CN110882409A - Composite hydrophilic fiber dressing and preparation method thereof - Google Patents
Composite hydrophilic fiber dressing and preparation method thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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Abstract
The invention belongs to the field of medicines, and particularly relates to a composite hydrophilic fiber dressing and a preparation method thereof. The composite hydrophilic fiber dressing prepared by the invention consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive fabric coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 35-45 parts of calcium alginate fibers, 30-45 parts of oxidized bamboo fibers and 20-35 parts of sodium carboxymethyl cellulose fibers, wherein the mixture A comprises the following raw materials in parts by weight: 20-35 parts of carboxymethyl chitosan, 3-5 parts of poloxamer and 1-3 parts of peppermint oil. The dressing disclosed by the invention is simple in preparation method, has excellent mechanical properties and an antibacterial function, and solves the problem that the original bamboo fiber dressing can prick skin to cause itching of a patient.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a composite hydrophilic fiber dressing and a preparation method thereof.
Background
Alginate is the salt of alginic acid, is the polymer of anhydrous D-mannuronic acid, has high hydrophilicity, and many clinical tests prove that the medical dressing prepared from the alginate not only has good hygroscopicity, but also can promote wound healing better than the traditional gauze. However, the sheet alginate dressing is easy to form gel after absorbing the wound exudate, and in the process of gel formation, calcium ions in the alginate dressing and sodium ions in the exudate are subjected to ion exchange to destroy the three-dimensional network structure of alginate, so that the sheet alginate dressing is locally broken, and cannot form complete sheet gel, which is inconvenient for medical staff to change the dressing. And the pure gel dressing has no antibacterial performance, and the effect is not ideal when the gel dressing is used for treating chronic wound surfaces with potential infection risks or mild infection. Therefore, it is required to develop a dressing which is excellent in mechanical properties and antibacterial function and is harmless to the human body.
Chinese patent CN106377791A discloses a bamboo alginate functional dressing, which is added with bamboo fiber, the bamboo fiber has stronger longitudinal and transverse strength, the mechanical property of single alginate fiber can be improved, and the problem that the alginate medical dressing is broken after absorbing seepage liquid is solved. Meanwhile, the bamboo fiber has natural antibacterial function and can kill most pathogenic bacteria. However, the original bamboo fiber has thick and hard hand feeling due to the regular arrangement of original bamboo fiber molecules, high crystallinity and orientation degree and high rigidity, and the dressing added with the original bamboo fiber can prick skin when being applied to a wound surface, so that the dressing generates itching feeling and causes discomfort to a human body of a patient.
The invention content is as follows:
aiming at the defects of the prior art, the technical problem to be solved by the invention is to provide the composite hydrophilic fiber dressing, the preparation method of the dressing is simple, the dressing has excellent mechanical property and antibacterial function, and meanwhile, the dressing solves the problem that the original bamboo fiber dressing can prick the skin and cause the patient to feel itchy.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the utility model provides a compound hydrophilic fiber dressing, compound hydrophilic fiber dressing comprises inlayer and skin, and the inlayer is the non-woven fabrics, and the skin is the medical ventilative adhesive tape that scribbles mixture A, the non-woven fabrics includes following raw materials and parts by weight: 35-45 parts of calcium alginate fibers, 30-45 parts of oxidized bamboo fibers and 20-35 parts of sodium carboxymethyl cellulose fibers, wherein the mixture A comprises the following raw materials in parts by weight: 20-35 parts of carboxymethyl chitosan, 3-5 parts of poloxamer and 1-3 parts of peppermint oil.
Further, the non-woven fabric comprises the following raw materials in parts by weight: 40-45 parts of calcium alginate fibers, 35-45 parts of oxidized bamboo fibers and 25-35 parts of sodium carboxymethyl cellulose fibers, wherein the mixture A comprises the following raw materials in parts by weight: 20-35 parts of carboxymethyl chitosan, 3-5 parts of poloxamer and 1-3 parts of peppermint oil.
Further, the preparation method of the oxidized bamboo fiber comprises the following steps:
a1, adding the bamboo fiber into 100-200 mL of distilled water, uniformly dispersing, and preparing a mixture with a material-liquid ratio of 1: (3-4) mixing the raw bamboo fiber;
a2, slowly dripping 5-8 mL of 0.1-1 mol/L sodium periodate into the bamboo fiber mixed solution obtained in the step A1, and reacting for 2-3 hours at constant temperature of 35-45 ℃ in a dark place to obtain an oxidized bamboo fiber solution;
a3, adding 35-50 mL of 0.1-0.2 mol/L glycerol solution into the oxidized bamboo fiber solution obtained in the step A2, soaking for 1-2 h, filtering, taking the precipitate, washing the precipitate with deionized water for 3-5 times, and then drying in vacuum to obtain the oxidized bamboo fiber.
Further, the preparation method of the non-woven fabric comprises the following steps:
b1, cutting the bamboo oxide raw fibers, the sodium carboxymethyl cellulose fibers and the calcium alginate fibers into bamboo oxide raw short fibers, sodium carboxymethyl cellulose short fibers and calcium alginate short fibers respectively;
b2, uniformly mixing the raw bamboo oxide short fibers, the sodium carboxymethyl cellulose short fibers and the calcium alginate short fibers, and then opening, mixing, carding, lapping, pre-needling, lower main needling, upper main needling, heat treatment and forming to obtain the non-woven fabric.
Furthermore, in the step B1, the filament number of the oxidized bamboo staple fiber is 1 to 2dtex, the fiber length of the oxidized bamboo staple fiber is 35 to 40mm, the filament number of the sodium carboxymethyl cellulose staple fiber is 3 to 5dtex, the length of the sodium carboxymethyl cellulose staple fiber is 35 to 40mm, the filament number of the calcium alginate staple fiber is 1 to 2dtex, and the fiber length of the calcium alginate staple fiber is 35 to 40 mm; in step B2, the temperature of the heat treatment is 110-130 ℃.
The invention also provides a preparation method of the composite hydrophilic fiber auxiliary material.
In order to solve the technical problems, the technical scheme is as follows:
a preparation method of a composite hydrophilic fiber dressing comprises the following steps:
c1, uniformly mixing the carboxymethyl chitosan, the poloxamer and the peppermint oil at normal temperature to form a mixture A;
c2, uniformly smearing the mixture A on a medical breathable adhesive plaster;
and C3, covering the non-woven fabric on the surface of the medical breathable adhesive tape coated with the mixture A, placing the medical breathable adhesive tape in a hot press, performing positive and negative hot pressing once at the temperature of 80-90 ℃, taking out the medical breathable adhesive tape, and cooling to room temperature to obtain the composite hydrophilic fiber dressing.
In addition, the invention also provides application of the composite hydrophilic fiber dressing to wound repair medicines or materials.
The bamboo fiber has stronger longitudinal and transverse strength, and the mechanical property of single alginate fiber can be improved by adding the bamboo fiber into the alginate dressing, but when the bamboo fiber dressing is used, a plurality of patients can feel that the wound surface is itchy; it has been found that the cause of itching is caused by mechanical stimulation of nerve endings in the lower layer of the skin epidermis by a large amount of thick and hard bamboo fibrils. In practice, the applicant finds that the itching feeling brought by the bamboo fiber can be avoided by firstly selectively oxidizing the bamboo fiber by using the sodium periodate and then combining the calcium alginate fiber, so that a patient feels comfortable when using the bamboo dressing. As can be seen from test example 1 of the present invention, the dressing of examples 1 to 3 of the present invention has an obvious therapeutic effect, more than 80% of rats can be cured after the dressing is applied, the wound is well healed, the wound is free of scars or obvious scars, and when the dressing of examples 1 to 3 of the present invention is used, the rats do not lick the limbs, the dressing can be removed in whole pieces, and no residue is left on the wound. Comparative examples 1 and 4, the bamboo fiber is used for replacing the oxidized bamboo fiber, more than 80% of rats can be cured after being applied with the dressing, but when the dressing is applied to a wound surface in the using process, the rats lick the limbs again, and dressing fragments are remained on the wound surface after the dressing is removed. Probably, the dressings prepared in examples 1 to 3 do not remain on the wound and can be removed in a whole piece because chemical bonds are formed between the modified oxidized bamboo fibers prepared from the bamboo fibers and carboxymethyl cellulose and a net-shaped structure is formed inside the dressings after the dressings absorb liquid.
Meanwhile, as can be seen from the test example 2 of the present invention, the dressings prepared in the embodiments 1 to 3 of the present invention have a breaking strength of 17.65MPa or more and a breaking elongation of 229% or more, and have no significant difference compared to the comparative example 1 (in which oxidized bamboo fiber is replaced by bamboo fiber), which indicates that the performance of the bamboo fiber is not changed by oxidation modification of the bamboo fiber, and the itching feeling of the wound skin caused by the bamboo fiber can be avoided.
Meanwhile, the applicant finds that the compounding of the bamboo oxide fibrils and the carboxymethyl chitosan has a synergistic effect, and the antibacterial performance of the dressing can be remarkably improved. It can be seen from the experimental example 2 of the present invention that the dressing prepared in the examples 1 to 3 has good antibacterial performance, the antibacterial performance against staphylococcus aureus is above 92.16%, and the antibacterial performance against escherichia coli is above 91.38%, the antibacterial performance of the dressing prepared in the comparative examples 2 to 3 (the raw materials lack carboxymethyl chitosan and oxidized bamboo fiber respectively) is significantly reduced by about 60%, and the antibacterial performance of the dressing prepared in the comparative example 4 (the raw materials lack carboxymethyl chitosan, and the oxidized bamboo fiber is replaced by bamboo fiber) is significantly reduced by about 70%.
In addition, poloxamer and peppermint oil are added, the poloxamer can play a certain role in protection and stabilization, the peppermint oil has a certain fatigue relieving effect and antibacterial performance, and in addition, the two substances can be used together to generate a certain effect of promoting wound healing.
Compared with the prior art, the invention has the following beneficial effects:
(1) the composite hydrophilic fiber dressing prepared by the invention has good tensile property and mechanical strength, can be removed in a whole piece, avoids dressing fragments from remaining on the surface of a wound, avoids the itching feeling of the wound surface caused by the bamboo fiber, and makes a patient feel comfortable when using the dressing.
(2) According to the invention, the bamboo oxide fibrils and the carboxymethyl chitosan are compounded and used to have a synergistic effect, so that the antibacterial performance of the auxiliary material can be obviously improved.
(3) The peppermint oil and the poloxamer are added at the same time, and the interaction of the peppermint oil and the poloxamer can generate certain effect of promoting wound healing.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
The bamboo fiber can be purchased from melt bamboo science and technology Limited in Sichuan; the poloxamers are available from Shanghai Hongyui plastication, Inc.; the carboxymethyl chitosan can be purchased from Qingdao Hai Ka Biotech limited; the peppermint oil is available from Letong chemical Co., Ltd; calcium alginate fibers are available from jiulong heinhui industrial trade company, Qingdao; sodium carboxymethylcellulose fiber is available from national specialty Chemicals, Inc. of Foshan.
Example 1 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 35 parts of calcium alginate fiber, 30 parts of oxidized bamboo fiber and 20 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 20 parts of carboxymethyl chitosan, 3 parts of poloxamer and 1 part of peppermint oil.
The preparation method of the oxidized bamboo fiber comprises the following steps:
a1, adding the bamboo fiber into 100mL of distilled water, uniformly dispersing, and preparing a mixture with a material-liquid ratio of 1: 3, mixing the raw bamboo fiber;
a2, slowly dripping 5mL of 0.1mol/L sodium periodate into the bamboo fiber mixed solution obtained in the step A1, and reacting for 2 hours in a dark place at the constant temperature of 35 ℃ to obtain an oxidized bamboo fiber solution;
a3, adding 35mL of 0.1mol/L glycerol solution into the oxidized bamboo fiber solution obtained in the step A2, soaking for 1.0h, filtering, taking the precipitate, washing the precipitate with deionized water for 3 times, and drying in vacuum to obtain the oxidized bamboo fiber.
The preparation method of the non-woven fabric comprises the following steps:
b1, cutting the oxidized bamboo fibril, the sodium carboxymethyl cellulose fiber and the calcium alginate fiber into oxidized bamboo fibril short fibers (the filament number is 1.5dtex, the fiber length is 38mm), sodium carboxymethyl cellulose short fibers (the filament number is 4dtex, the fiber length is 38mm) and calcium alginate short fibers (the filament number is 1.5dtex, the fiber length is 38 mm);
b2, uniformly mixing the raw bamboo oxide short fiber, the sodium carboxymethylcellulose short fiber and the calcium alginate short fiber, then opening, mixing, carding, lapping, pre-needling, lower main needling, upper main needling, performing heat treatment (at 120 ℃), and forming to obtain the non-woven fabric.
The preparation method of this example includes the following steps:
c1, uniformly mixing the carboxymethyl chitosan, the poloxamer and the peppermint oil at normal temperature to form a mixture A;
c2, uniformly smearing the mixture A on a medical breathable adhesive plaster;
and C3, covering the non-woven fabric on the surface of the medical breathable adhesive tape coated with the mixture A, placing the medical breathable adhesive tape in a hot press, carrying out positive and negative hot pressing once at 90 ℃, taking out the medical breathable adhesive tape, and cooling to room temperature to obtain the composite hydrophilic fiber dressing.
Example 2 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 45 parts of calcium alginate fiber, 45 parts of oxidized bamboo fiber and 35 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 35 parts of carboxymethyl chitosan, 5 parts of poloxamer and 3 parts of peppermint oil.
The preparation method of the oxidized bamboo fiber comprises the following steps:
a1, adding the bamboo fiber into 200mL of distilled water, uniformly dispersing, and preparing a mixture with a material-liquid ratio of 1: 4, mixing the raw bamboo fiber;
a2, slowly dripping 8mL of 1.0mol/L sodium periodate into the bamboo fiber mixed solution obtained in the step A1, and reacting for 3 hours in a dark place at the constant temperature of 45 ℃ to obtain an oxidized bamboo fiber solution;
a3, adding 50mL of 0.2mol/L glycerol solution into the oxidized bamboo fiber solution obtained in the step A2, soaking for 2.0h, filtering, taking the precipitate, washing the precipitate with deionized water for 5 times, and drying in vacuum to obtain the oxidized bamboo fiber.
The preparation method of the non-woven fabric comprises the following steps:
b1, cutting the oxidized bamboo fibril, the sodium carboxymethylcellulose fiber and the calcium alginate fiber into oxidized bamboo fibril short fibers (the filament number is 1dtex, the fiber length is 35mm), sodium carboxymethylcellulose short fibers (the filament number is 3dtex, the fiber length is 35mm) and calcium alginate short fibers (the filament number is 1dtex, the fiber length is 3 mm);
b2, uniformly mixing the raw bamboo oxide short fiber, the sodium carboxymethylcellulose short fiber and the calcium alginate short fiber, then opening, mixing, carding, lapping, pre-needling, lower main needling, upper main needling, performing heat treatment (110 ℃) and forming to obtain the non-woven fabric.
The manufacturing method of this example is different from that of example 1 only in that the temperature of the hot back and forth pressing in step C3 is 80 ℃.
Example 3 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 40 parts of calcium alginate fiber, 35 parts of oxidized bamboo fiber and 25 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 25 parts of carboxymethyl chitosan, 4 parts of poloxamer and 2 parts of peppermint oil.
The preparation method of the oxidized bamboo fiber comprises the following steps:
a1, adding the bamboo fiber into 150mL of distilled water, uniformly dispersing, and preparing a mixture with a material-liquid ratio of 1: 3.5 of a bamboo fiber mixed solution;
a2, slowly dripping 7mL of 1.0mol/L sodium periodate into the bamboo fiber mixed solution obtained in the step A1, and reacting for 2.5 hours at constant temperature of 40 ℃ in a dark place to obtain an oxidized bamboo fiber solution;
a3, adding 42mL of 0.15mol/L glycerol solution into the oxidized bamboo fiber solution obtained in the step A2, soaking for 1.5h, filtering, taking the precipitate, washing the precipitate with deionized water for 4 times, and drying in vacuum to obtain the oxidized bamboo fiber.
The preparation method of the non-woven fabric comprises the following steps:
b1, cutting the oxidized bamboo fibril, the sodium carboxymethylcellulose fiber and the calcium alginate fiber into oxidized bamboo fibril short fibers (the filament number is 1dtex, the fiber length is 35mm), sodium carboxymethylcellulose short fibers (the filament number is 3dtex, the fiber length is 35mm) and calcium alginate short fibers (the filament number is 1dtex, the fiber length is 3 mm);
b2, uniformly mixing the raw bamboo oxide short fiber, the sodium carboxymethylcellulose short fiber and the calcium alginate short fiber, then opening, mixing, carding, lapping, pre-needling, lower main needling, upper main needling, performing heat treatment (110 ℃) and forming to obtain the non-woven fabric.
The manufacturing method of this example is different from that of example 1 only in that the temperature of the hot back and forth pressing in step C3 is 85 ℃.
Comparative example 1 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 40 parts of calcium alginate fiber, 35 parts of bamboo fiber and 25 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 25 parts of carboxymethyl chitosan, 4 parts of poloxamer and 2 parts of peppermint oil.
The preparation of the nonwoven fabric and the preparation of comparative example 1 were similar to those of example 3.
The difference from example 3 is that comparative example 1 replaces oxidized bamboo fibers with bamboo fibers.
Comparative example 2 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 40 parts of calcium alginate fiber, 35 parts of oxidized bamboo fiber and 25 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 25 parts of carboxymethyl chitosan and 6 parts of peppermint oil.
The preparation methods of the oxidized bamboo fiber and the nonwoven fabric and the preparation method of comparative example 2 are similar to those of example 3.
The difference from example 3 is that comparative example 2 does not contain poloxamer.
Comparative example 3 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 40 parts of calcium alginate fiber, 35 parts of oxidized bamboo fiber and 25 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 40 parts of carboxymethyl chitosan, 4 parts of poloxamer and 2 parts of peppermint oil.
The preparation methods of the oxidized bamboo fiber and the nonwoven fabric and the preparation method of comparative example 3 are similar to those of example 3.
The difference from example 3 is that the content of carboxymethyl chitosan in comparative example 3 is greater than the range of the present invention.
Comparative example 4 composite hydrophilic fiber dressing
The composite hydrophilic fiber dressing consists of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 40 parts of calcium alginate fiber, 60 parts of bamboo fiber and 25 parts of sodium carboxymethyl cellulose fiber, wherein the mixture A comprises the following raw materials in parts by weight: 4 parts of poloxamer and 2 parts of peppermint oil.
The preparation of the nonwoven fabric and the preparation of comparative example 1 were similar to those of example 3.
The difference from example 3 is that comparative example 4 does not contain carboxymethyl chitosan and the oxidized bamboo fibers are replaced by bamboo fibers.
