CN110763748A - Portable blood sugar detector - Google Patents

Portable blood sugar detector Download PDF

Info

Publication number
CN110763748A
CN110763748A CN201810830566.5A CN201810830566A CN110763748A CN 110763748 A CN110763748 A CN 110763748A CN 201810830566 A CN201810830566 A CN 201810830566A CN 110763748 A CN110763748 A CN 110763748A
Authority
CN
China
Prior art keywords
voltage
electrode
circuit
conversion module
constant potential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810830566.5A
Other languages
Chinese (zh)
Inventor
陈晓琪
陈杰
李文超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwest A&F University
Original Assignee
Northwest A&F University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest A&F University filed Critical Northwest A&F University
Priority to CN201810830566.5A priority Critical patent/CN110763748A/en
Publication of CN110763748A publication Critical patent/CN110763748A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4161—Systems measuring the voltage and using a constant current supply, e.g. chronopotentiometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The utility model provides a portable blood sugar detector, belongs to sensor detection technical field, is mainly by working electrode, reference electrode, constant potential control and generating circuit, counter electrode, current-voltage conversion module, voltage conditioning circuit and singlechip constitute, its characterized in that: the portable blood sugar detector is reusable, reduces cost and is beneficial to monitoring blood sugar of patients in real time.

Description

Portable blood sugar detector
Technical Field
The invention relates to a portable blood sugar detector, and belongs to the technical field of sensor detection.
Background
As is well known, diabetes mellitus is a disease which endangers human beings, and the diabetes mellitus not only harms various tissues of human bodies, but also has serious influence on life, mental appearance and heart-interior activities of patients. At present, the blood sugar detector on the market adopts disposable test paper, can not be reused, wastes patient's cost. Therefore, there is a need for a small portable blood glucose monitor with a reusable blood glucose probe, high accuracy, low cost, and no infection or side effects, which can rapidly detect blood glucose concentration at home or in hospitals, and can promptly adopt treatment regimens and adjust daily habits. The invention develops a portable blood sugar detector.
Disclosure of Invention
In order to overcome the defects, the invention provides a portable blood sugar detector.
The invention is realized by the following technical scheme: the utility model provides a portable blood sugar detector, is mainly by working electrode, reference electrode, constant potential control and generating circuit, AD conversion module, counter electrode, current-voltage conversion module, voltage conditioning circuit, singlechip, keyboard module and liquid crystal display module constitute, its characterized in that: the working electrode and the reference electrode are both connected with a constant potential control and generation circuit, the constant potential control and generation circuit is connected with an AD conversion module, the counter electrode is connected with a current-voltage conversion module, the current-voltage conversion module is connected with a voltage conditioning circuit, the voltage conditioning circuit is connected with the AD conversion module, the AD conversion module is connected with the single chip microcomputer, and the keyboard module and the liquid crystal display module are both connected with the single chip microcomputer.
When the constant potential control and generation circuit is used for measurement, the whole formed by the three electrodes and the solution is equivalent to a group of impedances, and the impedance can be equivalent by using an equivalent circuit comprising a resistor and a capacitor, so that the working electrode is ensured to be constant in voltage, and a loop is required to be formed between the working electrode and the counter electrode. The operational amplifier is the core of the constant potential circuit, and mainly forms the negative feedback of the constant potential circuit, and selects the low-noise precision operational amplifier OPA 124.
The single chip microcomputer selects STM32F103, and the microprocessor sends high and low levels to control the working state of the sensor. In fact, whether the electrochemical reaction occurs or not is determined by controlling the existence or nonexistence of the working electrode and the reference electrode. A P-channel MOS tube A03401 and an NPN type triode C9013 are selected to form a control circuit. The threshold voltage of A03401 is-1.3V (maximum), and for a P-type high-side MOS transistor, when the voltage between a grid source and a grid source is VGS＜VGS(th)When the MOS tube is conducted, the voltage of the drain electrode is equal to the voltage of the source electrode, and conversely, the MOS tube is cut off, and the voltage of the drain electrode is zero. For NPN C9013, when the collector voltage is greater than the base voltage, and the base voltage is greater than the emitterWhen the voltage of the electrode is increased, the triode is conducted, and conversely, the triode is cut off.
