CN110841102B - Composite nanofiber elastic bandage and preparation method thereof - Google Patents
Composite nanofiber elastic bandage and preparation method thereof Download PDFInfo
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- CN110841102B CN110841102B CN201911197939.0A CN201911197939A CN110841102B CN 110841102 B CN110841102 B CN 110841102B CN 201911197939 A CN201911197939 A CN 201911197939A CN 110841102 B CN110841102 B CN 110841102B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0273—Adhesive bandages for winding around limb, trunk or head, e.g. cohesive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
- D01F6/70—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyurethanes
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/18—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from other substances
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4374—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece using different kinds of webs, e.g. by layering webs
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a composite nanofiber elastic bandage and a preparation method thereof, wherein the bandage is prepared by an electrostatic spinning device with a double-layer elastic membrane as a collector, the composite nanofiber elastic bandage is a three-layer composite nanofiber membrane with a double-fold structure and comprises a water absorption layer, a drug-carrying layer and a protective layer which are stacked from bottom to top, the bandage has better elastic performance, can stretch along with a joint when the joint moves, avoids the problems of constraint on the joint movement of a wounded part and bandage displacement, and simultaneously can ensure air permeability, promote wound healing, absorb wound exudate and reduce the risk of wound adhesion.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to a composite nanofiber elastic bandage and a preparation method thereof.
Background
Medical bandages are medical dressings that can be placed on wounds, which can be applied to external wounds, aid in wound healing, and isolate the external environment. The traditional medical bandage mostly adopts multilayer medical gauze, and the bandage material has a plurality of problems, firstly, the air permeability is general; secondly, the elasticity of the material is poor, especially when the joint of a patient is wounded, the traditional medical bandage cannot stretch along with the movement of the joint, the movement of the joint is restrained, the bandage can shift in the movement process, the using effect is greatly reduced, and finally, when the wound seeps more, the seepage cannot be absorbed in time, and the wound is easy to adhere to the wound, so that the secondary injury is caused.
The electrostatic spinning technology is a universal nano fiber preparation method, the nano fiber prepared by the method has the characteristics of high porosity, large specific surface area and the like, and the air permeability of the bandage can be improved to a certain extent by applying the nano fiber to the bandage or wound dressing, but the tensile property of the conventional electrospinning nano fiber film still cannot fully improve the elastic property of the bandage, cannot avoid the constraint on the joint movement of a wounded part, and has the problem that the bandage is easy to shift to influence the use effect.
Disclosure of Invention
Aiming at the defects in the prior art, the technical problem to be solved by the invention is to provide the composite nanofiber elastic bandage and the preparation method thereof, the bandage has better elastic performance, can stretch along with a joint when the joint moves, avoids the problems of constraint on the joint movement of a wounded part and bandage displacement, and simultaneously can ensure air permeability, promote wound healing, absorb wound exudate and reduce the risk of wound adhesion.
In order to achieve the purpose, the invention adopts the technical scheme that:
a preparation method of a composite nanofiber elastic bandage comprises the following steps:
(1) preparing a spinning solution: dissolving hydrophilic natural polymer material A in a solvent to prepare a spinning solution A, mixing hydrophilic natural polymer material B and active pharmaceutical ingredients, dissolving the mixture in the solvent to prepare a spinning solution B, and dissolving hydrophobic polymer material in the solvent to prepare a spinning solution C;
(2) building an electrostatic spinning device: the electrostatic spinning device comprises a high-voltage power supply, a liquid supply mechanism, a spinning spray head and a collector, wherein the positive electrode and the negative electrode of the high-voltage power supply are respectively connected with the spinning spray head and the collector; the collector comprises a conductive layer, a first elastic film and a second elastic film which are sequentially stacked from bottom to top, the first elastic film and the second elastic film are made of insulating materials, the first elastic film and the second elastic film are both in a stretching state and are fixedly mounted on the conductive layer, the first elastic film and the second elastic film are stretched in the same direction, the stretching amount of the first elastic film is larger than that of the second elastic film, a plurality of strip-shaped grooves are uniformly arranged on the first elastic film along the stretching direction of the first elastic film, the length direction of each strip-shaped groove is perpendicular to the stretching direction of the first elastic film, and round through holes are uniformly and densely distributed on the second elastic film; when the first elastic film and the second elastic film are in an unstretched state, the groove width of the strip-shaped groove is smaller than the diameter of the circular through hole;
(3) electro-spinning water-absorbing layer: injecting the spinning solution A into a liquid supply mechanism of an electrostatic spinning device, starting the electrostatic spinning device, adjusting spinning parameters, electro-spinning a layer of nanofiber membrane on a second elastic membrane of the collector to be used as a water absorption layer, and then closing the electrostatic spinning device;
(4) electro-spinning the drug-carrying layer: cleaning a liquid supply mechanism, injecting a spinning solution B into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electro-spinning a layer of nanofiber membrane on the upper surface of the water absorption layer to serve as a drug-loaded layer, and then closing the electrostatic spinning device;
(5) electro-spinning protective layer: cleaning a liquid supply mechanism, injecting a spinning solution C into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electrospinning a layer of nanofiber membrane on the upper surface of the drug-loaded layer to serve as an electrospinning protective layer, and then closing the electrostatic spinning device, namely preparing a three-layer composite nanofiber membrane on a collecting electrode;
(6) taking a film: and (3) restoring the original length of the second elastic membrane and the first elastic membrane, then shrinking the obtained three-layer composite nanofiber membrane to form a double-fold structure, and taking down the three-layer composite nanofiber membrane from the second elastic membrane to obtain the composite nanofiber elastic bandage.
Preferably, the hydrophilic natural polymer material A and the hydrophilic natural polymer material B are both one or more of chitosan, sodium alginate, gelatin and polyethylene oxide; the effective components of the medicine are one or more of epidermal growth factor, antibiotic, anti-scar gel and astragalus polysaccharide; the hydrophobic polymer material is one or more of thermoplastic polyurethane elastomer rubber, nylon-66 and polyvinylidene fluoride.
Preferably, the step (1) is: weighing 0.6g of chitosan and 0.01g of polyoxyethylene, mixing to obtain a hydrophilic natural polymer material A, adding 6.8ml of distilled water, and stirring at normal temperature to dissolve the mixture in the distilled water to obtain a spinning solution A; weighing 0.4g of chitosan and 0.01g of polyoxyethylene, mixing to obtain a hydrophilic natural polymer material B, adding 0.3g of astragalus polysaccharide as a medicinal active ingredient, adding 6.0g of alcohol, and stirring at normal temperature to dissolve the hydrophilic natural polymer material B and the astragalus polysaccharide in the alcohol to obtain a spinning solution B; 0.6g of thermoplastic polyurethane elastomer rubber is weighed as a hydrophobic polymer material, 4.4ml of N, N-dimethylformamide solution is added, and the mixture is stirred at the temperature of 40 ℃ to be dissolved in N, N-dimethylformamide to obtain spinning solution C.
Preferably, the spinning parameters of the step (3) and the step (4) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 0.75ml/h and spinning voltage of 10.5 kV; the spinning parameters of the step (5) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 0.75ml/h and spinning voltage of 12.5 kV.
Preferably, in the step (2), the conductive layer is a metal plate, one end of the first elastic membrane in the stretching direction is fixed on the metal plate through a first connecting component, and the other end of the first elastic membrane is detachably connected with the metal plate through a second connecting component; one end of the second elastic membrane along the stretching direction is also fixed on the metal plate through a first connecting part, and the other end of the second elastic membrane is detachably connected with the metal plate through a third connecting part; the first connecting component is a first pressing strip abutted to the upper surface of the second elastic film, the first pressing strip is perpendicular to the stretching direction of the second elastic film, first through holes capable of penetrating first fixing bolts are formed in two ends of the first pressing strip, a first screw hole assembly is arranged on the metal plate corresponding to the first through holes and comprises two first screw holes matched with the first fixing bolts, the two first screw holes are respectively formed under the two first through holes, and the two ends of the first pressing strip are respectively connected with the first screw holes through the first fixing bolts penetrating the first through holes.
Preferably, the second connecting part is a second pressing strip abutted against the upper surface of the first elastic film, the second pressing strip is arranged perpendicular to the stretching direction of the first elastic film, second through holes capable of penetrating second fixing bolts are formed in two end parts of the second pressing strip, a second screw hole assembly is arranged on the metal plate corresponding to the second through holes and comprises two second screw holes matched with the second fixing bolts, the two second screw holes are respectively arranged right below the two second through holes, the two end parts of the second pressing strip are respectively connected with the second screw holes through the second fixing bolts, and the second screw hole assemblies are arranged in a plurality and are uniformly distributed along the stretching direction of the first elastic film; the third connecting part is a third pressing strip which is abutted against the upper surface of the second elastic film, the third pressing strip is perpendicular to the stretching direction of the second elastic film, third through holes which can be communicated with the second screw holes are formed in two end parts of the third pressing strip, the third through holes can be penetrated by the second fixing bolts, and two end parts of the third pressing strip are respectively connected with the second screw holes through the second fixing bolts penetrating through the third through holes.
Preferably, the upper surface of the conductive layer is rectangular, the first elastic film and the second elastic film are both rectangular films, the long sides of the first elastic film and the second elastic film are arranged in parallel, the first elastic film and the second elastic film are stretched along the direction of the long side of the first elastic film, the short sides of the fixed ends of the first elastic film and the second elastic film are both arranged under the first pressing bar, the other short side of the first elastic film is arranged under the second pressing bar, and the other short side of the second elastic film is arranged under the third pressing bar; the first pressing strip, the second pressing strip and the third pressing strip are all made of insulating materials; the lower surfaces of the first pressing strip, the second pressing strip and the third pressing strip are provided with anti-skidding structures.
Preferably, in the step (2), the first elastic film is pre-stretched in the longitudinal direction thereof at a pre-stretch ratio of 100%, and the second elastic film is stretched in the same direction as the first elastic film at a pre-stretch ratio of 30%.
The invention also discloses a composite nanofiber elastic bandage which is prepared by adopting the preparation method, and the composite nanofiber elastic bandage is a three-layer composite nanofiber membrane with a double-fold structure and comprises a water absorption layer, a medicine carrying layer and a protective layer which are stacked from bottom to top.
Preferably, the medical self-adhesive tape further comprises two medical self-adhesive tapes, and the two medical self-adhesive tapes are respectively fixed at two end parts of the lower surface of the water absorption layer.
Compared with the prior art, the invention has the advantages and positive effects that: the composite nanofiber elastic bandage has good elastic performance, can stretch along with joints when the joints move, avoids the problems of constraint on the joint movement of the wounded part and bandage displacement, and simultaneously can ensure air permeability, promote wound healing, absorb wound exudate and reduce the risk of wound adhesion.
Drawings
FIG. 1 is a plan view of an electrospinning apparatus according to an embodiment;
FIG. 2 is a front view of an electrospinning apparatus according to an embodiment;
FIG. 3 is an optical photograph of the composite nanofiber elastic bandage prepared in example 1;
FIG. 4 is an SEM photograph of the composite nanofiber elastic bandage made in example 1;
FIG. 5 is an SEM photograph of the composite nanofiber elastic bandage prepared in example 1 after absorbing wound exudate;
in the above figures: the manufacturing method comprises the following steps of 1-a metal plate, 2-a first elastic membrane, 21-a strip-shaped groove, 3-a second elastic membrane, 31-a circular through hole, 4-a first pressing strip, 5-a third pressing strip, 6-a second pressing strip, 7-a first fixing bolt, 8-a second fixing bolt, 9-a second screw hole component and 91-a second screw hole.
Detailed Description
The invention is described in detail below by way of exemplary embodiments. It should be understood, however, that elements, structures and features of one embodiment may be beneficially incorporated in other embodiments without further recitation.
It should be noted that in the description of the present invention, the terms "inside", "outside", "upper", "lower", "left", "right", "front", "rear", and the like indicate orientations or positional relationships based on the positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.
A preparation method of a composite nanofiber elastic bandage comprises the following steps:
(1) preparing a spinning solution: dissolving hydrophilic natural polymer material A in a solvent to prepare a spinning solution A, mixing hydrophilic natural polymer material B and active pharmaceutical ingredients, dissolving the mixture in the solvent to prepare a spinning solution B, and dissolving hydrophobic polymer material in the solvent to prepare a spinning solution C;
(2) building an electrostatic spinning device: the electrostatic spinning device comprises a high-voltage power supply, a liquid supply mechanism, a spinning spray head and a collector, wherein the positive electrode and the negative electrode of the high-voltage power supply are respectively connected with the spinning spray head and the collector; the collector comprises a conductive layer, a first elastic film 2 and a second elastic film 3 which are sequentially stacked from bottom to top as shown in fig. 1 and 2, wherein the first elastic film 2 and the second elastic film 3 are both made of insulating materials, the first elastic film 2 and the second elastic film 3 are both in a stretching state and are fixedly mounted on the conductive layer, the first elastic film 2 and the second elastic film 3 are stretched along the same direction, the stretching amount of the first elastic film 2 is greater than that of the second elastic film 3, a plurality of strip-shaped grooves 21 are uniformly arranged on the first elastic film 2 along the stretching direction of the first elastic film, the length direction of the strip-shaped grooves 21 is perpendicular to the stretching direction of the first elastic film 2, and round through holes 31 are uniformly densely distributed on the second elastic film 3; when the first elastic film 2 and the second elastic film 3 are in an unstretched state, the groove width of the strip-shaped groove 21 is smaller than the diameter of the circular through hole 31;
(3) electro-spinning water-absorbing layer: injecting the spinning solution A into a liquid supply mechanism of an electrostatic spinning device, starting the electrostatic spinning device, adjusting spinning parameters, electro-spinning a layer of nanofiber membrane on a second elastic membrane of the collector to be used as a water absorption layer, and then closing the electrostatic spinning device;
(4) electro-spinning the drug-carrying layer: cleaning a liquid supply mechanism, injecting a spinning solution B into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electro-spinning a layer of nanofiber membrane on the upper surface of the water absorption layer to serve as a drug-loaded layer, and then closing the electrostatic spinning device;
(5) electro-spinning protective layer: cleaning a liquid supply mechanism, injecting a spinning solution C into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electrospinning a layer of nanofiber membrane on the upper surface of the drug-loaded layer to serve as an electrospinning protective layer, and then closing the electrostatic spinning device, namely preparing a three-layer composite nanofiber membrane on a collecting electrode;
(6) taking a film: and (3) restoring the original length of the second elastic membrane and the first elastic membrane, then shrinking the obtained three-layer composite nanofiber membrane to form a double-fold structure, and taking down the three-layer composite nanofiber membrane from the second elastic membrane to obtain the composite nanofiber elastic bandage.
The composite nanofiber elastic bandage is prepared by the preparation method, is a three-layer composite nanofiber membrane with a double-fold structure and comprises a water absorption layer, a medicine carrying layer and a protective layer which are stacked from bottom to top.
This application adopts the electrostatic spinning technique to combine special collector structure, has made the three-layer composite nanofiber membrane that has two fold structures, regards it as nanofiber elastic bandage, has better elasticity performance, can stretch out and draw back along with the joint when the joint activity, avoids the constraint and the bandage aversion problem to the position joint activity of wounding, still can ensure the gas permeability simultaneously, promotes wound healing, absorbs the wound exudate, reduces the wound and takes place the adhesion risk. Specifically, the method comprises the following steps:
the electrostatic spinning device built in the step (2) is provided with a special collector, the spinning solution is stretched under the action of electric field force, fibers are deposited on the upper surface of a pre-stretched second elastic membrane 3 to be in contact with the second elastic membrane 3, meanwhile, through the contact action of a through hole 31 and the pre-stretched first elastic membrane 2 below the second elastic membrane 3, through the combined action of the first elastic membrane 2 and the second elastic membrane 3 with different stretching amounts and different patterns, a double-fold structure is formed on the surface of the electrospun nanofibers, dense fine folds are formed between large folds of the double-fold structure which are periodically arranged, compared with a plane electrospun fiber membrane manufactured by adopting a conventional metal plate collector, or an electrospun fiber membrane manufactured by taking a single-layer pre-stretched elastic base material as a collector and having a single-fold structure, the fine folds formed between the large folds can effectively increase the stretching performance of the electrospun fiber membrane, the improvement of the tensile property of the electrospun nanofiber membrane exceeds the maximum pre-stretching amount limit of a single-layer elastic substrate material, and the tensile property and the specific surface area of the electrospun nanofiber membrane can be improved to a greater extent. The larger aperture of the circular through hole 31 enables the electrospun nanofibers deposited on the second elastic membrane 3 to be more fully contacted with the strip-shaped grooves 21 of the lower pre-stretched first elastic membrane 2, so as to ensure the formation of the double-fold structure of the electrospun nanofibers.
The composite nanofiber membrane prepared by the application has excellent tensile property and better elastic property, can stretch along with joints when the joints move, avoids the problems of constraint on joint movement of an affected part and bandage displacement, the super-large porosity of electrospun fiber can ensure the air permeability of the bandage and promote wound healing, meanwhile, the absorption layer which is made of hydrophilic high polymer material and has a double-fold structure has a larger specific surface area and can be fully contacted with a wound surface to absorb wound exudate and reduce the risk of wound adhesion, the double-fold structure of the drug-loaded layer can increase the specific surface area, so that the drug-loaded amount is increased, the wound exudate is beneficial to the precipitation of the effective components of the drugs in the drug-loaded layer after being wetted by the absorption layer, the effective components of the drugs in the drug-loaded layer are precipitated and then act on the wound to promote the wound healing, and meanwhile, the bandage material can provide micro pressure to the wound surface to promote the permeation of the effective components of the drugs when being used, the protective layer is a hydrophobic and breathable nanofiber membrane, so that the drug-loaded layer and the injured part can be protected, the effects of moisture preservation and ventilation can be achieved in the later treatment period, and the effect of improving the flexibility of the whole bandage can be achieved.
Specifically, the hydrophilic natural polymer material A and the hydrophilic natural polymer material B are one or more of chitosan, sodium alginate, gelatin and polyethylene oxide; the effective components of the medicine are one or more of epidermal growth factor, antibiotic, anti-scar gel and astragalus polysaccharide; the hydrophobic polymer material is one or more of thermoplastic polyurethane elastomer rubber, nylon-66 and polyvinylidene fluoride.
The hydrophilic natural polymer material A and the hydrophilic natural polymer material B are natural polymer materials such as chitosan and the like, and the materials have the performances of hydrophilicity, no toxicity, water solubility or natural degradation, and can effectively avoid secondary damage to wounds caused by adhesion; the effective components of the drug-loaded layer have the functions of resisting bacteria and diminishing inflammation or promoting skin regeneration and the like, can effectively promote wound healing and reduce the risk of wound inflammation; the protective layer is made of the hydrophobic polymer material with good tensile property, so that the tensile property of the composite nanofiber membrane can be effectively improved while the air permeability is ensured and the drug-loaded layer and the wound are protected, and the effect of reducing water evaporation to keep the bandage moist so as to promote the precipitation of active ingredients of the drug can be achieved.
Specifically, the liquid supply mechanism can comprise a syringe needle tube which is arranged on an injection pump; the spinning nozzle can include the metal syringe needle of locating on the syringe needle tubing, the metal syringe needle is connected the high voltage power supply positive pole, the conducting layer is connected the high voltage power supply negative pole. The electrospinning device may also include an airflow assisting device, such as a blower for supplying hot air to the spinning nozzle in the direction of the jet, or the like, and the liquid supply mechanism and the spinning nozzle of the electrospinning device may be arranged in other conventional manners.
Specifically, the conductive layer is a metal plate 1, the first elastic membrane 2 and the second elastic membrane 3 are both elastic rubber membranes, one end of the first elastic membrane 2 in the stretching direction is fixed on the metal plate 1 through a first connecting component, and the other end of the first elastic membrane is detachably connected with the metal plate 1 through a second connecting component; one end of the second elastic membrane 3 in the stretching direction thereof is also fixed to the metal plate 1 by a first connecting member, and the other end is detachably connected to the metal plate 1 by a third connecting member.
Specifically, first connecting part is the first layering 4 of butt at 3 upper surfaces of second elastic membrane, first layering 4 perpendicular to the 3 tensile direction settings of second elastic membrane, first layering 4 both ends all are equipped with the first through-hole that can wear to establish first fixing bolt 7, correspond on the metal sheet 1 first through-hole sets up first screw subassembly, first screw subassembly includes two and the first screw of 7 looks adaptations of first fixing bolt, and two first screw divide and locate under two first through-holes, first layering both ends are respectively through wearing to locate first fixing bolt 7 in the first through-hole is connected first screw.
Specifically, the second connecting part is a second pressing strip 6 which is abutted against the upper surface of the first elastic film 2, the second pressing strip 6 is perpendicular to the stretching direction of the first elastic film 2, the two ends of the second pressing strip 6 are respectively provided with a second through hole through which a second fixing bolt 8 can penetrate, a second screw hole assembly 9 is arranged on the metal plate 1 corresponding to the second through hole, the second screw hole assembly 9 comprises two second screw holes 91 matched with the second fixing bolts 8, the two second screw holes 91 are respectively arranged under the two second through holes, the two ends of the second pressing strip 6 are respectively connected with the second screw holes 91 through the second fixing bolts 8, and the second screw hole assembly 9 is arranged in a plurality of ways and is uniformly arranged along the stretching direction of the first elastic film 2. By adopting the structure, the second pressing strip 6 and the second screw hole assemblies 9 at different positions can be connected to flexibly adjust the stretching amount of the first elastic membrane 2, so that the double-fold nanofiber membrane with large folds and small folds arranged according to different proportions can be obtained, and the electrospinning device can more flexibly adjust the stretching performance of the electrospinning fiber.
Specifically, the third connecting part is a third pressing strip 5 abutted against the upper surface of the second elastic film 3, the third pressing strip 5 is perpendicular to the stretching direction of the second elastic film 3, third through holes capable of being communicated with the second screw holes 91 are formed in two end portions of the third pressing strip 5, the second fixing bolts 8 can be arranged in the third through holes in a penetrating mode, and two end portions of the third pressing strip 5 are respectively connected with the second screw holes 91 through the second fixing bolts 8 arranged in the third through holes in a penetrating mode. By adopting the structure, the third pressing strip 5 can be connected with the second screw hole assemblies 9 at different positions to flexibly adjust the stretching amount of the second elastic membrane 3, and the arrangement proportion of large wrinkles and small wrinkles of the electrospun fiber membrane can be more flexibly adjusted by combining the flexible adjustment of the stretching amount of the first elastic membrane 2, so that the electrospinning device can more flexibly adjust the stretching performance of electrospun fibers.
Specifically, as shown in fig. 1, the upper surface of conducting layer establish into rectangle first elastic membrane 2 with second elastic membrane 3 all establishes into rectangular membrane, first elastic membrane 2 with the long limit parallel arrangement of second elastic membrane 3, first elastic membrane 2 with second elastic membrane 3 all follows first elastic membrane 2 long limit direction is tensile, first elastic membrane 2 with under first layering 4 is all located to the minor face of second elastic membrane 3 stiff end, and another minor face of first elastic membrane 2 is located under second layering 6, and another minor face of second elastic membrane 3 is located under third layering 5.
Specifically, the first pressing strip 4, the second pressing strip 6 and the third pressing strip 5 are all made of insulating materials. The insulating material pressing strip can avoid the influence of the pressing strip on the electric field of the electrospinning device, so that the electrospinning process is more stable and controllable.
Specifically, the lower surfaces of the first pressing strip 4, the second pressing strip 6 and the third pressing strip 5 are all provided with anti-skidding structures. The arrangement of the anti-slip structure can increase the contact force between the pressing strip and the first elastic film 2 and the second elastic film 3, and the pressing strip can more firmly clamp and fix the first elastic film 2 and the second elastic film 3.
Specifically, in the step (2), the first elastic film is pre-stretched along the length direction of the first elastic film, the pre-stretching rate is 100%, and the second elastic film is stretched in the same direction as the first elastic film, and the pre-stretching rate is 30%.
Specifically, the composite nanofiber elastic bandage further comprises two medical adhesive strips, and the two medical adhesive strips are fixed at two end portions of the lower surface of the water absorbing layer respectively to facilitate the use and fixation of the bandage.
Example 1
The preparation method of the composite nanofiber elastic bandage adopts the electrostatic spinning device and the process steps of the embodiment, and the specific parameters are as follows:
the step (1) is as follows: weighing 0.6g of chitosan and 0.01g of polyethylene oxide (PEO) to be mixed to be used as a hydrophilic natural polymer material A, adding 6.8ml of distilled water, and stirring for 45min at normal temperature to dissolve the mixture in the distilled water to obtain a spinning solution A; weighing 0.4g of chitosan and 0.01g of polyethylene oxide (PEO) and mixing to obtain a hydrophilic natural polymer material B, adding 0.3g of astragalus polysaccharide to obtain a medicinal active ingredient, adding 6.0g of alcohol, and stirring at normal temperature for 45min to dissolve the hydrophilic natural polymer material B and the astragalus polysaccharide in the alcohol to obtain a spinning solution B; weighing 0.6g of thermoplastic polyurethane elastomer rubber (TPU) as a hydrophobic polymer material, adding 4.4ml of N, N-dimethylformamide solution, stirring at 40 ℃ for 1h to dissolve the thermoplastic polyurethane elastomer rubber in N, N-dimethylformamide to obtain spinning solution C;
the spinning parameters of the step (3) and the step (4) are that the spinning temperature is 40 ℃, the spinning distance is 12cm, the spinning solution propelling speed is 0.75ml/h, and the spinning voltage is 10.5 kV; the spinning parameters of the step (5) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 0.75ml/h and spinning voltage of 12.5 kV.
The surface topography of the elastic nanofiber bandage prepared by the preparation method of example 1 (the shooting surface is the surface of the water absorbing layer) is shown in fig. 3 and 4, it can be seen from fig. 3 that the elastic nanofiber bandage prepared by example 1 has wrinkles with two different sizes on the surface, the microstructure is shown in fig. 4, the protruding part in fig. 4 is a fine wrinkle of the fiber membrane, because the size of the macro wrinkle is larger, the macro wrinkle structure is not shown in the SEM picture, that is, the three-layer composite nanofiber membrane with the double wrinkle structure is prepared by the method of this example, and the maximum tensile rate of the elastic nanofiber bandage obtained by example 1 is 1050% and has excellent tensile elastic performance through tensile performance test.
The calculation method of the maximum stretching ratio comprises the following steps:
maximum draw ratio (maximum drawn length of film/original length of film) × 100%
The elastic nanofiber bandage obtained in example 1 is applied to a burn wound, the bandage is taken down after being applied for 1 day, a used bandage sample is observed by an electron microscope after being frozen and dried, the surface appearance of the obtained sample (the shooting surface is the surface of the water absorption layer) is shown in fig. 5, and it can be seen from fig. 5 that wound exudate is fully filled in the water absorption layer fiber membrane, namely the water absorption layer has a good absorption effect on wound exudate.
The absorption layer and the drug-loaded layer both adopt water-soluble chitosan as a matrix material of the nano-fiber, the chitosan fiber has antibacterial property and has the advantages of good biocompatibility, no toxicity, natural degradation, good air permeability, air bacterium blocking and the like, the absorption layer made of the chitosan can effectively absorb secretion of a wound surface to keep the wound surface dry, and secondary damage caused by adhesion can be avoided through the natural degradation of the absorption layer; the water solubility and degradation of the drug-loaded layer can promote the precipitation and release of the astragalus polysaccharide which is the active ingredient of the drug, so that the astragalus polysaccharide can effectively act on the wound surface and promote the recovery and healing of the wound; the protective layer adopts TPU with high elasticity, so that the flexible tensile property of the composite material can be effectively improved, and the elasticity of the bandage can be further improved.
Example 2
The preparation method of the composite nanofiber elastic bandage adopts the electrostatic spinning device and the process steps of the embodiment, and the specific parameters are as follows:
the step (1) is as follows: weighing 0.6g of chitosan and 0.01g of polyethylene oxide (PEO) to be mixed to be used as a hydrophilic natural polymer material A, adding 6.8ml of distilled water, and stirring for 45min at normal temperature to dissolve the mixture in the distilled water to obtain a spinning solution A; weighing 0.36g of sodium alginate and 0.01g of polyethylene oxide (PEO) as a hydrophilic natural polymer material B, dissolving the sodium alginate in 7.4ml of deionized water to prepare a solution A, adding 0.3g of astragalus polysaccharide into the polyethylene oxide, dissolving the astragalus polysaccharide in 6.0g of alcohol to prepare a solution B, and mixing the solution A and the solution B according to the volume ratio of 3: 2, uniformly mixing and stirring, adding 1.4g of triton-100 and 0.05g of dimethyl sulfoxide (DMSO) into the mixed solution, mixing and stirring for 3 hours, and performing centrifugal deaeration to obtain a spinning solution B; weighing 0.6g of thermoplastic polyurethane elastomer rubber (TPU) as a hydrophobic polymer material, adding 4.4ml of N, N-Dimethylformamide (DMF) solution, and stirring at 40 ℃ for 1h to dissolve the mixture in DMF to obtain a spinning solution C;
the spinning parameters of the step (3) are that the spinning temperature is 40 ℃, the spinning distance is 12cm, the spinning solution propelling speed is 0.75ml/h, and the spinning voltage is 10.5 kV; the spinning parameters of the step (4) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 1.0ml/h and spinning voltage of 15 kV; the spinning parameters of the step (5) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 0.75ml/h and spinning voltage of 12.5 kV.
The elastic nanofiber bandage obtained in example 2 has a maximum elongation of 1000% and excellent tensile elastic properties, as measured by tensile property tests.
Comparative example 1
And (3) replacing the collector in the step (2) in the example 1 with an elastic rubber membrane with the pre-stretching rate of 100%, and preparing the electro-spinning wrinkle nanofiber membrane as a first control nanofiber membrane by using the same preparation method steps, spinning solution formula and spinning parameters as in the example 1.
The first control nanofiber membrane obtained in comparative example 1 was measured to have a maximum tensile rate of 650% by tensile property test.
Comparative example 2
The metal plate 1 is used as a collector in the step (2) of the alternative embodiment 1, and the electrospun nanofiber membrane is prepared as a second control nanofiber membrane by the same preparation method steps, spinning solution formula and spinning parameters as those in the embodiment 1.
The maximum tensile rate of the second control nanofiber membrane obtained in comparative example 2 was 300% as measured by tensile property test.
It can be seen from the comparison of the maximum stretching ratios of the elastic nanofiber bandages obtained in the embodiment 1, the comparative examples 1 and 2 that the double-fold structure formed by electrospinning the collection mechanism in the embodiment 1 can effectively increase the stretching performance of the elastic nanofiber bandage, so that the improvement of the stretching performance of the elastic nanofiber bandage exceeds the maximum pre-stretching limit of a single-layer elastic base material, the stretching performance and the specific surface area of the elastic nanofiber bandage can be improved to a greater extent, and the elastic nanofiber bandage is better suitable for the use requirement of the elastic bandage.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.
