CN110755761A - Cavity drainage tube with built-in radioactive particle carrier - Google Patents

Cavity drainage tube with built-in radioactive particle carrier Download PDF

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Publication number
CN110755761A
CN110755761A CN201910975383.7A CN201910975383A CN110755761A CN 110755761 A CN110755761 A CN 110755761A CN 201910975383 A CN201910975383 A CN 201910975383A CN 110755761 A CN110755761 A CN 110755761A
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CN
China
Prior art keywords
tube
particle carrier
cavity
drainage
radioactive particle
Prior art date
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Pending
Application number
CN201910975383.7A
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Chinese (zh)
Inventor
阎尔坤
白红升
闫小强
田旭
崔贝
张海建
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Tianjin Co Ltd Of Saden Medicine Research Academy
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Tianjin Co Ltd Of Saden Medicine Research Academy
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Publication date
Application filed by Tianjin Co Ltd Of Saden Medicine Research Academy filed Critical Tianjin Co Ltd Of Saden Medicine Research Academy
Priority to CN201910975383.7A priority Critical patent/CN110755761A/en
Publication of CN110755761A publication Critical patent/CN110755761A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007Arrangements or means for the introduction of sources into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002Intraluminal radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0057Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The invention discloses a cavity drainage tube with a built-in radioactive particle carrier, which comprises a tube body, wherein the right end of the tube body is arranged by penetrating through a connector, the tube diameter of the left end of the tube body is arranged in a small manner, a fixing ring is arranged on the connector, a drainage cavity and a radioactive particle carrier are arranged in the tube body, and a particle cavity is arranged in the radioactive particle carrier. The radioactive particle carrier is placed in the tube body, so that the drainage tube not only has the function of radiotherapy during drainage, but also can take out and replace radioactive particles on the premise of not influencing drainage, and the separation of the drainage function and the radiotherapy function is realized. The section of the radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle, and the drainage space is larger, thereby being beneficial to drainage. The installation, the replacement and the position adjustment of the radioactive particles can be carried out in vitro, thereby avoiding the pain of patients caused by the operation in human body.

Description

Cavity drainage tube with built-in radioactive particle carrier
Technical Field
The invention relates to the field of medical materials, in particular to a cavity drainage tube with a built-in radioactive particle carrier.
Background
The cavity drainage tube is a medical instrument commonly used after a clinical major operation, and is mainly used for guiding pus, blood or other liquid accumulated in human tissues or in a body cavity out of the body, reducing the infection risk of a patient and improving the life quality. The malignant obstructive jaundice is a common disease difficult to treat clinically, and is mainly cholestasis and liver damage caused by pressing or invading common bile duct, common hepatic duct and main trunks of left and right hepatic ducts of hepatic duct cancer, pancreatic cancer, liver cancer and metastatic cancer. Due to the unique location of the tumor, surgical resection is difficult and risky, and most patients can only achieve symptomatic relief by palliative drainage.
The drainage technologies commonly used in clinic at present are a biliary drainage technology through a percutaneous transhepatic puncture route and a biliary stent technology developed on the basis of catheter drainage. A large number of clinical experiments show that the two technologies have obvious effect on bile drainage, can effectively relieve the pain of patients, cannot inhibit the growth of tumors and can not eradicate the tumor focus of the patients.
Brachytherapy is considered to be a simple and effective method for tumor therapy, in which radioactive seeds are implanted into a tumor, and the tumor is irradiated with radiation from a radioactive source for a long time, so as to kill or kill tumor cells. Based on this, the near-distance irradiation treatment technology and the biliary drainage technology are combined, and the development of a technology capable of fundamentally solving the tumor focus of the patient becomes the urgent need of the patients.
Chinese patent CN 101695458A (published: 2010, 4 and 21) discloses a biliary tract radiotherapy stent. The stent designed by the patent not only can keep the bile duct smooth through radial support, but also can kill tumor cells and inhibit tumor proliferation. However, when the product of the patent is used, the inner and outer brackets and the radioactive particles need to be placed in the narrow bile duct of the human body step by step, the operation is complex, and the success rate is low; in addition, the stent is easy to be blocked when in use, so that the actual opening time is short, and the inner stent and the outer stent are made of nickel-titanium metal, so the stent is expensive in manufacturing cost and difficult to popularize.
