CN110856691B - Implant coating device - Google Patents
Implant coating device Download PDFInfo
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- CN110856691B CN110856691B CN201810963227.4A CN201810963227A CN110856691B CN 110856691 B CN110856691 B CN 110856691B CN 201810963227 A CN201810963227 A CN 201810963227A CN 110856691 B CN110856691 B CN 110856691B
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- tablet
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- coating
- push rod
- implant
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- 238000000576 coating method Methods 0.000 title claims abstract description 115
- 239000011248 coating agent Substances 0.000 title claims abstract description 112
- 239000007943 implant Substances 0.000 title claims abstract description 62
- 239000003826 tablet Substances 0.000 claims abstract description 183
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000007599 discharging Methods 0.000 claims abstract description 6
- 239000004809 Teflon Substances 0.000 claims description 8
- 229920006362 Teflon® Polymers 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000013519 translation Methods 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims 9
- 239000012530 fluid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 16
- 239000004626 polylactic acid Substances 0.000 description 15
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 8
- 229960003086 naltrexone Drugs 0.000 description 8
- 239000004005 microsphere Substances 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003337 fertilizer Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides an implant coating device, which comprises a sheet discharging machine, a sheet pushing machine, a coating pool, a tablet pipeline, a tablet conveying device, a collecting device and an automatic control device, wherein the tablet discharging machine is used for discharging tablets; the slice arranging machine is connected with the slice pushing machine, and the coating pool is in an arc shape; the coating liquid is filled in the coating tank; the tablet conveying device is used for conveying implant tablets in the tablet pipeline, the collecting device is connected with the automatic control device, and the automatic control device is used for controlling the collecting device to horizontally move. The implant coating device provided by the invention has the advantages of simple structure and convenience in operation, and is suitable for mass production.
Description
Technical Field
The invention relates to a drug coating device, in particular to an implant coating device.
Background
In the research of slow release implant, the choice of biodegradable materials is crucial, polylactic acid is a polymer with excellent biocompatibility and degradability, the final products of metabolism in the body are water and carbon dioxide, the intermediate product lactic acid is also a normal sugar metabolite in the body, and the polylactic acid can not be aggregated any more and is a medical auxiliary material approved by FDA. In order to ensure compatibility of medicines, the implant coating is prepared by adopting materials which are the same as or similar to a slow-release matrix as far as possible, but the viscosity of polylactic acid is very high, the coated implants are mutually adhered, the coating yield is damaged, and the method is not suitable for coating operation. For example, chinese patent CN200610152903.7 discloses a long-acting sustained-release preparation of naltrexone, which adopts polylactic acid to coat naltrexone microspheres, chinese patent CN201110457641.6 discloses a long-acting naltrexone implant, which also uses DL-polylactic acid to coat naltrexone microspheres after tabletting. However, as mentioned above, because the polylactic acid has too high viscosity, the microspheres or tablets after coating are close to each other or contact with the bottom surface of the tray when being dried, which causes the surface adhesion of the coating film to break, thus affecting the release stability of the drug.
The existing research and open literature technology are all laboratory level preparation processes, and cannot be used for large-scale production, wherein a plurality of influence factors and obtained conditions for investigation and screening cannot be suitable for large-scale production, because the mode of adding an internal phase emulsion into an external phase solution is different due to different active ingredients wrapped by microspheres, the components of the solution are different, the adopted specific auxiliary material components are different, and the like, so that the optimal preparation process conditions are difficult to predict, and the slow-release microspheres with ideal slow-release effect and therapeutic effect can be obtained by re-research.
The Chinese patent (a slow release fertilizer coating device: 201810333180.3) is a slow release fertilizer coating device comprising a supporting device and a coating mechanism arranged on the supporting device; the coating mechanism comprises a coating cylinder and a feeding funnel fixed at the upper end of the coating cylinder; a screen is fixed on the inner surface of the peripheral side of the coating cylinder, and a discharge slot is formed at the joint of the screen and the side wall of the coating cylinder; the surface of the side wall of the coating cylinder is provided with a circular through hole matched with a liquid spraying pipe, and the liquid spraying pipe penetrates through the side wall of the coating cylinder through the circular through hole; and a heating pipe is fixed on the inner surface of the peripheral side of the coating cylinder. Although the coating device of the patent is simple, the liquid spraying pipe is used for coating, the incomplete coating and uneven coating can be caused, and the coated slow release fertilizer has thick coating, thin coating and poor uniformity, and the slow release performance is uneven, so that the cost is increased.
