CN110803390A - Rubber plug for in-vitro diagnostic reagent bottle and preparation method thereof - Google Patents
Rubber plug for in-vitro diagnostic reagent bottle and preparation method thereof Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
- B65D39/04—Cup-shaped plugs or like hollow flanged members
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/16—Halogen-containing compounds
- C08K2003/166—Magnesium halide, e.g. magnesium chloride
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C08K2003/265—Calcium, strontium or barium carbonate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/28—Nitrogen-containing compounds
- C08K2003/282—Binary compounds of nitrogen with aluminium
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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Abstract
The invention discloses a rubber plug for an in-vitro diagnostic reagent bottle and a method, the rubber plug comprises a plug cover and a plug neck extending out of the plug cover, the plug neck is uniformly provided with grooves along the circumferential direction, ribs are formed among the grooves, the ribs are formed by first rubber, and the other parts of the rubber plug except the ribs are formed by second rubber. The preparation method of the rubber plug provided by the invention comprises the steps of mixing, calendering, vulcanization bonding, trimming and sterilizing. The rubber plug for the in-vitro diagnostic reagent bottle provided by the invention has the advantage that the rubber plug part consisting of the secondary rubber can bear a certain low temperature. The rib of the stopper part is formed by the first rubber, so that the structural compactness of the part can be enhanced, the aging and the volatile matters can be reduced, and the sealing performance of the stopper part on the bottle mouth for the in-vitro diagnostic reagent contacted with the stopper part can be enhanced.
Description
Technical Field
The invention relates to the technical field of medical appliance articles, in particular to a rubber plug for an in-vitro diagnostic reagent bottle and a preparation method thereof.
Background
As a rubber stopper for a container for an in vitro diagnostic reagent bottle, a container having a circular stopper cap and a hollow stopper neck is widely used. In order to prevent the rubber plug from increasing the weather resistance, particularly the low-temperature resistance, in the production preparation and existing processes, the invention solves the problem of improving the low-temperature resistance by designing a second rubber formula. The low temperature resistance of the plug is improved, the sealing performance of the plug strength is required, and the plug neck needs to be further modified. According to the invention, by improving the shape of the plugging strength part and the rubber formula of the plugging strength part, the plugging strength part with a rib structure is formed by secondary vulcanization bonding in the production and preparation process, so that the sealing performance of the plugging strength part is improved.
Disclosure of Invention
The invention aims to provide a rubber plug for an in-vitro diagnostic reagent bottle, which has low-temperature resistance and has a plug strength for enhancing the sealing performance.
The technical scheme provided by the invention is as follows:
the utility model provides an external diagnostic reagent rubber buffer for bottle, its characterized in that, include the gag and by the gag neck that the gag extends, the groove is evenly seted up along its circumference to the gag neck, form the rib between the groove, the rib comprises first rubber, the rubber buffer removes the other parts of rib comprise second rubber.
A method for preparing rubber plug for in vitro diagnostic reagent bottle, the rubber plug prepared through the process of mixing, calendering, vulcanization bonding, trimming and sterilizing; in the kneading step, the first rubber material to be the rib portion is kneaded, rolled and vulcanized to be the rib; and mixing the second rubber raw material which becomes the other part of the rubber plug, calendering and vulcanizing and bonding the rib parts to form a rubber plug structure, and then preparing the rubber plug through the processes of trimming and sterilizing.
The technical scheme provided by the invention at least comprises the following beneficial effects:
the rubber plug for the in-vitro diagnostic reagent bottle provided by the invention has the advantage that the rubber plug part consisting of the secondary rubber can bear a certain low temperature. The rib of the stopper part is formed by the first rubber, so that the structural compactness of the part can be enhanced, the aging and the volatile matters can be reduced, and the sealing performance of the stopper part on the bottle mouth for the in-vitro diagnostic reagent contacted with the stopper part can be enhanced.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
FIG. 1 is a sectional view of a rubber stopper for an in vitro diagnostic reagent bottle according to the present invention;
1 stopper cap, 2 stopper strength, 20 ribs.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The invention provides a rubber plug for an in-vitro diagnostic reagent bottle, which comprises a plug cap 1 and a plug neck 2 extending from the plug cap 1, wherein grooves are uniformly formed in the plug neck 1 along the circumferential direction of the plug neck, ribs 20 are formed among the grooves, the ribs 20 are made of chlorinated butyl rubber, and the other parts of the rubber plug except the ribs 20 are made of second rubber as shown in figure 1.
