CN110893126B - Bipolar electric coagulation forceps of encephalic model for experimental animal and preparation method thereof - Google Patents

Bipolar electric coagulation forceps of encephalic model for experimental animal and preparation method thereof Download PDF

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CN110893126B
CN110893126B CN201911309437.2A CN201911309437A CN110893126B CN 110893126 B CN110893126 B CN 110893126B CN 201911309437 A CN201911309437 A CN 201911309437A CN 110893126 B CN110893126 B CN 110893126B
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forceps
rod
forceps rod
bipolar
net
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CN110893126A (en
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徐隋意
李常新
吴晓巍
李羚
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Shanxi Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to the technical field of preparation of medical animal experimental instruments, in particular to bipolar electric coagulation forceps of a brain model for experimental animals and a preparation method thereof. The preparation method is simple, can be additionally used on various known bipolar coagulation forceps structures, and is beneficial to specific experimental application.

Description

Bipolar electric coagulation forceps of encephalic model for experimental animal and preparation method thereof
Technical Field
The invention relates to the technical field of preparation of medical animal experimental instruments, in particular to bipolar electric coagulation forceps of a encephalaceae model for experimental animals and a preparation method thereof.
Background
Bipolar electrocoagulation was used as early as 1940 and was applied to microsurgery in 1966 by yasarginl for discharge coagulation of microvessels. The working principle is that the electric coagulation device is connected to an electric coagulation device host machine through a forceps wire, the sharp end of the forceps clamps a bleeding opening, the electric coagulation device releases current, a loop is formed between the two forceps points, high-frequency electric energy is provided for lesion tissue, and blood vessels between the two ends of the bipolar forceps are dehydrated, denatured and coagulated. Because the current only flows between the two forceps tips, the forceps can not burn other parts, and is very suitable for various microsurgery operations. Under the condition of normal saline, blood and cerebrospinal fluid, the hemostatic effect can still be achieved.
Because the electric coagulation is carried out at the tip part of the electric coagulation forceps, the electric conduction and heat dissipation effects of the forceps tip are very critical, the existing electric coagulation forceps have the support property and the elasticity requirement of the holding end in order to ensure the heat conduction and the electric conduction of the tip, and therefore, the forceps body is made of metal and mainly made of stainless steel, brass or titanium alloy. The left forceps piece and the right forceps piece are fixedly sprayed with insulating resin after being formed, the traditional manufacturing process is old, the process is complex, manual production is difficult, the production period is long, and the quality is uncontrollable.
In the current blood coagulation process of neurosurgery, when using traditional electric coagulation forceps, the tissue after blood coagulation can stick on the forceps tip in the blood coagulation process, when removing the forceps, the tissue that just completes blood coagulation can be damaged again, whether the adhesion is direct to be concerned with the quality of operation effect. The bipolar coagulation forceps in the market at present comprise disposable bipolar coagulation forceps and reusable bipolar coagulation forceps, and the problem of adhesion of the forceps and human tissues in the operation process exists. At present, the adhesion is reduced by a silver coating method in the prior art, but the silver coating can fall off and generate adhesive eschar after a long time.
For example, CN103393466A in the prior art discloses a non-adhesive bipolar coagulation forceps, which comprises a left forceps rod, a right forceps rod, and a forceps tip fixed on the head of the forceps rod, wherein a wire groove is formed in the inner side of the forceps rod, a conductive wire is arranged in the wire groove, the conductive wire is a hollow copper tube, one end of the conductive wire is fixedly connected with the forceps tip, the other end of the conductive wire is connected with a wire for connecting a main machine of the coagulation device, and a drip tube interface connected with medical water delivery equipment is arranged. The conductive wire can be used for conducting electricity and can also be used as a water dropping pipe, and the conductive wire has a simple structure and lower cost. Meanwhile, the forceps tip is made of integral silver alloy. The technical scheme relates to the reconstruction of structures and materials, and not only has complex process, but also has high cost.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide the bipolar electric coagulation forceps of the brain model for the experimental animal and the preparation method thereof. Lays a foundation for the clinical transformation application in the future.
