CN103232623B - Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof - Google Patents
Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof Download PDFInfo
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- CN103232623B CN103232623B CN201310174613.2A CN201310174613A CN103232623B CN 103232623 B CN103232623 B CN 103232623B CN 201310174613 A CN201310174613 A CN 201310174613A CN 103232623 B CN103232623 B CN 103232623B
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Abstract
The invention discloses a rubber syringe needle protective cap for a pre-encapsulation injection syringe. The protective cap is prepared from the following raw materials in parts by weight: 100 parts of synthesized polyisoprene rubber, 5-30 parts of alkaline white carbon black, 20-70 parts of calcined kaolin, 0.3-1.2 parts of peroxide, 0.5-1.0 part of stearic acid, 5-20 parts of polytetrafluoroethylene micro powder, 5-20 parts of ultra-high molecular weight polyethylene micro powder, 1-5 parts of titanium dioxide and 1-3 parts of carbon black. The rubber syringe needle protective cap has the obvious characteristics that a clean and simple peroxide sulfuration system is adopted, and a conventional complicated sulfur and zinc oxide promotion system is avoided. Special alkaline fillers are adopted, the sulfuration degree and speed of rubber are improved, and a smell problem caused by adopting the peroxide to sulfurate the polyisoprene rubber is reduced. The polytetrafluoroethylene micro powder and the ultra-high molecular weight polyethylene micro powder with good inertness and dispersibility are added into a formula, the lubricity and chemical inertness of the rubber are improved, and the viscous resistance of a rubber syringe needle protective cap product is improved.
Description
Technical field
The invention belongs to pre-encapsulated injector rubber accessory field, particularly relate to a kind of Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof.
Background technology
Tradition Rubber syringe needle protective cap for pre-encapsulation injection syringe, adopt traditional Sulfur of natural rubber or polyisoprene rubber, zinc oxide Promotion system, for improving vulcanization rate, state of vulcanization and curing efficiency, the Sulfur of usual employing high-content, also use sulfenamide and thiuram type accelerator, in process of production, the use of these materials is easy to cause rubber helmet " sulfuring up " phenomenon, the finished product ultraviolet absorptivity made and reducing substance and pH changing value are easy to exceed standard, so usually need to carry out high pressure extracting process with certain density bronsted lowry acids and bases bronsted lowry to product, production process complexity is loaded down with trivial details, easily cause product contamination and environmental pollution.So, develop that a kind of Recipe is simple, the Rubber syringe needle protective cap for pre-encapsulation injection syringe production method of energy-conserving and environment-protective, necessary.
Summary of the invention
The present invention want technical solution problem to be for the deficiency in background technology, a kind of recipe ingredient is simple, technical process is short, product performance are high Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof are provided.
In order to solve the problem by the following technical solutions: a kind of Rubber syringe needle protective cap for pre-encapsulation injection syringe, be prepared from by the starting material of following weight part: synthetic polyisoprenes rubber 100 parts, alkaline white carbon black 5-30 part, calcined kaolin 20-70 part, superoxide 0.3-1.2 part, stearic acid 0.5-1.0 part, ptfe micropowder 5-20 part, ultrahigh molecular weight polyethylene(UHMWPE) micro mist 5-20 part, titanium dioxide 1-5 part, carbon black 0.1-3 part.
Described superoxide is dicumyl peroxide, two (tert-butyl peroxide) diisopropylbenzene(DIPB), 2,5-diethyl-2,5-bis-(tert-butyl peroxide) hexane, t-tutyl cumyl peroxide or 2,5-dimethyl-2,5-bis-(tert-butyl peroxide)-3-hexane.
Production stage is as follows:
Batching: select starting material according to above-mentioned weight part, coordinate, weigh for subsequent use;
Banburying: adopt strong pressurizing formula Banbury mixer to be mixed by the starting material prepared, the banbury cycle time, the actual temperature of banburying sizing material, at 90-110 DEG C, made rubber unvulcanizate for subsequent use at 5-8 minute;
Open and produce bar: on opening rubber mixing machine, rubber unvulcanizate is cut into strip, park 8-24 hour, make batch mixing adhesive tape for subsequent use;
Injection moulding vulcanization: mixing adhesive tape is put into injection molding rubber vulcanizing machine, adopt high temperature fast injection molding sulfuration process, sulfurizing temperature range is at 175-195 DEG C, sulfide stress is 200-240bar, sulfuration clamp force is 400 tons, and screw tube temperature is 50-80 DEG C, and injection tube temperature is 70-90 DEG C, cold runner temperature is 70-90 DEG C, makes sulfide film for subsequent use;
Die-cut: under clean environment, adopt stamping machine and matching die to carry out die-cut process to sulfide film, make rubber needle helmet for subsequent use;
Cleaning, drying process: under clean environment, adopts medicinal rubber cleansing article machine, carries out cleaning, drying process to rubber needle helmet.
