CN110818547A - A method for extracting curcumin and gingerol from rhizoma Zingiberis recens - Google Patents
A method for extracting curcumin and gingerol from rhizoma Zingiberis recens Download PDFInfo
- Publication number
- CN110818547A CN110818547A CN201911228350.2A CN201911228350A CN110818547A CN 110818547 A CN110818547 A CN 110818547A CN 201911228350 A CN201911228350 A CN 201911228350A CN 110818547 A CN110818547 A CN 110818547A
- Authority
- CN
- China
- Prior art keywords
- gingerol
- curcumin
- ethanol
- ginger
- extracting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 104
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 title claims abstract description 63
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 235000002780 gingerol Nutrition 0.000 title claims abstract description 59
- 229940109262 curcumin Drugs 0.000 title claims abstract description 52
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 52
- 239000004148 curcumin Substances 0.000 title claims abstract description 52
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 95
- 241000234314 Zingiber Species 0.000 claims abstract description 34
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 34
- 235000008397 ginger Nutrition 0.000 claims abstract description 34
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 18
- 239000002002 slurry Substances 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 16
- 238000005406 washing Methods 0.000 claims abstract description 15
- 239000012528 membrane Substances 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 229920000344 molecularly imprinted polymer Polymers 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 11
- -1 1-butyl-3-methylimidazolium tetrafluoroborate Chemical compound 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000011068 loading method Methods 0.000 claims abstract description 7
- 238000001704 evaporation Methods 0.000 claims description 14
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 238000005516 engineering process Methods 0.000 claims description 9
- 239000000178 monomer Substances 0.000 claims description 9
- 239000003431 cross linking reagent Substances 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000000899 pressurised-fluid extraction Methods 0.000 claims description 7
- 239000003999 initiator Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 5
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims description 4
- 238000006073 displacement reaction Methods 0.000 claims description 4
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 4
- VMWSAPMBSQHTPI-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl-dimethylazanium propanoate Chemical compound CCC([O-])=O.C[NH+](C)CCOCCO VMWSAPMBSQHTPI-UHFFFAOYSA-N 0.000 claims description 3
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 claims description 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 3
- 238000000638 solvent extraction Methods 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 description 24
- 239000000047 product Substances 0.000 description 16
- 238000000605 extraction Methods 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000234299 Zingiberaceae Species 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000004537 pulping Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201911228350.2A CN110818547B (en) | 2019-12-04 | 2019-12-04 | A method for extracting curcumin and gingerol from rhizoma Zingiberis recens |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911228350.2A CN110818547B (en) | 2019-12-04 | 2019-12-04 | A method for extracting curcumin and gingerol from rhizoma Zingiberis recens |
Publications (2)
Publication Number | Publication Date |
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CN110818547A true CN110818547A (en) | 2020-02-21 |
CN110818547B CN110818547B (en) | 2022-05-27 |
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CN201911228350.2A Active CN110818547B (en) | 2019-12-04 | 2019-12-04 | A method for extracting curcumin and gingerol from rhizoma Zingiberis recens |
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CN (1) | CN110818547B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112806549A (en) * | 2020-12-30 | 2021-05-18 | 西安银能生物科技股份有限公司 | Ginger full-recycling treatment method |
CN115626870A (en) * | 2022-10-27 | 2023-01-20 | 湖南朗林生物资源股份有限公司 | Preparation method of gingerol |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080160116A1 (en) * | 2006-12-07 | 2008-07-03 | Herbalscience Singapore Pte. Ltd | Compositions and Methods Comprising Zingiber Species |
CN101381430A (en) * | 2008-10-09 | 2009-03-11 | 浙江工业大学 | Molecule brand polymer of curcumin, preparation method and application thereof |
CN103012095A (en) * | 2012-12-06 | 2013-04-03 | 山东农业大学 | Method for combined extraction of variety of functional components of ginger |
CN104277177A (en) * | 2014-10-28 | 2015-01-14 | 山东省分析测试中心 | Gingerol pseudo-template molecularly imprinted polymer and method for extracting gingerol from fresh gingers by using same |
-
2019
- 2019-12-04 CN CN201911228350.2A patent/CN110818547B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080160116A1 (en) * | 2006-12-07 | 2008-07-03 | Herbalscience Singapore Pte. Ltd | Compositions and Methods Comprising Zingiber Species |
CN101381430A (en) * | 2008-10-09 | 2009-03-11 | 浙江工业大学 | Molecule brand polymer of curcumin, preparation method and application thereof |
CN103012095A (en) * | 2012-12-06 | 2013-04-03 | 山东农业大学 | Method for combined extraction of variety of functional components of ginger |
CN104277177A (en) * | 2014-10-28 | 2015-01-14 | 山东省分析测试中心 | Gingerol pseudo-template molecularly imprinted polymer and method for extracting gingerol from fresh gingers by using same |
Non-Patent Citations (2)
Title |
---|
刘克建等: "分子印迹技术在天然活性成分分离纯化中的研究进展", 《食品工业科技》 * |
高晓东等: "多种生姜有效成分联合提取工艺", 《食品与发酵工业》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112806549A (en) * | 2020-12-30 | 2021-05-18 | 西安银能生物科技股份有限公司 | Ginger full-recycling treatment method |
CN115626870A (en) * | 2022-10-27 | 2023-01-20 | 湖南朗林生物资源股份有限公司 | Preparation method of gingerol |
CN115626870B (en) * | 2022-10-27 | 2023-12-19 | 湖南朗林生物资源股份有限公司 | Preparation method of gingerol |
Also Published As
Publication number | Publication date |
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CN110818547B (en) | 2022-05-27 |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method for extracting curcumin and gingerol from ginger Effective date of registration: 20230808 Granted publication date: 20220527 Pledgee: Gongqing Rural Commercial Bank branch of Limited by Share Ltd. Dean Pledgor: JIUJIANG HONGLI FOOD CO.,LTD. Registration number: Y2023980051408 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20220527 Pledgee: Gongqing Rural Commercial Bank branch of Limited by Share Ltd. Dean Pledgor: JIUJIANG HONGLI FOOD CO.,LTD. Registration number: Y2023980051408 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method for extracting curcumin and gingerol from ginger Granted publication date: 20220527 Pledgee: Gongqing Rural Commercial Bank branch of Limited by Share Ltd. Dean Pledgor: JIUJIANG HONGLI FOOD CO.,LTD. Registration number: Y2024980032592 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |