CN110876788A - Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof - Google Patents
Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof Download PDFInfo
- Publication number
- CN110876788A CN110876788A CN201910920138.6A CN201910920138A CN110876788A CN 110876788 A CN110876788 A CN 110876788A CN 201910920138 A CN201910920138 A CN 201910920138A CN 110876788 A CN110876788 A CN 110876788A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- radix
- medicinal powder
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036407 pain Effects 0.000 title claims abstract description 85
- 208000002193 Pain Diseases 0.000 title claims abstract description 82
- 239000003814 drug Substances 0.000 title claims abstract description 59
- 230000001737 promoting effect Effects 0.000 title claims abstract description 45
- 230000017531 blood circulation Effects 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000004863 Frankincense Substances 0.000 claims abstract description 29
- 241000218176 Corydalis Species 0.000 claims abstract description 28
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 20
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 20
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 19
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 18
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 18
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 17
- 244000306301 Caesalpinia sappan Species 0.000 claims abstract description 16
- 235000015162 Caesalpinia sappan Nutrition 0.000 claims abstract description 16
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 16
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 16
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 16
- 244000061520 Angelica archangelica Species 0.000 claims abstract description 15
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 15
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 15
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 15
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 14
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 14
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 14
- 235000015655 Crocus sativus Nutrition 0.000 claims abstract description 13
- 244000124209 Crocus sativus Species 0.000 claims abstract description 13
- 241000301400 Trogopterus Species 0.000 claims abstract description 13
- 240000001972 Gardenia jasminoides Species 0.000 claims abstract description 12
- 239000009136 dragon's blood Substances 0.000 claims abstract description 12
- 210000003608 fece Anatomy 0.000 claims abstract description 11
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 10
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 9
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 9
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 9
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims abstract description 8
- 240000005001 Paeonia suffruticosa Species 0.000 claims abstract description 8
- 235000018109 Cyperus longus Nutrition 0.000 claims abstract description 6
- 244000150195 Cyperus longus Species 0.000 claims abstract description 6
- 241000212322 Levisticum officinale Species 0.000 claims abstract description 6
- 235000005010 Scirpus paludosus Nutrition 0.000 claims abstract description 6
- 241000329195 Sparganium erectum Species 0.000 claims abstract description 6
- 239000001645 levisticum officinale Substances 0.000 claims abstract description 6
- 240000000260 Typha latifolia Species 0.000 claims abstract 5
- 241000675108 Citrus tangerina Species 0.000 claims abstract 4
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract 4
- 244000080767 Areca catechu Species 0.000 claims abstract 2
- 244000058416 Scirpus paludosus Species 0.000 claims abstract 2
- 239000000843 powder Substances 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
- 238000002156 mixing Methods 0.000 claims description 45
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 38
- 239000006187 pill Substances 0.000 claims description 29
- 238000001035 drying Methods 0.000 claims description 26
- 238000007873 sieving Methods 0.000 claims description 24
- 239000000706 filtrate Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 21
- 239000008187 granular material Substances 0.000 claims description 21
- 238000010298 pulverizing process Methods 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 19
- 244000235603 Acacia catechu Species 0.000 claims description 18
- 241000717739 Boswellia sacra Species 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 235000019698 starch Nutrition 0.000 claims description 16
- 239000008107 starch Substances 0.000 claims description 16
- 241001489978 Eupolyphaga Species 0.000 claims description 15
- 241001057584 Myrrha Species 0.000 claims description 15
- 210000000582 semen Anatomy 0.000 claims description 13
- 239000007779 soft material Substances 0.000 claims description 13
- 241001106477 Paeoniaceae Species 0.000 claims description 12
- 241000180649 Panax notoginseng Species 0.000 claims description 12
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 12
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 12
- 244000131316 Panax pseudoginseng Species 0.000 claims description 12
- 241000283956 Manis Species 0.000 claims description 11
- 244000197580 Poria cocos Species 0.000 claims description 11
- 235000008599 Poria cocos Nutrition 0.000 claims description 11
- 239000009286 sanguis draxonis Substances 0.000 claims description 11
- 238000002791 soaking Methods 0.000 claims description 11
- 241000283966 Pholidota <mammal> Species 0.000 claims description 10
- 235000013399 edible fruits Nutrition 0.000 claims description 9
- 241000112528 Ligusticum striatum Species 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000003826 tablet Substances 0.000 claims description 7
- 241000123844 Artemisia anomala Species 0.000 claims description 6
- 235000014290 Artemisia anomala Nutrition 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 235000018958 Gardenia augusta Nutrition 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 235000002598 Inula helenium Nutrition 0.000 claims description 4
- 244000116484 Inula helenium Species 0.000 claims description 4
- 244000272264 Saussurea lappa Species 0.000 claims description 4
- 235000006784 Saussurea lappa Nutrition 0.000 claims description 4
- 238000005096 rolling process Methods 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- 244000111489 Gardenia augusta Species 0.000 claims description 3
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 3
- 241000736199 Paeonia Species 0.000 claims description 2
- 238000007796 conventional method Methods 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 235000014375 Curcuma Nutrition 0.000 claims 3
- 244000164480 Curcuma aromatica Species 0.000 claims 3
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 3
- 235000005324 Typha latifolia Nutrition 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 64
- 210000004369 blood Anatomy 0.000 abstract description 64
- 230000008961 swelling Effects 0.000 abstract description 34
- 208000014674 injury Diseases 0.000 abstract description 25
- 230000008736 traumatic injury Effects 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 16
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 241000155668 Siphonostegia chinensis Species 0.000 abstract description 3
- 239000009759 San-Chi Substances 0.000 abstract description 2
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 description 33
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 description 33
- STCJJTBMWHMRCD-UHFFFAOYSA-N salvianolic acid B Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc2cc(O)c(O)c3OC(C(C(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)c23)c5ccc(O)c(O)c5 STCJJTBMWHMRCD-UHFFFAOYSA-N 0.000 description 33
- 206010042674 Swelling Diseases 0.000 description 30
- 238000000605 extraction Methods 0.000 description 28
- 239000000284 extract Substances 0.000 description 19
- 201000000736 Amenorrhea Diseases 0.000 description 18
- 206010001928 Amenorrhoea Diseases 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 231100000540 amenorrhea Toxicity 0.000 description 18
- 208000004998 Abdominal Pain Diseases 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- 208000032843 Hemorrhage Diseases 0.000 description 11
- 238000001816 cooling Methods 0.000 description 11
- 208000005171 Dysmenorrhea Diseases 0.000 description 10
- 206010013935 Dysmenorrhoea Diseases 0.000 description 10
- 230000000740 bleeding effect Effects 0.000 description 10
- 241001672694 Citrus reticulata Species 0.000 description 9
- 240000001398 Typha domingensis Species 0.000 description 8
- 230000004087 circulation Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 206010000077 Abdominal mass Diseases 0.000 description 6
- 235000018062 Boswellia Nutrition 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 6
- 208000034507 Haematemesis Diseases 0.000 description 6
- 238000000540 analysis of variance Methods 0.000 description 6
- 210000000038 chest Anatomy 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 244000186071 dragons blood palm Species 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 244000075634 Cyperus rotundus Species 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 208000019790 abdominal distention Diseases 0.000 description 5
- 208000001780 epistaxis Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 238000003809 water extraction Methods 0.000 description 5
- 208000019255 Menstrual disease Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000006286 aqueous extract Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 235000013974 saffron Nutrition 0.000 description 4
- 239000004248 saffron Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 208000034656 Contusions Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 241000220485 Fabaceae Species 0.000 description 3
- 208000000616 Hemoptysis Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 238000007493 shaping process Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- 235000006020 Acacia catechu Nutrition 0.000 description 2
- 244000205574 Acorus calamus Species 0.000 description 2
- 241000382455 Angelica sinensis Species 0.000 description 2
