CN110813167B - Micro-fluid mixer based on passive one-way valve structure and control method thereof - Google Patents
Micro-fluid mixer based on passive one-way valve structure and control method thereof Download PDFInfo
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- CN110813167B CN110813167B CN201911179386.6A CN201911179386A CN110813167B CN 110813167 B CN110813167 B CN 110813167B CN 201911179386 A CN201911179386 A CN 201911179386A CN 110813167 B CN110813167 B CN 110813167B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/2201—Control or regulation characterised by the type of control technique used
- B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
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Abstract
The invention provides a micro-fluid mixer based on a passive one-way valve structure and a control method thereof, wherein the micro-fluid mixer comprises two sample inlets, two sample inlet channels, one ends of which are respectively communicated with the two sample inlets, the other ends of the two sample inlet channels are mutually communicated and respectively connected with one end of a micro-channel, and the other end of the micro-channel is connected with a sample outlet; two sample inlet channels are respectively provided with a one-way valve, and a micro-channel is internally provided with a mixer one-way valve; the method includes the step of mixing the two samples in a microfluidic mixer. The invention has the beneficial effects that: the invention provides a passive one-way valve, which does not need additional equipment to provide power for the valve, utilizes a one-way micro valve structure to realize mixing of different samples, and the samples wait for opening time in the valve and are mixed in a molecular diffusion mode and a reverse direction; the mixing mode can simultaneously increase the contact area and the contact time between the reagents and has the characteristic of high mixing efficiency.
Description
Technical Field
The invention relates to the technical field of microfluid mixers, in particular to a microfluid mixer based on a passive one-way valve structure and a control method thereof.
Background
In recent years, microfluidic chip technology has been widely used in the fields of biomedical detection, chemical analysis, chemical sensing, molecular separation, nucleic acid sequencing and analysis, environmental monitoring, and the like. The micro valve is one of important parts of the micro-fluidic chip and plays an important role in the micro-fluidic chip. Most of the existing micro-valve structures need additional equipment for control, while the passive micro-valve utilizes the properties of certain materials to achieve the opening and closing functions of a channel, but cannot achieve the function of controlling the flow direction of fluid by a one-way valve. At present, a common one-way micro valve has a complex structure and complex requirements on instruments, and is inconvenient to process, assemble and use. The micromixer serves to mix the two reagents, in laminar flow, mixing can only take place by molecular diffusion. One way to increase the mixing between the liquids is to enhance the diffusion effect between the samples. To enhance the diffusion effect between samples, the contact area and contact time of the reagents during mixing can be increased.
At present, the micro mixer manufactured by using the micro valve has the same defects as the micro valve and has a complex structure. Manufacturing is difficult and requires external control equipment.
How to solve the above technical problems is the subject of the present invention.
Disclosure of Invention
The invention aims to provide a micro-fluid mixer based on a passive one-way valve structure and a control method thereof.
The invention is realized by the following measures: a microfluid mixer based on a passive one-way valve structure is characterized by comprising two sample inlets, two sample inlet channels, one ends of which are respectively communicated with the two sample inlets, the other ends of the two sample inlet channels are mutually communicated and are respectively connected with one end of a micro-channel, and the other end of the micro-channel is connected with a sample outlet;
the two sample inlet channels are respectively provided with a one-way valve, and each one-way valve consists of a one-way valve stop block and a one-way valve elastic film;
a mixer check valve is arranged in the micro-channel and consists of a mixer stop block arranged on the inner wall of the micro-channel and a mixer film arranged at the other end of the inner wall of the micro-channel;
the one-way valve elastic membrane and the mixer membrane are made of polydimethylsiloxane.
As a further optimization scheme of the microfluidic mixer based on the passive one-way valve structure, the mixer stop block is arranged on one side of the microchannel, and the width of the mixer stop block is half of the width of the microchannel.
As a further optimization scheme of the microfluidic mixer based on the passive one-way valve structure provided by the invention, the mixer film is arranged on the other side of the microchannel, is arranged opposite to the mixer stopper, is positioned at the downstream of the mixer stopper, and is attached to the mixer stopper, and the width of the mixer film is more than half of the width of the microchannel.
As a further optimization scheme of the microfluidic mixer based on the passive one-way valve structure, provided by the invention, the inlet cross-sectional areas of the two sample inlet channels are half of the inlet cross-sectional area of the microfluidic channel.
The one-way valve elastic membrane and the mixer membrane are made of polydimethylsiloxane; polydimethylsiloxane (PDMS) is a material having elasticity, and is deformed when an external force is applied, and is restored when the external force is removed.
