CN110916001A - Feed additive for preventing and controlling foot and limb diseases of barn-fed sheep and preparation method thereof - Google Patents
Feed additive for preventing and controlling foot and limb diseases of barn-fed sheep and preparation method thereof Download PDFInfo
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- CN110916001A CN110916001A CN201911278186.6A CN201911278186A CN110916001A CN 110916001 A CN110916001 A CN 110916001A CN 201911278186 A CN201911278186 A CN 201911278186A CN 110916001 A CN110916001 A CN 110916001A
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- rumen bypass
- vitamin
- premix
- methionine
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- 241001494479 Pecora Species 0.000 title claims abstract description 31
- 201000010099 disease Diseases 0.000 title claims abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 15
- 239000003674 animal food additive Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 210000004767 rumen Anatomy 0.000 claims abstract description 88
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 61
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 60
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- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 32
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 32
- 239000011710 vitamin D Substances 0.000 claims abstract description 32
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 32
- 229940046008 vitamin d Drugs 0.000 claims abstract description 32
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- 229930003427 Vitamin E Natural products 0.000 claims abstract description 30
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 30
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- 239000011709 vitamin E Substances 0.000 claims abstract description 30
- JZCAHRHZFBBFRZ-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;copper Chemical compound [Cu].CSCC[C@H](N)C(O)=O JZCAHRHZFBBFRZ-WCCKRBBISA-N 0.000 claims abstract description 24
- 229940110280 zinc methionine Drugs 0.000 claims abstract description 24
- CNMFGFBWPBBGKX-SCGRZTRASA-L zinc;(2s)-2-amino-4-methylsulfanylbutanoate Chemical compound [Zn+2].CSCC[C@H](N)C([O-])=O.CSCC[C@H](N)C([O-])=O CNMFGFBWPBBGKX-SCGRZTRASA-L 0.000 claims abstract description 24
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- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 22
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 22
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 22
- 239000011719 vitamin A Substances 0.000 claims abstract description 22
- 210000000003 hoof Anatomy 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims description 38
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 20
- 229910052725 zinc Inorganic materials 0.000 claims description 10
- 239000011701 zinc Substances 0.000 claims description 10
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 9
- 239000010949 copper Substances 0.000 claims description 9
- 229910052802 copper Inorganic materials 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims 1
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- 229910052782 aluminium Inorganic materials 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- 230000037149 energy metabolism Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- 208000010444 Acidosis Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102000055007 Cartilage Oligomeric Matrix Human genes 0.000 description 1
- 101710176668 Cartilage oligomeric matrix protein Proteins 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
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- 108010035532 Collagen Proteins 0.000 description 1
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- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000085 cashmere Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 238000006243 chemical reaction Methods 0.000 description 1
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- 235000021316 daily nutritional intake Nutrition 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 208000030175 lameness Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000006825 purine synthesis Effects 0.000 description 1
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- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- TUGDLVFMIQZYPA-UHFFFAOYSA-N tetracopper;tetrazinc Chemical compound [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2] TUGDLVFMIQZYPA-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A feed additive for preventing and controlling limb and foot diseases of barn feeding sheep and a preparation method thereof relate to a feed additive capable of preventing and controlling limb and foot diseases of barn feeding sheep and a preparation method thereof. The invention mainly aims to solve the problem that the comprehensive breeding benefit of barn-fed sheep is reduced because the barn-fed sheep is susceptible to hoof and limb diseases of the barn-fed sheep at present. The feed is composed of zinc methionine, copper methionine, rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and corncob powder. The preparation method comprises the following steps: zinc methionine, copper methionine and 20% of the total amount of the corncob meal are mixed to form premix A. And mixing a premix obtained by premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10 percent of the total amount of the corncob meal with 20 percent of the total amount of the corncob meal to form a premix B. And mixing the premix A, the premix B and the rest corncob meal. Has the advantages of reducing the level of the limb injury marker and preventing the foot and limb diseases of barn-fed sheep.
Description
Technical Field
The invention relates to a feed additive capable of preventing and controlling limb and foot diseases of barn feeding sheep and a preparation method thereof.
Background
At present, house feeding and captive breeding become a main production mode in sheep raising production, compared with grazing or semi-house feeding, the quantity of exercise of sheep raised in house feeding and captive breeding is reduced, the types of feed for daily food intake are reduced, and the supply of energy, protein and micronutrients is unbalanced, so that the acropodopathy or even acidosis of house feeding sheep is caused, which is represented as the arthrocele and inflammation of sheep, the joint is stiff and can not stand and walk seriously, the hoof clamp is skewed inside and outside, the split is abnormal, the hoof crown is enlarged or even the hoof shell falls off, and the feeding and the activity of sheep are influenced. In production, the ram can not normally collect and breed, the ewe can not normally breed and feed, the recessive economic loss of breeding is large, and the comprehensive breeding benefit of barn feeding sheep is reduced.
Disclosure of Invention
The invention aims to solve the technical problem of providing a feed additive for preventing and controlling foot and limb diseases of barn feeding sheep and a preparation method thereof. The additive can regulate and control the protein metabolism, energy metabolism and lipid metabolism of the barn-fed sheep, improve the oxidation resistance of the barn-fed sheep, and reduce the level of the limb injury marker, thereby achieving the purpose of preventing the hoof and limb diseases of the barn-fed sheep.
The above object is achieved by: it consists of the following nutrients: zinc methionine, copper methionine, rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and corncob powder.
Wherein zinc methionine accounts for 3.0-17.14% of the total weight, copper methionine accounts for 3.0-4.0% of the total weight, rumen bypass vitamin A accounts for 0.2-0.4% of the total weight, rumen bypass vitamin D accounts for 0.16-0.2% of the total weight, rumen bypass vitamin E accounts for 0.24-0.4% of the total weight, rumen bypass biotin accounts for 4.0-6.0% of the total weight, and corn cob powder accounts for 89.4-71.86% of the total weight.
The preparation method comprises the following steps: selecting zinc methionine with the zinc content of 17.1%, copper methionine with the copper content of 15%, rumen bypass vitamin A with the vitamin A content of 50 ten thousand international units per gram, rumen bypass vitamin D with the vitamin D content of 50 ten thousand international units per gram, rumen bypass vitamin E with the vitamin E content of 50%, rumen bypass biotin with the biotin content of 1% and high-quality corncob powder, and accurately weighing the components in proportion.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal. Subpackaging with aluminum foil bags with aluminum matte plated inside, each bag 5g, sealing, and storing in shade at 4-15 deg.C. The usage and dosage are as follows: the feed additive is mixed in concentrated feed according to the amount of 5 grams per day for each sheep to feed.
The invention has the advantages that: zinc has a key effect on the formation of animal hoof cutin, and zinc regulates the carbohydrate metabolism process of animals by influencing the synthesis, storage and release of insulin; zinc and copper are components of various enzymes (such as SOD) in animal bodies, play an important role in eliminating free radicals, protecting cell membranes from oxidative damage and the like, and improve the oxidation resistance of the bodies. Zinc methionine and copper methionine are organic trace elements, and have high absorption efficiency in small intestine, safety and no pollution. The vitamin A, the vitamin D and the vitamin E play a role in maintaining the integrity of cells, promoting the transportation and absorption of calcium and enhancing the oxidation resistance of tissues, thereby preventing the knee joint and hoof diseases of barn feeding sheep. Biotin, also called coenzyme R, is a coenzyme for many carboxylases and kinases, and plays a role in reducing the occurrence of acropodopathy by influencing the biological reactions of carbohydrate, lipid and protein metabolism, purine synthesis and the like. The rumen bypass vitamin can pass through the rumen of sheep without being damaged by microorganisms, can completely reach the small intestine and can be efficiently absorbed and utilized. Therefore, the additive can regulate and control the protein metabolism, the energy metabolism and the lipid metabolism of the barn feeding sheep, improve the oxidation resistance of the barn feeding sheep, reduce the level of the limb injury marker and achieve the purpose of preventing the hoof and limb diseases of the barn feeding sheep.
Application effect test data: 20 Liaoning cashmere goat ewes aged 3.80 + -0.25 years and weighed 40.52 + -1.65 kg were selected and randomly divided into two groups of 10 animals with the same feed. The test sheep are the sheep with limb and hoof diseases, and are manifested by symptoms of limb and hoof diseases such as knee joint swelling, lameness, hoof swelling, hoof clamp eversion and the like. The feed additive is added into the feed by 5g for each test group every day, the control group is not added, and after the test group is fed for 75 days, the test group results show that compared with the control group results through detection: the nitrogen metabolism efficiency is improved, and the serum urea level acid is reduced by 16.78%, and the urea nitrogen level is reduced by 34.98%. The oxidation resistance of the organism is improved, which is shown in that the activity of the serum glutathione peroxidase is improved by 23.46 percent; the catalase activity is improved by 30 percent, and the copper-zinc superoxide dismutase activity is improved by 84.75 percent. The limb health level is improved, and the serum limb hoof injury marker cartilage oligomeric matrix protein is reduced by 10.53%, the carboxyl terminal telopeptide of type II collagen is reduced by 18.19%, and the amino terminal telopeptide of type II A collagen is reduced by 15.78%. The symptom of the acromelic disease is obviously improved, and the recovery ratio of the symptom of the acromelic disease in the experimental group is improved by 41.74 percent.
Detailed Description
It consists of the following nutrients: zinc methionine, copper methionine, rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and corncob powder.
Wherein zinc methionine accounts for 3.0-17.14% of the total weight of the material, copper methionine accounts for 3.0-4.0% of the total weight of the material, rumen bypass vitamin A accounts for 0.2-0.4% of the total weight of the material, rumen bypass vitamin D accounts for 0.16-0.2% of the total weight of the material, rumen bypass vitamin E accounts for 0.24-0.4% of the total weight of the material, rumen bypass biotin accounts for 4.0-6.0% of the total weight of the material, and corncob powder accounts for 89.4-71.86% of the total weight of the material.
The preparation method comprises the following steps: selecting zinc methionine with the zinc content of 17.1%, copper methionine with the copper content of 15%, rumen bypass vitamin A with the vitamin A content of 50 ten thousand international units per gram, rumen bypass vitamin D with the vitamin D content of 50 ten thousand international units per gram, rumen bypass vitamin E with the vitamin E content of 50%, rumen bypass biotin with the biotin content of 1% and high-quality corncob powder, and accurately weighing the components in proportion.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal. Subpackaging with aluminum foil bags with aluminum matte plated inside, each bag 5g, sealing, and storing in shade at 4-15 deg.C. The usage and dosage are as follows: the feed additive is mixed in concentrated feed according to the amount of 5 grams per day for each sheep to feed.
Example 1, zinc methionine with a zinc content of 17.1% in an amount of 3% by weight of the total material, copper methionine with a copper content of 15% in an amount of 3.5% by weight of the total material, rumen bypass vitamin a with a vitamin a content of 50 ten thousand international units per gram in an amount of 0.4% by weight of the total material, rumen bypass vitamin D with a vitamin D content of 50 ten thousand international units per gram in an amount of 0.18% by weight of the total material, rumen bypass vitamin E with a vitamin E content of 50% in an amount of 0.24% by weight of the total material, rumen bypass biotin with a biotin content of 1% in an amount of 4.5% by weight of the total material, and corn cob meal with an amount of 88.18% by weight of the total material are selected.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10 percent of the total weight of corncob powder uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal.
Example 2, zinc methionine with a zinc content of 17.1% in an amount of 9% by weight of the total material, copper methionine with a copper content of 15% in an amount of 3% by weight of the total material, rumen bypass vitamin a with a vitamin a content of 50 ten thousand international units per gram in an amount of 0.3% by weight of the total material, rumen bypass vitamin D with a vitamin D content of 50 ten thousand international units per gram in an amount of 0.16% by weight of the total material, rumen bypass vitamin E with a vitamin E content of 50% in an amount of 0.32% by weight of the total material, rumen bypass biotin with a biotin content of 1% in an amount of 5% by weight of the total material, and corncob meal with an amount of 82.22% by weight of the total material are selected.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal.
Example 3, zinc methionine with a zinc content of 17.1% in an amount of 3% by weight of the total material, copper methionine with a copper content of 15% in an amount of 3% by weight of the total material, rumen bypass vitamin a with a vitamin a content of 50 ten thousand international units per gram in an amount of 0.2% by weight of the total material, rumen bypass vitamin D with a vitamin D content of 50 ten thousand international units per gram in an amount of 0.16% by weight of the total material, rumen bypass vitamin E with a vitamin E content of 50% in an amount of 0.24% by weight of the total material, rumen bypass biotin with a biotin content of 1% in an amount of 4% by weight of the total material, and corncob meal with an amount of 89.4% by weight of the total material are selected.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal.
Example 4, zinc methionine with 17.1% zinc content, copper methionine with 15% copper content, copper methionine with 4% copper content, rumen bypass vitamin a with 50 ten thousand international units per gram, vitamin D with 50 ten thousand international units per gram, rumen bypass vitamin D with 0.2% vitamin D content, 50% vitamin E with 0.4% vitamin E content, 1% biotin content, 6% biotin content, and 71.86% corn cob meal are selected, wherein the zinc methionine content accounts for 17.14% of the total weight of the material, the vitamin a content accounts for 50% of the total weight of the material, and the vitamin a content accounts for 50 ten thousand international units per gram, and the vitamin D content accounts for 0.4% of the total weight of the material.
Uniformly mixing the zinc methionine, the copper methionine and 20 percent of the total amount of the corncob meal to form premix A. Premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; and uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B.
And then uniformly mixing the premix A, the premix B and the residual corncob meal.
Claims (3)
1. A feed additive for preventing and controlling foot and limb diseases of barn feeding sheep and a preparation method thereof are characterized in that: consists of the following substances: zinc methionine, copper methionine, rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and corncob meal;
the preparation method comprises the following steps: uniformly mixing zinc methionine, copper methionine and 20 percent of the total amount of the corncob powder to form premix A;
premixing rumen bypass vitamin A, rumen bypass vitamin D, rumen bypass vitamin E, rumen bypass biotin and 10% of the total amount of corncob meal uniformly to obtain a premix; uniformly mixing the premix with 20 percent of the total amount of the corncob meal to form a premix B;
and uniformly mixing the premix A, the premix B and the rest corncob powder.
2. The feed additive for preventing and controlling hoof and limb diseases of barn feeding sheep as claimed in claim 1, and the preparation method thereof, wherein the feed additive comprises the following components: wherein zinc methionine accounts for 3.0-17.14% of the total weight of the material, copper methionine accounts for 3.0-4.0% of the total weight of the material, rumen bypass vitamin A accounts for 0.2-0.4% of the total weight of the material, rumen bypass vitamin D accounts for 0.16-0.2% of the total weight of the material, rumen bypass vitamin E accounts for 0.24-0.4% of the total weight of the material, rumen bypass biotin accounts for 4.0-6.0% of the total weight of the material, and corncob powder accounts for 89.4-71.86% of the total weight of the material.
3. The feed additive for preventing and controlling foot and limb diseases of barn feeding sheep and the preparation method thereof according to claim 1 or 2, wherein the feed additive comprises the following components: the zinc content of the zinc methionine is 17.1%, the copper content of the copper methionine is 15%, the vitamin A content of the rumen bypass vitamin A is 50 ten thousand international units per gram, the vitamin D content of the rumen bypass vitamin D is 50 ten thousand international units per gram, the vitamin E content of the rumen bypass vitamin E is 50%, and the biotin content of the rumen bypass biotin is 1%.
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