- 241000208173 Apiaceae Species 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 241000208229 Burseraceae Species 0.000 description 2
- 235000011996 Calamus deerratus Nutrition 0.000 description 2
- 241000131329 Carabidae Species 0.000 description 2
- 102000003712 Complement factor B Human genes 0.000 description 2
- 108090000056 Complement factor B Proteins 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 241000234646 Cyperaceae Species 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 2
- 241001282397 Manis pentadactyla Species 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000218201 Ranunculaceae Species 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 241000233945 Typhaceae Species 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 239000001560 acacia catechu Substances 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000009519 contusion Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000013401 experimental design Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 206010019847 hepatosplenomegaly Diseases 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008601 oleoresin Substances 0.000 description 2
- 238000013386 optimize process Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 238000012418 validation experiment Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 235000011446 Amygdalus persica Nutrition 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000233788 Arecaceae Species 0.000 description 1
- 235000003826 Artemisia Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 208000025978 Athletic injury Diseases 0.000 description 1
- 206010006272 Breast mass Diseases 0.000 description 1
- 206010006298 Breast pain Diseases 0.000 description 1
- 235000007627 Caesalpinia Nutrition 0.000 description 1
- 241000522234 Caesalpinia Species 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 241000159174 Commiphora Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000209020 Cornus Species 0.000 description 1
- 241000830532 Corydalis yanhusuo Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000963421 Curcuma kwangsiensis Species 0.000 description 1
- 235000003397 Curcuma kwangsiensis Nutrition 0.000 description 1
- 240000005629 Curcuma phaeocaulis Species 0.000 description 1
- 235000003391 Curcuma phaeocaulis Nutrition 0.000 description 1
- 241000963390 Curcuma wenyujin Species 0.000 description 1
- 235000003394 Curcuma wenyujin Nutrition 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241001489980 Eupolyphaga sinensis Species 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 241000555712 Forsythia Species 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 240000002045 Guettarda speciosa Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 208000008017 Hypohidrosis Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 241001113425 Iridaceae Species 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 241000244355 Ligusticum Species 0.000 description 1
- 241000244365 Ligusticum sinense Species 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 241000283967 Manidae Species 0.000 description 1
- 208000006662 Mastodynia Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 241000207834 Oleaceae Species 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 241000124464 Paeonia veitchii Species 0.000 description 1
- 241000488583 Panonychus ulmi Species 0.000 description 1
- 241000218180 Papaveraceae Species 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 235000015533 Prunus davidiana Nutrition 0.000 description 1
- 240000002381 Prunus davidiana Species 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 241001107098 Rubiaceae Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 241000239226 Scorpiones Species 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 241000233932 Sparganium Species 0.000 description 1
- 241001180441 Sparganium stoloniferum Species 0.000 description 1
- 229920001872 Spider silk Polymers 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010044334 Trance Diseases 0.000 description 1
- 241000301399 Trogopterus xanthipes Species 0.000 description 1
- 235000004224 Typha angustifolia Nutrition 0.000 description 1
- 241001518821 Typha orientalis Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047697 Volvulus Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 206010002512 anhidrosis Diseases 0.000 description 1
- 230000037001 anhydrosis Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 244000030166 artemisia Species 0.000 description 1
- 235000009052 artemisia Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 239000010639 cypress oil Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- RVRCFVVLDHTFFA-UHFFFAOYSA-N heptasodium;tungsten;nonatriacontahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W] RVRCFVVLDHTFFA-UHFFFAOYSA-N 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 201000007647 intestinal volvulus Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 208000024714 major depressive disease Diseases 0.000 description 1
- 201000003995 melancholia Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Insects & Arthropods (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Neurology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine for promoting blood circulation and relieving pain and a preparation method thereof, which is prepared from salvia miltiorrhiza, angelica tail, red paeony root, szechuan lovage rhizome, corydalis tuber, common burreed rhizome, frankincense, myrrh, peach seed, saffron crocus, sappan wood, ground beeltle, dragon's blood, sanchi, costustoot, nutgrass galingale rhizome, green tangerine peel, tree peony bark, weeping forsythia, zedoary, cattail pollen, Indian buead, gardenia, trogopterus dung, catechu, Siphonostegia chinensis; the invention has the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and can effectively treat soft traumatic injury, and swelling and pain due to blood stasis; the invention has the advantages of small toxic and side effect, short treatment period and good treatment effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine for promoting blood circulation and relieving pain and a preparation method thereof, belonging to the technical field of medicines.
Background
Traumatic injuries are mainly soft tissue injuries, including knife and gun, fall, blow, contusion, puncture, bruise, sports injuries and the like, and the injuries are mostly pain, swelling, bleeding or fracture, dislocation and the like, and also include some visceral injuries.
Blood stasis is a pathological product formed in the course of disease and also a pathogenic factor of some diseases. The formation causes are qi deficiency, qi stagnation, blood cold and blood heat which can cause blood stasis. Various traumas damage the skin and internal organs and cause the blood that leaves the meridians to accumulate in the body and form blood stasis. The clinical manifestations of blood stasis are painful like acupuncture, localized pain, tenderness, especially at night; the mass is bluish purple on the body surface and hard and immovable on the abdomen, called the accumulation of disease; recurrent bleeding with purple dark color, blood clot in the middle, or dark stool like cypress oil; dark complexion, scaly skin, purple dark nails of mouth, lips and paws, or purple spots of skin, red spider silks, or external exposure of abdominal green tendons, or swelling and pain of lower limbs; the woman's scanty menstruation, purple dark and blocking, or amenorrhea; a purple and dark tongue with ecchymosis, a thready and unsmooth pulse or intermittent pulse.
In the face of traumatic injury and swelling and pain due to blood stasis, although the existing western medicine oral administration has strong analgesic activity, the side effect can cause gastrointestinal dysfunction and damage to heart, liver and kidney to different degrees. Therefore, the invention provides the traditional Chinese medicine with the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, and the traditional Chinese medicine has important significance.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine for promoting blood circulation and relieving pain. The invention has the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and can effectively treat soft traumatic injury, and swelling and pain due to blood stasis; the invention has the advantages of small toxic and side effect, short treatment period and good treatment effect.
The technical scheme of the invention is as follows: a Chinese medicinal composition with blood circulation promoting and pain relieving effects comprises (by weight parts) Saviae Miltiorrhizae radix 4-14, radix Angelicae sinensis 4-14, radix Paeoniae Rubra 4-14, rhizoma Ligustici Chuanxiong 0.5-3, rhizoma corydalis 1-5, rhizoma Sparganii 5-15, Olibanum 1-9, Myrrha 1-9, semen Persicae 2-10, stigma croci Sativi 1-5, lignum sappan 2-10, Eupolyphaga Seu Steleophaga 0.5-3, sanguis Draxonis 1-3, Notoginseng radix 1-5, radix aucklandiae 2-10, rhizoma Cyperi 2-10, pericarpium Citri Reticulatae viride 2-10, cortex moutan 2-10, fructus forsythiae 2-10, Curcumae rhizoma 1-5, pollen Typhae 2-10, Poria 4-14, fructus Gardeniae 2-10, Oletum Trogopterori 2-10, Catechu 1-5, 2-10 parts of Siphonostegia chinensis Benth and 0.5-3 parts of pangolin scales.
In the traditional Chinese medicine for promoting blood circulation and relieving pain, the medicinal effective components of the medicine are calculated according to the weight parts, and the medicine comprises 7-11 parts of salvia miltiorrhiza, 7-11 parts of angelica tail, 7-11 parts of red paeony root, 1-2 parts of szechuan lovage rhizome, 2-4 parts of corydalis tuber, 8-12 parts of common burreed rhizome, 3-7 parts of frankincense, 3-7 parts of myrrh, 4-8 parts of peach seed, 2-4 parts of saffron crocus, 4-8 parts of sappan wood, 1-2 parts of ground beeltle, 1-3 parts of dragon's blood, 2-4 parts of pseudo-ginseng, 4-8 parts of costustoot, 4-8 parts of nutgrass galingale rhizome, 4-8 parts of green tangerine peel, 4-8 parts of tree peony bark, 4-8 parts of weeping forsythia capsule, 2-4 parts of zedoary, 4-8 parts of cattail pollen, 7-11, 4-8 parts of artemisia anomala and 1-2 parts of pangolin scales.
In the traditional Chinese medicine for promoting blood circulation and relieving pain, the medicinal effective components of the medicine are calculated according to the weight parts, and the medicine is prepared from 9 parts of salvia miltiorrhiza, 9 parts of angelica tail, 9 parts of red peony root, 1.5 parts of ligusticum wallichii, 3 parts of corydalis tuber, 10 parts of rhizoma sparganii, 5 parts of frankincense, 5 parts of myrrh, 6 parts of peach kernel, 3 parts of saffron, 6 parts of sappan wood, 1.5 parts of ground beetle, 2 parts of dragon's blood, 3 parts of pseudo-ginseng, 6 parts of elecampane, 6 parts of rhizoma cyperi, 6 parts of green tangerine peel, 6 parts of moutan bark, 6 parts of fructus forsythiae, 3 parts of curcuma zedoary, 6 parts of cattail pollen, 9 parts of poria cocos, 6 parts of cape jasmine, 6 parts of trogopterus.
The preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain comprises the steps of combining salvia miltiorrhiza, angelica tail, red paeony root, ligusticum wallichii, corydalis tuber, rhizoma sparganii, frankincense, myrrh, peach kernel, saffron, sappan wood, ground beeltle, dragon blood, pseudo-ginseng, costustoot, rhizoma cyperi, green tangerine peel, moutan bark, fructus forsythiae, curcuma zedoary, cattail pollen, poria cocos, gardenia, trogopterus dung, catechu, artemisia anomala and pangolin scales with auxiliary materials acceptable in the medicine, and processing the mixture according to a conventional method to prepare the corresponding medicine.
In the preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain, the medicine is as follows: pills, granules or tablets.
In the preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain, the pill is prepared by the following steps: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking with 12 times of water for 1h, heating and refluxing for 1h, filtering to obtain residue A, decocting residue A with 12 times of water for 1h, filtering to obtain residue B, decocting residue B with 12 times of water for 1h, filtering, discarding residue, mixing the three filtrates, concentrating to density of 1.0-1.1g/mL, mixing with medicine C, making into soft material, making into pill by plastic method, screening, placing the selected pill into coating pan, rolling, and drying at 60 deg.C.
In the preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain, the granules are prepared as follows: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of soluble starch, making into soft material, extruding, sieving, and drying.
In the preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain, the tablet is prepared by the following steps: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of compressible starch, grading, tabletting, and coating with fruit membrane.
The invention is prepared by Salvia miltiorrhiza, angelica tail, red paeony root, szechuan lovage rhizome, corydalis tuber, common burreed rhizome, frankincense, myrrh, peach seed, saffron, sappan wood, ground beeltle, dragon blood, sanchi, costustoot, nutgrass galingale rhizome, green tangerine peel, tree peony bark, weeping forsythia capsule, zedoary, cattail pollen, Indian buead, gardenia, trogopterus dung, catechu, artemisia anomala and pangolin, wherein the Salvia miltiorrhiza is dried root and rhizome of Salvia miltiorrhiza Salvia milli change Bunge of Labiatae; the main function of the medicine is to remove blood stasis, relieve pain, activate blood, dredge channels, clear heart and relieve restlessness; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris. The Angelica tail, which is the tail of the dried root of Diels (Oliv.) Angelica sinensis (Angelica sinensis) belonging to Umbelliferae, has the following effects: promoting blood circulation and removing blood stasis; the application comprises the following steps: amenorrhea, blood stasis, stagnation and swelling and pain. Radix Paeoniae Rubra, which is the dried root of Paeonia lactiflora pall or Paeonia veitchii Lynch of Ranunculaceae, has the functions of clearing heat, cooling blood, removing blood stasis and relieving pain; can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease. Rhizoma Ligustici Chuanxiong, dried rhizome of Ligusticum chuanxiong Hort (or Ligusticum wallichi Franch.) belonging to Umbelliferae; the functions are mainly used for activating blood and promoting qi circulation, and dispelling wind and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia. Rhizoma Corydalis is dried tuber of Corydalis yanhusuo W.T.Wang of Papaveraceae; the functions are mainly used for promoting blood circulation, benefiting qi and relieving pain; can be used for treating chest and hypochondrium, abdominal pain, amenorrhea, dysmenorrhea, puerperal blood stasis, traumatic injury, and swelling and pain. Rhizoma Sparganii is a dried tuber of Sparganium stoloniferum Buch. -ham. of Sparganium crispum of the family Sparganiaceae; the functions are mainly used for breaking blood and promoting qi circulation, and removing food retention and relieving pain. Can be used for treating abdominal mass, blood stasis, amenorrhea, food stagnation, and pain. Olibanum, which is oleoresin exuded from trunk skin wound of Boswellia carterii Birdw of Boswellia of Burseraceae, Boswellia Birdw. [ B.sacra Fluek. ], Boswellia Birdw., (Boswellia Birdw.) and Boswellia B.negecta M.Moore; the functions are mainly used for regulating qi and activating blood, relieving pain and dispelling toxin; it is indicated for stagnation of qi and blood, pain in the heart and abdomen, carbuncle, sore, swelling and toxin, traumatic injury, dysmenorrhea, and puerperal pain due to blood stasis. Myrrha is oleoresin extracted from trunk and bark of Commiphora myrrha Engl [ C.molmol Engl ] and other plants of Commiphora of Burseraceae; the functions are mainly used for dissipating blood stasis, reducing swelling and relieving pain; it is indicated for traumatic injury, incised wound, pain of bones and muscles, heart and abdomen, abdominal mass, amenorrhea, carbuncle, abscess, swelling and pain, anal fistula and eye disorders. Peach kernel, which is a dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch, a Rosaceae plant; the functions are mainly used for promoting blood circulation, removing blood stasis and relaxing bowel; can be used for treating amenorrhea, dysmenorrhea, abdominal mass, traumatic injury, intestinal dryness and constipation. Stigma croci, which is the upper part and stigma of croci Sativi style of Iridaceae; the functions are mainly used for promoting blood circulation and removing blood stasis, and dispersing stagnation and resolving masses; for melancholia, chest stuffiness and oppression, hematemesis, typhoid fever, mania, trance, amenorrhea, postpartum abdominal pain due to blood stasis, and traumatic injury. Lignum sappan, which is dried heartwood of Caesalpinia sappan of Caesalpinia of Leguminosae; the functions are mainly used for promoting blood circulation, removing blood stasis, relieving swelling and pain; can be used for treating amenorrhea, dysmenorrhea, puerperal stagnation, thoracico-abdominal pain, and traumatic swelling and pain. Eupolyphaga Seu Steleophaga is female dry body of Eupolyphaga sinensis Walker or Steleophaga planchi (Boleny) belonging to family Cyperaceae; the functions are mainly used for breaking blood stasis and reuniting bones and muscles; can be used for treating fracture of tendons and bones, amenorrhea due to blood stasis, and abdominal mass. Sanguis Draxonis is prepared from resin exuded from fruit of Daemonorops draco Blume of Palmae; the main function of the medicine is to remove blood stasis, relieve pain, stop bleeding and promote tissue regeneration; can be used for treating traumatic injury, internal injury, blood stasis and pain; bleeding caused by trauma is not limited. Notoginseng radix, which is dried root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae; the functions are mainly used for dissipating blood stasis and stopping bleeding, and relieving swelling and pain; can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain. Radix aucklandiae, which is dried root of Aucklandia lappaDecne of Compositae; the functions are mainly to promote the circulation of qi, relieve pain, invigorate the spleen and promote digestion. The functions are mainly to promote the circulation of qi, relieve pain, invigorate the spleen and promote digestion. Can be used for treating chest and abdominal distention and pain, dysentery, tenesmus, dyspepsia, and anorexia. Roasted Aucklandia lappa Decne, radix aucklandiae and Cornus Sessima to relieve diarrhea. Can be used for treating diarrhea and abdominal pain. Rhizoma Cyperi is dried rhizome of Cyperus rotundus L. of Cyperaceae; the functions are mainly used for promoting the circulation of qi, resolving depression, regulating menstruation and relieving pain; can be used for treating stagnation of qi due to stagnation of