CN102863701B - Rubber plug material for blood specimen collection and preparation method thereof - Google Patents
Rubber plug material for blood specimen collection and preparation method thereof Download PDFInfo
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- CN102863701B CN102863701B CN201210365014.4A CN201210365014A CN102863701B CN 102863701 B CN102863701 B CN 102863701B CN 201210365014 A CN201210365014 A CN 201210365014A CN 102863701 B CN102863701 B CN 102863701B
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Abstract
The invention relates to a chemical material, and particularly relates to a material for blood specimen collection and a preparation method thereof. The material for blood specimen collection is prepared by mixing the following raw materials in percentage by weight: 20-40% of synthetic rubber, 10-20% of thermoplastic elastomer, 30-50% of filler, 3-10% of crosslinking agent and 0.5-1.5% of colorant, wherein the synthetic rubber is butyl rubber, polyisobutylene rubber or halogenated butyl rubber; the thermoplastic elastomer is styryl elastomer or polyolefin thermoplastic elastomer; the filler is one or more of argil, talcum powder and white carbon black; the crosslinking agent is metal oxide or phenol formaldehyde resin; and the colorant is titanium white, carbon black or a mixture thereof. According to the invention, the prepared rubber plug material for an oral liquid has good mechanical strength and elasticity, can meet the operation requirements and processing requirements of the rubber plug for an oral liquid, and can also meet the requirements for the compatibility of liquid medicine which is in contact with the rubber plug after sealing.
Description
Technical field
The present invention relates to a kind of elastomeric material, specifically plug material and preparation method thereof for a kind of blood sample collection.
Background technology
The blood sample collection that existing market is used is a lot of by plug kind, and material is various.But existing oral liquid is bad with the material property of plug, there is difficulty of processing greatly and the bad defect of sealing property, some smells of also release that have, affect to user of service's meeting.
Summary of the invention
The object of the invention is exactly the defect for existing oral liquid rubber stopper material prescription, a kind of blood sample collection plug material is provided, it can either meet service requirements and the processing request of oral liquid rubber stopper, can meet again the requirement to contacted liquid medicine compatibleness after sealing.
Technical scheme of the present invention is such realization: it is mixed according to weight percent by following raw material:
Synthetic rubber 20%-40%, thermoplastic elastomer 10%-20%, filler 30%-50%, linking agent 3%-10%, tinting material 0.5%-1.5%, wherein synthetic rubber is isoprene-isobutylene rubber, polyisobutylene rubber or halogenated butyl rubber; Thermoplastic elastomer is styrene-based elastomer or polyolefins thermoplastic elastomer; Filler is one or more in potter's clay, talcum powder, white carbon black; Linking agent is metal oxide or resol; Tinting material is titanium dioxide, carbon black or its mixture.
The good technical scheme of the present invention is: the viscosity-average molecular weight of described isoprene-isobutylene rubber is 1.5 ten thousand to 200,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 20 to 100,0.3 3.0 mol%.Preferably the viscosity-average molecular weight of described isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.1+8(100 ° of C of mooney viscosity ML of described halogenated butyl rubber) degree of unsaturation of 20 to 100,0.1 3.0 mol%, the weight ratio of content of halogen is 0.5% 3.0%.Preferably 1+8(100 ° of C of mooney viscosity ML of described halogenated butyl rubber) degree of unsaturation of 40 to 70,0.7 2.0 mol%, the weight ratio of content of halogen is 0.5% 3.0%.Fusing point≤120 of described thermoplastic elastomer ° C.
Described polyolefin elastomer is ethylene-propylene copolymer or non-ethylene-propylene-diene copolymer altogether.
The better technical scheme of the present invention is such realization: it is mixed according to weight percent by following raw material:
Isoprene-isobutylene rubber 20%-40%, ethylene-propylene copolymer 10%-20%, filler 30%-50%, resol 3%-10%, tinting material 0.5%-1.5%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.
In the present invention, isoprene-isobutylene rubber is mainly for the barrier properties for gases to a satisfaction.If isoprene-isobutylene rubber consumption is less than 20% weight, just can not provide the gas barrier property of a satisfaction as oral liquid rubber stopper material.Due to isoprene-isobutylene rubber, to have larger compression set, impelling strength and hardness low, and tension set is large.Therefore, the effect of thermoplastic elastomer is the physicals that improves plug.In the weight range of thermoplastic elastic scale of construction decline 10% to 20%.If the thermoplastic elastic scale of construction exceedes total amount 20%, the impact of isoprene-isobutylene rubber possibly cannot obtain.On the other hand, if the weight that the thermoplastic elastic scale of construction is less than 10%, the impact of thermoplastic elastomer is may not can satisfactory.In sum, the physical strength of the material of preparing under formula condition of the present invention is best, and elasticity is also fine, and it can either meet service requirements and the processing request of oral liquid rubber stopper, can meet again the requirement to contacted liquid medicine compatibleness after sealing.Preparation method of the present invention is to be to rub in a stirrer by each material, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Embodiment
Below in conjunction with embodiment, the invention will be further described
Embodiment mono-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 40%, and ethylene-propylene copolymer 20%, filler 30%, resol 9%, tinting material 1%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.Fusing point≤120 of ethylene-propylene copolymer ° C.Preparation method is to be to rub in a stirrer by above-mentioned each material, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Embodiment bis-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 30%, ethylene-propylene copolymer 15%, filler 50%, resol 3.5%, tinting material 1.5%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.Fusing point≤120 of ethylene-propylene copolymer ° C.Preparation method is to be to rub in a stirrer by above-mentioned each material, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Embodiment tri-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 40%, styrene-based elastomer 10%, filler 50%, resol 9.5%, tinting material 0.5%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.Fusing point≤120 of ethylene-propylene copolymer ° C.Preparation method is to be to rub in a stirrer by above-mentioned each material, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Embodiment tetra-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 40%, styrene-based elastomer 10%, filler 50%, resol 9.5%, tinting material 0.5%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ° C) degree of unsaturation of 40 to 70,0.7 1.5mol%.Fusing point≤120 of ethylene-propylene copolymer ° C.Preparation method is to be to rub in a stirrer by above-mentioned each material, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Embodiment five
The present invention is mixed according to weight percent by following raw material: halogenated butyl rubber 20%, styrene-based elastomer 20%, filler 50%, resol 8.5%, tinting material 1.5%, filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black; 1+8(100 ° of C of mooney viscosity ML of halogenated butyl rubber) degree of unsaturation of 40 to 70,0.7 2.0 mol%, the weight ratio of content of halogen is 0.5% 3.0%.Preparation method rubs above-mentioned each material in a stirrer, at 130 ° of C to 190 ° of C, is preferably in 140 ° of C to 160 ° of C and mixes, with compression molding or injection system moulding.
Claims (7)
1. a blood sample collection plug material, it is mixed according to weight percent by following raw material:
Synthetic rubber 20%-40%, thermoplastic elastomer 10%-20%, filler 30%-50%, linking agent 3%-10%, tinting material 0.5%-1.5%, wherein synthetic rubber is isoprene-isobutylene rubber, polyisobutylene rubber or halogenated butyl rubber; Thermoplastic elastomer is styrene-based elastomer or polyolefins thermoplastic elastomer; Filler is one or more in potter's clay, talcum powder, white carbon black; Linking agent is metal oxide or resol; Tinting material is titanium dioxide, carbon black or its mixture.
2. a kind of blood sample collection plug material according to claim 1, the viscosity-average molecular weight of wherein said isoprene-isobutylene rubber is 1.5 ten thousand to 200,000,100 ℃ of 20 degree of unsaturation to 100,0.3～3.0mol% of mooney viscosity ML1+8.
3. a kind of blood sample collection plug material according to claim 1 and 2, the viscosity-average molecular weight of wherein said isoprene-isobutylene rubber is 80,000,100 ℃ of 40 degree of unsaturation to 70,0.7～1.5mol% of mooney viscosity ML1+8.
4. a kind of blood sample collection plug material according to claim 1,100 ℃ of 20 degree of unsaturation to 100,0.1～3.0mol% of mooney viscosity ML1+8 of wherein said halogenated butyl rubber, the weight ratio of content of halogen is 0.5%～3.0%.
5. according to a kind of blood sample collection plug material described in claim 1 or 4,100 ℃ of 40 degree of unsaturation to 70,0.7～2.0mol% of mooney viscosity ML1+8 of wherein said halogenated butyl rubber, the weight ratio of content of halogen is 0.5%～3.0%.
6. a kind of blood sample collection plug material according to claim 1, fusing point≤120 ℃ of wherein said thermoplastic elastomer.
7. a kind of blood sample collection plug material according to claim 1, wherein said polyolefin elastomer is ethylene-propylene copolymer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210365014.4A CN102863701B (en) | 2012-09-27 | 2012-09-27 | Rubber plug material for blood specimen collection and preparation method thereof |
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| CN201210365014.4A CN102863701B (en) | 2012-09-27 | 2012-09-27 | Rubber plug material for blood specimen collection and preparation method thereof |
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| CN102863701A CN102863701A (en) | 2013-01-09 |
| CN102863701B true CN102863701B (en) | 2014-07-09 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102850671B (en) * | 2012-09-27 | 2014-11-05 | 应城市恒天药业包装有限公司 | Oral liquid rubber plug material and preparation method thereof |
| CN103642137A (en) * | 2013-12-06 | 2014-03-19 | 应城市恒天药业包装有限公司 | Rubber plug material for transfusion medicines and preparation method thereof |
| CN103642135A (en) * | 2013-12-06 | 2014-03-19 | 应城市恒天药业包装有限公司 | Rubber stopper material for cephalosporin drug and preparation method thereof |
| CN103642136A (en) * | 2013-12-06 | 2014-03-19 | 应城市恒天药业包装有限公司 | Rubber plug material for freeze-dried medicines and preparation method thereof |
| CN103724843A (en) * | 2013-12-06 | 2014-04-16 | 应城市恒天药业包装有限公司 | Rubber plug material for penicillin drugs and preparation method thereof |
| CN104086909B (en) * | 2014-07-02 | 2016-04-27 | 合肥市再德高分子材料有限公司 | A kind of high-air-tightness elastomeric material |
| CN104140570B (en) * | 2014-07-14 | 2016-08-17 | 丹阳市金晟医用橡塑制品有限公司 | A kind of disposable blood sampling needle tip shield and manufacture method thereof |
| CN104877206A (en) * | 2015-05-29 | 2015-09-02 | 应城市恒天药业包装有限公司 | Surface-filmed brominated butyl rubber plug and production method thereof |
| CN110330732A (en) * | 2019-05-20 | 2019-10-15 | 浙江贝斯特医用科技有限公司 | Without zinc hemostix butyl rubber bung and its manufacturing process |
| CN110330731A (en) * | 2019-05-20 | 2019-10-15 | 浙江贝斯特医用科技有限公司 | Inexpensive hemostix butyl rubber bung and its manufacturing process |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200984186Y (en) * | 2006-09-01 | 2007-12-05 | 邹方明 | Blood taking needle |
| CN202143631U (en) * | 2011-07-19 | 2012-02-15 | 山东济海医疗科技股份有限公司 | Rubber plug of blood collecting tube |
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