CN110885454A - 基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 - Google Patents
基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 Download PDFInfo
- Publication number
- CN110885454A CN110885454A CN201811058830.4A CN201811058830A CN110885454A CN 110885454 A CN110885454 A CN 110885454A CN 201811058830 A CN201811058830 A CN 201811058830A CN 110885454 A CN110885454 A CN 110885454A
- Authority
- CN
- China
- Prior art keywords
- acrylamide
- acryloyl
- naaa
- heaa
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SBVKVAIECGDBTC-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanamide Chemical compound NC(=O)C(=C)CCO SBVKVAIECGDBTC-UHFFFAOYSA-N 0.000 title claims abstract description 159
- 239000000017 hydrogel Substances 0.000 title claims abstract description 75
- CHDKQNHKDMEASZ-UHFFFAOYSA-N n-prop-2-enoylprop-2-enamide Chemical compound C=CC(=O)NC(=O)C=C CHDKQNHKDMEASZ-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 101000958771 Homo sapiens N-acylethanolamine-hydrolyzing acid amidase Proteins 0.000 claims abstract description 72
- 102100038360 N-acylethanolamine-hydrolyzing acid amidase Human genes 0.000 claims abstract description 72
- 238000004132 cross linking Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 74
- 239000000243 solution Substances 0.000 claims description 65
- 239000011259 mixed solution Substances 0.000 claims description 50
- 238000006243 chemical reaction Methods 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- 101000655609 Streptomyces azureus Thiostrepton Proteins 0.000 claims description 34
- -1 acryloyl alaninamide Chemical compound 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 25
- 229910021641 deionized water Inorganic materials 0.000 claims description 25
- 238000005406 washing Methods 0.000 claims description 23
- FIAINKIUSZGVGX-DKWTVANSSA-N [(2s)-1-amino-1-oxopropan-2-yl]azanium;chloride Chemical compound Cl.C[C@H](N)C(N)=O FIAINKIUSZGVGX-DKWTVANSSA-N 0.000 claims description 15
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000007787 solid Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 239000012046 mixed solvent Substances 0.000 claims description 12
- 238000004108 freeze drying Methods 0.000 claims description 11
- 238000002390 rotary evaporation Methods 0.000 claims description 11
- 230000035484 reaction time Effects 0.000 claims description 3
- LOMQSVCSHVEDEB-UHFFFAOYSA-N CC(C(=O)C=C)C(=O)N Chemical compound CC(C(=O)C=C)C(=O)N LOMQSVCSHVEDEB-UHFFFAOYSA-N 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 4
- 239000001257 hydrogen Substances 0.000 abstract description 4
- 239000003431 cross linking reagent Substances 0.000 abstract description 2
- 239000000178 monomer Substances 0.000 abstract description 2
- 238000006116 polymerization reaction Methods 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 9
- 238000005286 illumination Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- PITFZUFGCRDZKQ-UHFFFAOYSA-N 6-aminohex-1-en-3-one Chemical compound NCCCC(=O)C=C PITFZUFGCRDZKQ-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2333/24—Homopolymers or copolymers of amides or imides
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811058830.4A CN110885454B (zh) | 2018-09-11 | 2018-09-11 | 基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811058830.4A CN110885454B (zh) | 2018-09-11 | 2018-09-11 | 基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110885454A true CN110885454A (zh) | 2020-03-17 |
CN110885454B CN110885454B (zh) | 2021-10-08 |
Family
ID=69745640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811058830.4A Active CN110885454B (zh) | 2018-09-11 | 2018-09-11 | 基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110885454B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113527714A (zh) * | 2021-06-03 | 2021-10-22 | 湖南工业大学 | 一种抗冻导电水凝胶及其制备方法和力响应传感应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110118380A1 (en) * | 2009-11-19 | 2011-05-19 | Ivoclar Vivadent Ag | Filled Dental Material Based on Polymerizable Dihydroxy-Phenylalanine Derivatives |
CN102936300A (zh) * | 2012-10-29 | 2013-02-20 | 天津大学 | 一种快速可控的制备水凝胶方法 |
