CN110846207A - Heating structure applied to nucleic acid extraction device and preparation method thereof - Google Patents
Heating structure applied to nucleic acid extraction device and preparation method thereof Download PDFInfo
- Publication number
- CN110846207A CN110846207A CN201911288205.3A CN201911288205A CN110846207A CN 110846207 A CN110846207 A CN 110846207A CN 201911288205 A CN201911288205 A CN 201911288205A CN 110846207 A CN110846207 A CN 110846207A
- Authority
- CN
- China
- Prior art keywords
- heating
- heat
- wire
- silica gel
- heat conduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
Abstract
The invention discloses a heating structure applied to a nucleic acid extraction device and a preparation method thereof, and relates to the technical field of heating. Set up a plurality of heating holes through the top at the heat conduction piece, set up the heater strip simultaneously in the bottom of heat conduction piece, and the area of the heater strip that every heating hole below set up is the same, make the heat of heater strip to every hole transmission the same, and then to the sample solution that draws the post and draw in the post that is arranged in the heating hole and heat the same, make sample solution reach invariable temperature, when realizing the extraction to nucleic acid in the sample solution, the inhomogeneous condition of temperature between the hole at center and edge can not appear, the uniformity of temperature between the hole at center and edge has been improved, good nucleic acid extraction effect has been guaranteed. In addition, the heat conducting silica gel is filled around the heating wire, around the wire joint and in the gap between the heating wire and the wire joint, so that the heat transfer effect is ensured, and the local burning of the heating wire due to poor heat transfer around the heating wire is avoided.
Description
Technical Field
The invention relates to the technical field of heating, in particular to a heating structure applied to a nucleic acid extraction device and a preparation method thereof.
Background
The biological macromolecular compound formed by polymerizing nucleic acid with many nucleotides is one of the most basic substances of life, and the nucleic acid is widely existed in animal and plant cells and microorganisms, and the nucleic acid in the organisms is often combined with protein to form nucleoprotein. The nucleic acid is mainly extracted from a sample solution containing the nucleic acid, and the sample solution needs to be heated continuously during the whole extraction process so as to reach a constant temperature, and the extraction of the nucleic acid is carried out at the constant temperature.
At present, the heating mechanism of the nucleic acid extracting apparatus generally comprises a heating plate, a heating plate and a heat insulating plate, wherein the heating plate is disposed on the bottom surface of the heating plate, the heat insulating plate is disposed on the top surface of the heating plate, a heating hole is disposed on the heating plate, a through hole is correspondingly disposed on the heat insulating plate, and an extracting column for placing a sample solution is disposed in the heating hole. The heating plate adopts resistance to generate heat, transfers the heat to the heating plate, and then transfers the heat to the extraction column and the sample solution in the extraction column, so as to realize the heating of the solution sample and make the solution sample reach a constant temperature.
However, the heating structure has an edge effect, which causes uneven temperature between the center and the edge of the hole and 2-3 ℃ temperature difference, and further causes 2-3 ℃ temperature difference between sample solutions in the extraction column between the holes, and finally affects the overall extraction effect of nucleic acid.
Disclosure of Invention
The heating structure comprises a heat conduction block, a plurality of heating holes are formed in the top of the heat conduction block, a heat conduction silica gel filling groove is formed in the bottom of the heat conduction block, a heating wire laying groove and a connector mounting groove are formed in the heat conduction silica gel filling groove, heating wires are laid in the heating wire laying groove, a wire connector is mounted in the connector mounting groove, heat conduction silica gel is filled in the heat conduction silica gel filling groove, the end of each heating wire is connected with a wire penetrating out of the heat conduction block through the wire connector, and the area of the heating wire laid below each heating hole is the same.
Preferably, the connector mounting grooves are two and are respectively located at the end of the heating wire laying groove.
Preferably, a wire guide hole is formed in a position, corresponding to the joint mounting groove, of the side wall of the heat conduction block, and the wire penetrates out of the heat conduction block through the wire guide hole.
Preferably, the height of the heat-conducting silica gel filled in the heat-conducting silica gel filling groove is flush with the bottom surface of the heat-conducting block.
Preferably, the heat conduction silica gel filling groove is internally provided with a temperature sensor mounting groove, a temperature sensor is laid in the temperature sensor mounting groove, the temperature sensor mounting grooves are arranged into two, and the two sides of the heating wire laying groove are arranged.
Preferably, a plurality of the heating holes are regularly arranged to form a heating hole matrix.
Preferably, one heating wire is correspondingly laid below each row of heating holes.
Preferably, the heating wires are laid in four rows, two rows in the middle are laid in a linear shape, two rows on two sides are laid in a regular curve shape, and a plurality of shapes which are similar to the cross sections of the heating holes and correspond to the positions of the heating holes are surrounded.
Preferably, the heat conduction block is provided in plurality, and the plurality of heat conduction blocks are arranged on the mounting plate at intervals.
In another aspect, the present invention provides a method for preparing a heating structure applied to a nucleic acid extraction apparatus, including:
s1, processing a heat-conducting silica gel filling groove at the bottom of the heat-conducting block, and processing a heating wire laying groove and a joint mounting groove in the heat-conducting silica gel filling groove;
s2, brushing heat-conducting silica gel in the heating wire laying groove and laying heating wires, wherein the areas of the heating wires laid below each heating hole are the same;
s3, connecting two ends of the heating wire with wires through wire connectors respectively, penetrating the wires out of the heat conducting block through wire holes, and laying the wire connectors in the connector mounting grooves;
s4, to heat conduction silica gel filling inslot filling heat conduction silica gel for the heat conduction silica gel height of filling with the bottom surface parallel and level of heat conduction piece makes simultaneously that the heater strip is laid the space between groove and the heater strip, the heater strip is laid the groove and is connected the space between the mounting groove and be full of heat conduction silica gel.
The invention has the beneficial effects that: according to the heating structure applied to the nucleic acid extraction device and the preparation method thereof provided by the embodiment of the invention, the plurality of heating holes are formed in the top of the heat conduction block, the heating wires are arranged at the bottom of the heat conduction block, and the areas of the heating wires arranged below the heating holes are the same, so that the heat transferred by the heating wires to each hole is the same, the temperature for heating the extraction column positioned in the heating holes and the sample solution in the extraction column is the same, the sample solution reaches a constant temperature, the nucleic acid in the sample solution is extracted, the condition of uneven temperature between the holes at the center and the edge is avoided, the temperature consistency between the holes at the center and the edge is improved, and a good nucleic acid extraction effect is ensured. In addition, the heat conducting silica gel is filled around the heating wire, around the wire joint and in the gap between the heating wire and the wire joint, so that the heat transfer effect is ensured, and the local burning of the heating wire due to poor heat transfer around the heating wire is avoided.
Drawings
FIG. 1 is a schematic cross-sectional view of the lower part of a heating structure applied to a nucleic acid isolation apparatus according to the present invention;
FIG. 2 is a schematic top view of a heating structure applied to a nucleic acid isolation apparatus according to the present invention;
FIG. 3 is a schematic sectional view A-A showing the structure of a heating structure applied to a nucleic acid extracting apparatus according to the present invention;
FIG. 4 is a schematic front view showing a heating structure applied to a nucleic acid isolation apparatus according to the present invention;
FIG. 5 is a schematic side view of a heating structure for use in the nucleic acid isolation apparatus according to the present invention;
FIG. 6 is a schematic side view showing another structure of a heating structure applied to a nucleic acid extracting apparatus according to the present invention;
in the figure, the meaning of each symbol is as follows:
1 heat conduction piece, 2 heating holes, 3 heater strip laying grooves, 4 temperature sensor mounting grooves, 5 joint mounting grooves, 6 wire holes and 7 heat conduction silica gel filling grooves.
Detailed description of the preferred embodiments
In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.
As shown in fig. 1 to 6, an embodiment of the present invention provides a heating structure applied to a nucleic acid extraction device, including a heat conduction block 1, where the top of the heat conduction block 1 is provided with a plurality of heating holes 2, the bottom of the heat conduction block 1 is provided with a heat conduction silica gel filling groove 7, the heat conduction silica gel filling groove 7 is provided with a heating wire laying groove 3 and a connector mounting groove 5, a heating wire is laid in the heating wire laying groove 3, a wire connector is mounted in the connector mounting groove 5, the heat conduction silica gel filling groove 7 is filled with heat conduction silica gel, an end of the heating wire is connected with a wire penetrating out of the heat conduction block 1 through the wire connector, and the areas of the heating wires laid below each heating hole 2 are the same.
Above-mentioned heating structure, in the use, connect the outside power of heat conduction piece through the wire, heat the heater strip, because the heater strip is located the below of heating hole to the heater strip can pass through the heat conduction piece and transmit to the heating hole with the heat, and then heats the sample solution that is arranged in the extraction post of heating hole and draws in the post, makes sample solution reach invariable temperature, realizes the extraction to nucleic acid in the sample solution.
Wherein, because the area of the heater strip laid below each heating hole is the same, so the heat that the heater strip transmits to each hole is the same, can not appear the uneven condition of temperature between the hole at center and edge to guarantee that the temperature of the sample solution in the heating hole at center and edge is the same, guarantee good nucleic acid extraction effect. In the actual use process, under the condition of room temperature of 25 ℃, the heating temperature is set to be 75 ℃, the temperature is measured after the heating is stabilized for 5 minutes, the temperature difference between the holes at the center and the edge is within 1 ℃, and the temperature difference between the holes of the existing heating structure is between 2 ℃ and 3 ℃, so that the heating structure provided by the embodiment is adopted, the temperature consistency between the holes at the center and the edge is improved, the consistency between the holes at the center and the edge of the nucleic acid extracting effect is further ensured, and the nucleic acid extracting effect is improved.
In addition, in this embodiment, after the heater strip is laid, through filling heat conduction silica gel, can guarantee all to fill in the clearance between heater strip and the heater strip laying groove, in the clearance between heater strip laying groove and the joint mounting groove heat conduction silica gel to guarantee that the heat of heater strip can obtain good transmission, and can not save and lead to the heater strip local burnout in the clearance on every side, and then cause the work of heating piece to receive the influence.
In the above structure, in order to ensure that the same heat can be generated under the condition that the areas of the heating wires laid below each heating hole are the same, the heating wires with appropriate resistivity can be selected according to the requirement of actual power. In an embodiment, Cr with an insulating coating may be used2ONi8And (4) heating wires.
The heating structure that this embodiment provided is at the concrete implementation in-process, can process preparation heat conduction silica gel filling groove in the bottom of heat conduction piece earlier, and set up the heater strip in heat conduction silica gel filling groove and lay groove and connect the mounting groove, this heater strip is laid the groove and can be set up according to the form of laying of heater strip, for example, as an embodiment, the heater strip is laid according to snakelike, then lay the groove with the heater strip and set up to snakelike, then lay the heater strip in the heater strip is laid the groove, lay the completion back, fill heat conduction silica gel in the heat conduction silica gel filling groove, all be full of heat conduction silica gel in the remaining space in the heat conduction silica gel filling groove of messenger. In addition, when the heating wires are laid, the heating function of the heating wires can be considered, and under the condition that the heating wires can uniformly heat the central heating holes and the edge heating holes, as many heating wires as possible are laid below the heating holes, so that the heating holes can be better heated. The joint mounting groove is used for installing the joint, and the heating wire can be connected with the wire through the joint, so that the joint mounting groove can be arranged at the end part of the heating wire laying groove during processing. In addition, in order to enable the wire to penetrate out of the heat conducting block and be connected with an external power supply, the heating wire is electrified, a wire hole can be formed in the corresponding position of the side wall of the heat conducting block and the joint mounting groove, and the wire penetrates out of the heat conducting block through the wire hole.
In this embodiment, the two connector mounting grooves 5 are respectively located at the end of the heating wire laying groove 3.
By adopting the structure, the space can be saved, the structure is compact, and the joint is convenient to be made at the end of the heating wire and connected with the lead.
In this embodiment, a wire guide hole 6 is disposed at a position of the side wall of the heat conducting block 1 corresponding to the joint mounting groove 5, and the wire penetrates out of the heat conducting block 1 through the wire guide hole 6.
In the structure, the end of the heating wire is connected with the lead through the joint, so that the connection operation of the heating wire and the lead is facilitated. The wire hole is arranged at the corresponding position of the side wall of the heat conduction hole, so that the wire can conveniently penetrate out of the heat conduction block.
In order to ensure the stability of the wire during the actual operation, the diameter of the wire entrance hole may be made slightly larger than the diameter of the wire.
In this embodiment, the height of the heat-conducting silica gel filled in the heat-conducting silica gel filling groove 7 is flush with the bottom surface of the heat-conducting block 1.
By adopting the structure, the heat of the heating wire can be conducted outwards through the heat-conducting silica gel with enough thickness, and the phenomenon that the local burning of the heating wire is caused because the heat of the heating wire can not be transmitted in time can be avoided.
In this embodiment, still be provided with temperature sensor mounting groove 4 in heat conduction silica gel filling groove 7, install temperature sensor in the temperature sensor mounting groove 4, temperature sensor mounting groove 4 sets up to two, and sets up the both sides that groove 3 was laid to the heater strip.