Test example 1 healing and removal test
1. Test subjects: the obtained dressings were prepared in examples 1 to 3 and comparative examples 1 to 4.
2. The test method comprises the following steps:
70 SD male rats weighing 220 +/-20 g each are randomly divided into 7 groups, 10 rats in each group are respectively marked, hairs are cut off on one side of the back spine, an incision with the length of 5 +/-0.2 cm and the depth of 0.5 +/-0.2 cm is cut by a scalpel, the dressings prepared in the invention examples 1-4 and the comparative examples 1-3 are respectively used, and the dressings are removed after use.
The treatment conditions of 7 groups of rats after being applied with the dressing are divided into four types of recovery, improvement and ineffectiveness and scratchiness. The treatment results are shown in table 1:
TABLE 1 healing test results
| Group of | Recovery (case) | Improvement (example) | Invalid (example) | Itching feeling (with/without) |
| Example 1 | 9 | 1 | 0 | Is free of |
| Example 2 | 9 | 1 | 0 | Is free of |
| Example 3 | 8 | 2 | 0 | Is free of |
| Comparative example 1 | 8 | 2 | 0 | Is provided with |
| Comparative example 2 | 2 | 2 | 6 | Is free of |
| Comparative example 3 | 2 | 3 | 5 | Is free of |
| Comparative example 4 | 7 | 3 | 0 | Is provided with |
(1) As can be seen from table 1, the dressing of examples 1 to 3 of the present invention has an obvious therapeutic effect, and 80% or more of rats can be cured after the dressing is applied, so that the wounds can be well healed, and the wounds have no scars or no obvious scars, wherein example 1 is the best example. When the dressing of the embodiment 1-3 of the invention is used, the rat does not lick the limb.
(2) Comparative example 1 and comparative example 4, the bamboo fiber is used for replacing the oxidized bamboo fiber, more than 80% of rats can be cured after being applied with the dressing, but when the dressing is applied to the wound surface in the using process, the rats can lick the limbs.
In the dressing prepared in the comparative examples 2-3 (poloxamer is absent in the comparative example 2 in the raw materials, and the content of carboxymethyl chitosan in the comparative example 3 is changed), only about 40-50% of rats can heal or improve, and 40-60% of rats have ineffective wound healing.
The wound surface condition was observed after removing the dressing from 7 groups of rats, and the results are shown in table 2:
TABLE 2 results of removal test
As can be seen from Table 2, the dressings of examples 1 to 3 of the present invention were all removable in one piece. Comparative examples 1 and 4, the oxidized bamboo fiber was replaced with bamboo fiber, and dressing pieces remained on the wound surface after removal.
Test example 2 measurement of mechanical Properties
The breaking strength and the breaking elongation of the dressings prepared in examples 1 to 3 and comparative examples 1 to 4 were measured by a universal dynamometer. Clamping distance: 50mm, 5mm in width and 100mm/min in drawing speed. The test was repeated 5 times, the results were averaged and the test results are shown in table 3:
TABLE 3 Performance test results
| Breaking Strength (MPa) | Elongation at Break (%) | |
| Example 1 | 18.35 | 243 |
| Example 2 | 17.98 | 238 |
| Example 3 | 20.65 | 269 |
| Comparative example 1 | 13.25 | 225 |
| Comparative example 2 | 14.18 | 176 |
| Comparative example 3 | 13.56 | 167 |
| Comparative example 4 | 12.39 | 214 |
As can be seen from table 3, the dressings prepared in examples 1 to 3 have breaking strength of 17.65MPa or more and breaking elongation of 229% or more, wherein example 3 is the best example, comparative examples 1 and 4 have significant differences from example 1 in that bamboo fibers are used instead of oxidized bamboo fibers; the mechanical properties of the dressings in comparative example 2 and comparative example 3 (comparative example 2 lacks poloxamer, and the content of carboxymethyl chitosan in comparative example 3 changes) are significantly different from those in example 3, and compared with example 3, the breaking strength is significantly reduced by about 30%, and the breaking elongation is significantly reduced by about 40%.