In order to realize the purpose of the invention, the technical scheme of the invention is as follows:
the bipolar electric coagulation forceps of the encephalic model for the experimental animal comprises a left forceps rod, a right forceps rod and a forceps tip fixed to the head of the forceps rod, and is characterized in that more than one forceps rod to forceps tip mesh disc structure is arranged between the left forceps rod and the right forceps rod or outside the forceps rods.
The reticular disc structure not only can be used as a buffer part between the forceps rods, but also contains more than one anticoagulant or vascular smooth muscle cell proliferation inhibition drug, can solve the problems of adhesion and the like, and has good biocompatibility.
As a preferable technical scheme of the invention, the reticular disc structure is woven by nickel-titanium alloy metal wire materials. The material has a certain shape memory function, can be expanded into a net structure under stress, and meanwhile, the net structure can be used as a medicine storage, and compared with other structure shapes and a traditional punching mode, the net structure has obvious advantages in the application of the invention.
In a preferred embodiment of the present invention, the mesh-like disk structure is coated or embedded with one or more anticoagulant drugs or vascular smooth muscle cell proliferation inhibitor drugs.
Wherein, the anticoagulant drugs comprise heparin and derivatives thereof;
the drugs for inhibiting vascular smooth muscle cell proliferation include rapamycin, everolimus, tacrolimus and the like.
The drug may be coated with one or more biocompatible carriers selected from one or more of polyglycolic acid (PGA), polylactic acid (PLA), L-polylactic acid (PLLA), Polycaprolactone (PCL), Polycyanoacrylate (PACA), polydioxanone, polyanhydrides, polyphosphazenes, amino acid polymers, poly-hydroxybutyrate and hydroxyvalerate, and copolymers thereof.
As a preferred technical scheme of the invention, more than two forceps rods to forceps tip reticular disc structures are arranged between the left forceps rod and the right forceps rod and are simultaneously positioned on the left forceps rod or the right forceps rod or are respectively positioned on the left forceps rod and the right forceps rod, and preferably, the two reticular disc structures are respectively positioned at different positions on the forceps rods. Therefore, the balance of the left forceps rod and the right forceps rod can be kept, and the mutual influence between the mesh disc structures can be avoided.
As a preferred technical scheme of the invention, more than two forceps rod to forceps tip net-shaped disc structures are arranged on the outer sides of the left forceps rod and the right forceps rod and are respectively positioned on the outer sides of the left forceps rod and the right forceps rod, and the two net-shaped disc structures are respectively positioned at the same position on the forceps rods. Therefore, the support not only can be used as the support of the inner wall of a blood vessel or tissue, but also can avoid the adhesion of instruments in the operation process, and can be taken out quickly and harmlessly after the operation.
As a preferred technical scheme of the invention, the forceps tips are provided with the connected water dripping pipe interfaces, so that cooling water can flow out from the water outlet when the forceps are used, the operation part is cooled, and the bipolar coagulation and the tissue of the operation part are effectively prevented from being adhered.
As a preferable technical scheme of the invention, the outer sides of the middle rear parts of the left forceps rod and the right forceps rod are provided with anti-skidding structures, so that the stability of the operation is ensured, and the misoperation is reduced.
The invention also aims to provide a preparation method of the bipolar electric coagulation forceps of the encephalic model for experimental animals, which comprises the following steps:
(1) weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure;
(2) and welding the mesh-shaped disc structure on a forceps rod of the bipolar coagulation forceps.
The preparation method is simple, can be additionally used on various known bipolar coagulation forceps structures, and is beneficial to specific experimental application.
Compared with the prior art, the invention has the beneficial effects that:
the bipolar coagulation forceps are provided with the reticular disc structure with a novel structure, the reticular disc structure is formed by weaving nickel-titanium alloy metal wire materials, can be expanded into a reticular structure under stress, can be used as a buffer part between forceps rods, can be used as a medicine storage tank, contains more than one anticoagulant or vascular smooth muscle cell proliferation inhibition medicine, can solve the problems of adhesion and the like, and has good biocompatibility, and meanwhile, compared with other structural shapes and the traditional punching mode, the reticular structure has obvious advantages in the application of the bipolar coagulation forceps.
The mesh disc structures are arranged in an alignment and staggered mode in the optimal structure of the bipolar electric coagulation forceps, so that the balance of the left forceps rod and the right forceps rod can be kept, and the mutual influence between the mesh disc structures is avoided; can also be used as the support of the inner wall of a blood vessel or tissue, avoids the adhesion of instruments in the operation process, and can be taken out quickly and harmlessly after the operation.
The preparation method is simple, and the mesh disc structure can be added to various known bipolar coagulation forceps structures for use, thereby being beneficial to specific experimental application.
Drawings
FIG. 1 is a schematic structural diagram of a traditional brain model bipolar coagulation forceps for experimental animals.
FIG. 2 is a schematic structural diagram of bipolar electric coagulation forceps of a brain model for experimental animals.
FIG. 3 is a schematic structural diagram of bipolar electric coagulation forceps of another brain model for experimental animals according to the present invention.
Fig. 4 is a schematic structural diagram of a mesh-shaped disc structure of the bipolar coagulation forceps of the present invention.
Wherein, the 1-bipolar electric coagulation forceps and the 2-reticular disk structure are arranged in the electric coagulation forceps.
Detailed Description
The present invention will be described in further detail with reference to examples and drawings, but the embodiments of the invention are not limited thereto.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1
Referring to fig. 2 and 4:
the bipolar electric coagulation forceps of the brain model for the experimental animal comprises a left forceps rod, a right forceps rod and a forceps tip fixed at the head of the forceps rod, and is characterized in that a mesh disc structure from the forceps rod to the forceps tip is arranged between the left forceps rod and the right forceps rod or outside the forceps rods.
The reticular disc structure is formed by weaving a nickel-titanium alloy metal wire material, and an anticoagulant drug is coated on or arranged in the reticular disc structure, wherein the anticoagulant drug is heparin and the like; the drug is coated with a biocompatible carrier selected from L-polylactic acid (PLLA).
The preparation method specifically comprises the following steps: weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure; then the reticular disc structure is welded on the forceps rod of the bipolar electric coagulation forceps, and then the medicine is coated.
Example 2
Referring to fig. 3 and 4:
the bipolar electric coagulation forceps of the brain model for the experimental animal comprises a left forceps rod, a right forceps rod and a forceps tip fixed at the head of the forceps rod, and is characterized in that a mesh disc structure from the forceps rod to the forceps tip is arranged between the left forceps rod and the right forceps rod or outside the forceps rods.
The reticular disc structure is formed by weaving a nickel-titanium alloy metal wire material, and an anticoagulant drug is coated on or arranged in the reticular disc structure, wherein the anticoagulant drug is heparin and the like; the drug is coated with a biocompatible carrier selected from polyglycolic acid (PGA).
The preparation method specifically comprises the following steps: weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure; then the reticular disc structure is welded on the forceps rod of the bipolar electric coagulation forceps, and then the medicine is coated.
Example 3
Referring to fig. 2, 3 and 4:
the bipolar electric coagulation forceps for the brain model for the experimental animal comprises a left forceps rod, a right forceps rod and forceps tips fixed to the heads of the forceps rods, and is characterized in that two forceps rod-to-forceps tip mesh disc structures are arranged between the left forceps rod and the right forceps rod or on the outer sides of the forceps rods and are respectively located on the left forceps rod and the right forceps rod, and the two mesh disc structures are respectively located at different positions on the forceps rods.
The reticular disc structure is formed by weaving a nickel-titanium alloy metal wire material, and an anticoagulant drug is coated on or arranged in the reticular disc structure, wherein the anticoagulant drug is heparin and the like; the drug is coated with a biocompatible carrier selected from L-polylactic acid (PLLA).
The preparation method specifically comprises the following steps: weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure; then the reticular disc structure is welded on the forceps rod of the bipolar electric coagulation forceps, and then the medicine is coated.
Example 4
Referring to fig. 2, 3 and 4:
the bipolar electric coagulation forceps for the brain model for the experimental animal comprises a left forceps rod, a right forceps rod and forceps tips fixed to the heads of the forceps rods, and is characterized in that more than two forceps rods to forceps tip mesh disc structures are arranged on the outer sides of the left forceps rod and the right forceps rod and are respectively located on the left forceps rod and the right forceps rod, and the two mesh disc structures are respectively located at the same position on the forceps rods.
