CN110799190B - 杂环化合物 - Google Patents

杂环化合物 Download PDF

Info

Publication number
CN110799190B
CN110799190B CN201880021628.6A CN201880021628A CN110799190B CN 110799190 B CN110799190 B CN 110799190B CN 201880021628 A CN201880021628 A CN 201880021628A CN 110799190 B CN110799190 B CN 110799190B
Authority
CN
China
Prior art keywords
group
membered
alkyl
optionally substituted
substituents selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880021628.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN110799190A (zh
Inventor
松永伸之
中畑崇
田中雄太
高萩洋希
宫本泰史
冈本玲
吉川武
寺尾嘉人
汤川猛史
挂川佳子
西川洋一
高木辉文
高桥昌志
M·科曼拉
L·宽
J·米由拉
马克·萨巴
史克拉·尼克拉斯
保罗·坦尼斯
约翰·汤玛斯
P·H·由
王海霞
王晓仑
白井淳也
大川友洋
盐川善右
涉谷章人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardurion Pharmaceuticals Inc
Original Assignee
Cardurion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardurion Pharmaceuticals Inc filed Critical Cardurion Pharmaceuticals Inc
Publication of CN110799190A publication Critical patent/CN110799190A/zh
Application granted granted Critical
Publication of CN110799190B publication Critical patent/CN110799190B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CN201880021628.6A 2017-03-27 2018-03-23 杂环化合物 Active CN110799190B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762476970P 2017-03-27 2017-03-27
US62/476,970 2017-03-27
PCT/US2018/024043 WO2018183112A1 (en) 2017-03-27 2018-03-23 Heterocyclic compound

Publications (2)

Publication Number Publication Date
CN110799190A CN110799190A (zh) 2020-02-14
CN110799190B true CN110799190B (zh) 2024-04-19

Family

ID=63671942

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880021628.6A Active CN110799190B (zh) 2017-03-27 2018-03-23 杂环化合物

Country Status (9)

