CN110811628A - Gait image analysis system with synchronous transcranial direct current stimulation function - Google Patents
Gait image analysis system with synchronous transcranial direct current stimulation function Download PDFInfo
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- CN110811628A CN110811628A CN201810918998.1A CN201810918998A CN110811628A CN 110811628 A CN110811628 A CN 110811628A CN 201810918998 A CN201810918998 A CN 201810918998A CN 110811628 A CN110811628 A CN 110811628A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/112—Gait analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
Abstract
The invention discloses a gait image analysis system with synchronous transcranial direct current stimulation function, which comprises: the device comprises a carrying platform, a driving movable arm, a driven movable arm and a horizontal bridge, wherein the driving movable arm and the driven movable arm are respectively arranged on two sides of the carrying platform, and the horizontal bridge is fixed between the upper ends of the driving movable arm and the driven movable arm; a first slide rail is arranged on one side of the carrying platform and is positioned under the driving movable arm, a second slide rail is arranged on the other side of the carrying platform and is positioned under the driven movable arm, and the first slide rail and the second slide rail are arranged in parallel; the front end and the rear end of one side of the loading platform with the driving movable arm are respectively fixed with a main belt wheel and a belt wheel pair, a transmission belt is arranged between the main belt wheel and the belt wheel pair, the first air-bearing sliding block is fixed on the transmission belt, and the main belt wheel is connected to a driving motor. The invention ensures the stability and reliability of the test result on the basis of effectively ensuring the test precision and accuracy, and the driving motor drives the active movable arm to move, so that the active movable arm moves more quickly and flexibly.
Description
Technical Field
The invention belongs to the technical field of biomedical engineering, and particularly relates to a gait image analysis system with a synchronous transcranial direct current stimulation function.
Background
Diseases such as nerve trauma (brain trauma or spinal injury), pain (inflammation, arthritis), neurodegenerative diseases (parkinson's disease, muscular atrophy) and muscle or nerve diseases (muscular dystrophy, motor dysfunction) are common diseases of the nervous system, and the motor, sensory and autonomic functions of animals are often damaged. Wherein, the motor function damage is the clear index of the above diseases, and the rehabilitation of the motor function is firstly shown when the medicine or the corresponding treatment means is effective. Therefore, the evaluation of the damaged motor function and the rehabilitation is an important index for effectively evaluating the curative effect and the rehabilitation of scientific research personnel in animal experiments, has important significance for research and development of medicines, is particularly important for objectively and accurately judging the motor capacity of a tested animal (such as a rat animal with damaged vertebrates), and is a generally accepted mainstream and objective evaluation index for gait analysis of experimental animals.
At present, rodent experimental animals are mainly detected by gait behaviors of rats and mice, the gait conditions of the animals in unit time are recorded by integrating a BBB scoring method, an animal rotation method and an ink blotting method through human visual inspection, and then offline analysis is carried out. These methods and techniques present several problems:
(1) the judgment standard is different from person to person, and the error of a test system is easily caused;
(2) the recording process has excessive participation of experimenters and excessive physical labor, and automatic observation and recording are not realized;
(3) in basic medical research, there has been no way to achieve simultaneous monitoring of central nervous system changes and animal gait.
Therefore, how to overcome the above technical problems has been the direction of efforts of those skilled in the art.
Disclosure of Invention
The invention provides a gait image analysis system with synchronous transcranial direct current stimulation function, which can record the holographic animal physiological data of gait and brain change, comprehensively analyze and evaluate the comprehensive curative effect of stimulation and drug treatment when giving relative transcranial electrical stimulation to brain areas, thus the comprehensive analysis system has important significance for basic medical research and drug research and development and has extremely wide application value.