In the prior art, a technology of coating by spraying coating liquid is also useful, for example, chinese patent document CN107638295A discloses a fluidized bed bottom spray coating device, particles move in a spiral shape in a guide cylinder, and particle coating is realized by spraying coating liquid. However, this method is not suitable for coating materials with high tackiness of polylactic acids.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the implant coating device which has a simple structure and is convenient to operate, and the problem that the prior art can only carry out coating preparation of implants in a laboratory and cannot carry out mass production is avoided.
In order to solve the technical problems, the technical scheme adopted by the invention is that the implant coating device comprises a sheet discharging machine, a sheet pushing machine, a coating pool, a tablet pipeline, a tablet conveying device, a collecting device and an automatic control system; the slice arranging machine is connected with the slice pushing machine, and the coating pool is in an arc shape; the coating liquid is filled in the coating tank; the tablet conveying device is used for conveying implant tablets in the tablet pipeline, and the collecting device is a special vessel with high anti-sticking performance.
Preferably, the collecting device is made of stainless steel with teflon (polytetrafluoroethylene) attached to the surface, the collecting device is a flat plate horizontally arranged, and the collecting device is connected with an automatic control device, and the automatic control device is used for controlling the collecting device to move on a horizontal plane.
Preferably, the tablet conduit comprises a first tablet conduit, a second tablet conduit, a third tablet conduit; the first tablet pipeline, the second tablet pipeline and the third tablet pipeline are all hard pipes, the hard pipes are made of stainless steel pipes, the first tablet pipeline, the second tablet pipeline and the third tablet pipeline are of an integrated structure, and the first tablet pipeline, the second tablet pipeline and the third tablet pipeline are sequentially connected;
the inlet of the first tablet pipeline is connected with the tablet pushing machine, and the outlet of the third tablet pipeline stretches into the collecting device.
Preferably, in the present invention, the first tablet pipeline is arranged in parallel, the inlet of the first tablet pipeline is connected with the tablet pushing machine, and the outlet of the first tablet pipeline is connected with the inlet of the second tablet pipeline; the second tablet pipeline is in an arc-shaped arrangement and is attached in the coating pool, and the third tablet pipeline is in an inclined arrangement.
Preferably, the third tablet duct is inclined at an angle of 10-15 °.
Preferably, the bottom end of the second tablet pipeline is attached to the inner side of the coating pool, and the second tablet pipeline is soaked in the coating liquid.
Preferably, the second tablet pipeline is provided with meshes, and the density of the meshes is at least 100/30 cm; the diameter of the mesh is 2mm.
Preferably, the diameter of the second tablet pipeline gradually decreases from the inlet to the outlet, the diameter of the second tablet pipeline is 0.5-1.5mm larger at the inlet than at the outlet, and the diameter of the second tablet pipeline is 1.5-2mm larger at the outlet than the diameter of the implant tablet.
Preferably, the second tablet duct and the third tablet duct are respectively provided with a first push rod track and a second push rod track; the first push rod track and the second push rod track are openings with the width of 2 mm.
The tablet conveying device comprises a first driving device, a rotary push rod, a second driving device and a translational push rod, and the first driving device is arranged at the circle center position of the coating pool; the upper end of the third tablet pipeline is provided with a second driving device; the first driving device and the second driving device are electrically connected with the automatic control device;
One end of the rotary push rod is connected with the first driving device, and the other end of the rotary push rod extends into the second tablet pipeline through a first push rod track;
one end of the translation push rod is connected with the second driving device, and the other end of the translation push rod extends into the third tablet pipeline through a second push rod track.
Preferably, the rotary push rod and the translational push rod are made of steel with teflon attached to the outer side, and the diameters of the rotary push rod and the translational push rod are 1.5mm.
Preferably, the coating liquid is PLA solution, and the concentration of the PLA solution is 5-9%.
Preferably, the time for the implant tablet to pass through the coating liquid in the second tablet pipeline is 15-40s;
the temperature of the coating liquid in the coating process is controlled at 33-40 ℃.
The invention provides a treatment process of an implant in an implant coating device, which comprises the following steps: the method comprises the steps that the implant tablets discharged from the tablet discharging machine enter a tablet pushing machine, the tablet pushing machine pushes the implant tablets into a tablet pipeline, the implant tablets enter a second tablet pipeline along a first tablet pipeline, the time of the implant tablets in the second tablet pipeline is controlled to be 15s-50s, preferably 30s, the temperature of the coating process is controlled to be 33-40 ℃, preferably 37 ℃; after coating in the second tablet conduit is completed, the implant tablet is pushed into the collection device for collection by the second drive means and the translating pusher.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the invention, the PLA with higher viscosity can be uniformly wrapped on the surface of the implant through a special coating device, so that the problem of incomplete coating caused by mutual adhesion is effectively avoided, and the problem of incomplete coating when the PLA is used as coating liquid in the prior art is overcome.