In order to better achieve the above object, the present invention further provides a control method of a microfluidic mixer based on a passive one-way valve structure, comprising the following steps:
s1: two samples respectively enter from a sample inlet, the flow of the samples can apply force F to a check valve stop block and a check valve elastic membrane, when the samples reach F in an inlet flow channel, the check valve elastic membrane deforms in length, the direction is the sample flow direction, the inlet flow channel is opened, and the samples flow into a micro flow channel;
s2: when a sample enters from the sample outlet, the sample flows along the micro-channel, so that the one-way valve elastic membrane and the mixer film deform towards the flow direction, and the micro-channel is completely sealed by the mixer film and the mixer block, so that the sample cannot flow;
s3: two samples enter two different sample inlet channels from a sample inlet at equal speed respectively, because the pressure in the sample inlet channels can not reach the opening condition of the one-way valve at the beginning, when the pressure in the sample inlet channels reaches the opening one-way valve, the two one-way valves in the sample inlet channels are opened at the same time, the samples in the two sample inlet channels flow into the micro-channel, because the samples continuously flow into the two sample inlet channels, the one-way valves can not be closed immediately after being opened, and the samples are closed after lasting for 0.5 period;
s4: the one-way valve of the mixer in the micro flow channel needs 1.5F when opened, the one-way valve of the micro mixer in the micro flow channel cannot be opened immediately when the one-way valves in the two sample inlet channels are opened, the sample waits for the one-way valve of the micro mixer in the micro flow channel to be opened in the micro flow channel, the two samples are quickly mixed in the micro flow channel based on the inertia force of the speed in the waiting opening time, the sample mixing is completed before the one-way valve of the micro mixer in the micro flow channel is opened, when the pressure in the micro flow channel reaches 1.5F, the one-way valve of the mixer in the micro flow channel is opened, the two well-mixed samples flow out from the sample outlet, the elastic membrane of the one-way valve is not closed immediately, and the one-way valve is closed after 0.2T;
s5: with this cycle, the mixed sample flows out in pulses into the next microfluidic mixer functional zone.
The invention has the beneficial effects that: the invention provides a passive one-way valve, which does not need additional equipment to provide power for the valve, utilizes a one-way micro valve structure to realize mixing of different samples, and the samples are mixed in a molecular diffusion mode and in a reverse direction within the waiting opening time of the valve; the mixing mode can simultaneously increase the contact area and the contact time between the reagents and has the characteristic of high mixing efficiency.
Drawings
Fig. 1 is a schematic structural diagram of a check valve and a micro mixer according to an embodiment of the invention.
Fig. 2 is a schematic view of the valve opening state of the check valve according to the embodiment of the invention.
Fig. 3 is a schematic view of a valve closing state of the check valve according to the embodiment of the invention.
Wherein the reference numerals are: 1. a sample inlet; 2. a check valve stop; 3. a one-way valve elastic membrane; 4. a mixer stop; 5. a mixer film; 6. a micro flow channel; 7. a sample outlet;
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. Of course, the specific embodiments described herein are merely illustrative of the invention and are not intended to be limiting.
It should be noted that the embodiments and features of the embodiments of the present invention may be combined with each other without conflict.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings, which are merely for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted", "connected" and "connected" are to be construed broadly, e.g. as being fixed or detachable or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the creation of the present invention can be understood by those of ordinary skill in the art through specific situations.
Example 1
Referring to fig. 1, 2 and 3, the present invention provides a microfluidic mixer based on a passive one-way valve structure, wherein the microfluidic mixer comprises two sample inlets 1, two sample inlet channels, one end of each sample inlet channel is respectively communicated with the two sample inlets 1, the width of each sample inlet channel is 0.1mm, the length of each sample inlet channel is 1.5mm, the other ends of the two sample inlet channels are mutually communicated and respectively connected with one end of a microchannel 6, the width of the microchannel 6 is 0.2mm, the length of the microchannel 6 is 2mm, and the other end of the microchannel 6 is connected with a sample outlet 7;
the two sample inlet channels are respectively provided with a one-way valve, and each one-way valve is composed of a one-way valve stop block 2 and a one-way valve elastic film 3; the check valve stopper 2 is 0.05mm wide and 0.1mm long, and the check valve elastic membrane 3 is 0.08mm wide and 0.003mm long.
A mixer check valve is arranged in the micro-channel 6 and consists of a mixer stop block 4 arranged on the inner wall of the micro-channel 6 and a mixer film 5 arranged at the other end of the inner wall of the micro-channel 6; the mixer stop 4 is 0.1mm wide and 0.2mm long, and the mixer film 5 is 0.16mm wide and 0.006mm long.