Described synthetic polyisoprenes rubber, Ziegler formulation and alkyl lithium catalyst type synthetic polyisoprenes rubber can be selected, the such as IR2200 of the NIPIL of Japanese auspicious father-in-law (ZEON) company, and the SKI-5pm of Russian NIZHNEKAMSK NEFTEKHIM company, and the IR307 etc. of Ke Teng KARTON company of the U.S..From whole Performance comparision, the IR307 of Ke Teng KARTON company of the preferred U.S..
Alkalescence white carbon black mainly in order to improve the intensity of sizing material, simultaneously can with peroxide vulcanization systems compatibility well, improve vulcanization rate and degree, reduce or avoid the unpleasant odor because peroxide vulcanization systems produces; The such as PH of Nyco SA of the employing U.S. is the alkaline white carbon black MD1250 etc. of 9.9.
Calcined kaolin can select general druggist rubber sundries calcined kaolin.
Superoxide is 2,5-diethyl-2,5-bis-(tert-butyl peroxide) hexanes preferably.
The preferred medical grade stearic acid of stearic acid.
Due to ptfe micropowder itself there is low viscosity and frictional force little, thus Rubber processing performance can be improved, improve release property, improve the non-stick property of rubber needle helmet goods simultaneously.Select the median size of polytetrafluoroethylene PTFE micro mist usually at 3-5 micron, such as can select the F5A of Solvay Solexis company, and the PTFE L-5F of DAIKIN company.
Ultrahigh molecular weight polyethylene(UHMWPE) UHMPE micro mist is added in rubber compounding, many performances such as oilness, wearability, shock-resistance, chemical proofing can be improved.Select the median size of ultrahigh molecular weight polyethylene(UHMWPE) UHMPE micro mist usually at 25-30 micron, such as can select the XM-220 of Mitsui chemicals company.
Titanium dioxide can select Rutile type Titanium Dioxide and anatase thpe white powder.
The present invention has following distinguishing feature: adopt very clean simple peroxide vulcanizing system, avoids Sulfur, zinc oxide Promotion system that tradition is complicated.Adopt special basic filler, improve state of vulcanization and the speed of sizing material, the odor problem that minimizing polyisoprene rubber adopts peroxide cure and produces.In formula, add inertia and the good ptfe micropowder of dispersiveness and ultrahigh molecular weight polyethylene(UHMWPE) micro mist, improve oilness and the unreactiveness of sizing material, improve the non-stick property of rubber needle helmet goods.Have employed new die design concept, plated titanium nitride or layers of chrome process are adopted to sulfurizing mould surface, improves the release property of rubber needle helmet, adopt efficient fluorine element class releasing agent to improve the release property of rubber needle helmet simultaneously.
Embodiment
The present invention is described further in conjunction with object lesson.
Embodiment 1: a kind of Rubber syringe needle protective cap for pre-encapsulation injection syringe, production stage is as follows: A, batching: accurately take synthetic polyisoprenes rubber 100 weight part, MD1250 alkalescence white carbon black 20 weight part, calcined kaolin 50 weight part, superoxide 1.0 weight part, stearic acid 1.0 weight part, ptfe micropowder 5 weight part, ultrahigh molecular weight polyethylene(UHMWPE) micro mist 10 weight part, titanium dioxide 3 weight part, carbon black 0.5 weight part, for subsequent use.
B, banburying: adopt the strong pressurizing formula Banbury mixer of 55 liters of capacity to be mixed by load weighted starting material, banbury cycle was at 8 minutes, and the actual temperature of banburying sizing material, at 100-110 DEG C, makes rubber unvulcanizate for subsequent use.
C, open and produce bar: on XK-550A opening rubber mixing machine, rubber unvulcanizate is cut into strip, park 8-24 hour, make mixing adhesive tape for subsequent use.
D, injection moulding vulcanization: mixing adhesive tape is put into German DESMA injection molding rubber vulcanizing machine, adopt high temperature fast injection molding sulfuration process, sulfurizing temperature range is at 180-185 DEG C, curing time is in 360-420 second, and sulfide stress is 240bar, and sulfuration clamp force is 400 tons, screw tube temperature is 80 DEG C, injection tube temperature is 90 DEG C, and cold runner temperature is 90 DEG C, makes sulfide film for subsequent use.Electrodeposited chromium layers process is adopted to sulfurizing mould surface, improves the release property of rubber needle helmet, adopt in sulfidation simultaneously and spray efficient fluorine element class releasing agent to improve the release property of rubber needle helmet.