Chinese patent CN 203677727U (published: 7/2/2014) discloses a three-cavity biliary tract drainage catheter capable of carrying radioactive particles. This patent has redesigned the structure of drainage tube, keeps somewhere two radioactive particle cavitys next to the drainage cavitys, has changed the single drainage function of traditional drainage tube for drainage and radiotherapy can go on simultaneously. During treatment, the drainage tube is inserted into a bile duct of a human body, and then the pushing and guiding needle is used for guiding in and adjusting the position of radioactive particles, and the guiding in and the adjusting of the position of the particles are very difficult due to the integrated structural design of the drainage tube and the complex human body structure; in addition, if particle replacement is carried out, the replacement of a new drainage tube is often required to be operated again, which brings great pain to the patient.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides a cavity drainage tube with a built-in radioactive particle carrier.
The second purpose of the invention is to provide a second cavity drainage tube with a radioactive particle carrier inside.
The technical scheme of the invention is summarized as follows:
the cavity drainage tube with the built-in radioactive particle carrier comprises a tube body 1, wherein the right end of the tube body penetrates through a connector 3, the tube diameter of the left end of the tube body is arranged in a small mode, a fixing ring 13 is arranged on the connector, a drainage cavity 7 and the radioactive particle carrier 2 are arranged in the tube body, and a particle cavity 6 is arranged in the radioactive particle carrier.
The left end of the tube body can be spirally arranged.
The cross section of the connector is oval or round.
The method can also be as follows: the near left end of the tube body 1 is provided with a thread guide hole 11, a thread guide 12 is arranged in the tube body 1, one end of the thread guide 12 penetrates through the thread guide hole 11 from the tube body 1 and then is connected with the tail end of the spiral part, and the other end of the thread guide 12 penetrates out of the right end of the tube body and is movably connected with a fixing ring 13.
The cavity drainage tube with the built-in radioactive particle carrier is provided with a side hole 5 which runs through the drainage cavity.
The inner surface of the cavity drainage tube internally provided with the radioactive particle carrier is provided with a limiting plate 8.
The section of the radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle; the number of the particle channels 6 is 1-8.
The second cavity drainage tube with the built-in radioactive particle carrier comprises a second tube body 21, wherein the right end of the second tube body penetrates through a second connector 23, the left end of the second tube body is connected with a two-fork tube 34 or a three-fork tube 35, the tube diameter of the left end of the two-fork tube or the three-fork tube is arranged in a small mode, a second fixing ring 33 is arranged on the second connector, a second drainage cavity 27 and a second radioactive particle carrier 22 are arranged in the second tube body, a second particle cavity 26 is arranged in the second radioactive particle carrier, and a second side hole 25 penetrating through the drainage cavity is formed in the second tube body, the two-fork tube or the three-fork tube.
The inner surface of the second pipe body is provided with a second limiting plate 28.
The section of the second radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle; the number of second particle channels 26 is 1-8.
The invention has the beneficial effects that:
① the invention changes the single drainage function of the traditional drainage tube, and puts the radioactive particle carrier into the tube body, which not only has the function of radiotherapy during drainage, but also can take out and replace the radioactive particles without affecting drainage, thus realizing the separation of drainage and radiotherapy functions.
② the section of the radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle, so the drainage space is larger, which is beneficial to drainage.
③ the radioactive particles can be installed, replaced and adjusted in position in vitro, so as to avoid the pain of the patient caused by the radioactive particles in human body.
Drawings
FIG. 1 is a schematic view of the structure of a cavity drainage tube with a radioactive particle carrier inside.
FIG. 2 is a schematic cross-sectional view of a tube body part of a cavity drainage tube with a radioactive particle carrier inside, wherein a limiting plate is arranged on the inner surface of the tube body and passes through a side hole.
Fig. 3 is a schematic diagram of the three-dimensional structure of the radioactive particle carrier of fig. 2.
FIG. 4 is a schematic view of the drainage tube with radioactive particle carrier inside, which is provided with a guide wire and two ends of the guide wire connected together.
FIG. 5 is a schematic cross-sectional view of a radioactive particle carrier, in which FIG. 5A is a line; fig. 5B is a regular triangle.