The one-way valve elastic membrane 3 and the mixer membrane 5 are made of polydimethylsiloxane; polydimethylsiloxane PDMS, which is an elastic material, deforms when an external force is applied, and recovers when the external force is removed.
Specifically, the mixer block 4 is disposed on one side of the micro flow channel 6, and has a width half that of the micro flow channel 6.
Specifically, the mixer film 5 is disposed on the other side of the microchannel 6, is disposed opposite to the mixer stopper 4, is located downstream of the mixer stopper 4, and is attached to the mixer stopper 4, and the width of the mixer film 5 is more than half of the width of the microchannel 6.
Specifically, the inlet cross-sectional areas of the two sample inlet channels are half the inlet cross-sectional area of the microchannel 6.
In order to better achieve the above object, the present invention further provides a control method of a microfluidic mixer based on a passive one-way valve structure, comprising the following steps:
s1: respectively feeding two samples of absolute ethyl alcohol and phosphate slow-release solution (PBS) from a sample inlet 1 at a pumping speed of 1e-4(0.0001) m/s, wherein the samples stay in an inlet flow channel because a check valve block 2 and a check valve elastic membrane 3 are mutually attached, the pressure of the samples in the flow channel reaches 3.88Pa when the samples stay for about 0.1s, the elastic membrane 3 of the check valve deflects and deforms in length, the direction is the flow direction of the samples, the inlet flow channel is opened, and the samples flow into a micro flow channel 6;
s2: when a sample enters from the sample outlet 7, the sample flows along the micro-channel 6, so that the one-way valve elastic membrane 3 and the mixer thin membrane 5 deform towards the flow direction, and the micro-channel 6 is completely sealed by the mixer thin membrane 5 and the mixer baffle 4, so that the sample cannot flow, because the one-way valve baffle 2 and the mixer baffle 4 are respectively arranged at the downstream of the deformation of the one-way valve elastic membrane 3 and the mixer thin membrane 5 and abut against the deformation displacement of the one-way valve elastic membrane 3 and the mixer thin membrane 5;
s3: respectively feeding two samples of absolute ethyl alcohol and phosphate slow-release solution (PBS) from a sample inlet 1 at a pumping speed of 1e-4(0.0001) m/s, wherein the sample stays in an inlet flow channel because no gap exists between a check valve block 2 and a check valve elastic membrane 3, and when the sample stays for 0.1s approximately, the pressure of the sample in the flow channel reaches 3.88Pa, the check valve elastic membrane 3 deflects and deforms, the inlet flow channel is opened, and the sample flows into a micro flow channel 6; because the sample continuously flows into the two sample inlet channels 2, the one-way valve cannot be closed immediately after being opened, and is closed after lasting for 0.05 s;
s4: when the one-way valve of the mixer in the micro-channel 6 is opened, the 5.81Pa is needed, when the one-way valve of the two samples of the anhydrous ethanol and the phosphate slow-release solution (PBS) are opened, the one-way valve of the micro-mixer in the micro-channel 6 is not immediately opened, the samples wait for the opening of the one-way valve of the micro-mixer in the micro-channel 6, the two samples are quickly mixed in the micro-channel 6 based on the inertia force of the speed in the waiting opening time, and the mixing of the samples is completed before the opening of the one-way valve of the micro-mixer in the micro-channel 6, when the pressure in the micro-channel 6 reaches 5.81Pa, the one-way valve of the mixer in the micro-channel 6 is opened, the two mixed samples flow out from the sample outlet 7, the elastic membrane of the one-way valve is not immediately closed, and is closed after about 0.02 s;
s5: with this cycle, the mixed sample flows out in pulses into the next microfluidic mixer functional zone.
Example 2
On the basis of the embodiment 1, referring to fig. 1 to 3, the invention provides a microfluidic mixer based on a passive one-way valve structure, which comprises two sample inlets 1, two sample inlet channels with one ends respectively communicated with the two sample inlets 1, the other ends of the two sample inlet channels are mutually communicated and respectively connected with one end of a microchannel 6, and the other end of the microchannel 6 is connected with a sample outlet 7;
the width of the two sample inlet channels was 0.1mm and the length was 1.5mm, and the width of the micro channel 6 was 0.2mm and the length was 2 mm.
The two sample inlet channels are respectively provided with a one-way valve, and each one-way valve is composed of a one-way valve stop block 2 and a one-way valve elastic film 3; the check valve is characterized in that the width of a check valve stop 2 is 0.05mm, the length of the check valve stop is 0.1mm, and the width of an elastic membrane 3 of the check valve is 0.08mm, and the length of the elastic membrane is 0.003 mm.
A mixer check valve is arranged in the micro-channel 6 and consists of a mixer stop block 4 arranged on the inner wall of the micro-channel 6 and a mixer film 5 arranged at the other end of the inner wall of the micro-channel 6; the mixer stopper 4 was 0.1mm wide and 0.2mm long, and the mixer film 5 was 0.16mm wide and 0.006mm long.
The one-way valve elastic membrane 3 and the mixer membrane 5 are made of polydimethylsiloxane; polydimethylsiloxane PDMS, which is an elastic material, deforms when an external force is applied, and recovers when the external force is removed.
Specifically, the mixer block 4 is disposed on one side of the micro flow channel 6, and has a width half that of the micro flow channel 6.
Specifically, the mixer thin film 5 is disposed on the other side of the microchannel 6, is disposed opposite to the mixer stopper 4, is located downstream of the mixer stopper 4, and has a gap with the mixer stopper 4, and the width of the mixer thin film 5 is more than half of the width of the microchannel 6.
Specifically, the inlet cross-sectional areas of the two sample inlet channels are half the inlet cross-sectional area of the microchannel 6.
In order to better achieve the above object, the present invention further provides a control method of a microfluidic mixer based on a passive one-way valve structure, comprising the following steps:
s1: respectively feeding two samples of absolute ethyl alcohol and polystyrene microspheres (the diameter is 8.0-8.9 microns and 2.5% w/v) from a sample inlet 1, wherein the pumping speed is 1e-4(0.0001) m/s, the sample can stay in an inlet flow channel because a gap is not formed between a check valve stop block and a check valve elastic membrane, when the sample stays for 0.1s approximately, the pressure of the sample in the flow channel reaches 3.88Pa, the check valve elastic membrane 3 deflects and deforms in length, the inlet flow channel is opened, and the sample flows into a micro flow channel 6;
s2: when a sample enters from the sample outlet 7, the sample flows along the micro-channel 6, so that the one-way valve elastic membrane 3 and the mixer thin membrane 5 deform towards the flow direction, and the micro-channel 6 is completely sealed by the mixer thin membrane 5 and the mixer baffle 4, so that the sample cannot flow, because the one-way valve baffle 2 and the mixer baffle 4 are respectively arranged at the downstream of the deformation of the one-way valve elastic membrane 3 and the mixer thin membrane 5 and abut against the deformation displacement of the one-way valve elastic membrane 3 and the mixer thin membrane 5;
s3: respectively feeding two samples of absolute ethyl alcohol and polystyrene microspheres (the diameter is 8.0-8.9 microns and 2.5% w/v) from a sample inlet 1, wherein the pumping speed is 1e-4(0.0001) m/s, the sample can stay in an inlet flow channel because a gap is not formed between a check valve stop block 2 and a check valve elastic membrane 3, when the sample stays for about 0.1s, the pressure of the sample in the flow channel reaches 3.88Pa, the check valve elastic membrane 3 deflects and deforms, the inlet flow channel is opened, and the sample flows into a micro flow channel 6; because the sample continuously flows into the two sample inlet channels, the one-way valve cannot be closed immediately after being opened, and is closed after lasting for 0.05 s;
s4: when the one-way valve of the mixer in the micro-channel 6 is opened, 5.81Pa is needed, when the one-way valve of the inlet channel of the two samples of anhydrous ethanol and polystyrene microspheres (the diameter is 8.0-8.9 microns and 2.5% w/v) is opened, the one-way valve of the micro-mixer in the micro-channel 6 is not immediately opened, the samples wait for the opening of the one-way valve of the micro-mixer in the micro-channel 6, the two samples are quickly mixed in the micro-channel 6 based on the inertia force of the speed in the waiting opening time, the sample mixing is completed before the opening of the one-way valve of the micro-mixer in the micro-channel 6, when the pressure in the micro-channel 6 reaches 5.81Pa, the one-way valve of the mixer in the micro-channel 6 is opened, the two mixed samples flow out from the sample outlet 7, the elastic membrane of the one-way valve is not immediately closed, and the one-way valve is closed after about 0.02 s;
s5: with this cycle, the mixed sample flows out in pulses into the next microfluidic mixer functional zone.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent replacements, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The microfluid mixer based on the passive one-way valve structure is characterized by comprising two sample inlets (1), two sample inlet channels, one ends of which are respectively communicated with the two sample inlets (1), the other ends of the two sample inlet channels are mutually communicated and respectively connected with one end of a micro-channel (6), and the other end of the micro-channel (6) is connected with a sample outlet (7);
the two sample inlet channels are respectively provided with a one-way valve, and each one-way valve is composed of a one-way valve stop block (2) and a one-way valve elastic film (3); a mixer check valve is arranged in the micro-channel (6), and the mixer check valve consists of a mixer stop block (4) arranged on one side of the inner wall of the micro-channel (6) and a mixer film (5) arranged on the other side of the inner wall of the micro-channel (6);
when the one-way valves in the two sample inlet channels are opened, the one-way valve of the mixer in the micro-channel (6) can not be opened immediately;
the one-way valve elastic membrane (3) and the mixer membrane (5) are made of polydimethylsiloxane.
