CN110870908A - 一种含姜黄素的草本滴眼液 - Google Patents

一种含姜黄素的草本滴眼液 Download PDF

Info

Publication number
CN110870908A
CN110870908A CN201811012691.1A CN201811012691A CN110870908A CN 110870908 A CN110870908 A CN 110870908A CN 201811012691 A CN201811012691 A CN 201811012691A CN 110870908 A CN110870908 A CN 110870908A
Authority
CN
China
Prior art keywords
parts
essence
curcumin
preservative
beautyberry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811012691.1A
Other languages
English (en)
Inventor
李达欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201811012691.1A priority Critical patent/CN110870908A/zh
Publication of CN110870908A publication Critical patent/CN110870908A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明了公开一种含姜黄素的草本滴眼液，属于医药化学品领域，包含以下组分及重量比：水80‑100、姜黄素40‑50、聚乙烯己内酰胺30‑45、景天精华20‑35、千日红精华20‑33、生地精华20‑29、蚺蛇胆精华18‑26、苍术精华18‑23、马唐精华16‑21、茉莉精华16‑19、甘菊精华15‑18、枸杞精华13‑16、紫云英精华10‑16、苍耳精华10‑13、石决明精华8‑13、紫珠精华8‑10、地喹氯铵6‑9、聚乙酸乙烯酯5‑8、聚乙二醇5‑8、珍珠粉3‑6、玄明粉2‑4、防腐剂1‑3，解决传统姜黄素眼药水吸收差，作用效果不强的问题。

Description

一种含姜黄素的草本滴眼液
技术领域
本发明涉及医药化学品领域，具体涉及一种含姜黄素的草本滴眼液。
背景技术
眼睛是人体最重要的器官之一，为人们适应社会生活提供了保障。身处信息时代，随着人们的生活方式和工作条件的改变，人们的用眼时间比过去数十年多出几倍，人们越来越多地依赖电脑、电视等视频显示终端进行各种活动，比如长时间用电脑工作、看电视、玩电子游戏等等，很容易使人们患视觉疲劳症，如果不注意休息，就容易引发各种眼部疾病。
姜黄素(curcumin)具有抗氧化、抗炎、清除自由基等广泛的药理学活性，在治疗角膜外伤或接受角膜手术时极易出现角膜上皮愈合延迟甚至不愈，临床表现为持续性角膜上皮损失、反复性角膜上皮糜烂、浅层角膜溃疡形成、继发严重角膜感染甚至失明等方面有着广阔的应用前景。但是姜黄素亲水性和亲脂性均差，吸收差，生物利用度低，且其分子结构不稳定，限制了其临床应用，因此，很有必要进一步探索既安全，又经济又有效的眼部治疗用姜黄素药物。
发明内容
本发明的目的在于，解决传统姜黄素眼药水吸收差，作用效果不强的问题，提供一种含姜黄素的草本滴眼液。
为了解决上述技术问题，本发明采用如下技术方案：
一种含姜黄素的草本滴眼液，包含以下组分及重量比：水80-100、姜黄素40-50、聚乙烯己内酰胺30-45、景天精华20-35、千日红精华20-33、生地精华20-29、蚺蛇胆精华18-26、苍术精华18-23、马唐精华16-21、茉莉精华16-19、甘菊精华15-18、枸杞精华13-16、紫云英精华10-16、苍耳精华10-13、石决明精华8-13、紫珠精华8-10、地喹氯铵6-9、聚乙酸乙烯酯5-8、聚乙二醇5-8、珍珠粉3-6、玄明粉2-4、防腐剂1-3。
优选的，包含以下组分及重量比：水96、姜黄素48、聚乙烯己内酰胺41、景天精华31、千日红精华26、生地精华23、蚺蛇胆精华23、苍术精华19、马唐精华19、茉莉精华17、甘菊精华16、枸杞精华15、紫云英精华13、苍耳精华11、石决明精华9、紫珠精华9、地喹氯铵8、聚乙酸乙烯酯6、聚乙二醇6、珍珠粉5、玄明粉3、防腐剂2。
优选的，所述防腐剂包括苯扎氯铵、洁尔灭、山梨酸醇中的一种或多种。
实施本发明，具有如下有益功效：
本发明以姜黄素为主要活性药物，景天精华、千日红精华、生地精华、蚺蛇胆精华、苍术精华、马唐精华、茉莉精华、甘菊精华、枸杞精华、紫云英精华、苍耳精华、石决明精华、紫珠精华等多种中草药草本精华为引导剂，在水和聚乙烯己内酰胺溶液的中溶解混合，并配以珍珠粉、玄明粉补充营养，地喹氯铵、聚乙酸乙烯酯、聚乙二醇能进一步帮助缓解眼睛疲劳，加快眼睛对姜黄素的吸收，令姜黄素更好地作用于人体。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将结合具体实施例对本发明作进一步地详细描述。
实施例1
一种含姜黄素的草本滴眼液，包含以下组分及重量比：水100、姜黄素50、聚乙烯己内酰胺45、景天精华35、千日红精华33、生地精华29、蚺蛇胆精华26、苍术精华23、马唐精华21、茉莉精华19、甘菊精华18、枸杞精华16、紫云英精华16、苍耳精华13、石决明精华13、紫珠精华10、地喹氯铵9、聚乙酸乙烯酯8、聚乙二醇8、珍珠粉6、玄明粉4、苯扎氯铵3。
实施例2
一种含姜黄素的草本滴眼液，包含以下组分及重量比：水96、姜黄素48、聚乙烯己内酰胺41、景天精华31、千日红精华26、生地精华23、蚺蛇胆精华23、苍术精华19、马唐精华19、茉莉精华17、甘菊精华16、枸杞精华15、紫云英精华13、苍耳精华11、石决明精华9、紫珠精华9、地喹氯铵8、聚乙酸乙烯酯6、聚乙二醇6、珍珠粉5、玄明粉3、洁尔灭2。
实施例3
一种含姜黄素的草本滴眼液，包含以下组分及重量比：水80、姜黄素40、聚乙烯己内酰胺30、景天精华20、千日红精华20、生地精华20、蚺蛇胆精华18、苍术精华18、马唐精华16、茉莉精华16、甘菊精华15、枸杞精华13、紫云英精华10、苍耳精华10、石决明精华8、紫珠精华8、地喹氯铵6、聚乙酸乙烯酯5、聚乙二醇5、珍珠粉3、玄明粉2、山梨酸醇1。
以上所揭露的仅为本发明一种较佳实施例而已，当然不能以此来限定本发明之权利范围，因此依本发明权利要求所作的等同变化，仍属本发明所涵盖的范围。

