CN110861377A - Composite sheet for medicine packaging and traditional Chinese medicine honeyed pill packaging prepared from same - Google Patents
Composite sheet for medicine packaging and traditional Chinese medicine honeyed pill packaging prepared from same Download PDFInfo
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- CN110861377A CN110861377A CN201911277448.7A CN201911277448A CN110861377A CN 110861377 A CN110861377 A CN 110861377A CN 201911277448 A CN201911277448 A CN 201911277448A CN 110861377 A CN110861377 A CN 110861377A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/088—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B11/00—Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
- B65B11/50—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2270/00—Resin or rubber layer containing a blend of at least two different polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/31—Heat sealable
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/40—Properties of the layers or laminate having particular optical properties
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7244—Oxygen barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7246—Water vapor barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Abstract
The invention provides a composite sheet for medicine packaging and a traditional Chinese medicine honeyed pill package prepared from the composite sheet. The composite sheet is suitable for cold stamping forming and comprises an outer layer, a middle layer and an inner layer, wherein the outer layer is a polyamide film, the middle layer is an aluminum foil, the inner layer is a heat sealing layer, and the inner layer is a co-extrusion composite film formed by the same or different resins. The composite sheet has the advantages of high breaking force, high cupping value, high heat seal strength, high peel strength and excellent barrier property, and is particularly suitable for preparing the package of the traditional Chinese medicine honeyed pills.
Description
Technical Field
The invention relates to the technical field of medicine packaging sheets, and particularly provides a composite sheet suitable for cold stamping forming and used for packaging Chinese medicine honey pills.
Background
The Chinese medicine honeyed pill is one of the main dosage forms of the Chinese medicine, and the packaging modes generally comprise the following two types: the method comprises the following steps of (1) carrying out wax dipping and packaging on a paper tube, wherein the packaging method comprises the steps of wrapping paper on a large honeyed pill, filling the paper honeyed pill into a paper barrel tube, covering the paper barrel tube, sticking a label, and finally carrying out wax sealing; (2) the spherical shell package is divided into wax shell and plastic shell, the wax shell is formed by placing unpacked big honeyed pills into a wax shell made by centrifugal casting method and then packaging, the plastic shell package is divided into naked pills and big honeyed pills, then the big honeyed pills are packaged into a hemispherical spherical shell, and after the plastic shell package is buckled, the wax shell is soaked and sealed.
However, neither paper tube wax-dipping package nor spherical shell package have the packaging defects of no light shielding, poor sealing performance and the like, and the traditional Chinese medicine honeyed pills often have the phenomenon of pill hardening, and particularly have the problem of drug effect reduction when the honeyed pills contain volatile precious and fine medicinal materials.
The existing aluminum-plastic blister packaging system formed by matching an outer nylon layer, an intermediate aluminum foil layer, an inner polyvinyl chloride (PVC) cold stamping forming composite sheet material and a medicinal aluminum foil has the height of a formed blister cup protrusion of 6-9mm generally, the maximum value of a test is not more than 12mm, and the blister cup protrusion value is limited, so that the existing aluminum-plastic blister packaging system can only be used for packaging capsules and tablets and cannot meet the existing requirements of various specifications for honey pills.
For common specifications such as
And
for honeyed pill preparations, suitable packaging sheets are currently lacking.
Accordingly, there is a need in the art for a new composite sheet for making a traditional Chinese medicine honeyed pill pack to solve the above problems.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a composite sheet for medicine packaging and a traditional Chinese medicine honeyed pill package prepared from the composite sheet. The composite sheet provided by the invention has the advantages of large breaking force, high cup bursting value, high heat seal strength, high peel strength and excellent barrier property, and is particularly suitable for preparing the package of the traditional Chinese medicine honeyed pills.
The composite sheet for medicine packaging is suitable for cold stamping forming and comprises an outer layer, a middle layer and an inner layer, wherein the outer layer is a polyamide film, the middle layer is an aluminum foil, the inner layer is a heat sealing layer, and the inner layer is composed of a co-extrusion composite film formed by the same or different resins.
Preferably, the outer polyamide layer is a biaxially oriented polyamide having a thickness of 15 to 40 μm, preferably 20 to 35 μm, more preferably 25 to 30 μm, and even more preferably 25 μm or 30 μm.
Preferably, the intermediate layer aluminum foil is an 8-series soft aluminum alloy foil, and has a thickness of 40 to 80 μm, preferably 45 to 75 μm, more preferably 50 to 70 μm, and still more preferably 50 μm, 65 μm, or 70 μm.
The type of resin forming the inner layer co-extruded composite film is not limited as long as it can be co-extruded into a film, heat-sealable, and applicable to pharmaceutical packaging.
Preferably, the inner-layer co-extrusion composite film is a three-layer structure consisting of a polyamide layer, a co-extrusion adhesive layer and a polyethylene layer in this order, wherein the polyamide layer is adjacent to the middle-layer aluminum foil. The thickness of the polyamide layer in the inner-layer co-extrusion composite film is 10-25 microns, preferably 15-20 microns, more preferably 15 microns and 20 microns; the thickness of the polyethylene layer in the inner layer co-extruded composite film is 40-80 μm, preferably 50-70 μm, more preferably 50 μm, 60 μm and 70 μm. The polyethylene in the polyethylene layer is preferably linear low density polyethylene. The co-extruded adhesive layer may use an adhesive resin known in the art to be suitable for pharmaceutical packaging and for co-extrusion of polyamide and polyethylene, preferably maleic anhydride grafted linear low density polyethylene. In the preferred scheme, two sides of the aluminum foil are compounded with polyamide to form a symmetrical structure, so that the aluminum foil is better protected, and particularly, pinholes and compound layering are not easy to occur on the aluminum foil after high cupping punch forming.
Preferably, the co-extrusion composite film of the inner layer is of a two-layer structure consisting of 30-35% of SEBS modified polypropylene layer and 5-10% of SEBS modified polypropylene layer, wherein the 30-35% of SEBS modified polypropylene layer is adjacent to the aluminum foil of the middle layer. The total thickness of the co-extruded composite film of the inner layer is 60-100 μm, preferably 70-90 μm, more preferably 70 μm and 90 μm.
The co-extrusion composite film of the inner layer can be prepared by utilizing automatic co-extrusion extruder set equipment, each extruder respectively heats and melts different raw materials to be extruded to a co-extrusion die head, and the extruded film tube is prepared by blowing to a proper size, cooling, shaping, slitting and rolling. Preferably, the composite surface of the prepared co-extruded film and the aluminum foil is subjected to 30-35 KHZ high-frequency corona treatment, so that the surface tension of the film surface is not lower than 52mN/m, and a good composite effect is achieved when the co-extruded film and the aluminum foil are composited.
The composite sheet for medicine packaging has composite adhesive, preferably polyurethane composite adhesive, between the outer layer and the middle layer and between the middle layer and the inner layer, and has dry coating amount of 3.5-10 g/m2Preferably 5.0g to 8.0g/m2In the meantime.
The composite sheet for medicine packaging is preferably compounded twice by a dry method, wherein the outer layer is compounded with the middle layer, the composite adhesive is used during compounding, and then the composite sheet is compounded with the inner layer, and the composite adhesive is used during compounding. The finished product after the compounding is cured in a curing chamber, so that the adhesive is fully crosslinked and cured. The temperature of the curing chamber is set to be 60 +/-5 ℃, and the curing time is not less than 7 multiplied by 24 h.
The composite sheet for medicine packaging is preferably used for packaging Chinese medicine honeyed pills.
The invention also provides a traditional Chinese medicine honeyed pill package prepared by using the composite sheet, which is characterized in that the composite sheet is formed into a bubble cap extending outwards by cold stamping forming, the inner layers of two pieces of cold stamping formed composite sheets are oppositely sealed by heat, and a sealing space for containing the traditional Chinese medicine honeyed pills is formed between the two bubble caps.
The experimental result of the invention shows that the composite sheet material has the following beneficial effects:
1. the composite sheet material has high breaking strength and large cupping value, and can meet the requirement of honeyed pills with common specification after cold stamping forming, such as
And
the requirement for packaging honeyed pills;
2. the composite sheet can be sealed and thermally sealed after being punched and formed, has high thermal sealing strength, forms a closed packaging system, and has reliable sealing and stable performance;
3. the composite sheet material of the invention can not be peeled or has large peeling strength between layers. The protection to the aluminum foil layer is excellent, and particularly, after the high cup-shaped protruding punch forming, the aluminum foil is not easy to have pinholes and composite delamination;
4. the composite sheet material has the advantages of light shading performance and high barrier performance, and the transmission amount of oxygen and water vapor is almost zero;
5. the composite sheet of the invention has no risk that the traditional package (PVC bubble cap) relates to vinyl chloride monomer and plasticizer, and each performance index completely meets the quality requirement of the medicine packaging sheet;
6. the space for containing the honeyed pills in the honeyed pill packaging structure is formed by butting the two bubble caps, so that the honeyed pill packaging structure has a larger containing space and can meet the packaging requirements of pills with different sizes and specifications. In the heat sealing stage, compared with the traditional Chinese medicine honeyed pill packaging structure on the market, the heat sealing of the final product can be finished without adopting an adhesive, and the preparation is convenient and quick.