CN104804115A (zh) * | 2015-04-21 | 2015-07-29 | 天津大学 | 一种高强度超分子水凝胶及其制备方法和应用 |
CN106866995A (zh) * | 2017-02-27 | 2017-06-20 | 江南大学 | 一种pnaga/pani自修复导电水凝胶的制备方法 |
CN108026217A (zh) * | 2015-07-20 | 2018-05-11 | 生命科技公司 | 聚合物颗粒 |
-
2018
- 2018-09-11 CN CN201811058830.4A patent/CN110885454B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110118380A1 (en) * | 2009-11-19 | 2011-05-19 | Ivoclar Vivadent Ag | Filled Dental Material Based on Polymerizable Dihydroxy-Phenylalanine Derivatives |
CN102936300A (zh) * | 2012-10-29 | 2013-02-20 | 天津大学 | 一种快速可控的制备水凝胶方法 |
CN104804115A (zh) * | 2015-04-21 | 2015-07-29 | 天津大学 | 一种高强度超分子水凝胶及其制备方法和应用 |
CN108026217A (zh) * | 2015-07-20 | 2018-05-11 | 生命科技公司 | 聚合物颗粒 |
CN106866995A (zh) * | 2017-02-27 | 2017-06-20 | 江南大学 | 一种pnaga/pani自修复导电水凝胶的制备方法 |
Non-Patent Citations (1)
Title |
---|
XIYANG DAI ET AL.: "A Mechanically Strong, Highly Stable, Thermoplastic, and Self-Healable Supramolecular Polymer Hydrogel", 《ADVANCED MATERIALS》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113527714A (zh) * | 2021-06-03 | 2021-10-22 | 湖南工业大学 | 一种抗冻导电水凝胶及其制备方法和力响应传感应用 |
CN113527714B (zh) * | 2021-06-03 | 2022-05-31 | 湖南工业大学 | 一种抗冻导电水凝胶及其制备方法和力响应传感应用 |
Also Published As
Publication number | Publication date |
---|---|
CN110885454B (zh) | 2021-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106633111B (zh) | 一种高强度聚乙烯醇基双网络水凝胶的制备方法 | |
CN105732999B (zh) | 高强度交联水凝胶和弹性体及其制备方法 | |
CA1056092A (en) | Water swellable poly (alkylene oxide) | |
Wang et al. | Preparation, swelling and water-retention properties of crosslinked superabsorbent hydrogels based on guar gum | |
CN107556423B (zh) | 双物理交联聚丙烯酸高强度、高韧性水凝胶的制备方法 | |
CN108484832B (zh) | 一种具有紫外、pH敏感的自愈合水凝胶的制备方法 | |
Gao et al. | Preparation and properties of a highly elastic galactomannan-poly (acrylamide-N, N-bis (acryloyl) cysteamine) hydrogel with reductive stimuli-responsive degradable properties | |
CN1974608A (zh) | 一种用电子束辐射聚合直接合成温敏性水凝胶的方法 | |
CN110885524A (zh) | 基于聚丙烯酰基甘氨酰胺和海藻酸钠的双网络水凝胶及其制备方法 | |
CN110885454B (zh) | 基于丙烯酰基丙氨酰胺和羟乙基丙烯酰胺的超分子水凝胶及其制备方法 | |
CN102977271A (zh) | 利用辉光放电电解等离子体引发聚合制备壳聚糖/丙烯酸复合材料的方法 | |
Selen et al. | Preparation of photodegradable polyacrylamide hydrogels via micellar copolymerization and determination of their phototunable elasticity and swelling behaviors | |
US9683070B2 (en) | Bio-based superabsorbents prepared via the macromonomer approach | |
Mutar et al. | Controlled release from crosslinked polyacrylic acid as drug delivery theophylline | |
Kalaleh et al. | Up-scalable synthesis of high porous superabsorbent polymer via alkaline hydrolysis of acrylamide using microwave irradiation: application in agriculture | |
CN111303348A (zh) | 一种光固化水性聚氨酯乳液及其制备方法和应用 | |
Felinto et al. | The swelling behavior of chitosan hydrogels membranes obtained by UV-and γ-radiation | |
CN113512131B (zh) | 一种多巴胺增强透明质酸凝胶及其制备方法和应用 | |
CN113185718A (zh) | 一种pH/温度双敏感型互穿网络水凝胶及其制备方法 | |
CN107857841A (zh) | 基于丙烯酰胺基甘氨酰胺的高强度共聚水凝胶及其制备方法 | |
CN110885391B (zh) | 基于双氢键的超分子水凝胶及其制备方法 | |
CN110734553A (zh) | 一种可降解高吸水树脂的制备方法 | |
Soleimani et al. | Preparation and swelling behavior of carrageenan-graft-polymethacrylamide superabsorbent hydrogel as a releasing drug system | |
CN113350572B (zh) | 一种医用温敏型水凝胶及其制备方法和应用 | |
Kalaleh et al. | Preparation of poly (sodium acrylate-co-acrylamide) superabsorbent copolymer via alkaline hydrolysis of acrylamide using microwave irradiation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: 300452 Binhai Industrial Research Institute Campus of Tianjin University, No. 48 Jialingjiang Road, Binhai New Area, Tianjin Patentee after: Tianjin University Address before: 300072 Tianjin City, Nankai District Wei Jin Road No. 92 Patentee before: Tianjin University |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20200317 Assignee: Tianjin Bihai Environmental Protection Technology Co.,Ltd. Assignor: Tianjin University Contract record no.: X2023120000009 Denomination of invention: Supramolecular hydrogel based on acrylamide and hydroxyethyl acrylamide and its preparation method Granted publication date: 20211008 License type: Common License Record date: 20230109 |