CN110776562B - 一种识别afp抗原的t细胞受体 - Google Patents

一种识别afp抗原的t细胞受体 Download PDF

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CN110776562B
CN110776562B CN201810854117.4A CN201810854117A CN110776562B CN 110776562 B CN110776562 B CN 110776562B CN 201810854117 A CN201810854117 A CN 201810854117A CN 110776562 B CN110776562 B CN 110776562B
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tcr
chain
amino acid
seq
ser
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CN110776562A (zh
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李懿
胡静
李骏
孙含丽
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Xiangxue Life Science Technology Guangdong Co ltd
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Xiangxue Life Science Technology Guangdong Co ltd
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Priority to CN201810854117.4A priority Critical patent/CN110776562B/zh
Priority to PCT/CN2019/098245 priority patent/WO2020024915A1/zh
Priority to JP2021529507A priority patent/JP7429455B2/ja
Priority to US17/264,649 priority patent/US12152065B2/en
Priority to CA3108466A priority patent/CA3108466A1/en
Priority to EP19845331.8A priority patent/EP3831845A4/en
Publication of CN110776562A publication Critical patent/CN110776562A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4264—Cancer antigens from embryonic or fetal origin
    • A61K40/4265—Alpha-feto protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201810854117.4A 2018-07-30 2018-07-30 一种识别afp抗原的t细胞受体 Active CN110776562B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201810854117.4A CN110776562B (zh) 2018-07-30 2018-07-30 一种识别afp抗原的t细胞受体
PCT/CN2019/098245 WO2020024915A1 (zh) 2018-07-30 2019-07-29 一种识别afp抗原的t细胞受体
JP2021529507A JP7429455B2 (ja) 2018-07-30 2019-07-29 Ａｆｐ抗原を識別するｔ細胞受容体
US17/264,649 US12152065B2 (en) 2018-07-30 2019-07-29 T cell receptor for identifying AFP antigen
CA3108466A CA3108466A1 (en) 2018-07-30 2019-07-29 T cell receptor for identifying afp antigen
EP19845331.8A EP3831845A4 (en) 2018-07-30 2019-07-29 T-LYMPHOCYTE RECEPTOR TO IDENTIFY AN AFP ANTIGEN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810854117.4A CN110776562B (zh) 2018-07-30 2018-07-30 一种识别afp抗原的t细胞受体

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CN110776562A CN110776562A (zh) 2020-02-11
CN110776562B true CN110776562B (zh) 2022-06-17

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US (1) US12152065B2 (enExample)
EP (1) EP3831845A4 (enExample)
JP (1) JP7429455B2 (enExample)
CN (1) CN110776562B (enExample)
CA (1) CA3108466A1 (enExample)
WO (1) WO2020024915A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111662374B (zh) * 2019-03-08 2023-01-24 香雪生命科学技术（广东）有限公司 一种识别afp抗原的高亲和力tcr
JP2023513350A (ja) * 2020-02-14 2023-03-30 アダプティミューン・リミテッド がんまたは腫瘍の治療の方法
CN113321727B (zh) * 2020-02-28 2024-04-09 香雪生命科学技术（广东）有限公司 一种识别afp抗原短肽的t细胞受体及其编码序列
CN113493505B (zh) * 2020-03-20 2026-07-10 香雪生命科学技术（广东）有限公司 识别afp抗原的高亲和力tcr
CN114057864B (zh) * 2020-07-30 2023-12-15 香雪生命科学技术（广东）有限公司 一种识别afp的高亲和力tcr
EP4347644A4 (en) * 2021-05-31 2026-01-14 Nanjing Legend Biotech Co Ltd ANTIBODIES TARGETTING AFP/MHC PEPTIDE COMPLEXES AND THEIR USES
JP7210677B1 (ja) * 2021-10-20 2023-01-23 デンカ株式会社 非水硬性セメント組成物及びセメント系材料

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6549564B2 (ja) 2013-06-26 2019-07-24 グアンドン シャンスエ ライフ サイエンス， リミテッド． 高安定性のｔ細胞受容体およびその製法と使用
GB201313377D0 (en) 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
CN104087592B (zh) * 2014-05-13 2016-01-27 天津医科大学总医院 Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途
CN114456272A (zh) * 2015-04-03 2022-05-10 优瑞科生物技术公司 靶向afp肽/mhc复合体的构建体及其用途
JP2018516879A (ja) * 2015-05-08 2018-06-28 ユーリカ セラピューティックス， インコーポレイテッド Ｈｐｖ１６−ｅ７ペプチド／ｍｈｃ複合体を標的化する構築物およびその使用
RU2018102526A (ru) * 2015-06-24 2019-07-25 Еурека Терапьютикс, Инк. Конструкции, направленные на комплексы пептида ny-eso-1/мнс, и их применение
GB201520575D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
CN105524884A (zh) * 2016-02-29 2016-04-27 时宏珍 Hla-a0201限制性抗afp抗原特异性ctl的制备方法
EP3622074A4 (en) * 2017-05-12 2021-01-13 Augusta University Research Institute, Inc. HUMAN ALPHA FETOPROTEIN SPECIFIC T CELL RECEPTORS AND THEIR USES
CN111662374B (zh) * 2019-03-08 2023-01-24 香雪生命科学技术（广东）有限公司 一种识别afp抗原的高亲和力tcr

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Publication number Publication date
JP7429455B2 (ja) 2024-02-08
EP3831845A4 (en) 2022-05-04
JP2021531834A (ja) 2021-11-25
US20210324034A1 (en) 2021-10-21
EP3831845A1 (en) 2021-06-09
CA3108466A1 (en) 2020-02-06
US12152065B2 (en) 2024-11-26
WO2020024915A1 (zh) 2020-02-06
CN110776562A (zh) 2020-02-11

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