7. The composite sheet can realize the automatic production of the traditional Chinese medicine honeyed pills, and improve the production efficiency;
8. compared with the existing package, the product quality of the traditional Chinese medicine honeyed pill is guaranteed within the effective period (36-60 months) more excellently.
Drawings
The composite sheet for medicine packaging and the packaging of the Chinese medicinal honeyed pill of the present invention are described below with reference to the accompanying drawings.
FIG. 1 is a schematic structural view of a composite sheet for pharmaceutical packaging of the present invention;
fig. 2 is a schematic structural view of a composite sheet material with an inner layer of PA co.pe for pharmaceutical packaging according to the present invention;
FIG. 3 is a schematic top view of a packaging structure for a honeyed pill of Chinese traditional medicine according to the present invention;
FIG. 4 is a schematic sectional view of the packaging structure of the honeyed pill taken along the direction A-A;
fig. 5 is an enlarged schematic view of a portion B in fig. 4.
Reference numerals:
1. a composite sheet; 11. an outer layer; 12. an intermediate layer; 13. an inner layer; 131. a PA layer; 132. Co-extruding an adhesive layer; 133. a PE layer; 14. a composite adhesive layer; 2. bubble caps.
Detailed Description
The present invention is described in further detail below with reference to specific examples, which are given only for the purpose of illustrating the present invention and are not intended to limit the scope of the present invention.
Example 1: preparation of the inner layer of the composite sheet of the invention
Example 1-1: preparation of PA co-PE co-extrusion composite film
Raw materials:
polyamide (PA, by Disman, the Netherlands, under the designation PA 6-F136-E2);
maleic anhydride-grafted Linear Low Density polyethylene adhesive resin for Co-extrusion (produced by Liander Barcel, used under the trade designation LLDPE)
3060)；
Linear low density polyethylene (LLDPE, product of DuPont Dowlex)TM2045G)。
The preparation method comprises the following steps:
three-layer co-extrusion film blow molding machine set is used and is provided with three extruders, the three raw materials are converted into weight proportion according to the designed thickness of the finished film and are automatically fed into each extruder bin, each extruder respectively heats and melts and extrudes different raw materials to a co-extrusion die head, the melting and extrusion temperature of PA6-F136-E2 is 250-280 ℃, and LLDPE
3060 the melt extrusion temperature is 230-260 deg.C, DOWLEXTMThe 2045G melt extrusion temperature is 220-250 ℃. The extruded film tube is blown (up-blown) to a proper size, air-cooled, shaped, cut and rolled to obtain a co-extruded film PA co.PE, which has a structure of polyamide/adhesive resin/polyethylene, wherein the polyamide surface is a composite surface with an aluminum foil, and the polyethylene surface is a heat-sealing surface of a composite sheet.
And (3) performing high-frequency corona treatment of 30-35 KHZ on the polyamide surface (the composite surface of the polyamide and aluminum foil) of the prepared PA co-PE co-extruded film to ensure that the surface tension of the film surface is not lower than 52 mN/m.
Examples 1 to 2: preparation of PP co-extruded composite film
Raw materials:
30-35% SEBS modified polypropylene (SEBS-PP, available from Wendland Wendburg under the brand SEBS-PP 8967);
5% -10% of SEBS modified polypropylene (SEBS-PP, available from Wendland Wendburg company under the trade designation SEBS-PP 5969).
The preparation method comprises the following steps:
the method comprises the steps of utilizing a three-layer coextrusion down-blowing and water-cooling PP film blow molding unit, using two extruders, automatically feeding two raw materials into each extruder bin according to the designed thickness of a finished film and the converted weight of 30-35% of SEBS modified polypropylene and 5-10% of SEBS modified polypropylene in a ratio of 2: 1, and respectively heating and melting and extruding the two raw materials to a coextrusion die head by each extruder. The temperature of the film blowing process is set to 185-210 ℃ in one section of the extruder barrel, 200-220 ℃ in two sections of the extruder barrel, 210-220 ℃ in a die head linking section (three sections), 215-220 ℃ in a die head heating zone and 15-30 ℃ of purified water for cooling (preferably 20 +/-2 ℃). And (3) after the extruded film tube is blown up (blown down) to a proper size, cooling, sizing and forming by water (purified water), rotating (continuously guiding), drawing, rolling, slitting and rolling to obtain the co-extruded PP co.PP film coiled material, wherein the structure of the co-extruded PP co.PP film coiled material is a two-layer structure of 30-35% of SEBS modified polypropylene/5-10% of SEBS modified polypropylene, 30-35% of SEBS modified polypropylene is a composite surface with an aluminum foil, and 5-10% of SEBS modified polypropylene is a heat-sealing surface of the composite sheet.
And (3) performing high-frequency corona treatment of 30-35% of SEBS modified polypropylene surface (composite surface with aluminum foil) of the prepared PPco-PP co-extrusion composite film at 30-35 KHZ, so that the surface tension of the film surface is not lower than 52 mN/m.
Example 2: preparation of composite sheets 01 to 05 of the invention
Raw materials:
outer layer: a food grade biaxially oriented polyamide (nylon, PA) film with a thickness of 25 μm and 30 μm;
an intermediate layer: food grade alloy soft aluminum foil with the mark of AL-8021-O, the thickness of 50 μm, 65 μm and 70 μm;
inner layer: the PA co.pe co-extruded composite film prepared in example 1-1, the PP co.pp co-extruded composite film prepared in example 1-2;
composite adhesive: two-component (main agent and curing agent) solvent type polyurethane composite adhesive.
The preparation method comprises the following steps:
a special dry compound machine for cold-forming composite sheets is used (the composite machine is suitable for compounding the sheets with the thickness of a finished product being more than 0.14mm, the width of the compounding operation is less than 850mm, and the working speed is not more than 80 m/min).
First compounding, compounding the outer polyamide film and the middle layer aluminum foil. Respectively placing the outer layer polyamide film coiled material and the middle layer soft aluminum foil AL-8021-O at a first unwinding position (the polyamide film composite surface faces a gluing coating roller) of a dry-type compound machine,In the second unreeling position, the three-section drying temperature of the compound machine is respectively set to be 55-65 ℃, the two-section drying temperature is set to be 60-70 ℃ and the three-section drying temperature is set to be 70-80 ℃; the on-machine viscosity of the composite adhesive (the adhesive groove is provided with an automatic viscosity control device) is 23-25S (coating 4 cups at 25 ℃), and the coating weight of a dry base is controlled to be 5.0-6.0 g/m2(ii) a The composite operation speed is 55-60 m/min; setting the temperature of the composite roller to be 65-75 ℃ and the composite pressure to be 0.4-0.6 MPa; the set temperature of the cooling guide roller is less than 20 ℃, and the composite semi-finished product is prepared by rolling after cooling.
And secondly, compounding, namely placing the semi-finished coiled material prepared by the first compounding at a first unreeling position (the aluminum foil faces to a gluing coating roller) of a dry compounding machine, placing an inner layer PA co-PE co-extrusion composite film or a PP co-extrusion composite film at a second unreeling position, finishing second compounding according to the first compounding operation parameters, and reeling to prepare a composite sheet.
The finished coiled material after the two-layer curing is cured in a curing chamber, so that the adhesive is fully crosslinked and cured. The temperature of the curing chamber is set to be 60 +/-5 ℃, and the curing time is not less than 7 multiplied by 24 h.
And cutting the cured composite sheet into finished coiled materials of the composite sheet according to the requirements of the product.
The structure of the composite sheet prepared by the invention is shown in figure 1. The structure of the composite sheet material with the inner layer of the paco.pe prepared by the invention is shown in fig. 2.