The reticular disc structure is formed by weaving a nickel-titanium alloy metal wire material, and an anticoagulant drug is coated on or arranged in the reticular disc structure, wherein the anticoagulant drug is heparin and the like; the drug is coated with a biocompatible carrier selected from L-polylactic acid (PLLA).
The preparation method specifically comprises the following steps: weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure; then the reticular disc structure is welded on the forceps rod of the bipolar electric coagulation forceps, and then the medicine is coated.
Example 5
Referring to fig. 2, 3 and 4:
the bipolar electric coagulation forceps for the brain model for the experimental animal comprises a left forceps rod, a right forceps rod and forceps tips fixed to the heads of the forceps rods, and is characterized in that two forceps rod-to-forceps tip mesh disc structures are arranged between the left forceps rod and the right forceps rod or on the outer sides of the forceps rods and are respectively located on the left forceps rod and the right forceps rod, and the two mesh disc structures are respectively located at different positions on the forceps rods. And more than two forceps rods to forceps tip net-shaped disc structures are arranged on the outer sides of the left forceps rod and the right forceps rod and are respectively positioned on the left forceps rod and the right forceps rod, and the two net-shaped disc structures are respectively positioned at the same position on the forceps rods.
The reticular disc structure is formed by weaving a nickel-titanium alloy metal wire material, and an anticoagulant drug is coated on or arranged in the reticular disc structure, wherein the anticoagulant drug is heparin and the like; the drug is coated with a biocompatible carrier selected from L-polylactic acid (PLLA).
The preparation method specifically comprises the following steps: weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure; then the reticular disc structure is welded on the forceps rod of the bipolar electric coagulation forceps, and then the medicine is coated.
Example 6
On the basis of the embodiment 5, the forceps tips are provided with the connected drip tube interfaces.
Example 7
On the basis of the embodiment 6, the forceps tips are provided with the connected drip tube interfaces.
Example 8
5 rats are taken, bipolar coagulation forceps operation is simulated, the bipolar coagulation forceps of the embodiment 7 are adopted, no adhesion exists in the experimental process, and no blood vessel or tissue damage is caused in the operation process. Greatly reduces the adhesion times of the traditional bipolar coagulation forceps in the using process.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (4)

1. The bipolar electric coagulation forceps of the encephalic model for the experimental animal is characterized by comprising a left forceps rod, a right forceps rod and a forceps tip fixed at the head of the forceps rod, and is characterized in that more than one forceps rod to forceps tip net-shaped disc structures are arranged between the left forceps rod and the right forceps rod and outside the forceps rods;
the reticular disc structure is woven by nickel-titanium alloy metal wire materials;
the reticular disc structure is coated or internally provided with more than one anticoagulant or vascular smooth muscle cell proliferation inhibition drug;
more than two forceps rods to forceps tip net-shaped disc structures are arranged between the left forceps rod and the right forceps rod and are positioned on the left forceps rod or the right forceps rod simultaneously or respectively, and the two net-shaped disc structures are positioned at different positions on the forceps rods respectively;
more than two forceps rod to forceps tip net-shaped disc structures are arranged on the outer sides of the left forceps rod and the right forceps rod and are respectively located on the outer sides of the left forceps rod and the right forceps rod, and the two net-shaped disc structures are respectively located on the same positions of the forceps rods.
2. The bipolar electric coagulation forceps of the brain model for the experimental animal as claimed in claim 1, wherein the forceps tips are provided with a connected drip tube interface.
3. The bipolar electric coagulation forceps of the experimental animal brain model, according to claim 1, characterized in that the outer sides of the middle and rear parts of the left and right forceps rods are provided with anti-slip structures.
4. A method for preparing bipolar coagulation forceps of a brain model for experimental animals according to any one of claims 1 to 3, comprising the following steps:
(1) weaving a nickel-titanium alloy metal wire material into a net-shaped disc structure;
(2) and welding the mesh-shaped disc structure on a forceps rod of the bipolar coagulation forceps.
CN201911309437.2A 2019-12-18 2019-12-18 Bipolar electric coagulation forceps of encephalic model for experimental animal and preparation method thereof Active CN110893126B (en)

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