liver-qi, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, chest and abdominal distention and fullness, hernia due to cold, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea. Pericarpium Citri Reticulatae viride, which is the pericarp of dried young or immature fruit of Citrus reticulata Blanco of Rutaceae and its cultivar; the functions are mainly used for soothing the liver, breaking qi, removing food retention and resolving stagnation; can be used for treating distending pain in chest and hypochondrium, hernia, breast nodule, acute mastitis, food stagnation, and abdominal pain. Cortex moutan is dried root bark of Paeonia suffruticosa Andr. of Ranunculaceae; the functions are mainly used for clearing heat and cooling blood, and promoting blood circulation and removing blood stasis; can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning cool, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, and pain. Forsythia suspensa (Forsythia Suspensa (Thunb.) Vahl, dried fruit of Forsythia suspensa (Forsythia) of Oleaceae; the main functions are clearing away heat and toxic material, relieving swelling and dissipating stagnation; can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, macula, and stranguria with heat. Curcumae rhizoma is dried rhizome of Curcuma zedoaria Curcuma phaeocaulis Val, Curcuma Kwangsiensis S.G.Leeat C.F.Liang or Curcuma wenyujin Y.H.Chen et C.Ling; the functions are mainly used for breaking blood and promoting qi circulation, removing food retention and relieving pain; . Can be used for treating abdominal pain due to blood stasis, hepatosplenomegaly, abdominal distention and pain, abdominal accumulation, amenorrhea due to blood stasis, traumatic injury, and food stagnation. Pollen Typhae is dry pollen of Typhaceae plant Typha angustifolia L, Typha orientalis Presl, or congeneric plant; the functions are mainly used for stopping bleeding, removing blood stasis and treating stranguria; can be used for treating hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, swelling and pain, and stranguria with blood. Poria, is dried sclerotium of Wolf of Poria cocos (Schw.) Cos (belonging to Polyporaceae); the functions are mainly used for promoting diuresis and eliminating dampness, strengthening spleen and calming heart; can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. Gardenia jasminoides Ellis is dried mature fruit of Gardenia jasminoides Ellis of Rubiaceae, and its root can also be used as medicine. The function is mainly used for fruits: purging fire, relieving restlessness, clearing heat, inducing diuresis, cooling blood and removing toxicity. Can be used for treating vexation due to fever, jaundice, dark urine, stranguria with blood, pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; externally treating sprain, contusion and pain; root: purging fire and removing toxicity, clearing heat and promoting diuresis, cooling blood and dissipating blood stasis. Can be used for treating infectious hepatitis, traumatic injury, and toothache due to pathogenic wind-fire. Trogopterus dung is dry feces of Trogopterus Xanthipes Milne-Edwards or Trogopterus volvulus L of Trogopterus; the function is mainly used for promoting blood circulation and relieving pain when used unprocessed; treating pain due to blood and qi in heart and abdomen, amenorrhea, and puerperal pain due to blood stasis; externally treating snake, scorpion and centipede bite; stir-baked for stopping bleeding. Catechu, which is dried soft extract of peeled branch and dried stem of Acacia catechu (L.f.) Willd of Acacia of Leguminosae; is dry extract obtained by decocting and concentrating dry branches of Acacia catechu (L.) Willd. of Acacia of Leguminosae with water; the functions are mainly used for clearing heat, reducing phlegm, healing sore and stopping bleeding; can be used for treating cough due to lung heat, hemoptysis, diarrhea, and infantile dyspepsia; it is externally used for treating intractable sores and ulcers, skin eczema, aphtha and tonsillitis. Herba Artemisiae Anomalae, which is dry whole plant of Siphonostegia chinensis Benth of Scrophulariaceae; has effects in promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, cooling blood, stopping bleeding, clearing away heat, and removing dampness; can be used for treating traumatic injury, traumatic hemorrhage, blood stasis, menoxenia, puerperal pain, scar, dysentery, bloody stranguria, jaundice due to damp-heat pathogen, edema, abdominal distention, and leukorrhagia; squama Manis, squama Manis of Manispentadactyla Linnaeus of Manispentadactyla of Manidae; the functions are mainly used for stimulating the menstrual flow and promoting lactation, reducing swelling and expelling pus, and dispelling wind and dredging collaterals; can be used for treating amenorrhea and abdominal mass, galactostasis, carbuncle, swelling, sore, arthralgia, numbness and contracture.
Square solution: after traumatic injury, local vessel rupture, hemorrhage, blood stasis due to blood stasis, heat dissipation due to blood stasis, blocked vessel obstruction, and local swelling and pain with red swelling are difficult to endure. The pain due to qi injury, swelling due to injury, qi failing to move, blood moving, blood consuming qi, swelling and pain, and fixed position. Therefore, the traditional Chinese medicine is used for treating the diseases by a method of cooling blood and stopping bleeding, activating blood and dissolving stasis, and promoting qi circulation and relieving pain and swelling, wherein in the formula, angelica, saffron, red paeony root, sappan wood, peach kernel, salvia miltiorrhiza, artemisia anomala and cattail pollen activate blood and dissolve stasis; olibanum, Myrrha, sanguis Draxonis, Notoginseng radix, rhizoma corydalis, radix aucklandiae, rhizoma Cyperi, Oletum Trogopterori, Catechu, and rhizoma Ligustici Chuanxiong have effects in promoting blood circulation, activating qi-flowing, and relieving pain; rhizoma Sparganii, Curcumae rhizoma, Eupolyphaga Seu Steleophaga, pericarpium Citri Reticulatae viride, squama Manis, Poria, removing blood stasis, dredging channels, and relieving swelling and pain; cortex moutan, fructus Gardeniae, and fructus forsythiae have effects in clearing away heat and cooling blood;
the inventors have made the following studies on the drug of the present invention
Experimental example:
first, the research of pill extraction process
1 determination of salvianolic acid B content
1.1 chromatographic conditions
A chromatographic column: ZORBAX SB-C18(250mm4.6mm, 5 μm); mobile phase: acetonitrile-0.1% phosphoric acid solution (21: 79); flow rate: 1.2 mL/min; the detection wavelength is 286 nm; the column temperature is 20 ℃; the amount of the sample was 10. mu.L. The theoretical plate number is not less than 6000 calculated by salvianolic acid B. Under the selected chromatographic conditions, the salvianolic acid B chromatographic peak can be separated from the adjacent chromatographic peak in the sample by a baseline, the separation degree is more than 1.5, the theoretical plate number is more than 6000, the tailing factor T is between 0.95 and 1.05, and the negative interference is avoided.
1.2 preparation of control solutions
Taking appropriate amount of salvianolic acid B as reference, precisely weighing, and adding methanol-water (8: 2) mixed solution to obtain solution containing 0.1mg per 1 ml. (see FIG. 1)
1.3 preparation of test solutions
Precisely weighing 1/20 prescription dose of radix Salviae Miltiorrhizae, radix Paeoniae Rubra, rhizoma Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, rhizoma Curcumae, herba Artemisiae Anomalae, pollen Typhae, fructus Gardeniae, 1/40 amount of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae, and Poria, adding 12 times amount of water, heating and refluxing, extracting for 2 times, 1 hr each time, cooling the medicinal liquid to room temperature, filtering, mixing the filtrates, standing for 2 hr, collecting the supernatant, passing through microporous filter membrane, and sampling 10 μ L to high performance liquid chromatography for determination. (see FIG. 2)
1.4 preparation of negative control solution
Preparing a negative sample without the salvia miltiorrhiza according to the prescription requirement, and preparing a negative control solution without the salvia miltiorrhiza by the same preparation method of the test solution. The sample size was 10. mu.L, as determined by high performance liquid chromatography. (see FIG. 3)
2 determination of Dry extract yield
Weighing partial medicinal materials of the total prescription amount of water extract, performing tests according to a test schedule, and concentrating decoction (combination) to 1: measuring 10ml at 1 hour, placing in a dry constant-weight evaporation dish, volatilizing in water bath, drying at 105 deg.C for 3 hr, cooling in a drier for 0.5 hr, weighing, recording, and calculating to obtain extract rate.
Dry extract yield (%) ═ Vm1/10m
In the formula: v is the total volume of the concentrated liquid in milliliters (ml)
m is the crude drug mass of the water-extracted medicinal material. The unit is gram (g)
m1Is 10ml of concentrated solution dry extract mass, and the unit is gram (g)
3 extraction process for optimizing pill by orthogonal test method
3.1 orthogonal experimental design
Using an orthogonal test method, L9(34) Orthogonal table arrangement experiment, and optimization of water decoction extraction process of part of medicinal materials. The preliminary tests show that the factors which have great influence on the content of the effective component salvianolic acid B are as follows: water addition, decoction time and decoction times. The content of salvianolic acid B is used as an evaluation index, and the extraction time (A), the extraction frequency (B) and the extraction volume (C) are used as influence factors to optimize, wherein the factors and the levels are shown in Table 1.
TABLE 1 factor and level design table
3.2 results of orthogonal test and analysis of variance
1/20 prescription dose of salvia miltiorrhiza, red paeony root, szechuan lovage rhizome, corydalis tuber, common burreed rhizome, frankincense, myrrh, peach seed, sappan wood, ground beeltle, tree peony bark, zedoary, calamus mollis, cattail pollen, gardenia and 1/40 prescription dose of angelica, costustoot, nutgrass galingale rhizome, green tangerine orange peel, weeping forsythia and tuckahoe are precisely weighed, extracted according to an orthogonal table, and the content and the dry paste yield of the salvianolic acid B are measured according to the methods of '2.1' and '2.2'. The results are shown in Table 2 and the analysis of variance is shown in Table 3.
TABLE 2L9(34) Protocol and results of orthogonal experiments
Note: the total score (((cream yield/maximum cream yield) × 0.2+ (salvianolic acid B content/maximum salvianolic acid B extraction) × 0.8) × 100%
TABLE 3 statistical analysis of salvianolic acid B content in orthogonal experiments
Note: f0.05(1,2) ═ 19
By taking the content of salvianolic acid B as an index, the extreme difference analysis of the test results in Table 3 shows that the main and secondary action sequences of all factors are sequentially extraction times, extraction time and extraction volume, namely C>B>A. ANOVA showed that A, B, C factors differed insignificantly (p > 0.05). Visual analysis from Table 2, A among the A factors1＞A3＞A2Therefore, A is selected1(ii) a Factor B in factor B2＞B3＞B1Therefore, B is selected2(ii) a Factor C of C3＞C2＞C1Therefore, C is selected3It can be concluded from this that the best extraction process is based on salvianolic acid B as indexA1B2C3. Namely, 12 times of water is added, and the extraction is carried out for 2 times, each time for 1 hour.
3.3 validation experiments
The medicinal materials of the water extraction part are extracted according to the optimized extraction process conditions, the content of the salvianolic acid B in the extracting solution and the dry extract yield are measured, the result is shown in table 4, the extraction is carried out according to the optimized process, and the content of the salvianolic acid B and the dry extract yield are both in higher levels, which shows that the process is reasonable, feasible, stable and reliable.
TABLE 4 three lots of verification test results of pill water extraction process
Second, research on pill forming process
2.1 examination of the concentration temperature of the extract
And (3) carrying out rotary steaming and direct fire concentration on the water extract obtained by extraction at 60 ℃, 70 ℃, 80 ℃ and 90 ℃ respectively to a certain volume, pouring the water extract into a small beaker, carrying out water bath concentration at 60 ℃, 70 ℃, 80 ℃ and 90 ℃ and direct fire concentration to 40ml, adding the medicinal powder to prepare a soft material, then preparing a pill by a plastic method, and gradually heating to 80 ℃ at 50 ℃ for drying to obtain the pill. The content of salvianolic acid B is taken as an evaluation index. (lg pill powder is taken out and added into a conical flask, 10ml of 80% methanol is added, precision weighing is carried out, ultrasonic treatment is carried out for 30min, the pill powder is taken out and weighed, 80% methanol is used for complementing the weight, and the subsequent filtrate is taken and filtered through a microporous filter membrane, thus obtaining the compound capsule) the results are shown in table 5.
TABLE 5 examination of the concentration temperature of the aqueous extract
From the above table, it can be seen that: the pill is concentrated at 80 deg.C and dried to obtain the highest content of salvianolic acid B. Therefore, 80 ℃ is selected as the concentration and drying temperature of the pill.
2.2 pellet formation study
Concentrating the extractive solution at 80 deg.C with rotary evaporator to about 75mL, pouring into beaker, concentrating in 80 deg.C water bath to 40mL, adding the medicinal powder when the relative density of the concentrated solution is 1.0546, shaping, and drying at 50 deg.C to 80 deg.C.
2.3 pill drying time study
Placing the pill in evaporation dish with constant weight, parallel 2 parts, drying in oven at 105 deg.C until the water content of the pill is not more than 9.0%. The results are shown in Table 6.
TABLE 6 moisture content (%) -of pellets at different drying times
And (4) conclusion: as can be seen from the above table, the pellets dried for 7 hours achieved the moisture requirement. Therefore, the best shaping process of the pill comprises concentrating the extractive solution at 80 deg.C to about 75mL by rotary evaporator, concentrating in 80 deg.C water bath until the relative density is 1.0546(40mL), adding the medicinal powder, shaping, and drying in oven at 50 deg.C to 80 deg.C for 7 hr.
The preparation method of the pill is determined as follows: pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking with 12 times of water for 1h, heating and refluxing for 1h, filtering to obtain residue A, decocting residue A with 12 times of water for 1h, filtering to obtain residue B, decocting residue B with 12 times of water for 1h, filtering, discarding residue, mixing the three filtrates, concentrating to density of 1.0-1.1g/mL, mixing with medicine C, making into soft material, making into pill by plastic method, screening, placing the selected pill into coating pan, rolling, and drying at 60 deg.C.
Extraction process research of granule
1 content determination of salvianolic acid B in salvia miltiorrhiza medicinal material
According to 2015 edition of Chinese pharmacopoeia, about 0.15g of radix salviae miltiorrhizae powder (screened by a No. three sieve) is taken, precisely weighed, placed in a conical flask with a plug, 50ml of (methanol: water: 8:2) is precisely added, the weight is weighed, ultrasonic treatment is carried out for 30min, cooling to room temperature is carried out, weighing is carried out, the loss weight is complemented by (methanol: water: 8:2), shaking is carried out uniformly, filtering is carried out, 10 mul of subsequent filtrate is taken, and the content of salvianolic acid B in the radix salviae miltiorrhizae medicinal material is determined to be 3.7 percent and meets the requirement of the pharmacopoeia (the content of salvianolic acid B is not less than 3.0 percent.
2 determination of Dry extract yield
Weighing the water-extracted part of the medicinal materials according to the total prescription amount, testing according to a test schedule, weighing 10ml of the decoction (combination) when the decoction is concentrated to 1:1, putting the concentrated decoction into a dry constant-weight evaporation dish, volatilizing the decoction in water bath, drying the decoction at 105 ℃ for 3h, then putting the dried decoction into a dryer, cooling the dried decoction for 0.5h, weighing, recording and calculating to obtain the extract rate.