Example 3: preparation of comparative composite sheets 01-08
Raw materials:
outer layer: a food grade biaxially oriented polyamide (nylon, PA) film with a thickness of 25 μm and 30 μm;
an intermediate layer: food grade alloy soft aluminum foil with the mark of AL-8021-O, the thickness of 50 μm, 65 μm and 70 μm;
inner layer: a calendered film of polyvinyl chloride (PVC) for food packaging having a film thickness of 60 μm or 80 μm, or a blown film of linear low density Polyethylene (PE) having a film thickness of 55 μm or 60 μm or 80 μm or 90 μm;
composite adhesive: two-component (main agent and curing agent) solvent type polyurethane composite adhesive.
The preparation method comprises the following steps:
a special dry compound machine for cold-forming composite sheets is used (the composite machine is suitable for compounding the sheets with the thickness of a finished product being more than 0.14mm, the width of the compounding operation is less than 850mm, and the working speed is not more than 80 m/min).
First compounding, compounding the outer polyamide film and the middle layer aluminum foil. Respectively placing an outer layer polyamide film coiled material and an intermediate layer aluminum foil AL-8021-O at a first unwinding position (the polyamide film composite surface faces a gluing coating roller) and a second unwinding position of a dry compound machine, wherein the three-section drying temperature of the compound machine is respectively set to be 55-65 ℃, the two-section drying temperature is 60-70 ℃ and the three-section drying temperature is 70-80 ℃; the on-machine viscosity of the composite adhesive (the adhesive groove is provided with an automatic viscosity control device) is 23-25S (coating 4 cups at 25 ℃), and the coating weight of a dry base is controlled to be 5.0-6.0 g/m2(ii) a The composite operation speed is 55-60 m/min; setting the temperature of the composite roller to be 65-75 ℃ and the composite pressure to be 0.4-0.6 MPa; the set temperature of the cooling guide roller is less than 20 ℃, and the composite semi-finished product is prepared by rolling after cooling.
And secondly, compounding, namely placing the semi-finished coiled material prepared by the first compounding at a first unreeling position (the aluminum foil faces to a gluing coating roller) of a dry compounding machine, placing a polyvinyl chloride (PVC) calendered film or a linear low density Polyethylene (PE) blown film for inner layer food packaging at a second unreeling position, finishing second compounding according to the first compounding operation parameters, and rolling to prepare a composite sheet.
The finished coiled material after the two-layer curing is cured in a curing chamber, so that the adhesive is fully crosslinked and cured. The temperature of the curing chamber is set to be 60 +/-5 ℃, and the curing time is not less than 7 multiplied by 24 h.
And cutting the cured composite sheet into finished coiled materials of the composite sheet according to the requirements of the product.
Example 4: preparation of comparative composite sheet 09
Raw materials:
outer layer: a food grade biaxially oriented polyamide (nylon, PA) film with a thickness of 25 μm;
an intermediate layer: food grade alloy soft aluminum foil with the trade name of AL-8021-O and the thickness of 65 mu m;
a secondary inner layer: a food grade biaxially oriented polyamide (nylon, PA) film with a thickness of 15 μm;
inner layer: a blown film of linear low density Polyethylene (PE) having a film thickness of 65 μm;
composite adhesive: two-component (main agent and curing agent) solvent type polyurethane composite adhesive.
The preparation method comprises the following steps:
the special dry compound machine for cold forming compound sheet is used (which is characterized in that the special dry compound machine is suitable for compounding the sheet with the thickness of a finished product being more than 0.14mm, the width of the compounding operation is less than 850mm, and the working speed is not more than 80 m/min).
First compounding, compounding the outer polyamide layer and the middle aluminum foil. Respectively placing a polyamide film (with the thickness of 25 mu m) coiled material and a soft aluminum foil 8021-O (with the thickness of 65 mu m) for compounding at a first unreeling position (the polyamide film faces a gluing coating roller) and a second unreeling position of a dry compounding machine, wherein the three-section drying temperature of the compounding machine is respectively set to be 55-65 ℃, 60-70 ℃ at a second section and 70-80 ℃ at a third section; the viscosity of the adhesive on the machine (the adhesive groove is provided with an automatic viscosity control device) is 23-25S (coating 4 cups at 25 ℃), and the coating weight of the dry base is controlled to be 4.0-5.0 g/m2(ii) a The composite operation speed is 50-60 m/min; the temperature of the composite roller is set to be 65-75 ℃, and the composite pressure is set to be 0.4-0.6 MPa; the set temperature of the cooling guide roller is less than 20 ℃, and the composite semi-finished product is prepared by rolling after cooling.
And secondly, placing the semi-finished coiled material prepared by the first compounding at a first unreeling position (the aluminum foil faces to the gluing coating roller) of the dry compounding machine, placing the secondary inner layer polyamide film (15 mu m) at a second unreeling position, finishing second compounding according to the first compounding operation parameters, and rolling to obtain a semi-finished product of the three-layer composite sheet.
Thirdly, the semi-finished coiled material prepared by the second compounding is placed at the first unreeling position (a secondary inner layer polyamide film is opposite to a gluing coating roller) of a dry compounding machine, an inner layer polyethylene film (65 mu m) is placed at the second unreeling position, and the compounding process parameters before the coating process are controlled (the coating amount of the dry base of the adhesive is controlled to be 3.5-4.5 g/m)2) And finishing the third compounding, and rolling to obtain the 4-layer composite sheet with the structure of four layers of polyamide/aluminum foil/polyamide/polyethylene.
The finished coiled material after the two-layer process is cured in a curing chamber, i.e. the adhesive is fully crosslinked and cured. The temperature of the curing chamber is set to be 60 +/-5 ℃, and the curing time is not less than 7 multiplied by 24 h.
And cutting the cured composite sheet into finished coiled materials of the composite sheet according to the requirements of the product.
Example 5: performance testing of composite sheets of the invention and comparative composite sheets
Each performance test was conducted on the inventive composite sheets 01 to 05 and comparative composite sheets 01 to 09 obtained from the above examples.
As shown in table 1, the column of the structure of the composite sheet shows the specific composition of each layer of each composite sheet and the thickness of each layer. Taking the composite sheet 01 of the invention as an example, the structure is PA25/AL50/PA15co.PE50, namely the outer layer of the composite sheet 01 of the invention is a polyamide film with the thickness of 25 μm; the middle layer is an aluminum foil with the thickness of 50 mu m; the inner layer is a coextruded film of polyamide with a thickness of 15 μm and polyethylene with a thickness of 50 μm. Taking the composite sheet 04 of the invention as an example, the structure is PA25/AL50/ppco.pp70, that is, the outer layer of the composite sheet 04 of the invention is a polyamide film with the thickness of 25 μm; the middle layer is an aluminum foil with the thickness of 50 mu m; the inner layer is a coextruded composite film of polypropylene and polypropylene having a total thickness of 70 μm.
Specific performance test items and methods are as follows, and the test results are shown in table 1.
1. Breaking force test and cupping test
Testing an instrument: GBW-60Z type full-automatic cup drawing testing machine (Jinm Shangtai)
The test basis is as follows: GB/T4156-2007/ISO 20482: 2003 Eleksen cupping test for thin metal plates and thin strips
The test principle is as follows: a punch with a spherical end is pressed against a test piece clamped in the backing die and the pressing die to form a notch until a through crack occurs. The instrument automatically measures the depth of the dent (cupping value) and the maximum force value (breaking force) according to the displacement of the punch.
The test method comprises the following steps: taking a proper amount of samples, and cutting the samples into 5 pieces of samples with the width of 10mm and the length of 30 mm; the test speed is set to be 10 mm/min; the test data is not less than 5 groups, and the minimum value is taken as a test result.
2. Heat seal Strength test
The detection basis is as follows: YBB00122003-2015 Heat seal Strength determination
Testing an instrument: GBB-F Heat sealing instrument (Guangzhou label line), XLW electronic tension tester (Jinan Languang)
The detection method comprises the following steps: taking a proper amount of the product, cutting 4 small pieces of 100mm multiplied by 100mm, respectively superposing and sealing the inner layer heat sealing surfaces of 2 composite sheets, carrying out heat sealing at the temperature of 155 +/-5 ℃, under the pressure of 0.2MPa for 1 second, cutting a sample with the width of 15mm from the heat sealing part, and taking 3 middle pieces for testing. The heat seal strength was measured by heat seal strength measurement (YBB00122003-2015), and the average heat seal strength of 6 samples was measured as N/15 mm.
3. Peel Strength test
The detection basis is as follows: YBB00102003-2015 Peel Strength assay
Testing an instrument: XLW electronic tension tester (Jinnan Languang)
The detection method comprises the following steps: an appropriate amount of the sample was taken, 50mm of each end in the width direction of the sample was removed, and 5 samples each having a longitudinal and transverse width of 15.0 mm. + -. 1.0mm and a length of 200mm were uniformly cut out. The compounding direction is the longitudinal direction. Measured according to peel strength measurement (YBB 00102003-2015). The minimum value tested is the test result. The unit is N/15mm (if the composite layer cannot be peeled off or the composite layer is broken, the peel strength is acceptable).
4. Water vapor transmission test
The detection method is based on YBB00092003-2015 determination of water vapor transmission capacity
Using an instrument: w3/230 water vapor transmission rate test system (Jinnan Languang product)
The detection method comprises the following steps: taking a proper amount of the product, and measuring according to the fourth method (infrared detector method) of determination of water vapor transmission capacity, wherein the inner layer heat sealing surface faces to the low humidity side in the test, the test temperature is 38 +/-0.5 ℃, the relative humidity is 90% +/-2%, and the maximum value is the test result.
And (3) analyzing an experimental result:
as for the test results of the breaking force and the cupping value, the breaking force and the cupping value of the composite sheet material 01-05 of the invention are obviously higher than those of the comparative composite sheet material 01-08. The height of the cupping after cold stamping of the composite sheets 02, 03 and 05 of the invention may even exceed 15 mm. Although the breaking force of the comparative composite sheet 09 is equivalent to that of the composite sheet of the present invention, when the composite sheet is pressed to a height of cupping similar to that of the present invention, separation between the PA layer and the PE layer occurs, so that the product cannot be applied, and in order to ensure normal bonding of the PA layer and the PE layer in the comparative composite sheet 09, the maximum value of cupping can be pressed to 11.25-12.65.
The heat seal strength of the inventive composite sheets 01-05 was significantly higher than the comparative composite sheets 01-04 as seen from the heat seal strength test results. Although all were heat sealed by PE, the heat seal strength of the composite sheets 01-03 of the present invention was higher than that of the comparative sheets 05-09 due to the change in the overall structure of the sheets. The composite sheet material can be firmly combined between two heat-sealed parts (namely inner layers of two composite sheet materials) after heat sealing and cooling, so that a good sealing effect is ensured, and the bag is not easy to break.
As for the results of the peel strength test, the composite sheets 01 to 05 according to the present invention have an excellent composite effect between the aluminum foil layer and the inner layer co-extruded composite film layer, and are not peelable or have high peel strength therebetween.
As for the results of the barrier property test, the composite sheets 01 to 05 of the present invention all had a water vapor transmission of 0.1 to 0.2g (m)224h), the composite sheet of the invention has good high barrier properties.
In conclusion, the composite sheet material of the invention has excellent cold stamping forming performance, sealing performance, good high barrier performance and the like, and all performance indexes of the composite sheet material not only meet but also are far higher than the quality requirements of the medicine packaging sheet material. Because of its high cupping value, it is especially suitable for packing honeyed bolus of Chinese medicine.
Example 6: the composite sheet material of the invention is used for preparing the package of the honeyed pill of traditional Chinese medicine
The composite sheet material 01-05 of the invention is formed into bubble caps extending outwards by cold stamping, and then the heat sealing surfaces of the inner layers of the two cold stamping composite sheet materials are oppositely sealed by heat, so that a sealing space for containing the Chinese medicinal honeyed pills is formed between the two bubble caps.
Fig. 3-5 show the structure schematic diagram of the traditional Chinese medicine honeyed pill package prepared by using the composite sheet material of the invention, but the traditional Chinese medicine honeyed pill package structure of the invention is not only the ten-pill package structure shown in fig. 3, but also can be prepared into single pills, double pills and the like, and the number of the contained traditional Chinese medicine honeyed pills is not limited.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments shown in the drawings, but it is apparent that those skilled in the art should not be limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can fall into the protection scope of the invention.
Claims (10)
1. The composite sheet for medicine packaging is suitable for cold stamping forming and comprises an outer layer, a middle layer and an inner layer, wherein the outer layer is a polyamide film, the middle layer is an aluminum foil, the inner layer is a heat sealing layer, and the inner layer is composed of a co-extrusion composite film formed by the same or different resins.
2. The composite sheet for pharmaceutical packaging according to claim 1, wherein the inner-layer co-extruded composite film is a three-layer structure consisting of a polyamide layer, a co-extruded adhesive layer, and a polyethylene layer in this order, wherein the polyamide layer is adjacent to the middle-layer aluminum foil.
3. The composite sheet for pharmaceutical packaging according to claim 2, wherein the polyamide layer in the inner layer co-extruded composite film has a thickness of 10 to 25 μm, preferably 15 to 20 μm; the thickness of the polyethylene layer in the inner-layer co-extruded composite film is 40-80 μm, preferably 50-70 μm.
4. The composite sheet for pharmaceutical packaging of claim 3, wherein the polyethylene in the polyethylene layer is linear low density polyethylene.
5. The composite sheet for medicine packaging as claimed in claim 1, wherein the co-extrusion composite film of the inner layer is a two-layer structure composed of 30-35% of SEBS modified polypropylene layer and 5-10% of SEBS modified polypropylene layer, and the 30-35% of SEBS modified polypropylene layer is adjacent to the aluminum foil of the middle layer.
6. The composite sheet for pharmaceutical packaging according to claim 5, wherein the total thickness of the co-extruded composite film of the inner layer is 60 to 100 μm, preferably 70 to 90 μm.
7. The composite sheet for pharmaceutical packaging according to claim 1, wherein the surface of the coextruded composite film on the inner layer adjacent to the aluminum foil on the intermediate layer is corona-treated at a high frequency of 30 to 35KHZ, and the surface tension of the film surface is not lower than 52 mN/m.
8. The composite sheet for pharmaceutical packaging according to any one of claims 1 to 7, wherein the outer polyamide layer is a biaxially oriented polyamide having a thickness of 15 to 40 μm, preferably 20 to 35 μm, more preferably 25 to 30 μm; the middle layer aluminum foil is an 8-series soft aluminum alloy foil, and the thickness is 40-80 μm, preferably 45-75 μm, and more preferably 50-70 μm.
9. Composite sheet for pharmaceutical packaging according to claim 8, characterised in that between the outer and intermediate layers and between the intermediate and inner layers there is a composite adhesive, preferably a polyurethane composite adhesive, with a dry basis coat weight of between 3.5 and 10g/m2Preferably 5.0g to 8.0g/m2In the meantime.
10. A package of a honeyed pill of a traditional Chinese medicine prepared by using the composite sheet material as claimed in any one of claims 1 to 9, wherein the composite sheet material is formed into a bubble cap extending outwards by cold stamping, the inner layers of the two cold stamping composite sheet materials are oppositely sealed by heat, and a sealed space for containing the honeyed pill of the traditional Chinese medicine is formed between the two bubble caps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911277448.7A CN110861377A (en) | 2019-12-12 | 2019-12-12 | Composite sheet for medicine packaging and traditional Chinese medicine honeyed pill packaging prepared from same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911277448.7A CN110861377A (en) | 2019-12-12 | 2019-12-12 | Composite sheet for medicine packaging and traditional Chinese medicine honeyed pill packaging prepared from same |
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| Publication Number | Publication Date |
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| CN110861377A true CN110861377A (en) | 2020-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201911277448.7A Pending CN110861377A (en) | 2019-12-12 | 2019-12-12 | Composite sheet for medicine packaging and traditional Chinese medicine honeyed pill packaging prepared from same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111746840A (en) * | 2020-06-20 | 2020-10-09 | 湖北福人金身药业有限公司 | Oral liquid filling method |
| CN114872404A (en) * | 2022-02-16 | 2022-08-09 | 江阴宝柏包装有限公司 | High-flatness recyclable bubble cap base film and preparation method thereof |
| CN117753782A (en) * | 2024-02-21 | 2024-03-26 | 山西广华源药用包装有限公司 | Calendaring molding machine for aluminum foil processing |
| CN117753782B (en) * | 2024-02-21 | 2024-05-03 | 山西广华源药用包装有限公司 | Calendaring molding machine for aluminum foil processing |
-
2019
- 2019-12-12 CN CN201911277448.7A patent/CN110861377A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111746840A (en) * | 2020-06-20 | 2020-10-09 | 湖北福人金身药业有限公司 | Oral liquid filling method |
| CN114872404A (en) * | 2022-02-16 | 2022-08-09 | 江阴宝柏包装有限公司 | High-flatness recyclable bubble cap base film and preparation method thereof |
| CN117753782A (en) * | 2024-02-21 | 2024-03-26 | 山西广华源药用包装有限公司 | Calendaring molding machine for aluminum foil processing |
| CN117753782B (en) * | 2024-02-21 | 2024-05-03 | 山西广华源药用包装有限公司 | Calendaring molding machine for aluminum foil processing |
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