Claims (9)
1. A preparation method of a composite nanofiber elastic bandage is characterized by comprising the following steps:
(1) preparing a spinning solution: dissolving hydrophilic natural polymer material A in a solvent to prepare a spinning solution A, mixing hydrophilic natural polymer material B and active pharmaceutical ingredients, dissolving the mixture in the solvent to prepare a spinning solution B, and dissolving hydrophobic polymer material in the solvent to prepare a spinning solution C;
(2) building an electrostatic spinning device: the electrostatic spinning device comprises a high-voltage power supply, a liquid supply mechanism, a spinning spray head and a collector, wherein the positive electrode and the negative electrode of the high-voltage power supply are respectively connected with the spinning spray head and the collector; the collector comprises a conductive layer, a first elastic film and a second elastic film which are sequentially stacked from bottom to top, the first elastic film and the second elastic film are made of insulating materials, the first elastic film and the second elastic film are both in a stretching state and are fixedly mounted on the conductive layer, the first elastic film and the second elastic film are stretched in the same direction, the stretching amount of the first elastic film is larger than that of the second elastic film, a plurality of strip-shaped grooves are uniformly arranged on the first elastic film along the stretching direction of the first elastic film, the length direction of each strip-shaped groove is perpendicular to the stretching direction of the first elastic film, and round through holes are uniformly and densely distributed on the second elastic film; when the first elastic film and the second elastic film are not stretched, the groove width of the strip-shaped groove is smaller than the diameter of the circular through hole; the conducting layer is a metal plate, one end of the first elastic membrane along the stretching direction of the first elastic membrane is fixed on the metal plate through a first connecting part, and the other end of the first elastic membrane is detachably connected with the metal plate through a second connecting part; one end of the second elastic membrane along the stretching direction is also fixed on the metal plate through a first connecting part, and the other end of the second elastic membrane is detachably connected with the metal plate through a third connecting part; the first connecting component is a first pressing strip which is abutted against the upper surface of the second elastic film, the first pressing strip is arranged perpendicular to the stretching direction of the second elastic film, two ends of the first pressing strip are respectively provided with a first through hole through which a first fixing bolt can penetrate, a first screw hole component is arranged on the metal plate corresponding to the first through hole, the first screw hole component comprises two first screw holes matched with the first fixing bolts, the two first screw holes are respectively arranged under the two first through holes, and the two ends of the first pressing strip are respectively connected with the first screw holes through the first fixing bolts penetrating the first through holes;
(3) electro-spinning water-absorbing layer: injecting the spinning solution A into a liquid supply mechanism of an electrostatic spinning device, starting the electrostatic spinning device, adjusting spinning parameters, electro-spinning a layer of nanofiber membrane on a second elastic membrane of the collector to be used as a water absorption layer, and then closing the electrostatic spinning device;
(4) electro-spinning the drug-carrying layer: cleaning a liquid supply mechanism, injecting a spinning solution B into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electro-spinning a layer of nanofiber membrane on the upper surface of the water absorption layer to serve as a drug-loaded layer, and then closing the electrostatic spinning device;
(5) electro-spinning protective layer: cleaning a liquid supply mechanism, injecting a spinning solution C into the liquid supply mechanism, starting an electrostatic spinning device, adjusting spinning parameters, directly electrospinning a layer of nanofiber membrane on the upper surface of the drug-loaded layer to serve as an electrospinning protective layer, and then closing the electrostatic spinning device, namely preparing a three-layer composite nanofiber membrane on a collecting electrode;
(6) taking a film: and (3) restoring the original length of the second elastic membrane and the first elastic membrane, then shrinking the obtained three-layer composite nanofiber membrane to form a double-fold structure, and taking down the three-layer composite nanofiber membrane from the second elastic membrane to obtain the composite nanofiber elastic bandage.
2. The preparation method of the composite nanofiber elastic bandage as claimed in claim 1, wherein the hydrophilic natural polymer material A and the hydrophilic natural polymer material B are both one or more of chitosan, sodium alginate, gelatin and polyethylene oxide; the effective components of the medicine are one or more of epidermal growth factor, antibiotic, anti-scar gel and astragalus polysaccharide; the hydrophobic polymer material is one or more of thermoplastic polyurethane elastomer rubber, nylon-66 and polyvinylidene fluoride.
3. The method for preparing a composite nanofiber elastic bandage as claimed in claim 2, wherein the step (1) is: weighing 0.6g of chitosan and 0.01g of polyoxyethylene, mixing to obtain a hydrophilic natural polymer material A, adding 6.8ml of distilled water, and stirring at normal temperature to dissolve the mixture in the distilled water to obtain a spinning solution A; weighing 0.4g of chitosan and 0.01g of polyoxyethylene, mixing to obtain a hydrophilic natural polymer material B, adding 0.3g of astragalus polysaccharide as a medicinal active ingredient, adding 6.0g of alcohol, and stirring at normal temperature to dissolve the hydrophilic natural polymer material B and the astragalus polysaccharide in the alcohol to obtain a spinning solution B; 0.6g of thermoplastic polyurethane elastomer rubber is weighed as a hydrophobic polymer material, 4.4ml of N, N-dimethylformamide solution is added, and the mixture is stirred at the temperature of 40 ℃ to be dissolved in N, N-dimethylformamide to obtain spinning solution C.