E, die-cut: under clean environment, to adopt special stamping machine and matching die to carry out die-cut process to sulfide film, make rubber needle helmet for subsequent use.
F, cleaning, drying process: under clean environment, adopt the medicinal rubber cleansing article machine that German HUBER company is special, carry out cleaning, drying process to product.
The Rubber syringe needle protective cap for pre-encapsulation injection syringe of producing according to the method described above, operation is simple, need not again through complicated soda acid extracting treatment process, quality product can meet the physics of YBB00102004 pre-encapsulated injector polyisoprene rubber needle-covering cap, chemistry and biological property requirement.
Embodiment 2-7 is method according to embodiment 1 and step, according to the recipe ingredient requirement of above-mentioned Rubber syringe needle protective cap for pre-encapsulation injection syringe, as shown in table 1, manufactures Rubber syringe needle protective cap for pre-encapsulation injection syringe of the present invention.
Table 1
The Rubber syringe needle protective cap for pre-encapsulation injection syringe that embodiment 2-7 produces, quality product can meet the physics of YBB00102004 pre-encapsulated injector polyisoprene rubber needle-covering cap, chemistry and biological property requirement.
Embodiment 8: a kind of Rubber syringe needle protective cap for pre-encapsulation injection syringe, is prepared from by the starting material of following weight part: synthetic polyisoprenes rubber 100 parts, alkaline white carbon black 5-30 part, calcined kaolin 20-70 part, superoxide 0.3-1.2 part, stearic acid 0.5-1.0 part, ptfe micropowder 5-20 part, ultrahigh molecular weight polyethylene(UHMWPE) micro mist 5-20 part, titanium dioxide 1-5 part, carbon black 0.1-3 part.
Production stage is as follows:
A, batching: select starting material according to above-mentioned weight part, coordinate, weigh for subsequent use;
B, banburying: adopt strong pressurizing formula Banbury mixer to be mixed by the starting material prepared, the banbury cycle time, the actual temperature of banburying sizing material, at 90-110 DEG C, made rubber unvulcanizate for subsequent use at 5-8 minute;
C, open and produce bar: on opening rubber mixing machine, rubber unvulcanizate is cut into strip, park 8-24 hour, make batch mixing adhesive tape for subsequent use;
D, injection moulding vulcanization: mixing adhesive tape is put into injection molding rubber vulcanizing machine, adopt high temperature fast injection molding sulfuration process, sulfurizing temperature range is at 175-195 DEG C, sulfide stress is 200-240bar, sulfuration clamp force is 400 tons, and screw tube temperature is 50-80 DEG C, and injection tube temperature is 70-90 DEG C, cold runner temperature is 70-90 DEG C, makes sulfide film for subsequent use;
E, die-cut: under clean environment, adopt stamping machine and matching die to carry out die-cut process to sulfide film, make rubber needle helmet for subsequent use;
F, cleaning, drying process: under clean environment, adopt medicinal rubber cleansing article machine, carry out cleaning, drying process to rubber needle helmet.
Embodiment 9: a kind of Rubber syringe needle protective cap for pre-encapsulation injection syringe, is prepared from by the starting material of following weight part: synthetic polyisoprenes rubber 100 parts, alkaline white carbon black 10-20 part, calcined kaolin 40-50 part, superoxide 0.8-1.0 part, stearic acid 0.7-1.0 part, ptfe micropowder 10-15 part, ultrahigh molecular weight polyethylene(UHMWPE) micro mist 10-15 part, titanium dioxide 3-5 part, carbon black 0.1-1 part.
Other are with embodiment 8.
Claims (2)
1. a Rubber syringe needle protective cap for pre-encapsulation injection syringe, is characterized in that being prepared from by the starting material of following weight part: synthetic polyisoprenes rubber 100 parts, alkaline white carbon black 5-30 part, calcined kaolin 20-70 part, superoxide 0.3-1.2 part, stearic acid 0.5-1.0 part, ptfe micropowder 5-20 part, ultrahigh molecular weight polyethylene(UHMWPE) micro mist 5-20 part, titanium dioxide 1-5 part, carbon black 0.1-3 part;
Production stage is as follows:
Batching: select starting material according to above-mentioned weight part, coordinate, weigh for subsequent use;
Banburying: adopt strong pressurizing formula Banbury mixer to be mixed by the starting material prepared, the banbury cycle time, the actual temperature of banburying sizing material, at 90-110 DEG C, made rubber unvulcanizate for subsequent use at 5-8 minute;
Open and produce bar: on opening rubber mixing machine, rubber unvulcanizate is cut into strip, park 8-24 hour, make batch mixing adhesive tape for subsequent use;
Injection moulding vulcanization: mixing adhesive tape is put into injection molding rubber vulcanizing machine, adopt high temperature fast injection molding sulfuration process, sulfurizing temperature range is at 175-195 DEG C, sulfide stress is 200-240bar, sulfuration clamp force is 400 tons, and screw tube temperature is 50-80 DEG C, and injection tube temperature is 70-90 DEG C, cold runner temperature is 70-90 DEG C, makes sulfide film for subsequent use; Wherein, plated titanium nitride or layers of chrome process are adopted to sulfurizing mould surface;
Die-cut: under clean environment, adopt stamping machine and matching die to carry out die-cut process to sulfide film, make rubber needle helmet for subsequent use;
Cleaning, drying process: under clean environment, adopts medicinal rubber cleansing article machine, carries out cleaning, drying process to rubber needle helmet.