Claims (3)

1.一种含姜黄素的草本滴眼液，其特征在于，包含以下组分及重量比：水80-100、姜黄素40-50、聚乙烯己内酰胺30-45、景天精华20-35、千日红精华20-33、生地精华20-29、蚺蛇胆精华18-26、苍术精华18-23、马唐精华16-21、茉莉精华16-19、甘菊精华15-18、枸杞精华13-16、紫云英精华10-16、苍耳精华10-13、石决明精华8-13、紫珠精华8-10、地喹氯铵6-9、聚乙酸乙烯酯5-8、聚乙二醇5-8、珍珠粉3-6、玄明粉2-4、防腐剂1-3。
2.根据权利要求1所述含姜黄素的草本滴眼液，其特征在于，包含以下组分及重量比：水96、姜黄素48、聚乙烯己内酰胺41、景天精华31、千日红精华26、生地精华23、蚺蛇胆精华23、苍术精华19、马唐精华19、茉莉精华17、甘菊精华16、枸杞精华15、紫云英精华13、苍耳精华11、石决明精华9、紫珠精华9、地喹氯铵8、聚乙酸乙烯酯6、聚乙二醇6、珍珠粉5、玄明粉3、防腐剂2。
3.根据权利要求1或2所述含姜黄素的草本滴眼液，其特征在于，所述防腐剂包括苯扎氯铵、洁尔灭、山梨酸醇中的一种或多种。
CN201811012691.1A 2018-08-31 2018-08-31 一种含姜黄素的草本滴眼液 Pending CN110870908A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811012691.1A CN110870908A (zh) 2018-08-31 2018-08-31 一种含姜黄素的草本滴眼液

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811012691.1A CN110870908A (zh) 2018-08-31 2018-08-31 一种含姜黄素的草本滴眼液

Publications (1)

Publication Number Publication Date
CN110870908A true CN110870908A (zh) 2020-03-10

Family

ID=69715821

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811012691.1A Pending CN110870908A (zh) 2018-08-31 2018-08-31 一种含姜黄素的草本滴眼液

Country Status (1)

Country Link
CN (1) CN110870908A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114271653A (zh) * 2021-11-24 2022-04-05 吉祥三宝高科纺织有限公司 黑苦荞草本清眠安神枕

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114271653A (zh) * 2021-11-24 2022-04-05 吉祥三宝高科纺织有限公司 黑苦荞草本清眠安神枕
CN114271653B (zh) * 2021-11-24 2023-08-29 吉祥三宝高科纺织有限公司 黑苦荞草本清眠安神枕

Similar Documents

Publication Publication Date Title
BRPI0414455A (pt) métodos para usar células regenerativas no tratamento de doença vascular periférica e distúrbios afins
CN103637978B (zh) 一种稳定的含菠萝蛋白酶的凝胶
CN110870908A (zh) 一种含姜黄素的草本滴眼液
CN102766548A (zh) 一种抗菌消炎、护肤美容的药皂及其制备方法
CN105687230A (zh) 一种祛痣膏及其制备方法
CN109394815A (zh) 一种婴幼儿皮肤滋养组合物及其制备方法
CN108813636A (zh) 益肝多肽组合物及其应用
CN101376870B (zh) 能活血化瘀排毒止痒的中草药酒
CN104430836A (zh) 一种草莓保鲜剂及其制备方法
CN103933206B (zh) 一种用于治疗老年人皮肤瘙痒的药剂洗剂
CN109432155A (zh) 一种婴幼儿湿疹组合物及其制备方法
CN101991687A (zh) 一种治疗烧伤的外用药物组方
US10166180B2 (en) Treatment of keratinized tissues
CN104323934A (zh) 一种新型去黑头保湿洗面奶
CN107308212A (zh) 一种活血消肿药的配方
CN106110293A (zh) 口腔溃疡喷剂及其制备方法
CN102451292A (zh) 治疗高血压饮用水的配方及制作方法
CN106728269A (zh) 一种治疗疣的中药组合物
CN1286470C (zh) 治疗痤疮的药物及其制备方法
CN102600300B (zh) 一种治疗红眼病的外用药水及其制备方法
CN109966246A (zh) 一种多索茶碱注射剂型组合物
RU2538175C1 (ru) Способ консервативного лечения наружных толстокишечных свищей
CN104351223A (zh) 一种防治百合叶枯病的方法
CN103585165B (zh) 一种治疗脚气的药物
CN1899357B (zh) 柿子霜药品的生产方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200310