is replaced by a black ginger extract;
comparative example 2.3 is provided, which is distinguished from example 3 in that the roxburgh rose powder of the invention is replaced by acerola powder, yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 2.4 is provided, which comparative example 2.4 differs from example 3 in that: the gamma-aminobutyric acid is replaced by wild jujube kernel powder, and the blood orange powder is replaced by a black ginger extract;
comparative example 2.5 is provided, which is distinguished from example 3 in that gamma-aminobutyric acid according to the present invention is replaced with spina date seed powder, yeast β -glucan is replaced with chitosan oligosaccharide;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The stability of the sleep-aiding solid beverages prepared in comparative example 2.1, comparative example 2.2, comparative example 2.3, comparative example 2.4, and comparative example 2.5 was observed. The results were similar to those in group E above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 3.1 is provided, which is distinguished from example 3 in that the Rosa roxburghii powder of the invention is replaced by acerola powder, gamma-aminobutyric acid is replaced by spina date seed powder, yeast β -glucan is replaced by chitosan oligosaccharide;
comparative example 3.2 is provided, which is distinguished from example 3 in that the roxburgh rose powder of the invention is replaced by acerola powder, the blood orange powder by a black ginger extract, the yeast β -glucan by chitosan oligosaccharide;
comparative example 3.3 is provided, which is distinguished from example 3 in that gamma-aminobutyric acid according to the present invention is replaced with spine date seed powder, blood orange powder is replaced with black ginger extract, yeast β -glucan is replaced with chitosan oligosaccharide;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The stability of the sleep-aiding solid beverages prepared in comparative example 3.1, comparative example 3.2, and comparative example 3.3 was observed. The results were similar to those in group F above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 7.1 is provided, which is distinguished from example 3 by the following: adjusting the mass part of the blood orange powder to 0.2 part;
comparative example 7.2 is provided, which is different from example 3 in that the mass part of yeast β -glucan is adjusted to 0.4 part;
comparative example 7.3 is provided, which comparative example 7.3 differs from example 3 in that: adjusting the mass part of the gamma-aminobutyric acid to 0.1 part;
comparative example 7.4 is provided, which is distinguished from example 3 by the following: adjusting the mass part of xanthan gum to 0.1 part;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The stability of the sleep-aiding solid beverages prepared in comparative example 7.1, comparative example 7.2, comparative example 7.3, and comparative example 7.4 was observed. The results were similar to those in group J above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 8.1 is provided, which comparative example 8.1 differs from example 3 in that: adjusting the mass part of the blood orange powder to 0.5 part;
comparative example 8.2 is provided, which is different from example 3 in that the mass part of yeast β -glucan is adjusted to 0.6 part;
comparative example 8.3 is provided, which comparative example 8.3 differs from example 3 in that: adjusting the mass part of the gamma-aminobutyric acid to 0.3 part;
comparative example 8.4 is provided, which comparative example 8.4 differs from example 3 in that: adjusting the mass part of xanthan gum to 0.4 part;
the sleep-aiding solid beverage prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The stability of the sleep-aiding solid beverages prepared in comparative example 8.1, comparative example 8.2, comparative example 8.3, and comparative example 8.4 was observed. The results were similar to those in the K group described above.
It is to be understood that the invention disclosed is not limited to the particular methodology, protocols, and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.
Those skilled in the art will also recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.
Claims (10)
1. A sleep-aiding solid beverage, wherein the beverage comprises roxburgh rose powder, blood orange powder, yeast β -glucan, gamma-aminobutyric acid and xanthan gum.
2. The beverage of claim 1, wherein the roxburgh rose powder is 7-9 parts by mass.
3. The beverage as claimed in claim 1, wherein the blood orange powder is 0.25-0.35 part by weight.
4. The beverage according to claim 1, wherein the yeast β -glucan is 0.48 to 0.53 parts by mass.
5. The beverage according to claim 1, wherein the gamma-aminobutyric acid is present in an amount of 0.18 to 0.22 parts by mass.
6. The beverage according to claim 1, wherein the xanthan gum is present in an amount of 0.2 to 0.3 parts by mass.
7. The sleep-aiding solid beverage comprises the following components in parts by weight:
7-9 parts of roxburgh rose powder, 0.25-0.35 part of blood orange powder, 0.48-0.53 part of yeast β -glucan, 0.18-0.22 part of gamma-aminobutyric acid and 0.2-0.3 part of xanthan gum.
8. The sleep-aiding solid beverage comprises the following components in parts by weight:
8 parts of roxburgh rose powder, 0.3 part of blood orange powder, 0.5 part of yeast β -glucan, 0.2 part of gamma-aminobutyric acid and 0.25 part of xanthan gum.
9. A sleep-aiding food product, wherein the food product comprises the beverage according to any one of claims 1 to 8.
10. Use of a beverage according to any one of claims 1 to 8 in the preparation of a sleep-aid food.
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| CN116098255A (en) * | 2022-12-28 | 2023-05-12 | 民强(昆山)食品科技有限公司 | Beverage before sleeping and preparation method thereof |
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| CN116098255A (en) * | 2022-12-28 | 2023-05-12 | 民强(昆山)食品科技有限公司 | Beverage before sleeping and preparation method thereof |
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