The rubber plug part made of the second rubber can endure certain low temperature. The rib of the plug part is formed by the chlorobutyl rubber, so that the structural compactness of the part can be enhanced, the migrated substances and volatile matters are reduced, and meanwhile, the sealing performance of the plug part on the bottle mouth for the in-vitro diagnostic reagent contacted with the plug part is enhanced.
Specifically, the second rubber comprises 18-26 parts by weight of silicone rubber, 2-6 parts by weight of nitrile rubber, 19-25 parts by weight of polyurethane rubber, 15-18 parts by weight of ethylene propylene rubber, 4-9 parts by weight of stearic acid, 0.5-3 parts by weight of polytetrafluoroethylene, 5-8 parts by weight of magnesium chloride, 3-8 parts by weight of epoxy resin, 4-6 parts by weight of aluminum nitrate, 1-7 parts by weight of hexaaminocaproic acid, 5-15 parts by weight of calcium carbonate, 1-5 parts by weight of zinc stearate, 2-5 parts by weight of maleic anhydride, 5-10 parts by weight of muscovite powder and 1-3 parts by weight of cobalt boracylate. Wherein, the polymer of the silicon rubber is selected from one or more of polydimethylsiloxane, polydiethylsiloxane, polymethylpropylsiloxane, polymethyl (gamma-fluoropropylsiloxane), poly-toluylene siloxane and poly-diphenyl siloxane. In the second rubber, the mass ratio of the silicone rubber, the nitrile rubber, the polyurethane rubber and the ethylene propylene rubber is preferably 5:1:6: 4.
The chlorinated butyl rubber comprises 95-105 parts by weight of chlorinated butyl rubber CIIR1240, 75-85 parts by weight of calcined kaolin, 3-6 parts by weight of zinc oxide, 4.6-5.2 parts by weight of white carbon black, 6-8 parts by weight of talcum powder, 0.8-1.3 parts by weight of PE wax, 0.27-0.34 part by weight of carbon black, 1.7-2.2 parts by weight of titanium dioxide and 0.8-1.6 parts by weight of p-tert-butylphenol disulfide.
The invention also provides a preparation method of the rubber plug for the in vitro diagnostic reagent bottle, which is characterized in that the rubber plug is prepared through the working procedures of mixing, rolling, vulcanization bonding, trimming and disinfection; in the mixing step, the chlorobutyl rubber raw material to be the rib part is mixed, rolled and vulcanized to be the rib; and mixing the second rubber raw material which becomes the other part of the rubber plug, calendering and vulcanizing and bonding the rib parts to form a rubber plug structure, and then preparing the rubber plug through the processes of trimming and sterilizing.
Examples of different ratios of the second rubber are listed below.
Example 1
The second rubber comprises 26 parts by weight of silicon rubber, 3 parts by weight of nitrile rubber, 20 parts by weight of polyurethane rubber, 15 parts by weight of ethylene propylene rubber, 8 parts by weight of stearic acid, 0.5 part by weight of polytetrafluoroethylene, 8 parts by weight of magnesium chloride, 3 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 1 part by weight of hexaaminocaproic acid, 8 parts by weight of calcium carbonate, 1 part by weight of zinc stearate, 5 parts by weight of maleic anhydride, 5 parts by weight of muscovite powder and 1 part by weight of cobalt boracylate.
Example 2
The second rubber comprises 18 parts by weight of silicon rubber, 2 parts by weight of nitrile rubber, 25 parts by weight of polyurethane rubber, 18 parts by weight of ethylene propylene rubber, 4 parts by weight of stearic acid, 3 parts by weight of polytetrafluoroethylene, 8 parts by weight of magnesium chloride, 3 parts by weight of epoxy resin, 4 parts by weight of aluminum nitrate, 7 parts by weight of hexaaminocaproic acid, 15 parts by weight of calcium carbonate, 5 parts by weight of zinc stearate, 2 parts by weight of maleic anhydride, 7 parts by weight of muscovite powder and 2 parts by weight of cobalt boracylate.
Example 3
The second rubber comprises 20 parts by weight of silicon rubber, 4 parts by weight of nitrile rubber, 24 parts by weight of polyurethane rubber, 16 parts by weight of ethylene propylene rubber, 5 parts by weight of stearic acid, 2 parts by weight of polytetrafluoroethylene, 5 parts by weight of magnesium chloride, 6 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 6 parts by weight of hexaaminocaproic acid, 10 parts by weight of calcium carbonate, 4 parts by weight of zinc stearate, 5 parts by weight of maleic anhydride, 10 parts by weight of muscovite powder and 2 parts by weight of cobalt boracylate.
Example 4
The second rubber comprises 23 parts by weight of silicon rubber, 5 parts by weight of nitrile rubber, 22 parts by weight of polyurethane rubber, 17 parts by weight of ethylene propylene rubber, 7 parts by weight of stearic acid, 1 part by weight of polytetrafluoroethylene, 6 parts by weight of magnesium chloride, 6 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 4 parts by weight of hexaaminocaproic acid, 12 parts by weight of calcium carbonate, 3 parts by weight of zinc stearate, 3 parts by weight of maleic anhydride, 6 parts by weight of muscovite powder and 3 parts by weight of cobalt boracylate.
Example 5
The second rubber comprises 24 parts by weight of silicon rubber, 6 parts by weight of nitrile rubber, 19 parts by weight of polyurethane rubber, 18 parts by weight of ethylene propylene rubber, 9 parts by weight of stearic acid, 0.5 part by weight of polytetrafluoroethylene, 7 parts by weight of magnesium chloride, 6 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 3 parts by weight of hexaaminocaproic acid, 5 parts by weight of calcium carbonate, 2 parts by weight of zinc stearate, 4 parts by weight of maleic anhydride, 9 parts by weight of muscovite powder and 1 part by weight of cobalt boracylate.
Comparative example 1
The second rubber comprises 27 parts by weight of silicon rubber, 7 parts by weight of nitrile rubber, 26 parts by weight of polyurethane rubber, 19 parts by weight of ethylene propylene rubber, 9 parts by weight of stearic acid, 0.5 part by weight of polytetrafluoroethylene, 7 parts by weight of magnesium chloride, 6 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 3 parts by weight of hexaaminocaproic acid, 5 parts by weight of calcium carbonate, 2 parts by weight of zinc stearate, 4 parts by weight of maleic anhydride, 9 parts by weight of muscovite powder and 1 part by weight of cobalt boracylate.
Comparative example 2
The second rubber comprises 17 parts by weight of silicon rubber, 1 part by weight of nitrile rubber, 18 parts by weight of polyurethane rubber, 14 parts by weight of ethylene propylene rubber, 9 parts by weight of stearic acid, 0.5 part by weight of polytetrafluoroethylene, 7 parts by weight of magnesium chloride, 6 parts by weight of epoxy resin, 5 parts by weight of aluminum nitrate, 3 parts by weight of hexaaminocaproic acid, 5 parts by weight of calcium carbonate, 2 parts by weight of zinc stearate, 4 parts by weight of maleic anhydride, 9 parts by weight of muscovite powder and 1 part by weight of cobalt boracylate.
Different second rubbers were compounded at different ratios to produce a comparison of the properties of the second rubbers, the results are shown in Table 1.