The invention has the advantages that: the portable blood sugar detector is based on the sensing of the enzyme-free glucose sensor to blood sugar, can be repeatedly used, reduces the cost and is beneficial to the real-time monitoring of the blood sugar of patients.
Drawings
FIG. 1 is a schematic diagram of the system of the present invention.
In the figure, the device comprises a working electrode 1, a reference electrode 2, a constant potential control and generation circuit 3, an AD conversion module 4, a counter electrode 5, a current-voltage conversion module 6, a voltage conditioning circuit 7, a singlechip 8, a singlechip 9, a keyboard module 10 and a liquid crystal display module.
Detailed Description
The utility model provides a portable blood sugar detector, a portable blood sugar detector is mainly become by working electrode 1, reference electrode 2, constant potential control and generating circuit 3, AD conversion module 4, counter electrode 5, current-voltage conversion module 6, voltage conditioning circuit 7, singlechip 8, keyboard module 9 and liquid crystal display module 10, its characterized in that: the working electrode 1 and the reference electrode 2 are both connected with a constant potential control and generation circuit 3, the constant potential control and generation circuit 3 is connected with an AD conversion module 4, the counter electrode 5 is connected with a current-voltage conversion module 6, the current-voltage conversion module 6 is connected with a voltage conditioning circuit 7, the voltage conditioning circuit 7 is connected with the AD conversion module 4, the AD conversion module 4 is connected with a single chip microcomputer 8, and the keyboard module 9 and the liquid crystal display module 10 are both connected with the single chip microcomputer 8.
In the constant potential control and generation circuit 3, when measuring, the whole formed by the three electrodes and the solution is equivalent to a group of impedance, and an equivalent circuit comprising a resistor and a capacitor can be used for realizing the equivalent, so that the working electrode is ensured to be in constant voltage, and a loop is required to be formed between the working electrode and the counter electrode. The operational amplifier is the core of the constant potential circuit, and mainly forms the negative feedback of the constant potential circuit, and selects the low-noise precision operational amplifier OPA 124.
The single chip microcomputer 8 selects the STM32F103, and the microprocessor sends high and low levels to control the working state of the sensor.In fact, whether the electrochemical reaction occurs or not is determined by controlling the existence or nonexistence of the working electrode and the reference electrode. A P-channel MOS tube A03401 and an NPN type triode C9013 are selected to form a control circuit. The threshold voltage of A03401 is-1.3V (maximum), and for a P-type high-side MOS transistor, when the voltage between a grid source and a grid source is VGS＜VGS(th)When the MOS tube is conducted, the voltage of the drain electrode is equal to the voltage of the source electrode, and conversely, the MOS tube is cut off, and the voltage of the drain electrode is zero. For the NPN C9013, when the voltage of the collector is greater than the voltage of the base electrode, and the voltage of the base electrode is greater than the voltage of the emitter, the triode is conducted, and conversely, the triode is cut off.
When the device works, the working electrode, the reference electrode and the counter electrode are all arranged in a reaction solution, the constant potential circuit provides constant voltage to enable electrochemical reaction to occur, the reaction is carried out on the surface of the working electrode, the generated current is between the working electrode and the counter electrode, the current direction comprises the positive direction and the negative direction, and a small layer of oxidase is modified on the conductive surface of the working electrode. During detection, enzyme catalysis oxygen reacts with blood sugar to generate hydrogen peroxide and gluconic acid, and the current is larger when the blood sugar concentration is higher and the hydrogen peroxide is more; or the enzyme directly reacts with the blood sugar, namely the reaction is generated on the surface of the working electrode, the higher the blood sugar concentration is, the more transferred electrons are generated by the reaction, and the larger the current is. The voltage of the working electrode relative to the reference electrode is 0.7V, because at 0.7V, the current response of the electrochemical reaction is the largest, indicating the highest sensitivity of the sensor. The sensor outputs a weak current signal, and a current-to-voltage circuit must be designed to convert current into voltage so as to be identified by the ADC. The weak voltage signals are amplified, so that the minimum precision of each change of the output current of the sensor is 0.08uA, the amplified voltage can be reflected, the voltage range also needs to be within the input range of the ADC, the amplified voltage is transmitted to the AD conversion module after filtering, the AD conversion module is transmitted to the single chip microcomputer STM32F103 to be processed and operated, and the result is displayed on a liquid crystal display with a chip being TLI 9325.
It will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in the embodiments described above without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims.