2. The microfluidic mixer based on passive one-way valve structure according to claim 1, characterized in that the mixer stop (4) is placed on the side of the inner wall of the microchannel (6) and has a width half the width of the microchannel (6).
3. The microfluidic mixer based on the passive one-way valve structure according to claim 2, wherein the mixer membrane (5) is disposed on the other side of the inner wall of the microchannel (6), is disposed opposite to the mixer block (4), is located downstream of the mixer block (4), and is attached to the mixer block (4), and the width of the mixer membrane (5) is more than half of the width of the microchannel (6).
4. The microfluidic mixer based on passive one-way valve structure according to claim 1 or 2, characterized in that the inlet cross-sectional area of the two sample inlet channels is half of the inlet cross-sectional area of the microchannel (6).
5. A method for controlling a microfluidic mixer based on a passive one-way valve structure according to any one of claims 1 to 3, comprising the steps of:
s1: two samples enter from a sample inlet (1) respectively, the flowing of the samples can apply force to a check valve stop block (2) and a check valve elastic membrane (3), when the applied force reaches F, the check valve elastic membrane (3) deforms in length, the direction is the sample flowing direction, an inlet flow channel is opened, and the samples flow into a micro flow channel (6);
s2: when a sample enters from the sample outlet (7), the sample flows along the micro-channel (6), so that the one-way valve elastic membrane (3) and the mixer film (5) deform towards the flow direction, and the micro-channel (6) is completely sealed by the mixer film (5) and the mixer block (4) and the sample cannot flow because the one-way valve block (2) and the mixer block (4) are respectively arranged at the downstream of the deformation of the one-way valve elastic membrane (3) and the mixer film (5) and abut against the deformation displacement of the one-way valve elastic membrane (3) and the mixer film (5);
s3: two samples enter two different sample inlet channels from a sample inlet (1) at equal speed respectively, because the pressure in the sample inlet channels can not reach the opening condition of the one-way valve at the beginning, when the pressure in the sample inlet channels reaches the opening one-way valve, the two one-way valves in the sample inlet channels are opened at the same time, the samples in the two sample inlet channels flow into a micro-channel (6), because the samples continuously flow into the two sample inlet channels, the one-way valve can not be closed immediately after being opened, and the samples are closed after lasting for 0.5 period;
s4: the opening of a one-way valve of a mixer in the micro-channel (6) needs 1.5F, when the one-way valves in inlet channels of two samples are opened, the one-way valve of the mixer in the micro-channel (6) cannot be opened immediately, the samples wait for the opening of the one-way valve of the mixer in the micro-channel (6), and in the waiting time for opening, the two samples are quickly mixed in the micro-channel (6) based on the inertia force of speed, and before the opening of the one-way valve of the mixer in the micro-channel (6), the mixing of the samples is completed, when the pressure in the micro-channel (6) reaches 1.5F, the one-way valve of the mixer in the micro-channel (6) is opened, the two mixed samples flow out from a sample outlet (7), the one-way valve of the mixer is not closed immediately, and the one-way valve of the mixer is closed after 0.2T;
s5: with this cycle, the mixed sample flows out in pulses into the next microfluidic mixer functional zone.
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| CN114370528A (en) * | 2020-10-14 | 2022-04-19 | 中国科学院理化技术研究所 | Passive micro-valve device and method for manufacturing micro-valve swinging piece based on liquid metal |
| CN114160222B (en) * | 2021-12-21 | 2022-11-29 | 南通大学 | Micro-fluidic chip structure and method based on cell electrical characteristics and electromagnetic micro-valve |
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| CN107606252A (en) * | 2017-08-02 | 2018-01-19 | 南京岚煜生物科技有限公司 | Passive check valve for micro-fluidic chip |
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