(2) The diameters of the tablet pipelines (especially the second tablet pipeline) and the implant tablets in the coating device provided by the invention are very important, the diameter difference between the diameter of the outlet of the second tablet pipeline and the diameter of the implant tablets is 1.5-2mm, the consistency of the coating thickness of the implant tablets can be effectively ensured, and the problem of uneven coating quality is avoided.
(3) The invention provides an implant coating device for the first time, which has the advantages of simple structure and convenient operation, and avoids the problem that the prior art can only carry out coating preparation of implants in a laboratory and cannot carry out mass production.
(4) The pipe diameter of the second tablet pipeline provided by the invention is gradually reduced from the inlet to the outlet, so that the integrity of the coating is ensured, and the thickness of the implant tablet is uniform.
(5) The coating integrity, uniformity, thickness and coating speed of the coating device provided by the invention are related to the aperture of the second tablet pipeline, the concentration of the coating liquid and the elapsed time in the coating liquid, so that the coating is prevented from being too slow, the coating liquid is easy to permeate inwards, and the microspheres and the framework are damaged;
(6) The implant coating device provided by the invention can realize one-piece one-package, mutual non-adhesion and temperature control, ensure that the coating difference of each implant tablet is very small, and the release degree difference of each tablet in a release degree test is less than 3%.
(7) The first driving device and the rotary push rod provided by the invention can control the soaking and coating time of each implant tablet in the coating solution, so as to control the coating thickness of each tablet, and when the time of the implant tablet passing through the coating solution is 30s, the coating thickness is proper and the integrity is good.
(8) The collecting device in the coating device is a highly anti-sticking vessel, is made of steel with teflon attached to the surface, and can move, so that falling implant tablets can be prevented from repeatedly falling in a space position, and the implant tablets are prevented from being stuck together.
Drawings
FIG. 1 is a schematic diagram of an implant coating device according to the present invention;
the specific meanings of the symbols in the drawings are as follows:
1: a sheet arranging machine; 2: a sheet pusher; 3: a coating pool; 4: coating liquid; 5: a collecting device; 6: a first tablet conduit; 7: a second tablet conduit; 8: a third tablet conduit; 9: a first driving device; 10: a second driving device; 11: rotating the push rod; 12: and translating the push rod.
Detailed Description
The following describes the embodiments of the present invention in detail with reference to the drawings.
Referring to fig. 1, fig. 1 is a schematic structural view of an encapsulation device for an implant according to the present invention.
An implant coating device comprises a slice arranging machine 1, a slice pushing machine 2, a coating pool 3, a tablet pipeline, a tablet conveying device, a collecting device 5 and an automatic control system; the sheet arranging machine 1 is connected with the sheet pushing machine 2, the sheet pushing machine 2 is positioned at one end of the coating pool 3, and the coating pool 3 is arc-shaped; coating liquid 4 is filled in the coating pool 3; the tablet conduit has an inlet connected to the pusher 2 and an outlet connected to the collecting device 5, and the tablet delivery device is used for delivering implant tablets in the tablet conduit.
The collecting device 5 provided by the invention is a flat plate which is horizontally arranged, the collecting device 5 is connected with the automatic control device, the automatic control device is used for controlling the collecting device to horizontally move, the collecting device 5 is made of stainless steel with Teflon attached to the surface, and the collecting device 5 is highly anti-sticking, so that falling implant tablets can be prevented from repeatedly falling in a space position, and the implant tablets are prevented from being stuck together.
The implant coating device provided by the invention further comprises a micro motor, the tablet pushing machine 2 is electrically connected with the micro motor, a push tablet is arranged in the tablet pushing machine 2 and is electrically connected with the automatic control device, and the automatic control device is used for controlling the micro motor to drive the push tablet to push the implant tablets to move.
The tablet pipeline provided by the invention comprises a first tablet pipeline 6, a second tablet pipeline 7 and a third tablet pipeline 8; the first tablet pipeline 6, the second tablet pipeline 7 and the third tablet pipeline 8 are all hard pipes, the hard pipes are made of stainless steel, the first tablet pipeline 6, the second tablet pipeline 7 and the third tablet pipeline 8 are of an integrated structure, and the first tablet pipeline 6, the second tablet pipeline 7 and the third tablet pipeline 8 are sequentially connected; the inlet of the first tablet conduit 6 is connected to the tablet pusher 2 and the outlet of the third tablet conduit 8 is connected to the collecting device 5. The third tablet pipeline is obliquely arranged 8, and the inclination angle is 10-15 degrees.
The first tablet pipeline 6 provided by the invention is arranged in parallel, the inlet of the first tablet pipeline 6 is connected with the tablet pushing machine, and the outlet of the first tablet pipeline 6 is connected with the inlet of the second tablet pipeline 7; the second tablet pipeline 7 is arranged in an arc shape and is attached in the coating pool 3, and the third tablet pipeline 8 is arranged in an inclined manner.
The bottom end of the second tablet pipeline 7 provided by the invention is attached to the inner side of the coating pool 3, and the second tablet pipeline 7 is soaked in the coating liquid 4. The length of the second tablet pipeline 7 provided by the invention is 30cm, dense meshes are arranged on the second tablet pipeline 7, and the density of the meshes is at least 100/30 cm; the diameter of the mesh was 2mm.
The diameter of the second tablet pipeline 7 is gradually smaller from the inlet to the outlet, and the diameter of the outlet of the second tablet pipeline 7 is different from the diameter of the implant tablet by 1.5-2mm. When the diameter of the pipe diameter inlet of the second tablet pipeline 7 is 0.9mm larger than that of the pipe diameter outlet of the second tablet pipeline 7 is 1.5mm larger than that of the implant tablet, the thickness and the integrity of the coating are better.
The second tablet duct 7 and the third tablet duct 8 provided in the present invention are provided with a first push rod rail and a second push rod rail, respectively; the first push rod track and rotatory push rod 11 looks adaptation, and first push rod track is the opening of width for 2mm, and rotatory push rod 11 diameter is 1.5mm, and the second push rod track and translation push rod 12 looks adaptation, and the second push rod track is the opening of width for 2mm, and translation push rod 12 diameter is 1.5mm.
The tablet conveying device provided by the invention comprises a first driving device 9, a rotary push rod 11, a second driving device 10 and a translational push rod 12, wherein the first driving device 9 is arranged at the circle center position of the coating pool 3; the upper end of the third tablet pipeline 7 is provided with a second driving device 10; the first driving device 9 and the second driving device 10 are electrically connected with the automatic control device;
One end of a rotary push rod 11 is connected with the first driving device 9, and the other end of the rotary push rod extends into the second tablet pipeline 7 through a first push rod track; one end of the translation push rod 12 is connected with the second driving device 10, and the other end of the translation push rod extends into the third tablet track 8 through the second push rod track. The rotary push rod 11 and the translational push rod 12 are made of steel material with teflon attached to the outer side, wherein the teflon is actually made of polytetrafluoroethylene.
The coating liquid 4 provided by the invention is PLA solution, the molecular weight of PLA (polylactic acid) in the coating liquid 4 is 5-7 ten thousand, and the concentration of the PLA solution is 5-9%.
EXAMPLE 1 naltrexone implant coating procedure
(1) Dissolving polylactic acid with the molecular weight of 6 ten thousand in dichloromethane to form coating liquid with the concentration of 6%, and placing the coating liquid in a coating pool for later use;
(2) The naltrexone implant tablets are pushed into the first tablet pipeline by a tablet pushing machine, then enter the second tablet pipeline, and are moved from the inlet to the outlet of the second tablet pipeline by a first driving device to be coated, wherein the coating time is 30s, and the temperature is 37 ℃.
Wherein the density of the meshes on the second tablet pipeline is 100/30 cm; the diameter of the mesh is 2mm, the diameter of the inlet of the second tablet pipeline is 0.9mm larger than that of the outlet of the second tablet pipeline, and the diameter of the outlet of the second tablet pipeline is 1.5mm larger than that of the naltrexone implant tablet.
The film thickness of the naltrexone implant tablet obtained by the coating device is 0.002-0.003mm, and the coating integrity is 100%.
The above-described series of detailed descriptions are merely specific illustrations of possible embodiments of the invention, which are not intended to limit the scope of the invention, and various changes made by those skilled in the art without departing from the spirit of the invention.
Claims (9)
1. The implant coating device is characterized by comprising a tablet discharging machine, a tablet pushing machine, a coating pool, a tablet pipeline, a tablet conveying device, a collecting device and an automatic control device; the slice arranging machine is connected with the slice pushing machine, and the coating pool is in an arc shape; the coating liquid is filled in the coating tank; the tablet conveying device is used for conveying implant tablets in the tablet pipeline;
the tablet pipelines comprise a first tablet pipeline, a second tablet pipeline and a third tablet pipeline; the first tablet pipeline, the second tablet pipeline and the third tablet pipeline are all stainless steel pipes, and are of an integrated structure, and the first tablet pipeline, the second tablet pipeline and the third tablet pipeline are sequentially connected;
the inlet of the first tablet pipeline is connected with the tablet pushing machine, and the outlet of the third tablet pipeline is connected with the collecting device;
The second tablet pipeline is provided with a first push rod track, and the third tablet pipeline is provided with a second push rod track;
the bottom end of the second tablet pipeline is attached to the inner side of the coating pool, and the second tablet pipeline is soaked in the coating liquid; and the second tablet pipeline is provided with meshes.
2. The implant capsule apparatus of claim 1, wherein the collection means is a horizontally disposed plate, the collection means is connected to an automatic control means for controlling the horizontal movement of the collection means, and the collection means is made of stainless steel material with teflon attached to the surface.
3. The implant capsule apparatus of claim 1, wherein the first pushrod track and the second pushrod track are each openings having a width of 2mm.
4. The implant capsule device of claim 1, wherein the mesh density is at least 100/30 cm; the diameter of the mesh is 2mm.
5. The implant capsule device of claim 1, wherein the diameter of the second tablet conduit is progressively smaller from the inlet to the outlet, the diameter of the second tablet conduit being between 0.5 mm and 1.5mm greater at the inlet than at the outlet, and the diameter of the second tablet conduit outlet being between 1.5mm and 2mm greater than the diameter of the implant tablet.
6. The implant capsule device of claim 3, wherein the tablet delivery device comprises a first driving device, a rotary push rod, a second driving device and a translational push rod, and the first driving device is arranged at the circle center position of the capsule pool; the upper end of the third tablet pipeline is provided with a second driving device;
the first driving device and the second driving device are electrically connected with the automatic control device;
One end of the rotary push rod is connected with the first driving device, and the other end of the rotary push rod extends into the second tablet pipeline through a first push rod track;
one end of the translation push rod is connected with the second driving device, and the other end of the translation push rod extends into the third tablet pipeline through a second push rod track.
7. The implant capsule device of claim 6, wherein the rotary push rod and the translational push rod are steel materials with teflon attached to the surfaces, and the diameters of the rotary push rod and the translational push rod are 1.5mm.
8. The implant coating apparatus of claim 1, wherein the coating liquid is a PLA solution, and the concentration of the PLA solution is 5-9%.
9. The implant capsule apparatus of claim 2, wherein the time for the implant tablet to pass through the capsule fluid in the second tablet conduit is 15-40s;
the temperature of the coating liquid in the coating process is controlled at 33-40 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810963227.4A CN110856691B (en) | 2018-08-22 | 2018-08-22 | Implant coating device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810963227.4A CN110856691B (en) | 2018-08-22 | 2018-08-22 | Implant coating device |
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| CN110856691A CN110856691A (en) | 2020-03-03 |
| CN110856691B true CN110856691B (en) | 2024-07-12 |
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| CN115518048B (en) * | 2022-09-28 | 2023-11-07 | 深圳善康医药科技股份有限公司 | Naltrexone and risperidone compound sustained-release implant, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209596217U (en) * | 2018-08-22 | 2019-11-08 | 深圳善康医疗健康产业有限公司 | A kind of implant coating device |
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| KR101014874B1 (en) * | 2008-04-29 | 2011-02-15 | (주)크레템 | Dispenser of free shape type tablet for medicine packing apparatus and tablet dispensing method thereof |
| CN101766537B (en) * | 2010-02-26 | 2013-08-07 | 罗彦凤 | Dry-method coating machine |
| JP5830618B1 (en) * | 2015-01-30 | 2015-12-09 | 大原薬品工業株式会社 | Method for producing multilayer film coated tablets for laser printing |
| CN107792417B (en) * | 2017-10-24 | 2023-08-22 | 福州法莫优科机械科技有限公司 | Full-automatic tablet split charging device and split charging method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN209596217U (en) * | 2018-08-22 | 2019-11-08 | 深圳善康医疗健康产业有限公司 | A kind of implant coating device |
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Address after: 6G, 6th floor, central business building, 88 Fuhua 1st Road, Futian District, Shenzhen, Guangdong 518000 Applicant after: Shenzhen shankang Pharmaceutical Technology Co.,Ltd. Address before: 6G, 6th floor, central business building, 88 Fuhua 1st Road, Futian District, Shenzhen, Guangdong 518000 Applicant before: SHENZHEN SCIENCARE MEDICAL INDUSTRIES Co.,Ltd. |
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