Claims (3)

1. The utility model provides a portable blood sugar detector, is mainly by working electrode, reference electrode, constant potential control and generating circuit, AD conversion module, counter electrode, current-voltage conversion module, voltage conditioning circuit, singlechip, keyboard module and liquid crystal display module constitute, its characterized in that: the working electrode and the reference electrode are both connected with a constant potential control and generation circuit, the constant potential control and generation circuit is connected with an AD conversion module, the counter electrode is connected with a current-voltage conversion module, the current-voltage conversion module is connected with a voltage conditioning circuit, the voltage conditioning circuit is connected with the AD conversion module, the AD conversion module is connected with the single chip microcomputer, and the keyboard module and the liquid crystal display module are both connected with the single chip microcomputer.
2. The portable blood glucose monitor of claim 1, wherein: when the constant potential control and generation circuit is used for measurement, the whole formed by the three electrodes and the solution is equivalent to a group of impedances, and the impedance can be equivalent by using an equivalent circuit comprising a resistor and a capacitor, so that the working electrode is ensured to be constant in voltage, and a loop is required to be formed between the working electrode and the counter electrode. The operational amplifier is the core of the constant potential circuit, and mainly forms the negative feedback of the constant potential circuit, and selects the low-noise precision operational amplifier OPA 124.
3. The portable blood glucose monitor of claim 1, wherein: the single chip microcomputer selects STM32F103, and the microprocessor sends high and low levels to control the working state of the sensor. In fact, whether the electrochemical reaction occurs or not is determined by controlling the existence or nonexistence of the working electrode and the reference electrode. A P-channel MOS tube A03401 and an NPN type triode C9013 are selected to form a control circuit. The threshold voltage of A03401 is-1.3V (maximum), and for a P-type high-side MOS transistor, when the voltage between a grid source and a grid source is VGS＜VGS(th)When the MOS tube is conducted, the voltage of the drain electrode is equal to the voltage of the source electrode, and conversely, the MOS tube is cut off, and the voltage of the drain electrode is zero. For NPN type C9013, when collecting currentWhen the voltage of the base electrode is greater than that of the base electrode, the triode is conducted when the voltage of the base electrode is greater than that of the emitter electrode, and conversely, the triode is cut off.
CN201810830566.5A 2018-07-26 2018-07-26 Portable blood sugar detector Pending CN110763748A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810830566.5A CN110763748A (en) 2018-07-26 2018-07-26 Portable blood sugar detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810830566.5A CN110763748A (en) 2018-07-26 2018-07-26 Portable blood sugar detector

Publications (1)

Publication Number Publication Date
CN110763748A true CN110763748A (en) 2020-02-07

Family

ID=69327349

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810830566.5A Pending CN110763748A (en) 2018-07-26 2018-07-26 Portable blood sugar detector

Country Status (1)

Country Link
CN (1) CN110763748A (en)

Similar Documents

Publication Publication Date Title
US7347925B2 (en) Biosensor for monitoring an analyte content with a partial voltage generated therefrom
US20010041830A1 (en) Apparatus for measurment and control of the content of glucose, lactate or other metabolites in biological fluids
US10383555B2 (en) Detection of contamination at sensor contacts
CN104055525A (en) Implantable type low-consumption wireless blood glucose monitor
Dieffenderfer et al. Towards a sweat-based wireless and wearable electrochemical sensor
CN113842142A (en) Wearable continuous blood glucose detection device and method
CN110487872A (en) A kind of electrochemica biological sensor and its method for sensing based on spatula
CN110763748A (en) Portable blood sugar detector
JP4392279B2 (en) Biological information measuring device
CN107045068A (en) Portable physiological Indexs measure instrument and its detection method based on micro-fluidic paper chip
CN104188662A (en) Blood-sampling-free type blood sugar monitoring device and use method thereof
CN201788165U (en) Portable intelligent blood glucose meter
EP3873341B1 (en) Switch circuitry for a fluid monitoring device
CN101968450B (en) Embedded porphyrin sensor array-based saliva sugar and urine sugar detector
CN205786455U (en) A kind of Portable pesticide residue measurer
Chhiba et al. Design of a non-invasive blood glucose meter connected to an Android diabetes monitoring application
CN117770808A (en) Low-power consumption glucose concentration information acquisition device
CN206627533U (en) Portable physiological Indexs measure instrument based on micro-fluidic paper chip
CN107898468A (en) A kind of new blood sugar measuring system based on smart mobile phone
Wang et al. Highly Linear Amperometric Glucose Detection System Realized in Deep Submicron CMOS Technology
Li et al. Development of the portable blood glucose meter for self-monitoring of blood glucose
CN219179489U (en) Current sampling device for in-vivo monitor and analyte in-vivo monitor
CN213302230U (en) Intelligent blood sugar detector based on embedded system
CN219578881U (en) Glucose monitoring probe and glucose monitor
CN212780627U (en) Limit current type oxygen sensor signal acquisition system

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200207