In order to achieve the purpose, the invention adopts the technical scheme that: a gait image analysis system with synchronous transcranial direct current stimulation function, comprising: the walking box body is divided into an upper cavity area and a lower cavity area by the electric stimulation electrode connected with the recorder connected with the central control processor through a lead, and the cold light source camera is positioned in the lower cavity area and arranged on a bottom plate of the walking box body;
the cold light source camera is used for acquiring gait image information of the tested animal through multiple angles;
the recorder is used for storing the gait image information from the cold light source camera and transmitting the gait image information to the central control processor;
the central control processor is used for controlling the intensity and frequency of the electric stimulation and receiving gait image information from the recorder;
the electrical stimulation electrode further comprises a shell body, a sleeve, a sealing end cover and a circuit adapter, wherein one end of the shell body is a conical end, the other end of the shell body is a cylindrical end, the conical end is provided with a hole, the sleeve is embedded into the hole and is in threaded sealing connection with the inner wall of the conical end, one end of a cotton core rod is embedded into the sleeve, the other end of the cotton core rod is exposed out of the sleeve, the cylindrical end of the shell body is in threaded sealing connection with the sealing end cover, so that a cavity for containing physiological saline is formed, the circuit adapter is embedded into a central through hole of the sealing end cover, a through hole for supplementing the physiological saline is formed in an area between the sealing end cover and the circuit adapter, a rubber sealing head is embedded,
be located have a lateral wall in the cavity and open the stand pipe that has a plurality of small openings, this stand pipe front end and sheathed tube rear end fixed connection, the stand pipe rear end contacts with the front end of circuit adapter, and a spring is located the stand pipe and is located between sleeve pipe and the circuit adapter.
The further improved technical scheme in the technical scheme is as follows:
1. in the scheme, the device also comprises a wireless transmitting module and a signal collecting electrode arranged in the animal to be detected, wherein the signal collecting electrode is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; and the wireless transmitting module connected to the signal collecting electrode is used for transmitting the received holographic physiological signal to the central control processor in a wireless mode.
2. In the scheme, the device also comprises a light source positioned in the lower cavity area and used for irradiating the surface of the transparent running board.
3. In the above scheme, the transparent running plate is a transparent glass plate or a transparent plastic plate.
4. In the above scheme, a sealing ring is arranged between the cylindrical end of the shell body and the sealing end cover.
5. In the above scheme, the cold light source camera is a 120-frame high-speed low-illumination giga cold light source camera.
6. In the above scheme, the length of shell body is 25~30 mm.
7. In the scheme, the length of the cotton core rod exposed out of the sleeve is 1.2-1.5 mm.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
1. the gait image analysis system with the synchronous transcranial direct current stimulation function can acquire the gait image information, simultaneously can give related transcranial electrical stimulation to a brain area, record the gait and the holographic animal physiological data changed by the brain, perform comprehensive analysis and evaluate the comprehensive curative effect of stimulation and drug treatment, so that the comprehensive analysis system has important significance for basic medical research and drug research and development and has extremely wide application value; the system also comprises a wireless transmitting module and a signal collecting electrode arranged in the animal to be detected, wherein the signal collecting electrode is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; the wireless transmitting module connected to the signal collecting electrode is used for transmitting the received holographic physiological signals to the central control processor in a wireless mode, so that the animal can freely move without constraint, and the detection is more accurate.
2. The gait image analysis system with the synchronous transcranial direct current stimulation function has the advantages that the electric stimulation electrode has good conductivity, the conductivity change caused by the oxidation of the metal electrode is avoided, the stability of direct current in the long-term stimulation process is further ensured, the interference of weak current change or current noise on experimental research can be effectively eliminated, and the accuracy of direct current research is improved; in addition, a through hole for supplementing the normal saline is formed in the area between the sealing end cover and the circuit adapter, and a rubber sealing head is embedded into the through hole, so that the normal saline is conveniently added into the cavity, the stability of the content of the normal saline is favorably kept, the parameters of electrical stimulation are more stable, and the repeatability of detection data is good; in addition, it is located it has the stand pipe that a lateral wall opened has a plurality of small openings in the cavity, and this stand pipe front end and sheathed tube rear end fixed connection, the contact of stand pipe rear end and the front end of circuit adapter, a spring are located the stand pipe and are located between sleeve pipe and the circuit adapter, and existing being favorable to guaranteeing cotton plug after used repeatedly many times, can not squint, also are favorable to keeping cotton plug and wait to detect the stability of animal pressure.
Drawings
FIG. 1 is a schematic view of a partial structure of a gait image analysis system according to the invention;
FIG. 2 is a partial electrical block diagram of a gait image analysis system of the invention;
fig. 3 is a schematic diagram of an electrical stimulation electrode structure in the gait image analysis system of the invention.
In the above drawings: 1. a traveling box body; 2. an electrical stimulation electrode; 3. a central control processor; 4. a recorder; 5. a cold light source camera; 6. a transparent running board; 7. a housing body; 71. a tapered end; 72. a cylindrical end; 73. a hole; 8. a sleeve; 9. sealing the end cap; 91. a central through hole; 10. a circuit adapter; 11. cotton core rods; 12. a cavity; 13. a through hole; 14. a rubber sealing head; 15. a guide tube; 151. a leak hole; 16. a spring; 17. a wireless transmitting module; 18. collecting a signal electrode; 191. an upper cavity area; 192. a lower cavity region; 20. a light source; 21. a seal ring; 22. and (4) conducting wires.
Detailed Description
The invention is further described with reference to the following figures and examples:
example 1: a gait image analysis system with synchronous transcranial direct current stimulation function, comprising: the walking box comprises a walking box body 1, an electrical stimulation electrode 2 used for performing cranial direct current stimulation on an animal to be detected, a central control processor 3, a recorder 4 and a cold light source camera 5, wherein the electrical stimulation electrode 2 is connected to the recorder 4 connected with the central control processor 3 through a lead 22, a transparent running plate 6 is installed in the middle of the walking box body 1 so as to divide the walking box body 1 into an upper cavity area 191 and a lower cavity area 192, and the cold light source camera 5 is located in the lower cavity area and installed on a bottom plate of the walking box body 1;
the cold light source camera 5 is used for acquiring gait image information of the tested animal through multiple angles;
the recorder 4 is used for storing the gait image information from the cold light source camera 5 and transmitting the gait image information to the central control processor 3;
the central control processor 3 is used for controlling the strength and frequency of the electric stimulation and receiving the gait image information from the recorder 4;
the electrical stimulation electrode 2 further comprises a shell body 7, a sleeve 8, a sealing end cover 9 and a circuit adapter 10, wherein one end of the shell body 7 is a conical end 71, the other end of the shell body is a cylindrical end 72, the conical end 71 is provided with a hole 73, the sleeve 8 is embedded into the hole 73 and is in threaded sealing connection with the inner wall of the conical end 71, one end of a cotton core rod 11 is embedded into the sleeve 8, the other end of the cotton core rod is exposed out of the sleeve 8, the cylindrical end 72 of the shell body 7 is in threaded sealing connection with the sealing end cover 9, so that a cavity 12 for containing physiological saline is formed, the circuit adapter 10 is embedded into a central through hole 91 of the sealing end cover 9, a through hole 13 for supplementing the physiological saline is formed in an area between the sealing end cover 9 and the circuit adapter 10, and a rubber sealing head 14 is embedded,
the circuit adapter is characterized in that a guide pipe 15 with a plurality of leak holes 151 formed in the side wall is arranged in the cavity 12, the front end of the guide pipe 15 is fixedly connected with the rear end of the sleeve 8, the rear end of the guide pipe 15 is in contact with the front end of the circuit adapter 10, and a spring 16 is arranged in the guide pipe 15 and between the sleeve 8 and the circuit adapter 10.
The device also comprises a wireless transmitting module 17 and a signal collecting electrode 18 arranged in the animal to be detected, wherein the signal collecting electrode 18 is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; the wireless transmitting module 17 connected to the signal collecting electrode 18 is used for transmitting the received holographic physiological signal to the central control processor 3 in a wireless mode.
The transparent running plate 6 is a transparent glass plate,
a sealing ring 21 is provided between the cylindrical end 72 of the housing body 7 and the end cap 9.
The cold light source camera 5 is a 120-frame high-speed low-illumination giga cold light source camera.
The length of the shell body 7 is 26mm, and the length of the cotton plug 11 exposed out of the sleeve 8 is 1.3 mm.