FIG. 6 is a schematic view of a second cavity drainage tube with a radioactive particle carrier inside, wherein FIG. 6A is a schematic view of a left end of a second tube connected to a bifurcated tube; FIG. 6B is a schematic view of the left end of the second tube being connected to the Y-tube; FIG. 6C is a schematic view of the second tube body being connected to the two-way tube at the left end and the two-way tube being arranged in a spiral manner.
FIG. 7 is a schematic cross-sectional view of a second lumen drainage tube body part with a radioactive particle carrier inside (the section of the radioactive particle carrier is Y-shaped).
FIG. 8 is a schematic three-dimensional structure of a tube body and a connector of a drainage tube portion of a lumen with a radioactive particle carrier inside.
FIG. 9 is a schematic three-dimensional structure of a second drainage tube with a radioactive particle carrier inside and a connector.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
The cavity drainage tube with the built-in radioactive particle carrier comprises a tube body 1, wherein the right end of the tube body penetrates through a connector 3, the tube diameter of the left end of the tube body is arranged in a small mode, a fixing ring 13 (shown in figure 1) is arranged on the connector, a drainage cavity 7 and the radioactive particle carrier 2 are arranged in the tube body, and a particle cavity 6 (shown in figures 2 and 3) is arranged in the radioactive particle carrier.
The left end of the tube may be in a coiled arrangement (see figure 4). The invention can be prevented from falling off after being placed in the treatment part of the body. The cross section of the connecting head is oval or round (see fig. 8).
The method can also be as follows: the near left end of the tube body 1 is provided with a thread guide hole 11 (see figure 4), a thread guide 12 is arranged in the tube body 1, one end of the thread guide 12 penetrates through the thread guide hole 11 from the tube body 1 and then is connected with the tail end of the spiral part, and the other end of the thread guide 12 penetrates out of the right end of the tube body and is movably connected with a fixing ring 13 to prevent falling off.
The cavity drainage tube with the built-in radioactive particle carrier is provided with a side hole 5 which runs through the drainage cavity.
The inner surface of the cavity drainage tube internally provided with the radioactive particle carrier is provided with a limiting plate 8. The two limiting plates form a limiting plate pair, and the radioactive particle carrier is limited by the limiting plate pair.
The side holes 5 are arranged in a manner of avoiding the limiting plate pairs, so that the side holes are prevented from being blocked by radioactive particle carriers, and the number of the side holes is preferably 6.
The section of the radioactive particle carrier is in a straight line shape (figure 5A), a cross shape (figure 2), a Y shape or a regular triangle shape (figure 5B); the number of said particle channels 6 is 1, 2, 3, 4, 5, 6, 7 or 8.
The material of the pipe body is preferably polyether polyurethane, silicon rubber, polyester, polymethyl methacrylate, polyvinyl chloride or polypropylene.
Radioactive particles such as cesium 131, yttrium 90, phosphorus 32, palladium 103, gold 198, iodine 125 or ytterbium 169, preferably iodine 125.
The second cavity drainage tube with a built-in radioactive particle carrier (see fig. 6A and 6B) comprises a second tube body 21, the right end of the second tube body penetrates through a second connector 23, the left end of the second tube body is connected with a two-fork tube 34 or a three-fork tube 35, the tube diameter of the left end of the two-fork tube or the three-fork tube is arranged in a small manner, and the left end of the two-fork tube or the three-fork tube can also be arranged in a spiral manner (see fig. 6C) to prevent the drainage tube from falling off after being placed in a treatment part of a machine body.
The second connector is provided with a second fixing ring 33, a second drainage cavity 27 and a second radioactive particle carrier 22 are arranged in the second tube, a second particle cavity 26 is arranged in the second radioactive particle carrier, and a second side hole 25 penetrating through the drainage cavity is arranged on the second tube, the two fork tubes or the three fork tubes.
The second tube inner surface is provided with a second stopper plate 28 (see fig. 7).
The section of the second radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle; the number of second particle channels 26 is 1, 2, 3, 4, 5, 6, 7 or 8.
The cross section of the second connector is oval or round (see fig. 9).
The side holes are arranged in a manner of avoiding the limiting plate pairs, so that the radioactive particle carriers are prevented from blocking the side holes.