4. The method for preparing the composite nanofiber elastic bandage as claimed in claim 3, wherein the spinning parameters of the step (3) and the step (4) are that the spinning temperature is 40 ℃, the spinning distance is 12cm, the advancing speed of the spinning solution is 0.75ml/h, and the spinning voltage is 10.5 kV; the spinning parameters of the step (5) are spinning temperature of 40 ℃, spinning distance of 12cm, spinning solution advancing speed of 0.75ml/h and spinning voltage of 12.5 kV.
5. The method for preparing the composite nanofiber elastic bandage according to claim 1, wherein the second connecting part is a second pressing strip abutted against the upper surface of the first elastic film, the second pressing strip is arranged perpendicular to the stretching direction of the first elastic film, second through holes capable of being penetrated by second fixing bolts are arranged at two end parts of the second pressing strip, a second screw hole assembly is arranged on the metal plate corresponding to the second through holes and comprises two second screw holes matched with the second fixing bolts, the two second screw holes are respectively arranged right below the two second through holes, two end parts of the second pressing strip are respectively connected with the second screw holes through the second fixing bolts, and the second screw hole assemblies are arranged in a plurality and are uniformly distributed along the stretching direction of the first elastic film; the third connecting part is a third pressing strip which is abutted against the upper surface of the second elastic film, the third pressing strip is perpendicular to the stretching direction of the second elastic film, third through holes which can be communicated with the second screw holes are formed in two end parts of the third pressing strip, the third through holes can be penetrated by the second fixing bolts, and two end parts of the third pressing strip are respectively connected with the second screw holes through the second fixing bolts penetrating through the third through holes.
6. The method for preparing a composite nanofiber elastic bandage as claimed in claim 5, wherein the upper surface of the conductive layer is rectangular, the first elastic film and the second elastic film are rectangular films, the long sides of the first elastic film and the second elastic film are arranged in parallel, the first elastic film and the second elastic film are stretched along the direction of the long side of the first elastic film, the short sides of the fixed ends of the first elastic film and the second elastic film are both arranged under the first pressing strip, the other short side of the first elastic film is arranged under the second pressing strip, and the other short side of the second elastic film is arranged under the third pressing strip; the first pressing strip, the second pressing strip and the third pressing strip are all made of insulating materials; the lower surfaces of the first pressing strip, the second pressing strip and the third pressing strip are provided with anti-skidding structures.
7. The method of claim 6, wherein the first elastic film is pre-stretched along the length of the first elastic film in step (2) to a pre-stretch ratio of 100%, and the second elastic film is co-stretched with the first elastic film to a pre-stretch ratio of 30%.
8. A composite nanofiber elastic bandage, which is prepared by the preparation method of any one of claims 1 to 7, is a three-layer composite nanofiber membrane with a double-fold structure, and comprises a water absorption layer, a drug-carrying layer and a protective layer which are stacked from bottom to top.
9. The composite nanofiber elastic bandage as claimed in claim 8, further comprising two medical self-adhesive strips, wherein the two medical self-adhesive strips are respectively fixed on two end portions of the lower surface of the water absorbing layer.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11291372A (en) * | 1998-04-07 | 1999-10-26 | Mitsui Chem Inc | Stretchable nonwoven fabric laminate |
| CN201939586U (en) * | 2011-01-25 | 2011-08-24 | 苏州美迪斯医疗运动用品有限公司 | Single-surface wrinkle self-adhesion elastic bondage |
| CN208448216U (en) * | 2017-04-18 | 2019-02-01 | 青岛科技大学 | A kind of novel nano composite wound bandage |
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| US9486977B2 (en) * | 2012-07-18 | 2016-11-08 | The Glad Products Company | Multi-ply puckered films formed by discontinuous lamination of films having different rebound ratios |
| CN103768650A (en) * | 2014-01-26 | 2014-05-07 | 深圳市博立生物材料有限公司 | Wound regenerating and repairing bandage and manufacture method thereof |
| CN104894750B (en) * | 2015-06-16 | 2017-05-03 | 青岛大学 | Force-sensitive stretchable electro-spinning patterning conductive nanofiber membrane and preparation method thereof |
| KR101841195B1 (en) * | 2015-09-22 | 2018-03-23 | 고려대학교 산학협력단 | Self-healing composite material, apparatus and method for manufacturing the same |
| CN105970350B (en) * | 2016-05-16 | 2019-03-19 | 常州大学 | A kind of preparation method and applications of Stretchable polymeric composite material |
| CN106390177B (en) * | 2016-09-28 | 2020-07-14 | 深圳先进技术研究院 | Chitosan-based multilayer nanofiber membrane dressing and preparation method and application thereof |
| CN106983902A (en) * | 2017-04-18 | 2017-07-28 | 青岛科技大学 | A kind of novel nano composite wound bandage |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11291372A (en) * | 1998-04-07 | 1999-10-26 | Mitsui Chem Inc | Stretchable nonwoven fabric laminate |
| CN201939586U (en) * | 2011-01-25 | 2011-08-24 | 苏州美迪斯医疗运动用品有限公司 | Single-surface wrinkle self-adhesion elastic bondage |
| CN208448216U (en) * | 2017-04-18 | 2019-02-01 | 青岛科技大学 | A kind of novel nano composite wound bandage |
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