In the structure, the temperature sensor is arranged, so that the temperature in the heating structure can be detected, the temperature which can be reached by each heating hole can be obtained according to the detected temperature data, the temperature difference condition of the heating holes at the center and the edge can be judged, or the thermal resistance, the heating power and the like of the heating wire can be adjusted, so that the heating wire can reach the required temperature.
In this embodiment, the plurality of heating holes 2 are regularly arranged to form a heating hole matrix.
Through set up a plurality of heating holes on the heat conduction piece to make the heating hole arrange according to regular shape and form the heating hole matrix, be convenient for lay the heater strip at the below rule of heat conduction piece, be favorable to batch production. And simultaneously meets the heating requirement of a plurality of regularly arranged extraction columns containing sample solution.
In this embodiment, one heating wire is correspondingly laid below each row of the heating holes 2.
In the structure, one heating wire is laid below the single-row heating holes, so that the heating requirement of all the single-row heating holes can be met on the basis that the heating wire with a certain thermal resistivity has a long service life. Meanwhile, the single heating wire is adopted, the laying difficulty of the heating wire and the arranging difficulty of the heating wire laying groove can be reduced, the using number of the joints between the heating wire and the lead and the installation times of the joints and the lead can be reduced, and the material cost and the operation difficulty are reduced.
In this embodiment, the heating wires are laid in four rows, two rows in the middle are laid in a linear shape, two rows on two sides are both laid in a regular curve shape, and a plurality of shapes which are similar to the cross sections of the heating holes 2 and correspond to the positions of the heating holes 2 are surrounded.
By adopting the structure, the temperature difference among the heating holes can be ensured to be small, and the temperature difference between the central part and the edge part of the same heating hole is also ensured to be small, so that the heat obtained by the heating holes is uniform, the sample solution in the extraction column in the heating hole is ensured to be uniformly heated, and a good nucleic acid extraction effect is achieved. In addition, adopt above-mentioned structure can gather the heater strip of more areas to heating hole below, also guarantee simultaneously that the edge of heating hole also distributes and have the heater strip, so, can use less heater strip to provide more heat.
In this embodiment, the heating wires are laid in two rows, and the two rows are both laid in a regular curve shape, and are surrounded into a plurality of shapes which are similar to the cross sections of the heating holes 2 and correspond to the positions of the heating holes 2.
By adopting the structure, the heat of the central part and the edge part of the heating hole can be ensured to be more uniform, and the nucleic acid extraction effect is better.
In this embodiment, the heat conduction block 1 is provided in plurality, and the plurality of heat conduction blocks 1 are arranged on the mounting plate at intervals.
In order to satisfy the heating demand of the appearance that draws of different specifications, heating structure can include a plurality of heat conduction pieces, and through setting up a plurality of heat conduction pieces and forming a holistic heating module on same mounting panel, correspond a plurality of extraction modules that draw the post formation, adopt this kind of structure, when certain heat conduction piece goes wrong wherein, can only carry out problem investigation and maintenance work to this heat conduction piece, need not be to whole heating module, so can reduce work load, improve work efficiency. For example, as an embodiment, the heating holes included in one heat conduction block may be arranged in a row of eight, or may be arranged in two rows of eight.
The invention also provides a nucleic acid extraction device, which comprises the heating structure and the extraction column, wherein the extraction column can extend into the heating hole of the heating structure.
The detailed structure and function of the heating structure can be referred to the above description, and will not be described herein.
The invention also provides a preparation method of the heating structure applied to the nucleic acid extraction device, which comprises the following steps:
s1, processing a heat-conducting silica gel filling groove at the bottom of the heat-conducting block, and processing a heating wire laying groove and a joint mounting groove in the heat-conducting silica gel filling groove;
s2, brushing heat-conducting silica gel in the heating wire laying groove and laying heating wires, wherein the areas of the heating wires laid below each heating hole are the same;
s3, connecting two ends of the heating wire with wires through wire connectors respectively, penetrating the wires out of the heat conducting block through wire holes, and laying the wire connectors in the connector mounting grooves;
s4, to heat conduction silica gel filling inslot filling heat conduction silica gel for the heat conduction silica gel height of filling with the bottom surface parallel and level of heat conduction piece makes simultaneously that the heater strip is laid the space between groove and the heater strip, the heater strip is laid the groove and is connected the space between the mounting groove and be full of heat conduction silica gel.