Country Link
US (2) US10543212B2 (enExample)
EP (1) EP3600327A4 (enExample)
JP (1) JP7249950B2 (enExample)
KR (1) KR102638678B1 (enExample)
CN (1) CN110799190B (enExample)
AU (1) AU2018243691B2 (enExample)
CA (1) CA3058182A1 (enExample)
TW (1) TWI789381B (enExample)
WO (1) WO2018183112A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7249950B2 (ja) 2017-03-27 2023-03-31 カーデュリオン・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニー ヘテロ環化合物
JP7569688B2 (ja) 2017-12-22 2024-10-18 ハイバーセル，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体
WO2020068846A1 (en) * 2018-09-25 2020-04-02 Heterocyclic Compound Heterocyclic compound
JP7447098B2 (ja) * 2018-09-25 2024-03-11 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド アミノピリミジン化合物
WO2020140054A1 (en) 2018-12-28 2020-07-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
EP4048664A1 (en) * 2019-10-25 2022-08-31 Gilead Sciences, Inc. Glp-1r modulating compounds
SI4097097T1 (sl) 2020-01-29 2025-04-30 Gilead Sciences, Inc. Spojine, ki modulirajo glp-1r
KR102563111B1 (ko) * 2020-03-18 2023-08-04 주식회사 엘지화학 Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법
WO2021187886A1 (ko) * 2020-03-18 2021-09-23 주식회사 엘지화학 Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법
JP2023543038A (ja) 2020-09-28 2023-10-12 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド 縮合ヘテロアリール化合物およびＣａＭＫＩＩ阻害剤としてのその使用
EP4247804A1 (en) 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
WO2022192428A1 (en) 2021-03-11 2022-09-15 Gilead Sciences, Inc. Glp-1r modulating compounds
EP4304712A1 (en) 2021-03-11 2024-01-17 Gilead Sciences, Inc. Glp-1r modulating compounds
WO2022216094A1 (ko) * 2021-04-08 2022-10-13 주식회사 엘지화학 Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법
MX2023012418A (es) 2021-04-21 2023-10-31 Gilead Sciences Inc Compuestos de modulacion de glp-1r de carboxi-bencimidazol.
US20250170101A1 (en) * 2021-12-29 2025-05-29 Psy Therapeutics, Inc. Monoacylglycerol lipase inhibitors and use thereof for the treatment and management of pain and related conditions
EP4457213A4 (en) 2021-12-29 2025-12-17 Psy Therapeutics Inc INHIBITION OF MONOACYLGLYCEROL LIPASE (MAGL)
CN114621312B (zh) * 2022-03-24 2022-11-15 陕西师范大学 一种寡肽烷基侧链的选择性修饰方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011724A2 (en) * 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Neuroprotective 2-pyridinamine compositions and related methods
WO2010038081A2 (en) * 2008-10-03 2010-04-08 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
JP2010523568A (ja) * 2007-04-05 2010-07-15 アムジエン・インコーポレーテツド オーロラキナーゼ調節物質及び使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60136731D1 (de) 2000-09-20 2009-01-08 Ortho Mcneil Pharm Inc Pyrazine derivate als tyrosin kinase modulatoren
AU2004261484A1 (en) 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
JP2007504229A (ja) 2003-09-02 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体−５のモジュレーターとしてのビピリジルアミン類およびエーテル類
WO2009032703A1 (en) 2007-08-28 2009-03-12 Irm Llc 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
GB0821307D0 (en) * 2008-11-21 2008-12-31 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
EP2638018A1 (en) * 2010-11-09 2013-09-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
EP2763976B1 (en) 2011-10-05 2016-05-18 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
AU2013250378B2 (en) 2012-04-17 2016-01-14 Fujifilm Corporation Nitrogen-containing heterocyclic compound or salt thereof
JP7249950B2 (ja) * 2017-03-27 2023-03-31 カーデュリオン・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニー ヘテロ環化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011724A2 (en) * 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Neuroprotective 2-pyridinamine compositions and related methods
JP2010523568A (ja) * 2007-04-05 2010-07-15 アムジエン・インコーポレーテツド オーロラキナーゼ調節物質及び使用方法
WO2010038081A2 (en) * 2008-10-03 2010-04-08 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Pyrimidine-based inhibitors of CaMKⅡδ";Babu Mavunkel等;《Bioorganic & Medicinal Chemistry Letters》;20080304;第2404-2408页，尤其是第2407页表5，第2408页左栏最后1段 *

Also Published As

Publication number Publication date
TWI789381B (zh) 2023-01-11
JP7249950B2 (ja) 2023-03-31
AU2018243691A1 (en) 2019-10-24
US20200230137A1 (en) 2020-07-23
WO2018183112A1 (en) 2018-10-04
US20180280389A1 (en) 2018-10-04
CN110799190A (zh) 2020-02-14
TW201904959A (zh) 2019-02-01
KR20200027917A (ko) 2020-03-13
CA3058182A1 (en) 2018-10-04
US10543212B2 (en) 2020-01-28
US11197858B2 (en) 2021-12-14
AU2018243691B2 (en) 2022-05-12
KR102638678B1 (ko) 2024-02-19
EP3600327A4 (en) 2020-10-28
JP2020515575A (ja) 2020-05-28
EP3600327A1 (en) 2020-02-05

Similar Documents

Publication Publication Date Title
CN110799190B (zh) 杂环化合物
CA3071825A1 (en) Heterocyclic compound
US11795172B2 (en) Substituted imidazo[1,2-b]pyridazines and [1,2,4]triazolo[4,3-b]pyridazines as CaMKII inhibitors
CN111918863B (zh) 杂环化合物
JP7764027B2 (ja) 複素環化合物
EP3856188B1 (en) Aminopyrimidine compound

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Country or region after: U.S.A.

Address after: Massachusetts, USA

Applicant after: Cardurion Pharmaceutical Co.,Ltd.

Address before: Massachusetts, USA

Applicant before: Kadurian Pharmaceutical Co.,Ltd.

Country or region before: U.S.A.

CB02 Change of applicant information
GR01 Patent grant
GR01 Patent grant
TG01 Patent term adjustment
TG01 Patent term adjustment