Test example 3 antimicrobial Property measurement
The dressings prepared in examples 1-3 and comparative examples 1-4 are subjected to antibacterial performance detection according to GB15979-2002, and the detection results are as follows:
TABLE 4 results of the measurement of antibacterial property
| Group of | Staphylococcus aureus | Escherichia coli |
| Example 1 | 92.16％ | 91.38％ |
| Example 2 | 92.52％ | 91.58％ |
| Example 3 | 93.15％ | 92.67％ |
| Comparative example 1 | 88.57％ | 87.31％ |
| Comparative example 2 | 31.23％ | 32.89％ |
| Comparative example 3 | 36.67％ | 36.12％ |
| Comparative example 4 | 27.66％ | 27.43％ |
As can be seen from table 4, the dressings prepared in examples 1 to 3 have good antibacterial performance, the antibacterial activity against staphylococcus aureus is 92.16% or more, the antibacterial activity against escherichia coli is 91.38% or more, and the dressing has strong antibacterial activity against these bacteria, wherein example 3 is the best example of the present invention. Compared with the example 3, the dressing prepared in the comparative example 1 (the bamboo fiber replaces the oxidized bamboo fiber) has the antibacterial performance reduced by about 5%, the alginate dressing prepared in the comparative examples 2-3 (the comparative example 2 in the raw material lacks poloxamer, and the content of carboxymethyl chitosan in the comparative example 3 is changed) has the antibacterial performance remarkably reduced by more than 60%, and the dressing prepared in the comparative example 4 (the raw material lacks carboxymethyl chitosan, and the oxidized bamboo fiber is replaced by the bamboo fiber) has the antibacterial performance remarkably reduced by about 70%.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (7)
1. The composite hydrophilic fiber dressing is characterized by consisting of an inner layer and an outer layer, wherein the inner layer is non-woven fabric, the outer layer is a medical breathable adhesive tape coated with a mixture A, and the non-woven fabric comprises the following raw materials in parts by weight: 35-45 parts of calcium alginate fibers, 30-45 parts of oxidized bamboo fibers and 20-35 parts of sodium carboxymethyl cellulose fibers, wherein the mixture A comprises the following raw materials in parts by weight: 20-35 parts of carboxymethyl chitosan, 3-5 parts of poloxamer and 1-3 parts of peppermint oil.
2. The composite hydrophilic fiber dressing of claim 1, wherein the non-woven fabric comprises the following raw materials in parts by weight: 40-45 parts of calcium alginate fibers, 35-45 parts of oxidized bamboo fibers and 25-35 parts of sodium carboxymethyl cellulose fibers, wherein the mixture A comprises the following raw materials in parts by weight: 20-35 parts of carboxymethyl chitosan, 3-5 parts of poloxamer and 1-3 parts of peppermint oil.
3. The composite hydrophilic fiber dressing of claim 1, wherein the preparation method of the oxidized bamboo fibers comprises the following steps:
a1, adding the bamboo fiber into 100-200 mL of distilled water, uniformly dispersing, and preparing a mixture with a material-liquid ratio of 1: (3-4) mixing the raw bamboo fiber;
a2, slowly dripping 5-8 mL of 0.1-1 mol/L sodium periodate into the bamboo fiber mixed solution obtained in the step A1, and reacting for 2-3 hours at constant temperature of 35-45 ℃ in a dark place to obtain an oxidized bamboo fiber solution;
a3, adding 35-50 mL of 0.1-0.2 mol/L glycerol solution into the oxidized bamboo fiber solution obtained in the step A2, soaking for 1-2 h, filtering, taking the precipitate, washing the precipitate with deionized water for 3-5 times, and then drying in vacuum to obtain the oxidized bamboo fiber.