TABLE 1 comparison of Secondary rubber Properties
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 | Comparative example 2 | |
| Glass transition temperature of | -94℃ | -102℃ | -122℃ | -106℃ | -91℃ | -62℃ | -47℃ |
| Brittleness temperature C | -56℃ | -65℃ | -63℃ | -61℃ | -55℃ | -34℃ | -36℃ |
| Solvent resistance | Superior food | Superior food | Superior food | Superior food | Superior food | Difference (D) | Difference (D) |
| Bending strength MPa | 191 | 185 | 202 | 186 | 183 | 120 | 132 |
| Aging resistance of 3000h | Superior food | Superior food | Superior food | Superior food | Superior food | Difference (D) | Difference (D) |
| Clarity and color | Conform to | Conform to | Conform to | Conform to | Conform to | Conform to | Is not in compliance with |
| Change in pH value | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.2 | 1.5 |
| Absorbance of ultraviolet | ≤0.2 | ≤0.2 | ≤0.2 | ≤0.2 | ≤0.2 | ≤0.5 | ≤0.3 |
| Easily oxidized substance | ≤3.0ml | ≤3.0ml | ≤3.0ml | ≤3.0ml | ≤3.0ml | ≤3.0ml | ≤3.0ml |
| Ammonium ion | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm | ≤4ppm | ≤5ppm |
| Zinc ion | ≤5ug/mL | ≤5ug/mL | ≤5ug/mL | ≤5ug/mL | ≤5ug/mL | ≤8ug/mL | ≤8ug/mL |
| Heavy metals | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm | ≤2ppm |
| Evaporation of residue | ≤2.0mg | ≤2.0mg | ≤2.0mg | ≤2.0mg | ≤2.0mg | ≤2.0mg | ≤2.0mg |
| Volatile sulfur compounds | Conform to | Conform to | Conform to | Conform to | Conform to | Conform to | Is not in compliance with |
| In vitro growthCompatibility of materials | Conform to | Conform to | Conform to | Conform to | Conform to | Is not in compliance with | Conform to |
As can be seen from Table 1, the compound of example 3 has the best low temperature resistance, solvent resistance and aging resistance, the bending is the highest, the clarity meets the relevant regulations, and the indexes of pH change, ultraviolet absorbance, oxidizable substances, ammonium ions, zinc ions, heavy metals, evaporation residues, volatile sulfides, and in vitro biocompatibility meet the relevant regulations. The solvent resistance refers to tolerance, such as organic solvents like methanol, ethanol, acetone, benzene, heptane, ethyl acetate, tetrahydrofuran, formazan dimethylamine, etc., and organic acids, organic bases, inorganic acids and inorganic bases.
Further, examples of different compounding ratios of the rubber of the rib portion are listed below.
Example 6
The first rubber comprises 105 parts by weight of chlorinated butyl rubber CIIR1240, 75 parts by weight of calcined kaolin, 6 parts by weight of zinc oxide, 4.6 parts by weight of white carbon black, 6-8 parts by weight of talcum powder, 0.9 part by weight of PE wax, 0.34 part by weight of carbon black, 1.7 parts by weight of titanium dioxide and 0.8 part by weight of p-tert-butylphenol disulfide.
Example 7
The first rubber comprises 105 parts by weight of chlorinated butyl rubber CIIR1240, 85 parts by weight of calcined kaolin, 4 parts by weight of zinc oxide, 5.0 parts by weight of white carbon black, 7 parts by weight of talcum powder, 1.2 parts by weight of PE wax, 0.32 part by weight of carbon black, 2.0 parts by weight of titanium dioxide and 1.6 parts by weight of p-tert-butylphenol disulfide.
Example 8
The first rubber comprises 100 parts by weight of chlorinated butyl rubber CIIR1240, 80 parts by weight of calcined kaolin, 3 parts by weight of zinc oxide, 5.2 parts by weight of white carbon black, 8 parts by weight of talcum powder, 0.8 part by weight of PE wax, 0.27 part by weight of carbon black, 2.2 parts by weight of titanium dioxide and 1.4 parts by weight of p-tert-butylphenol disulfide.
Example 9
The first rubber comprises 97 parts by weight of chlorinated butyl rubber CIIR1240, 78 parts by weight of calcined kaolin, 5 parts by weight of zinc oxide, 4.8 parts by weight of white carbon black, 6 parts by weight of talcum powder, 1.1 parts by weight of PE wax, 0.31 part by weight of carbon black, 1.8 parts by weight of titanium dioxide and 1.2 parts by weight of p-tert-butylphenol disulfide.
Example 10
The first rubber comprises 95 parts by weight of chlorinated butyl rubber CIIR1240, 82 parts by weight of calcined kaolin, 4 parts by weight of zinc oxide, 4.7 parts by weight of white carbon black, 7 parts by weight of talcum powder, 1.3 parts by weight of PE wax, 0.29 part by weight of carbon black, 1.9 parts by weight of titanium dioxide and 1.0 part by weight of p-tert-butylphenol disulfide.
Comparative example 3
The first rubber comprises 107 parts by weight of chlorinated butyl rubber CIIR1240, 74 parts by weight of calcined kaolin, 7 parts by weight of zinc oxide, 4.5 parts by weight of white carbon black, 5 parts by weight of talcum powder, 1.4 parts by weight of PE wax, 0.26 part by weight of carbon black, 1.6 parts by weight of titanium dioxide and 1.7 parts by weight of p-tert-butylphenol disulfide.
Comparative example 4
The first rubber comprises 94 parts by weight of chlorinated butyl rubber CIIR1240, 86 parts by weight of calcined kaolin, 2 parts by weight of zinc oxide, 5.4 parts by weight of white carbon black, 9 parts by weight of talcum powder, 0.7 part by weight of PE wax, 0.35 part by weight of carbon black, 2.3 parts by weight of titanium dioxide and 0.7 part by weight of p-tert-butylphenol disulfide.
TABLE 2 comparison of rib rubber Properties
As can be seen from Table 2, the compound of example 8 has the best low temperature resistance, solvent resistance and aging resistance, the bending thereof is all the highest, the clarity thereof meets the relevant regulations, and the indexes of pH change, ultraviolet absorbance, oxidizable substances, ammonium ions, zinc ions, heavy metals, evaporation residues, volatile sulfides, and in vitro biocompatibility meet the relevant regulations. The solvent resistance refers to tolerance, such as organic solvents like methanol, ethanol, acetone, benzene, heptane, ethyl acetate, tetrahydrofuran, formazan dimethylamine, etc., and organic acids, organic bases, inorganic acids and inorganic bases. In addition, the elasticity and strength performance of the ribs are also evaluated through hardness, tensile strength and elongation, and examples 6-10 all have excellent elasticity and strength performance and can play a role in strengthening sealing.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (5)
1. The utility model provides an external diagnostic reagent rubber buffer for bottle, its characterized in that, include the gag and by the gag neck that the gag extends, the groove is evenly seted up along its circumference to the gag neck, form the rib between the groove, the rib comprises first rubber, the rubber buffer removes the other parts of rib comprise second rubber.
2. The rubber stopper for in vitro diagnostic reagent bottles according to claim 1, wherein the second rubber comprises 18 to 26 parts by weight of silicone rubber, 2 to 6 parts by weight of nitrile rubber, 19 to 25 parts by weight of polyurethane rubber, 15 to 18 parts by weight of ethylene propylene rubber, 4 to 9 parts by weight of stearic acid, 0.5 to 3 parts by weight of polytetrafluoroethylene, 5 to 8 parts by weight of magnesium chloride, 3 to 8 parts by weight of epoxy resin, 4 to 6 parts by weight of aluminum nitrate, 1 to 7 parts by weight of hexaaminocaproic acid, 5 to 15 parts by weight of calcium carbonate, 1 to 5 parts by weight of zinc stearate, 2 to 5 parts by weight of maleic anhydride, 5 to 10 parts by weight of muscovite powder, and 1 to 3 parts by weight of cobalt boracylate.
3. The rubber stopper for the in-vitro diagnostic reagent bottle according to claim 2, wherein the mass ratio of the silicone rubber, the nitrile rubber, the polyurethane rubber and the ethylene propylene rubber is 5:1:6: 4.
4. The rubber stopper for in vitro diagnostic reagent bottles of claim 1, wherein the first rubber comprises 95 to 105 parts by weight of chlorinated butyl rubber CIIR1240, 75 to 85 parts by weight of calcined kaolin, 3 to 6 parts by weight of zinc oxide, 4.6 to 5.2 parts by weight of white carbon black, 6 to 8 parts by weight of talcum powder, 0.8 to 1.3 parts by weight of PE wax, 0.27 to 0.34 parts by weight of carbon black, 1.7 to 2.2 parts by weight of titanium dioxide, and 0.8 to 1.6 parts by weight of p-tert butyl phenol disulfide.
5. A method for preparing a rubber plug for an in vitro diagnostic reagent bottle is characterized in that the rubber plug is prepared according to any one of the claims 1 to 3 through the procedures of mixing, calendering, vulcanization bonding, trimming and disinfection;
in the kneading step, the first rubber material to be the rib portion is kneaded, rolled and vulcanized to be the rib; and mixing the second rubber raw material which becomes the other part of the rubber plug, calendering and vulcanizing and bonding the rib parts to form a rubber plug structure, and then preparing the rubber plug through the processes of trimming and sterilizing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114835980A (en) * | 2022-06-07 | 2022-08-02 | 安徽中马橡塑制品有限公司 | Medical antibacterial anti-puncturing rubber plug and preparation method thereof |
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Application publication date: 20200218 |