Example 2: a gait image analysis system with synchronous transcranial direct current stimulation function, comprising: the walking box comprises a walking box body 1, an electrical stimulation electrode 2 used for performing cranial direct current stimulation on an animal to be detected, a central control processor 3, a recorder 4 and a cold light source camera 5, wherein the electrical stimulation electrode 2 is connected to the recorder 4 connected with the central control processor 3 through a lead 22, a transparent running plate 6 is installed in the middle of the walking box body 1 so as to divide the walking box body 1 into an upper cavity area 191 and a lower cavity area 192, and the cold light source camera 5 is located in the lower cavity area and installed on a bottom plate of the walking box body 1;
the cold light source camera 5 is used for acquiring gait image information of the tested animal through multiple angles;
the recorder 4 is used for storing the gait image information from the cold light source camera 5 and transmitting the gait image information to the central control processor 3;
the central control processor 3 is used for controlling the strength and frequency of the electric stimulation and receiving the gait image information from the recorder 4;
the electrical stimulation electrode 2 further comprises a shell body 7, a sleeve 8, a sealing end cover 9 and a circuit adapter 10, wherein one end of the shell body 7 is a conical end 71, the other end of the shell body is a cylindrical end 72, the conical end 71 is provided with a hole 73, the sleeve 8 is embedded into the hole 73 and is in threaded sealing connection with the inner wall of the conical end 71, one end of a cotton core rod 11 is embedded into the sleeve 8, the other end of the cotton core rod is exposed out of the sleeve 8, the cylindrical end 72 of the shell body 7 is in threaded sealing connection with the sealing end cover 9, so that a cavity 12 for containing physiological saline is formed, the circuit adapter 10 is embedded into a central through hole 91 of the sealing end cover 9, a through hole 13 for supplementing the physiological saline is formed in an area between the sealing end cover 9 and the circuit adapter 10, and a rubber sealing head 14 is embedded,
the circuit adapter is characterized in that a guide pipe 15 with a plurality of leak holes 151 formed in the side wall is arranged in the cavity 12, the front end of the guide pipe 15 is fixedly connected with the rear end of the sleeve 8, the rear end of the guide pipe 15 is in contact with the front end of the circuit adapter 10, and a spring 16 is arranged in the guide pipe 15 and between the sleeve 8 and the circuit adapter 10.
The device also comprises a wireless transmitting module 17 and a signal collecting electrode 18 arranged in the animal to be detected, wherein the signal collecting electrode 18 is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; the wireless transmitting module 17 connected to the signal collecting electrode 18 is used for transmitting the received holographic physiological signal to the central control processor 3 in a wireless mode.
A light source 20 is also included in the lower cavity area 192 for illuminating the surface of the transparent running plate 6.
The transparent running plate 6 is a transparent plastic plate,
a sealing ring 21 is provided between the cylindrical end 72 of the housing body 7 and the end cap 9.
The length of the shell body 7 is 28mm, and the length of the cotton plug 11 exposed out of the sleeve 8 is 1.4 mm.
The gait image analysis system of the embodiment realizes the synchronous recording of animal gait, brain electroencephalogram activity and brain region activation, analyzes the characteristics of gait image data and brain electrophysiological data, and classifies animal behavior and brain electrophysiological characteristics based on the existing animal behavior and brain electrophysiological and image database; the wired or wireless brain analysis and brain control and gait image recognition analysis method and system for biomedical drug effect evaluation are provided, and the requirements of an experimental device on wired or wireless acquisition and analysis of animal brain signals, brain area control intervention and gait behavior synchronous detection are met through technical improvement and function optimization.
When the gait image analysis system is adopted, the gait image information is collected, and simultaneously, the gait image information can be given to related transcranial electrical stimulation in a brain area, the holographic animal physiological data of gait and brain changes is recorded, the comprehensive analysis is carried out, and the comprehensive curative effect of stimulation and drug treatment is evaluated, so that the comprehensive analysis system has important significance for basic medical research and drug research and development, and has extremely wide application value; the system also comprises a wireless transmitting module and a signal collecting electrode arranged in the animal to be detected, wherein the signal collecting electrode is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; the wireless transmitting module connected to the signal collecting electrode is used for transmitting the received holographic physiological signals to the central control processor in a wireless mode, so that free and unrestrained movement of animals is realized, and the detection is more accurate; the animal can move freely without binding, so that the detection is more accurate; in addition, the physiological saline is conveniently added into the cavity, so that the stability of the content of the physiological saline is favorably kept, the parameters of electrical stimulation are more stable, and the repeatability of detection data is good; in addition, it is located it has the stand pipe that a lateral wall opened has a plurality of small openings in the cavity, and this stand pipe front end and sheathed tube rear end fixed connection, the contact of stand pipe rear end and the front end of circuit adapter, a spring are located the stand pipe and are located between sleeve pipe and the circuit adapter, and existing being favorable to guaranteeing cotton plug after used repeatedly many times, can not squint, also are favorable to keeping cotton plug and wait to detect the stability of animal pressure.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All equivalent changes and modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (8)
1. A gait image analysis system with synchronous transcranial direct current stimulation function is characterized in that: the method comprises the following steps: the device comprises a walking box body (1), an electrical stimulation electrode (2) used for performing cranial direct current stimulation on an animal to be detected, a central control processor (3), a recorder (4) and a cold light source camera (5), wherein the electrical stimulation electrode (2) is connected to the recorder (4) connected with the central control processor (3) through a lead (22), a transparent running plate (6) is installed in the middle of the walking box body (1), so that the walking box body (1) is divided into an upper cavity area (191) and a lower cavity area (192), and the cold light source camera (5) is located in the lower cavity area and is installed on a bottom plate of the walking box body (1);
the cold light source camera (5) is used for acquiring gait image information of the tested animal through multiple angles;
the recorder (4) is used for storing the gait image information from the cold light source camera (5) and transmitting the gait image information to the central control processor (3);
the central control processor (3) is used for controlling the strength and frequency of the electric stimulation and receiving gait image information from the recorder (4);
the electrical stimulation electrode (2) further comprises a shell body (7), a sleeve (8), a sealing end cover (9) and a circuit adapter (10), one end of the shell body (7) is a conical end (71), the other end of the shell body is a cylindrical end (72), the conical end (71) is provided with a hole (73), the sleeve (8) is embedded into the hole (73) and is in threaded sealing connection with the inner wall of the conical end (71), one end of a cotton core rod (11) is embedded into the sleeve (8) and the other end of the cotton core rod is exposed out of the sleeve (8), the cylindrical end (72) of the shell body (7) is in threaded sealing connection with the sealing end cover (9) so as to form a cavity (12) for containing physiological saline, the circuit adapter (10) is embedded into a central through hole (91) of the sealing end cover (9), a through hole (13) for supplementing the physiological saline is formed in an area between the sealing end cover (9) and the circuit adapter (10, a rubber sealing head (14) is embedded in the through hole (13),
be located guide tube (15) that have a lateral wall to open and have a plurality of small openings (151) in cavity (12), the rear end fixed connection of this guide tube (15) front end and sleeve pipe (8), the front end contact of guide tube (15) rear end and circuit adapter (10), a spring (16) are located guide tube (15) and are located between sleeve pipe (8) and circuit adapter (10).
2. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1, characterized in that: the device also comprises a wireless transmitting module (17) and a signal collecting electrode (18) arranged in the animal to be detected, wherein the signal collecting electrode (18) is used for monitoring the holographic physiological signal of the central nervous system of the animal to be detected; and the wireless transmitting module (17) connected to the signal collecting electrode (18) is used for transmitting the received holographic physiological signal to the central control processor (3) in a wireless mode.
3. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: also included is a light source (20) located in the lower cavity region (192) for illuminating the surface of the transparent running plate (6).
4. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: the transparent running plate (6) is a transparent glass plate or a transparent plastic plate.
5. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: a sealing ring (21) is arranged between the cylindrical end (72) of the shell body (7) and the sealing end cover (9).
6. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: the cold light source camera (5) is a 120-frame high-speed low-illumination gigabit cold light source camera.
7. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: the length of the shell body (7) is 25-30 mm.
8. A gait image analysis system with synchronous transcranial direct current stimulation according to claim 1 or 2, characterized in that: the length of the cotton core rod (11) exposed out of the sleeve (8) is 1.2-1.5 mm.
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| CN114272523A (en) * | 2021-12-27 | 2022-04-05 | 燕山大学 | Portable animal transcranial ultrasonic stimulation and brain and muscle electric wireless acquisition system |
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