In the method, the space in the heating wire laying groove can just place the heating wire, namely the diameter of the section of the heating wire laying groove can be slightly larger than that of the heating wire, so that less space is left between the heating wire and the heating wire laying groove on the basis of ensuring the smooth laying of the heating wire, and the situation that the heat of the heating wire cannot be well transferred due to incomplete filling of heat-conducting silica gel caused by overlarge gaps, and further the use of a heating block is influenced due to local burning-out of the heating wire is avoided; when the heating wire is processed, the coiling mode of the heating wire can correspond to the laying mode of the heating wire, so that the heating holes at the top of the heat conducting block are uniformly distributed, and the length is strictly calculated, so that the requirement of heating power is met;
the laid heating wires can adopt Cr20Ni80 heating wires with insulating coatings, and proper resistivity is selected according to the requirement of actual power.
In addition, in order to ensure that the heat of the heating wire can be fully and uniformly transferred to the heating hole, in the process of filling the heat-conducting silica gel, the heat-conducting silica gel is filled in the gap between the heating wire and the heating wire laying groove and the gap between the heating wire laying groove and the joint mounting groove, and simultaneously, before the heating wire is laid, the heat-conducting silica gel is firstly brushed in the heating wire laying groove.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention. It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. The utility model provides a be applied to heating structure of nucleic acid extraction element, a serial communication port, including the heat conduction piece, the top of heat conduction piece is provided with a plurality of heating holes, the bottom of heat conduction piece is provided with heat conduction silica gel filling groove, heat conduction silica gel filling inslot is provided with the heater strip and lays groove and connect the mounting groove, the heater strip is laid the inslot and has been laid the heater strip, connect and install wire joint in the mounting groove, heat conduction silica gel filling inslot filling heat conduction silica gel, the end of heater strip passes through wire joint with wear out to the outside wire of heat conduction piece is connected, every the heating hole below is laid the area of heater strip is the same.
2. The heating structure for a nucleic acid extracting apparatus according to claim 1, wherein the joint mounting grooves are provided in two and are respectively located at ends of the heating wire laying groove.
3. The heating structure for a nucleic acid isolation apparatus according to claim 3, wherein a wire guide hole is provided in a side wall of the heat-conducting block at a position corresponding to the joint mounting groove, and the wire passes through the wire guide hole to the outside of the heat-conducting block.
4. The heating structure for a nucleic acid isolation apparatus according to claim 1, wherein the height of the heat-conducting silica gel filled in the heat-conducting silica gel filling groove is flush with the bottom surface of the heat-conducting block.
5. The heating structure for a nucleic acid isolation apparatus according to claim 1, wherein the heat-conducting silica gel filling groove is further provided therein with temperature sensor mounting grooves, in which the temperature sensors are mounted, the temperature sensor mounting grooves are provided in two and are provided on both sides of the heater strip laying groove.
6. The heating structure for a nucleic acid isolation apparatus according to claim 1, wherein a plurality of the heating wells are arranged regularly to form a heating well matrix.
7. The heating structure for a nucleic acid isolation apparatus according to claim 6, wherein one heating wire is disposed under each row of the heating holes.
8. The heating structure for a nucleic acid extracting apparatus according to claim 7, wherein the heating wires are laid in four rows, the middle two rows are laid in a straight shape, and both the two rows on both sides are laid in a regular curved shape to enclose a plurality of shapes similar to the cross-section of the heating holes and corresponding to the positions of the heating holes.
9. The heating structure for a nucleic acid isolation apparatus according to claim 1, wherein the heat-conducting block is provided in plurality, and a plurality of the heat-conducting blocks are provided at intervals on the mounting plate.
