CN1107844A - 二氢化茚衍生物和其制法及合成该衍生物的中间体 - Google Patents

二氢化茚衍生物和其制法及合成该衍生物的中间体 Download PDF

Info

Publication number
CN1107844A
CN1107844A CN94113330A CN94113330A CN1107844A CN 1107844 A CN1107844 A CN 1107844A CN 94113330 A CN94113330 A CN 94113330A CN 94113330 A CN94113330 A CN 94113330A CN 1107844 A CN1107844 A CN 1107844A
Authority
CN
China
Prior art keywords
indane
compound
pyridazin
group
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94113330A
Other languages
English (en)
Chinese (zh)
Inventor
石田昭彦
本间光一
谷藤道久
西山信右
奥村文和
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of CN1107844A publication Critical patent/CN1107844A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN94113330A 1993-12-28 1994-12-28 二氢化茚衍生物和其制法及合成该衍生物的中间体 Pending CN1107844A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP335250/93 1993-12-28
JP33525093 1993-12-28

Publications (1)

Publication Number Publication Date
CN1107844A true CN1107844A (zh) 1995-09-06

Family

ID=18286423

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94113330A Pending CN1107844A (zh) 1993-12-28 1994-12-28 二氢化茚衍生物和其制法及合成该衍生物的中间体

Country Status (11)

Country Link
US (1) US5686452A (enExample)
EP (1) EP0661273B1 (enExample)
KR (1) KR950017968A (enExample)
CN (1) CN1107844A (enExample)
AT (1) ATE180251T1 (enExample)
CA (1) CA2138812A1 (enExample)
DE (1) DE69418582D1 (enExample)
DK (1) DK0661273T3 (enExample)
MX (1) MX9500251A (enExample)
SG (1) SG48755A1 (enExample)
TW (1) TW288012B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118631A (en) * 1995-06-27 2002-05-23 Tanabe Seiyaku Co History of pyridazinone and processes for their preparation
US20040151759A1 (en) * 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
EP2328586A2 (en) * 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL88314A (en) * 1987-11-18 1994-05-30 Tanabe Seiyaku Co Sulphonylamino indane derivatives, their preparation and pharmaceutical compositions containing them
US5409956A (en) * 1991-03-01 1995-04-25 Zeria Pharmaceutical Co., Ltd. Indan derivative and thromboxane antagonist containing the same
CA2099743A1 (en) * 1992-07-02 1994-01-03 Akihiko Ishida Pyridazinone derivatives and processes for preparing the same
CA2139088A1 (en) * 1993-12-28 1995-06-29 Akihiko Ishida Indane derivatives, processes for preparing the same and synthetic intermediate of the same

Also Published As

Publication number Publication date
DK0661273T3 (da) 1999-11-08
SG48755A1 (en) 1998-05-18
CA2138812A1 (en) 1995-06-29
ATE180251T1 (de) 1999-06-15
EP0661273B1 (en) 1999-05-19
MX9500251A (es) 1997-04-30
US5686452A (en) 1997-11-11
KR950017968A (ko) 1995-07-22
EP0661273A1 (en) 1995-07-05
TW288012B (enExample) 1996-10-11
DE69418582D1 (de) 1999-06-24

Similar Documents

Publication Publication Date Title
EP3180319B1 (en) Novel pyridazones and triazinones for the treatment and prophylaxis of hepatitis b virus infection
CN1237180A (zh) 噻吩并－三唑并二氮杂䓬化合物及其医药用途
WO2005095419A1 (ja) チアゾロピリミジン誘導体
JPH054983A (ja) イソキノリノン誘導体、その製造方法およびその誘導体を有効成分として含有する５−ｈｔ３ レセプター拮抗剤
EP3624804A1 (en) Histone deacetylases (hdacs) inhibitors
CN1270518A (zh) 治疗或预防肾小球病的组合物
CN1208411A (zh) 苯并呋喃羧酸胺和磺酰胺
CN1802154A (zh) 吡啶n－氧化物抗病毒药
CN1432007A (zh) αLβ2介导细胞粘连的抑制剂
CN1019911C (zh) 新的苯并嗪衍生物的制备方法
CN1141940C (zh) 多环噻唑体系用于制备预防或治疗肥胖的药物的用途
CN88100986A (zh) 芳香基哌嗪基-亚烷基苯基-杂环化合物
CN1148362C (zh) 多环的2-氨基噻唑体系、它们的制备方法和包含这些化合物的药物
CN1107844A (zh) 二氢化茚衍生物和其制法及合成该衍生物的中间体
EP0136198A1 (fr) Dérivés de triazolo pyrimidine, leur procédé de préparation et leur application thérapeutique en tant que toni-cardiaques
JP6943239B2 (ja) Ｋｃｎｑ２〜５チャネル活性化剤
CN1070190A (zh) 杂环取代的喹啉甲氧基苯乙酰胺
CN1082045A (zh) 咪唑并吡啶
CN1083066A (zh) 噻吩并噻嗪衍生物和它们的制备方法及应用
CN1023480C (zh) 3-芳基-5-烷硫基-4h-1，2，4-三唑衍生物的制备方法
CN1328555A (zh) 吡啶并吡嗪化合物的新的盐及其结晶
CN1291190A (zh) 5-取代的嘧啶－2－基氧基羧酸衍生物及其制法和作为内皮肽拮抗剂的用途
CN1170823C (zh) [5-氯-6-苯基-2-(4-三氟甲基苯基)-4-嘧啶氨基]乙酰胺衍生物,该衍生物的制备方法、包含该衍生物的药物组合物以及制备这些化合物的中间体
CA2015626A1 (fr) Derives benzothiazolinoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1112925A (zh) 咪唑吡啶衍生物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication