CN103724843A - Rubber plug material for penicillin drugs and preparation method thereof - Google Patents
Rubber plug material for penicillin drugs and preparation method thereof Download PDFInfo
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- CN103724843A CN103724843A CN201310656579.2A CN201310656579A CN103724843A CN 103724843 A CN103724843 A CN 103724843A CN 201310656579 A CN201310656579 A CN 201310656579A CN 103724843 A CN103724843 A CN 103724843A
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- rubber
- thermoplastic elastomer
- plug material
- propylene
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C08L23/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
- C08L23/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/04—Thermoplastic elastomer
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention relates to a chemical material, in particular to a rubber plug material for penicillin drugs and a preparation method thereof. The rubber plug material is prepared by mixing the following raw materials in percentage by weight: 20%-40% of synthetic rubber, 10%-20% of thermoplastic elastomer, 30%-50% of fillers, 3%-8.5% of cross-linking agents and 0.5%-1.5% of colorants, wherein the synthetic rubber is butyl rubber, polyisobutene rubber or halogenated butyl rubber; the thermoplastic elastomer is styryl elastomer or polyolefin thermoplastic elastomer; the fillers are one or more of argil, talc powders and white carbon black; the cross-linking agents are metal oxide or phenolic resin; the colorants are titanium dioxide, carbon black or mixtures thereof. The rubber plug material for penicillin drugs prepared by the invention is high in mechanical strength and good in flexibility, and can both meet usage requirements and processing requirements for rubber plug materials for penicillin drugs, and meet the requirements for the compatibility when liquid drugs are in contact with the rubber plug materials after sealing.
Description
Technical field
The present invention relates to a kind of chemical material, specifically plug material and preparation method thereof for a kind of penicillin medicine.
Background technology
The plug kind that existing market penicillin medicine is used is a lot, and material is various.But because the material property of plug is bad,, there is difficulty of processing greatly and the bad defect of sealing property in the inner a certain or Cucumber existing, and some smells of also release that have affect to user of service's meeting.
Summary of the invention
Object of the present invention is exactly the deficiency in order to solve existing penicillin medicine plug material, a kind of penicillin medicine plug material and preparation method thereof is provided, it can either meet service requirements and the processing request of penicillin medicine plug, can meet again the requirement to contacted liquid medicine compatibleness after sealing.
The technical solution used in the present invention is: a kind of penicillin medicine plug material, it is mixed according to weight percent by following raw material: synthetic rubber 20%-40%, thermoplastic elastomer 10%-20%, filler 30%-50%, linking agent 3%-8.5%, tinting material 0.5%-1.5%, wherein synthetic rubber is isoprene-isobutylene rubber, polyisobutene or halogenated butyl rubber; Thermoplastic elastomer is styrene-based elastomer or polyolefins thermoplastic elastomer; Filler is by one or more in potter's clay, talcum powder, white carbon black; Linking agent is metal oxide or resol; Tinting material is titanium dioxide, carbon black or its mixture.
The good technical scheme of the present invention is: the viscosity-average molecular weight of described isoprene-isobutylene rubber is 1.5 ten thousand to 150,000, mooney viscosity ML1+8(100 ℃) 20 to 100,0.3～3.0mol% degree of unsaturation.The viscosity-average molecular weight of preferred described isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ℃) 40 to 70,0.7～1.5mol% degree of unsaturation.The mooney viscosity ML1+8(100 ℃ of described halogenated butyl rubber) 20 to 100,0.1～3.0mol% degree of unsaturation, the weight ratio of content of halogen is 0.5%～3.0 %.The mooney viscosity ML1+8(100 ℃ of preferred described halogenated butyl rubber) 40 to 70,0.7～2.0MOL% degree of unsaturation, the weight ratio of content of halogen is 0.5%～3.0%.Fusing point≤120 ℃ of described thermoplastic elastomer.
Described polyolefins thermoplastic elastomer is ethylene-propylene copolymer or non-ethylene-propylene-diene copolymer altogether.The mooney viscosity ML1+4(100 ℃ of preferred described polyolefins thermoplastic elastomer) 30 to 95, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.The mooney viscosity ML1+4(100 ℃ of preferred described polyolefins thermoplastic elastomer) 40 to 80, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.
Preparation method of the present invention rubs above-mentioned various materials in a stirrer, at 130 ℃ to 190 ℃, is preferably under the condition of 140 ℃ to 160 ℃ and mixes, with compression molding or injection system moulding.