2. according to the Rubber syringe needle protective cap for pre-encapsulation injection syringe described in claim 1, it is characterized in that: described superoxide is dicumyl peroxide, two (tert-butyl peroxide) diisopropylbenzene(DIPB), 2,5-diethyl-2,5-bis-(tert-butyl peroxide) hexane, t-tutyl cumyl peroxide or 2,5-dimethyl-2,5-bis-(tert-butyl peroxide)-3-hexane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310174613.2A CN103232623B (en) | 2013-05-13 | 2013-05-13 | Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof |
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| CN201310174613.2A CN103232623B (en) | 2013-05-13 | 2013-05-13 | Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof |
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| CN103232623A CN103232623A (en) | 2013-08-07 |
| CN103232623B true CN103232623B (en) | 2015-07-15 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104744744A (en) * | 2015-03-04 | 2015-07-01 | 安徽华峰医药橡胶有限公司 | Polyisoprene gasket synthesized by medicinal film |
| CN104744745A (en) * | 2015-03-04 | 2015-07-01 | 安徽华峰医药橡胶有限公司 | Polyisoprene gasket directly contacted with medicinal liquor |
| CN106317507B (en) * | 2016-08-31 | 2018-07-10 | 山东省药用玻璃股份有限公司 | The structure of pre-encapsulated injector helmet, preparation method and its rubber helmet |
| CN111690184B (en) * | 2020-05-28 | 2022-07-19 | 郑州翱翔医药科技股份有限公司 | Protective cap for pre-filled and sealed syringe and manufacturing method thereof |
| CN112552610A (en) * | 2020-12-09 | 2021-03-26 | 郑州大学 | Sterilization-penetration-resistant glue-mixing protective cap for pre-filled and sealed injector and preparation method thereof |
| CN112755328B (en) * | 2021-02-02 | 2023-12-15 | 江苏华兰药用新材料股份有限公司 | Prefilled syringe protective cap, preparation method and device thereof |
| CN114213724B (en) * | 2021-12-27 | 2023-11-28 | 湖北华强科技股份有限公司 | Needle-containing rubber protective cap for prefilled syringe and preparation method thereof |
| CN115819897B (en) * | 2022-11-29 | 2023-11-28 | 湖北华强科技股份有限公司 | Brominated butyl/polyisoprene rubber gasket and production method thereof |
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| CN101247838A (en) * | 2005-08-26 | 2008-08-20 | 贝克顿迪肯森公司 | Methods of sterilizing elastomeric sealing articles |
| CN101759886A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Precharging type syringe needle sheath |
| CN102702587A (en) * | 2012-06-01 | 2012-10-03 | 青岛华仁塑胶医药用品有限公司 | Synthetic polyisoprene rubber plug for injection and preparation method thereof |
| CN202875977U (en) * | 2012-10-18 | 2013-04-17 | 郑州市翱翔医药包装有限公司 | Needle head hard protective cap for pre-potting injector |
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2013
- 2013-05-13 CN CN201310174613.2A patent/CN103232623B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101247838A (en) * | 2005-08-26 | 2008-08-20 | 贝克顿迪肯森公司 | Methods of sterilizing elastomeric sealing articles |
| CN101759886A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Precharging type syringe needle sheath |
| CN102702587A (en) * | 2012-06-01 | 2012-10-03 | 青岛华仁塑胶医药用品有限公司 | Synthetic polyisoprene rubber plug for injection and preparation method thereof |
| CN202875977U (en) * | 2012-10-18 | 2013-04-17 | 郑州市翱翔医药包装有限公司 | Needle head hard protective cap for pre-potting injector |
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Address after: 452483 Dengfeng City, Henan Province, Li Zhuang Industrial Park, the three Patentee after: ZHENGZHOU AOXIANG PHARMACEUTICAL PACKING CO., LTD. Address before: 452483 Dengfeng City, Henan Province, Li Zhuang Industrial Park, the three Patentee before: Zhengzhou Aoxiang Pharmaceutical Packing Co., Ltd. |