4. The composite hydrophilic fiber dressing of claim 1, wherein the non-woven fabric is prepared by the following method:
b1, cutting the bamboo oxide raw fibers, the sodium carboxymethyl cellulose fibers and the calcium alginate fibers into bamboo oxide raw short fibers, sodium carboxymethyl cellulose short fibers and calcium alginate short fibers respectively;
b2, uniformly mixing the raw bamboo oxide short fibers, the sodium carboxymethyl cellulose short fibers and the calcium alginate short fibers, and then opening, mixing, carding, lapping, pre-needling, lower main needling, upper main needling, heat treatment and forming to obtain the non-woven fabric.
5. The composite hydrophilic fiber dressing of claim 4, wherein in step B1, the filament number of the oxidized bamboo staple fiber is 1-2dtex, the fiber length of the oxidized bamboo fiber is 35-40mm, the filament number of the sodium carboxymethyl cellulose staple fiber is 3-5dtex, the length of the sodium carboxymethyl cellulose staple fiber is 35-40mm, the filament number of the calcium alginate staple fiber is 1-2dtex, and the fiber length of the calcium alginate staple fiber is 35-40 mm; in step B2, the temperature of the heat treatment is 110-130 ℃.
6. The method for preparing the composite hydrophilic fiber dressing according to any one of claims 1 to 5, which is characterized by comprising the following steps:
c1, uniformly mixing the carboxymethyl chitosan, the poloxamer and the peppermint oil at normal temperature to form a mixture A;
c2, uniformly smearing the mixture A on a medical breathable adhesive plaster;
and C3, covering the non-woven fabric on the surface of the medical breathable adhesive tape coated with the mixture A, placing the medical breathable adhesive tape in a hot press, performing positive and negative hot pressing once at the temperature of 80-90 ℃, taking out the medical breathable adhesive tape, and cooling to room temperature to obtain the composite hydrophilic fiber dressing.
7. The application of the composite hydrophilic fiber dressing according to any one of claims 1 to 5 in wound repair medicines or materials.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111743976A (en) * | 2020-07-03 | 2020-10-09 | 广西医科大学 | Application of silicon dioxide aerogel in preparation of osteoarthritis treatment drug |
| CN114246973A (en) * | 2020-09-25 | 2022-03-29 | 南京大可实业有限公司 | Medical dressing material and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721291A (en) * | 2013-12-19 | 2014-04-16 | 褚加冕 | Method for preparing fast haemostatic dressing |
| CN107115555A (en) * | 2017-04-28 | 2017-09-01 | 广东泰宝医疗科技股份有限公司 | A kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof |
| CN107412840A (en) * | 2017-09-13 | 2017-12-01 | 冯威 | It is a kind of that there is the hemostatic composition for stablizing drug effect |
| CN108578754A (en) * | 2018-04-20 | 2018-09-28 | 广东泰宝医疗器械技术研究院有限公司 | A kind of preparation method of the far infrared bamboo fiber dressing containing sugar |
-
2019
- 2019-12-16 CN CN201911300289.8A patent/CN110882409B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721291A (en) * | 2013-12-19 | 2014-04-16 | 褚加冕 | Method for preparing fast haemostatic dressing |
| CN107115555A (en) * | 2017-04-28 | 2017-09-01 | 广东泰宝医疗科技股份有限公司 | A kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof |
| CN107412840A (en) * | 2017-09-13 | 2017-12-01 | 冯威 | It is a kind of that there is the hemostatic composition for stablizing drug effect |
| CN108578754A (en) * | 2018-04-20 | 2018-09-28 | 广东泰宝医疗器械技术研究院有限公司 | A kind of preparation method of the far infrared bamboo fiber dressing containing sugar |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111743976A (en) * | 2020-07-03 | 2020-10-09 | 广西医科大学 | Application of silicon dioxide aerogel in preparation of osteoarthritis treatment drug |
| CN114246973A (en) * | 2020-09-25 | 2022-03-29 | 南京大可实业有限公司 | Medical dressing material and preparation method thereof |
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