10. A method for preparing a heating structure for a nucleic acid isolation apparatus according to any one of claims 1 to 9, comprising:
s1, processing a heat-conducting silica gel filling groove at the bottom of the heat-conducting block, and processing a heating wire laying groove and a joint mounting groove in the heat-conducting silica gel filling groove;
s2, brushing heat-conducting silica gel in the heating wire laying groove and laying heating wires, wherein the areas of the heating wires laid below each heating hole are the same;
s3, connecting two ends of the heating wire with wires through wire connectors respectively, penetrating the wires out of the heat conducting block through wire holes, and laying the wire connectors in the connector mounting grooves;
s4, to heat conduction silica gel filling inslot filling heat conduction silica gel for the heat conduction silica gel height of filling with the bottom surface parallel and level of heat conduction piece makes simultaneously that the heater strip is laid the space between groove and the heater strip, the heater strip is laid the groove and is connected the space between the mounting groove and be full of heat conduction silica gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911288205.3A CN110846207A (en) | 2019-12-15 | 2019-12-15 | Heating structure applied to nucleic acid extraction device and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911288205.3A CN110846207A (en) | 2019-12-15 | 2019-12-15 | Heating structure applied to nucleic acid extraction device and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110846207A true CN110846207A (en) | 2020-02-28 |
Family
ID=69609174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911288205.3A Pending CN110846207A (en) | 2019-12-15 | 2019-12-15 | Heating structure applied to nucleic acid extraction device and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110846207A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113373042A (en) * | 2021-06-09 | 2021-09-10 | 北京卓诚惠生生物科技股份有限公司 | Modularization nucleic acid extraction, amplification and detection all-in-one machine |
| CN113462556A (en) * | 2021-09-02 | 2021-10-01 | 德诺杰亿（北京）生物科技有限公司 | Heating assembly of nucleic acid extractor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090197778A1 (en) * | 2006-06-27 | 2009-08-06 | Zenteris Gmbh | Heated Reaction Chamber For Processing A Biochip And Method For Controlling Said Reaction Chamber |
| US20140021193A1 (en) * | 2012-07-17 | 2014-01-23 | Shu-Chien Chao | Heating module |
| CN208684985U (en) * | 2018-07-24 | 2019-04-02 | 詹洪亮 | A kind of positioning heating device for nucleic acid extraction deep-well plates |
-
2019
- 2019-12-15 CN CN201911288205.3A patent/CN110846207A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090197778A1 (en) * | 2006-06-27 | 2009-08-06 | Zenteris Gmbh | Heated Reaction Chamber For Processing A Biochip And Method For Controlling Said Reaction Chamber |
| US20140021193A1 (en) * | 2012-07-17 | 2014-01-23 | Shu-Chien Chao | Heating module |
| CN208684985U (en) * | 2018-07-24 | 2019-04-02 | 詹洪亮 | A kind of positioning heating device for nucleic acid extraction deep-well plates |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113373042A (en) * | 2021-06-09 | 2021-09-10 | 北京卓诚惠生生物科技股份有限公司 | Modularization nucleic acid extraction, amplification and detection all-in-one machine |
| CN113462556A (en) * | 2021-09-02 | 2021-10-01 | 德诺杰亿（北京）生物科技有限公司 | Heating assembly of nucleic acid extractor |
| CN113462556B (en) * | 2021-09-02 | 2021-12-28 | 德诺杰亿（北京）生物科技有限公司 | Heating assembly of nucleic acid extractor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110846207A (en) | Heating structure applied to nucleic acid extraction device and preparation method thereof | |
| CN211645182U (en) | Be applied to nucleic acid extraction element's heating structure and nucleic acid extraction element | |
| CN109417360A (en) | Photovoltaic module and its array with turning terminal box | |
| CN204101203U (en) | A kind of thermopair | |
| DE602004016322D1 (en) | CAP FOR CONTROLLING THE REAR VARIATION FOR USE WITH A PLUG MOUNT | |
| CN205025047U (en) | Heat conduction floor slab | |
| CN116951982A (en) | Electrode graphitization power transmission curve optimization method | |
| CN208369871U (en) | A kind of special-shaped heat-generating pipe of proofing box | |
| CN110015840B (en) | Shaping furnace | |
| CN205259431U (en) | Power generation brick | |
| CN115164601A (en) | Silicon wafer heating furnace auxiliary heating plate arranged between heating furnace wire and shell | |
| CA3104614C (en) | Electric power module and method for assembling it | |
| CN205153445U (en) | Energy -conservation floor that generates heat | |
| CN202254761U (en) | Bidirectional-flow gas radiation heating kiln | |
| CN204005031U (en) | A kind of graphite insulating structure | |
| CN207452296U (en) | A kind of new single crystal furnace heater structure | |
| CN108708527A (en) | A kind of fever ceramic tile and heat-generating system | |
| CN208762492U (en) | Biochemical reaction heating device | |
| RU2006127789A (en) | WELL OPERATION DEVICE | |
| CN201620562U (en) | Self-heating floor | |
| CN201236455Y (en) | Combined parquet floor | |
| CN103687102B (en) | A kind of super large carbon crystal heating panel and manufacture method thereof | |
| CN204616120U (en) | One can extended type temperature selflimiting electric tracing band | |
| CN205156109U (en) | Floor that generates heat of even heat conduction | |
| CN216411130U (en) | Mud sand core resistivity measurement bracket |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200228 |
|
| RJ01 | Rejection of invention patent application after publication |