Dry extract yield (%) ═ V.m1/10·m×100％
In the formula: v is the total volume of the concentrated liquid in milliliters (ml)
m is the crude drug mass of the water-extracted medicinal material. The unit is gram (g)
m1Is 10ml of concentrated solution dry extract mass, and the unit is gram (g)
3 adopting orthogonal test method to optimize the extraction process
3.1 orthogonal experimental design
Extracting the water-extracted part of the medicinal materials by an extraction process L9(34) Orthogonal tables were experimentally designed. The preliminary test shows that the factors which have great influence on the content of the effective components are as follows: water addition, decoction time and decoction times. The content of salvianolic acid B is used as an evaluation index, and the extraction time (A), the extraction frequency (B) and the extraction volume (C) are used as influence factors to optimize, wherein the factors and the levels are shown in a table 7.
TABLE 7 factor and level design Table
3.2 results of orthogonal test and analysis of variance
Precisely weighing the formula amount of salvia miltiorrhiza, red paeony root, szechuan lovage rhizome, yanhusuo, common burreed rhizome, frankincense, myrrh, peach seed, sappan wood, ground beeltle, tree peony bark, zedoary, calamus mollis, cattail pollen and gardenia, and the half formula amount of angelica, costus root, nutgrass galingale rhizome, green tangerine orange peel, weeping forsythia and tuckahoe, extracting according to an orthogonal table, and measuring the content of salvianolic acid B and the yield of dry paste according to the methods under '1.1.4' and '1.2'. The results are shown in Table 8 and the analysis of variance is shown in Table 9.
TABLE 8L9(34) Protocol and results of orthogonal experiments
Note: the total score (((cream yield/maximum cream yield) × 0.2+ (salvianolic acid B content/maximum salvianolic acid B extraction) × 0.8) × 100%
TABLE 9 statistical analysis of salvianolic acid B content in orthogonal experiments
Note: f0.05(1,2) ═ 19
By taking the content of salvianolic acid B as an index, the extreme difference analysis of the test results in Table 3 shows that the main and secondary action sequences of all factors are sequentially extraction times, extraction time and extraction volume, namely C>B>A. ANOVA showed that A, B, C factors differed insignificantly (p > 0.05). Visual analysis from Table 2, A among the A factors1＞A3＞A2Therefore, A is selected1(ii) a Factor B in factor B2＞B3＞B1Therefore, B is selected2(ii) a Factor C of C3＞C2＞C1Therefore, C is selected3From this, it can be concluded that the optimal extraction process is A1B2C3 with salvianolic acid B as the index, i.e. 12 times of water extraction for 1h, 2 times each.
3.3 validation experiments
The medicinal materials of the water extraction part are extracted according to the optimized extraction process conditions, the content of the salvianolic acid B in the extracting solution and the dry extract yield are measured, the result is shown in table 10, the extraction is carried out according to the optimized process, and the content of the salvianolic acid B and the dry extract yield are both in higher level, which shows that the process is reasonable, feasible, stable and reliable.
TABLE 10 Water extraction of granule Process three batches of validation test results
Fourthly, research on forming process of granules
1 examination of concentration temperature of extract
Concentrating the water extractive solution with rotary steaming at 60 deg.C, 70 deg.C, 80 deg.C, 90 deg.C and direct fire to a certain volume, pouring into a small beaker, concentrating at 60 deg.C, 70 deg.C, 80 deg.C, 90 deg.C in water bath and direct fire to 40ml, adding 70g of soluble starch and medicinal powder, making into soft material, extrusion granulating, drying at 80 deg.C, grading, and making into granule. The content of salvianolic acid B is taken as an evaluation index. (lg of the granules were placed in an erlenmeyer flask, 10ml of 80% methanol was added, precision weighing was performed, sonication was performed for 30min, the granules were taken out, weighed, the weight was made up with 80% methanol, and the subsequent filtrate was filtered through a microfiltration membrane.) the results are shown in Table 11.
TABLE 11 examination of the concentration temperature of the aqueous extract
From the above table, it can be seen that: the highest content of salvianolic acid B can be obtained when the granule is concentrated and dried at 80 deg.C. Therefore, 80 ℃ is selected as the concentration temperature of the aqueous extract liquid.
2 investigation of addition of auxiliary materials
Dextrin and starch are respectively selected in the test, and the result shows that the dextrin has high viscosity and cannot be molded; starch is selected as the auxiliary material, and the granules formed by using the starch as the auxiliary material have good fluidity. Finally, the adding amount of the starch is examined, and the influence of 60g, 70g and 80g of the starch on granule forming is respectively examined. The results show that the soft material made of 60g of starch is sticky and not good for extrusion sieving; the soft material made of 80g of starch is too loose, resulting in poor granule formability; the soft material prepared from 70g of starch achieves the purposes of 'kneading into lumps with hands and dispersing with hands', and has better particle formability. Therefore, 70g was selected.
3 examination of particle drying temperature
Spreading 10g of wet granules on an enamel plate with a thickness of less than 2mm, drying in parallel for 3 parts at 60 deg.C, 70 deg.C and 80 deg.C for 30min, respectively, taking appropriate amount of granules obtained at different drying temperatures, preparing test solution according to the method of "determination of salvianolic acid B content", and determining, the results are shown in Table 12.
TABLE 12 Peak area of Salvianolic acid B in particles at different drying temperatures
And (4) conclusion: as can be seen from the above table, the drying temperature of the pellets was preferably 80 ℃ and 80 ℃ was selected as the drying temperature of the pellets.
4 particle drying time investigation
About 1.5g of dry granules are taken, put into an evaporation dish with constant weight, and 3 parts in parallel are put into an oven with the temperature of 80 ℃ for drying until the weight is constant, and the water content of the granules cannot exceed 8.0 percent. The results are shown in Table 13.
TABLE 13 moisture content (%)
And (4) conclusion: as can be seen from the above table, the granules were dried for 30 min.
The preparation method of the granules is determined as follows: pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of soluble starch, making into soft material, extruding, sieving, and drying.
Compared with the prior art, the traditional Chinese medicine has the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and can effectively treat soft traumatic injury and blood stasis and swelling pain; the invention has the advantages of small toxic and side effect, short treatment period and good treatment effect, and achieves the aim of the invention.
Drawings
FIG. 1 chromatogram of salvianolic acid B control in the experimental example of the invention;
FIG. 2 is a high liquid level map of an aqueous extract in an experimental example of the present invention;
FIG. 3 is a high-level chromatogram of a negative control solution in an experimental example of the present invention.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Example 1.
A traditional Chinese medicine for promoting blood circulation and relieving pain is prepared by the following steps: weighing 9g of salvia miltiorrhiza, 9g of angelica tail, 9g of red paeony root, 1.5g of ligusticum wallichii, 3g of corydalis tuber, 10g of rhizoma sparganii, 5g of frankincense, 5g of myrrh, 6g of peach kernel, 3g of saffron crocus, 6g of sappan wood, 1.5g of ground beeltle, 2g of dragon's blood, 3g of pseudo-ginseng, 6g of costustoot, 6g of rhizoma cyperi, 6g of green tangerine peel, 6g of moutan bark, 6g of fructus forsythiae, 3g of curcuma zedoary, 6g of pollen typhae, 9g of poria cocos, 6g of gardenia, 6g of trogopterus dung, 3g of catechu, 6g of artemisia anomala chinensis and 1.5g of pangolin, crushing the pseudo-ginseng; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking with 12 times of water for 1h, heating and refluxing for 1h, filtering to obtain residue A, decocting residue A with 12 times of water for 1h, filtering to obtain residue B, decocting residue B with 12 times of water for 1h, filtering, discarding residue, mixing the three filtrates, concentrating to density of 1.0-1.1g/mL, mixing with medicine C, making into soft material, making into pill by plastic method, screening, placing the selected pill into coating pan, rolling, drying at 60 deg.C, and making into 0.5 g/pill.
The usage and dosage are as follows: it is administered orally 2-3 times daily, 5 pills each time.
Example 2. A traditional Chinese medicine for promoting blood circulation and relieving pain is prepared by the following granules: 163.63g of salvia miltiorrhiza, 163.63g of angelica tail, 163.62g of red paeony root, 27.27g of ligusticum wallichii, 54.55g of corydalis tuber, 181.82g of rhizoma sparganii, 90.91g of frankincense, 90.91g of myrrh, 109.09g of peach kernel, 54.55g of saffron crocus, 109.09g of sappan wood, 27.27g of ground beetle, 36.36g of dragon's blood, 54.55g of pseudo-ginseng, 109.09g of costustoot, 109.09g of rhizoma cyperi, 109.08g of green tangerine peel, 109.08g of moutan bark, 109.09g of fructus forsythiae, 54.54g of curcuma zedoary, 109.09g of pollen typhae, 163.63g of poria, 109.09g of gardenia, 109.0 g of trogopterus dung, 54.54g of catechu, 109.09g of herba artemisiae and 27.27g of pangolin, and the pseudo-ginseng, the dragon; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of soluble starch, making into soft material, squeezing, sieving, and drying to obtain 20 g/bag.
The usage and dosage are as follows: orally administered 2-3 times per day, and dissolved in boiled water 1 bag each time.
Example 3. A traditional Chinese medicine for promoting blood circulation and relieving pain is prepared by the following steps: weighing 11 parts of salvia miltiorrhiza, 11 parts of angelica tail, 11 parts of red paeony root, 2 parts of ligusticum wallichii, 4 parts of corydalis tuber, 12 parts of rhizoma sparganii, 7 parts of frankincense, 7 parts of myrrh, 8 parts of peach kernel, 4 parts of saffron crocus, 8 parts of sappan wood, 2 parts of ground beeltle, 3 parts of dragon's blood, 4 parts of pseudo-ginseng, 8 parts of elecampane, 8 parts of rhizoma cyperi, 8 parts of pericarpium citri reticulatae viride, 8 parts of moutan bark, 8 parts of fructus forsythiae, 4 parts of curcuma zedoary, 8 parts of pollen typhae, 11 parts of poria cocos, 8 parts of gardenia, 8 parts of trogopterus dung, 4 parts of catechu, 8 parts of artemisia peichiana and 2 parts of pangolin, crushing pseudo-; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of compressible starch, grading, tabletting, coating with fruit membrane, and making into tablet 0.25 g/tablet.
The usage and dosage are as follows: it is administered orally 2-3 times daily, 4 tablets each time.
Claims (8)
1. A traditional Chinese medicine for promoting blood circulation and relieving pain is characterized in that: the medicinal effective components are calculated according to the weight parts, and comprise 4-14 parts of salvia miltiorrhiza, 4-14 parts of angelica tail, 4-14 parts of red paeony root, 0.5-3 parts of szechuan lovage rhizome, 1-5 parts of corydalis tuber, 5-15 parts of common burreed rhizome, 1-9 parts of frankincense, 1-9 parts of myrrh, 2-10 parts of peach seed, 1-5 parts of saffron crocus, 2-10 parts of sappan wood, 0.5-3 parts of ground beeltle, 1-3 parts of dragon's blood, 1-5 parts of pseudo-ginseng, 2-10 parts of costus root, 2-10 parts of nutgrass galingale rhizome, 2-10 parts of green tangerine peel, 2-10 parts of tree peony bark, 2-10 parts of weeping forsythia, 1-5 parts of zedoary, 2-10 parts of common cattail pollen, 4-14 parts of tuckahoe, 2-10 parts of cape jasmine fruit, 2-10 parts, Pangolin scales 0.5-3 parts.
2. The traditional Chinese medicine for promoting blood circulation to arrest pain according to claim 1, characterized in that: the medicinal effective components of the medicine are calculated according to the weight parts, and comprise 7-11 parts of salvia miltiorrhiza, 7-11 parts of angelica tail, 7-11 parts of red peony root, 1-2 parts of ligusticum wallichii, 2-4 parts of corydalis tuber, 8-12 parts of rhizoma sparganii, 3-7 parts of frankincense, 3-7 parts of myrrh, 4-8 parts of peach kernel, 2-4 parts of saffron crocus, 4-8 parts of sappan wood, 1-2 parts of ground beeltle, 1-3 parts of dragon's blood, 2-4 parts of pseudo-ginseng, 4-8 parts of costus root, 4-8 parts of rhizoma cyperi, 4-8 parts of green tangerine peel, 4-8 parts of moutan bark, 4-8 parts of fructus forsythiae, 2-4 parts of curcuma zedoary, 4-8 parts of cattail pollen, 7-11 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of trogopterus dung, 2, Pangolin scales 1-2 parts.
3. The traditional Chinese medicine for promoting blood circulation to arrest pain according to claim 2, characterized in that: the medicinal effective components of the medicine are calculated according to the weight parts, and the medicine is prepared from 9 parts of salvia miltiorrhiza, 9 parts of angelica tail, 9 parts of red paeony root, 1.5 parts of ligusticum wallichii, 3 parts of corydalis tuber, 10 parts of rhizoma sparganii, 5 parts of frankincense, 5 parts of myrrh, 6 parts of peach kernel, 3 parts of saffron crocus, 6 parts of sappan wood, 1.5 parts of ground beeltle, 2 parts of dragon blood, 3 parts of pseudo-ginseng, 6 parts of elecampane, 6 parts of rhizoma cyperi, 6 parts of green tangerine peel, 6 parts of tree peony bark, 6 parts of fructus forsythiae, 3 parts of curcuma zedoary, 6 parts of cattail pollen, 9 parts of poria cocos, 6 parts of cape jasmine fruit, 6 parts of trogopterus dung.
4. A method for preparing the traditional Chinese medicine for promoting blood circulation and relieving pain as claimed in any one of claims 1 to 3, which is characterized in that: combining salvia miltiorrhiza, angelica tail, red paeony root, ligusticum wallichii, rhizoma corydalis, rhizoma sparganii, frankincense, myrrh, peach kernel, saffron crocus, sappan wood, ground beeltle, dragon's blood, pseudo-ginseng, elecampane, rhizoma cyperi, pericarpium citri reticulatae viride, moutan bark, fructus forsythiae, curcuma zedoary, cattail pollen, poria cocos, gardenia, trogopterus dung, catechu, artemisia anomala and pangolin with auxiliary materials acceptable in medicines, processing according to a conventional method, and preparing the corresponding medicine.
5. The preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain as claimed in claim 4, which is characterized in that: the medicine is as follows: pills, granules or tablets.
6. The preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain as claimed in claim 5, which is characterized in that: the pill is prepared by the following steps: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking with 12 times of water for 1h, heating and refluxing for 1h, filtering to obtain residue A, decocting residue A with 12 times of water for 1h, filtering to obtain residue B, decocting residue B with 12 times of water for 1h, filtering, discarding residue, mixing the three filtrates, concentrating to density of 1.0-1.1g/mL, mixing with medicine C, making into soft material, making into pill by plastic method, screening, placing the selected pill into coating pan, rolling, and drying at 60 deg.C.
7. The preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain as claimed in claim 5, which is characterized in that: the granules are prepared by: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of soluble starch, making into soft material, extruding, sieving, and drying.
8. The preparation method of the traditional Chinese medicine for promoting blood circulation and relieving pain as claimed in claim 5, which is characterized in that: the tablets are prepared by: weighing the above materials in proportion, pulverizing Notoginseng radix, sanguis Draxonis, stigma croci Sativi, Catechu, Oletum Trogopterori, and squama Manis, and sieving with 100 mesh sieve to obtain medicinal powder A; dividing radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria into two parts respectively, pulverizing one part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, sieving with 100 mesh sieve to obtain medicinal powder B, and mixing medicinal powder A and medicinal powder B to obtain medicinal powder C; mixing Saviae Miltiorrhizae radix, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, rhizoma corydalis, rhizoma Sparganii, Olibanum, Myrrha, semen Persicae, lignum sappan, Eupolyphaga Seu Steleophaga, cortex moutan, Curcumae rhizoma, herba Artemisiae Anomalae, pollen Typhae, and fructus Gardeniae with another equal part of radix Angelicae sinensis, radix aucklandiae, rhizoma Cyperi, pericarpium Citri Reticulatae viride, fructus forsythiae and Poria, soaking in water for 1h, decocting with 8 times of water for 1.5h, decocting for 3 times, filtering with 8 layers of gauze, mixing the filtrates, concentrating the filtrate at 60 deg.C to relative density of 1.15, mixing with medicine C, adding conventional amount of compressible starch, grading, tabletting, and coating with fruit membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910920138.6A CN110876788A (en) | 2019-09-26 | 2019-09-26 | Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910920138.6A CN110876788A (en) | 2019-09-26 | 2019-09-26 | Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110876788A true CN110876788A (en) | 2020-03-13 |
Family
ID=69727790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910920138.6A Pending CN110876788A (en) | 2019-09-26 | 2019-09-26 | Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110876788A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686182A (en) * | 2020-07-08 | 2020-09-22 | 西南医科大学附属中医医院 | Chinese medicinal composition for removing blood stasis and relieving pain and preparation method thereof |
| CN112516277A (en) * | 2020-11-17 | 2021-03-19 | 南京钜力智能制造技术研究院有限公司 | Traditional Chinese medicine for promoting blood circulation, removing blood stasis, removing dampness and expelling toxin and preparation method thereof |
| CN113456786A (en) * | 2021-08-23 | 2021-10-01 | 威海德尚医中医药科技有限公司 | Traditional Chinese medicine formula with effects of promoting blood circulation and removing blood stasis and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911345A (en) * | 2006-08-15 | 2007-02-14 | 黄南锡 | Decoction for treating sharp ache type menorrhalgia, and its prepn. method |
| CN101053653A (en) * | 2007-05-16 | 2007-10-17 | 北京艺信堂医药研究所 | Traditional Chinese medicinal composition for treating endometriosis sterility |
| CN101361935A (en) * | 2008-09-11 | 2009-02-11 | 泰安市中医二院 | Blood-activating emergency pill and preparation method thereof |
| CN103432328A (en) * | 2013-09-09 | 2013-12-11 | 王建忠 | Traditional Chinese medicine formula for treating femoral head necrosis by traditional Chinese medicine fuming moxibustion therapy |
| CN104740552A (en) * | 2013-12-27 | 2015-07-01 | 林少梅 | Traditional Chinese medicine for treating endometriosis |
| CN104984252A (en) * | 2015-07-23 | 2015-10-21 | 四川金堂海纳生物医药技术研究所 | Decoction for treating traumatic intracranial hematoma and preparation method thereof |
| CN105617290A (en) * | 2016-03-16 | 2016-06-01 | 烟台市华文欣欣医药科技有限公司 | Application of medicinal composition in preparing medicine for promoting circulation and removing stasis |
-
2019
- 2019-09-26 CN CN201910920138.6A patent/CN110876788A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911345A (en) * | 2006-08-15 | 2007-02-14 | 黄南锡 | Decoction for treating sharp ache type menorrhalgia, and its prepn. method |
| CN101053653A (en) * | 2007-05-16 | 2007-10-17 | 北京艺信堂医药研究所 | Traditional Chinese medicinal composition for treating endometriosis sterility |
| CN101361935A (en) * | 2008-09-11 | 2009-02-11 | 泰安市中医二院 | Blood-activating emergency pill and preparation method thereof |
| CN103432328A (en) * | 2013-09-09 | 2013-12-11 | 王建忠 | Traditional Chinese medicine formula for treating femoral head necrosis by traditional Chinese medicine fuming moxibustion therapy |
| CN104740552A (en) * | 2013-12-27 | 2015-07-01 | 林少梅 | Traditional Chinese medicine for treating endometriosis |
| CN104984252A (en) * | 2015-07-23 | 2015-10-21 | 四川金堂海纳生物医药技术研究所 | Decoction for treating traumatic intracranial hematoma and preparation method thereof |
| CN105617290A (en) * | 2016-03-16 | 2016-06-01 | 烟台市华文欣欣医药科技有限公司 | Application of medicinal composition in preparing medicine for promoting circulation and removing stasis |
Non-Patent Citations (1)
| Title |
|---|
| 陈玉华 等: "内服痛经胶囊加外敷痛经散治疗痛经152例", 《中国临床医生》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686182A (en) * | 2020-07-08 | 2020-09-22 | 西南医科大学附属中医医院 | Chinese medicinal composition for removing blood stasis and relieving pain and preparation method thereof |
| CN112516277A (en) * | 2020-11-17 | 2021-03-19 | 南京钜力智能制造技术研究院有限公司 | Traditional Chinese medicine for promoting blood circulation, removing blood stasis, removing dampness and expelling toxin and preparation method thereof |
| CN113456786A (en) * | 2021-08-23 | 2021-10-01 | 威海德尚医中医药科技有限公司 | Traditional Chinese medicine formula with effects of promoting blood circulation and removing blood stasis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2474314B1 (en) | Antiphlogistic, antioncotic and analgesic chinese herbal composition preparative method and usage thereof | |
| CN103784820B (en) | For treating Chinese medicine formula and the Chinese medicinal capsule of cardiovascular stasis coronary heart disease | |
| CN110876788A (en) | Traditional Chinese medicine for promoting blood circulation and relieving pain and preparation method thereof | |
| CN110624040A (en) | Pharmaceutical preparation for treating fracture injury at middle stage and preparation method thereof | |
| CN102078569A (en) | Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof | |
| CN104997882A (en) | Traditional Chinese medicine for treating adenomyosis | |
| CN101361911A (en) | External skin composition with wrinkle-dispelling function and production method thereof | |
| CN104435686A (en) | Use of traditional Chinese medicine preparation in preparation of medicine for treating skin itch and eczema papulosum | |
| CN110624033A (en) | Traditional Chinese medicine for reunion of bone and tendon and preparation method thereof | |
| CN103736017A (en) | Traditional Chinese medicine composition for treating intercostal neuralgia and preparation method of traditional Chinese medicine composition | |
| CN103432419A (en) | Traditional Chinese medicinal composition for treating dysfunctional uterine bleeding and preparation method of preparation thereof | |
| CN115282229B (en) | Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof | |
| CN1246031C (en) | Chinese patent drug-Fuyan capsdule for treating chronic pelvic inflammation | |
| CN101474356A (en) | Chinese medicine granular formulation for treating spinal cord and relevant diseases | |
| CN104352966A (en) | Traditional Chinese medicine composition for treating dysmenorrhea | |
| CN104524164A (en) | Traditional Chinese medicine preparation for treating pruritus and eczema papulosum and preparation method thereof | |
| CN101569682B (en) | Medical composition for treating rheumatoid arthritis and preparation method | |
| CN104055990A (en) | Traditional Chinese medicine for treating uterine myoma and preparation method thereof | |
| CN1814196A (en) | Chinese medicine composition for treating functional metrorrhagia and use thereof | |
| CN108619471B (en) | Danhuang stasis removing capsule and preparation process thereof | |
| CN113197991A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method and application thereof | |
| CN107029055B (en) | Traditional Chinese medicine compound preparation for treating leukemia caused by liver heat and blood stasis and preparation method thereof | |
| CN112704723A (en) | A Chinese medicinal preparation for treating dysmenorrhea and its preparation method | |
| CN102078531A (en) | Medicine for treating hypertension and preparation method thereof | |
| CN104688862A (en) | Drug for treating qi deficiency and blood stasis type stroke and preparation method and detection method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200313 |
|
| RJ01 | Rejection of invention patent application after publication |