In the present invention, isoprene-isobutylene rubber is mainly for the barrier properties for gases to a satisfaction.If isoprene-isobutylene rubber consumption is less than 20% weight, as with the plug material of the high intermiscibility of penicillin medicine, the gas barrier property of a satisfaction just can not be provided.Therefore to have larger compression set, impelling strength and hardness low for isoprene-isobutylene rubber, and tension set is large.The effect of thermoplastic elastomer is the physicals that improves plug.The thermoplastic elastic scale of construction is in 10% to 20% weight range.If the thermoplastic elastic scale of construction exceedes total amount 20%, the effect of isoprene-isobutylene rubber cannot show; On the other hand, if the thermoplastic elastic scale of construction is less than 10%, the effect of thermoplastic elastomer does not reach service requirements.In order to improve capsule forming, particularly injection molding, having added a predetermined alkene is basic polymkeric substance.In sum, the physical strength of the plug of preparing under formula condition of the present invention is good, and elasticity is also fine, and it can either meet service requirements and the processing request of penicillin medicine plug, can meet again the requirement to contacted liquid medicine compatibleness after sealing.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail, be convenient to be well understood to the present invention, but they do not form restriction to the present invention.
Embodiment mono-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 40%, ethylene-propylene copolymer 20%, filler 35%, resol 3.5%, tinting material 1.5%.The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ℃) 40 to 70,0.7～1.5mol% degree of unsaturation.Fusing point≤120 ℃ of ethylene-propylene copolymer, mooney viscosity ML1+4(100 ℃) 40 to 80, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.Filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black.Preparation method rubs above-mentioned each material in a stirrer, at 130 ℃ to 190 ℃, is preferably under the condition of 140 ℃ to 160 ℃ and mixes, with compression molding or injection system moulding.
Embodiment bis-
The present invention is mixed according to weight percent by following raw material: isoprene-isobutylene rubber 30%, ethylene-propylene copolymer 15%, filler 50%, resol 4%, tinting material 1%.The viscosity-average molecular weight of isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ℃) 40 to 70,0.7～1.5mol% degree of unsaturation.Fusing point≤120 ℃ of ethylene-propylene copolymer, mooney viscosity ML1+4(100 ℃) 40 to 80, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.Filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black.Preparation method rubs above-mentioned each material in a stirrer, at 130 ℃ to 190 ℃, is preferably under the condition of 140 ℃ to 160 ℃ and mixes, with compression molding or injection system moulding.
Embodiment tri-
The present invention is mixed according to weight percent by following raw material: halogenated butyl rubber 30%, ethylene-propylene copolymer 20%, filler 45%, resol 4.5%, tinting material 0.5%.The mooney viscosity ML1+8(100 ℃ of halogenated butyl rubber) 40 to 70,0.7～1.5mol% degree of unsaturation, the weight ratio of content of halogen is 0.5%～3.0%.Fusing point≤120 ℃ of ethylene-propylene copolymer, mooney viscosity ML1+4(100 ℃) 40 to 80.Filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black.Preparation method rubs above-mentioned each material in a stirrer, at 130 ℃ to 190 ℃, is preferably under the condition of 140 ℃ to 160 ℃ and mixes, with compression molding or injection system moulding.
Embodiment tetra-
The present invention is mixed according to weight percent by following raw material: halogenated butyl rubber 35%, non-ethylene-propylene-diene copolymer 20% altogether, filler 40%, resol 3.5%, tinting material 1.5%.The mooney viscosity ML1+8(100 ℃ of halogenated butyl rubber) 40 to 70,0.7～1.5mol% degree of unsaturation, the weight ratio of content of halogen is 0.5%～3.0%.Non-fusing point≤120 ℃ of ethylene-propylene-diene copolymer altogether, mooney viscosity ML1+4(100 ℃) 40 to 80, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.Filler is mixed according to the part by weight of 2:1:1 by potter's clay, talcum powder, white carbon black.Preparation method rubs above-mentioned each material in a stirrer, at 130 ℃ to 190 ℃, is preferably under the condition of 140 ℃ to 160 ℃ and mixes, with compression molding or injection system moulding.
Claims (10)
1. a penicillin medicine plug material, it is characterized in that, it is mixed according to weight percent by following raw material: synthetic rubber 20%-40%, thermoplastic elastomer 10%-20%, filler 30%-50%, linking agent 3%-8.5%, tinting material 0.5%-1.5%, wherein synthetic rubber is isoprene-isobutylene rubber, polyisobutene or halogenated butyl rubber; Thermoplastic elastomer is styrene-based elastomer or polyolefins thermoplastic elastomer; Filler is by one or more in potter's clay, talcum powder, white carbon black; Linking agent is metal oxide or resol; Tinting material is titanium dioxide, carbon black or its mixture.
2. a kind of penicillin medicine plug material according to claim 1, is characterized in that: the viscosity-average molecular weight of described isoprene-isobutylene rubber is 1.5 ten thousand to 150,000, mooney viscosity ML1+8(100 ℃) 20 to 100,0.3～3.0mol% degree of unsaturation.
3. a kind of penicillin medicine plug material according to claim 1 and 2, is characterized in that: the viscosity-average molecular weight of described isoprene-isobutylene rubber is 80,000, mooney viscosity ML1+8(100 ℃) 40 to 70,0.7～1.5mol% degree of unsaturation.
4. a kind of penicillin medicine plug material according to claim 1, it is characterized in that: the mooney viscosity ML1+8(100 ℃ of described halogenated butyl rubber) 20 to 100, the degree of unsaturation of 0.1～3.0mol%, the weight ratio of content of halogen is 0.5%～3.0%.
5. according to a kind of penicillin medicine plug material described in claim 1 or 4, it is characterized in that: the mooney viscosity ML1+8(100 ℃ of described halogenated butyl rubber) 40 to 70, the degree of unsaturation of 0.7～2.0MOL%, the weight ratio of content of halogen is 0.5%～3.0%.
6. a kind of penicillin medicine plug material according to claim 1, is characterized in that: fusing point≤120 ℃ of described thermoplastic elastomer.
7. a kind of penicillin medicine plug material according to claim 1, is characterized in that: described polyolefins thermoplastic elastomer is ethylene-propylene copolymer or non-ethylene-propylene-diene copolymer altogether.
8. according to a kind of penicillin medicine plug material described in claim 1 or 7, it is characterized in that: the mooney viscosity ML1+4(100 ℃ of described polyolefins thermoplastic elastomer) 30 to 95, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.
9. a kind of penicillin medicine plug material according to claim 8, it is characterized in that: the mooney viscosity ML1+4(100 ℃ of described polyolefins thermoplastic elastomer) 40 to 80, partial cross-linked ethylene-propylene elastomeric, propylene grafted ethene-propylene elastomeric.
10. a penicillins medical rubber plug preparation method, is characterized in that: the various materials described in claim 1 to 9 are rubbed in a stirrer, under the condition of 130 ℃ to 190 ℃, mixed, with compression molding or injection system moulding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310656579.2A CN103724843A (en) | 2013-12-06 | 2013-12-06 | Rubber plug material for penicillin drugs and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310656579.2A CN103724843A (en) | 2013-12-06 | 2013-12-06 | Rubber plug material for penicillin drugs and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN103724843A true CN103724843A (en) | 2014-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310656579.2A Pending CN103724843A (en) | 2013-12-06 | 2013-12-06 | Rubber plug material for penicillin drugs and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104877206A (en) * | 2015-05-29 | 2015-09-02 | 应城市恒天药业包装有限公司 | Surface-filmed brominated butyl rubber plug and production method thereof |
| CN105037979A (en) * | 2015-05-29 | 2015-11-11 | 应城市恒天药业包装有限公司 | Surface film forming chlorinated butyl rubber stopper and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87107410A (en) * | 1986-12-31 | 1988-08-03 | Bp化学有限公司 | Filled elastomer blends |
| CN101189300A (en) * | 2005-04-12 | 2008-05-28 | 莫门蒂夫功能性材料公司 | Process for making a thermoplastic vulcanizate composition |
| CN102086287A (en) * | 2009-12-03 | 2011-06-08 | 江苏润德医用材料有限公司 | Thermoplastic elastomer material and plastic plug made of same |
| CN102850671A (en) * | 2012-09-27 | 2013-01-02 | 应城市恒天药业包装有限公司 | Oral liquid rubber plug material and preparation method thereof |
| CN102863701A (en) * | 2012-09-27 | 2013-01-09 | 应城市恒天药业包装有限公司 | Rubber plug material for blood specimen collection and preparation method thereof |
-
2013
- 2013-12-06 CN CN201310656579.2A patent/CN103724843A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87107410A (en) * | 1986-12-31 | 1988-08-03 | Bp化学有限公司 | Filled elastomer blends |
| CN101189300A (en) * | 2005-04-12 | 2008-05-28 | 莫门蒂夫功能性材料公司 | Process for making a thermoplastic vulcanizate composition |
| CN102086287A (en) * | 2009-12-03 | 2011-06-08 | 江苏润德医用材料有限公司 | Thermoplastic elastomer material and plastic plug made of same |
| CN102850671A (en) * | 2012-09-27 | 2013-01-02 | 应城市恒天药业包装有限公司 | Oral liquid rubber plug material and preparation method thereof |
| CN102863701A (en) * | 2012-09-27 | 2013-01-09 | 应城市恒天药业包装有限公司 | Rubber plug material for blood specimen collection and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104877206A (en) * | 2015-05-29 | 2015-09-02 | 应城市恒天药业包装有限公司 | Surface-filmed brominated butyl rubber plug and production method thereof |
| CN105037979A (en) * | 2015-05-29 | 2015-11-11 | 应城市恒天药业包装有限公司 | Surface film forming chlorinated butyl rubber stopper and preparation method thereof |
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Application publication date: 20140416 |