The material of the second tube is preferably polyether polyurethane, silicone rubber, polyester, polymethyl methacrylate, polyvinyl chloride or polypropylene.
Second radioactive particles such as cesium 131, yttrium 90, phosphorus 32, palladium 103, gold 198, iodine 125 or ytterbium 169, preferably iodine 125.
The use of the invention:
the radioactive particles are arranged in the particle cavity channel outside the body, and the tumor is locally radiated and treated by adjusting the position of the radioactive particle carrier. The number and length of the radioactive particles are determined according to the length of the lesion of the patient, and the activity of the radioactivity is determined according to factors such as the tumor cytology type and the sensitivity to radiotherapy.
The tube body penetrates through the connector, and the right end of the tube body is connected with the syringe or the drainage bag to guide accumulated pus, blood or other liquid out of the body.
When the cavity drainage tube with the built-in radioactive particle carrier is used, firstly, according to factors such as the part, the length and the like of a tumor displayed by imaging, a computer aided Treatment Planning System (TPS) is used for calculating and is used as a reference for installing the quantity, the position and the coverage length of radioactive particles; secondly, radioactive particles such as iodine 125 particles are installed in the tube body in vitro; the cavity drainage tube internally provided with the radioactive particle carrier comprises a left end which is in a straight type and a spiral structure, and a two-fork tube and a three-fork tube, wherein the left end of the drainage tube is straightened manually and is arranged in a drainage tube conveying pipe; then the drainage tube delivery pipe is inserted into the tumor part of the human body, the drainage tube delivery pipe is taken out, and the drainage tube carrying the radioactive particles is restored and is left in the body for radiotherapy.
The drainage tube changes the single drainage function of the traditional drainage tube, and the radioactive particle carrier is placed in the drainage tube, so that the drainage tube not only has the function of radiotherapy during drainage, but also can take out and replace radioactive particles on the premise of not influencing drainage, and the separation of the drainage function and the radiotherapy function is realized. Meanwhile, the installation, the replacement and the position adjustment of the radioactive particles can be carried out in vitro, so that the pain of a patient caused by the operation in a human body is avoided.
The section of the radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle, so that the drainage space is larger, and drainage is facilitated.

Claims (10)

1. The cavity drainage tube with the built-in radioactive particle carrier comprises a tube body (1), wherein the right end of the tube body penetrates through a connector (3), the tube diameter of the left end of the tube body is arranged in a small mode, a fixing ring (13) is arranged on the connector, a drainage cavity (7) and the radioactive particle carrier (2) are arranged in the tube body, and the cavity drainage tube is characterized in that a particle cavity (6) is arranged inside the radioactive particle carrier.
2. The cavity drainage tube with radioactive particle carrier inside according to claim 1, wherein the left end of the tube body is spirally disposed.
3. The cavity drainage tube with a built-in radioactive particle carrier of claim 1, wherein the cross section of said connector is oval or circular.
4. The cavity drainage tube with a built-in radioactive particle carrier according to claim 2, wherein a guide wire hole (11) is formed at the near left end of the tube body (1), a guide wire (12) is arranged in the tube body (1), one end of the guide wire (12) passes through the guide wire hole (11) from the inside of the tube body (1) and then is connected with the tail end of the spiral part, and the other end of the guide wire (12) passes through the right end of the tube body and is movably connected with the fixing ring (13).
5. The radioactive particle carrier-embedded cavity drainage tube according to any one of claims 1 to 4, wherein a side hole (5) penetrating through the drainage cavity is formed in the tube body.
6. The cavity drainage tube with radioactive particle carrier built in according to one of claims 1 to 4, wherein the inner surface of the tube body is provided with a limiting plate (8).
7. The cavity drainage tube with a built-in radioactive particle carrier of claim 1, wherein the section of the radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle; the number of the particle channels (6) is 1-8.
8. Cavity way drainage tube of built-in radioactive particle carrier, including second body (21), the right-hand member of second body runs through second connector (23) and sets up, characterized by, the left end connection of second body has bifurcated pipe (34) or bifurcated pipe (35), the pipe diameter of the left end of bifurcated pipe or bifurcated pipe is set up easily, is provided with solid fixed ring of second (33) on the second connector, is provided with second drainage cavity way (27) and second radioactive particle carrier (22) in the second body, and the inside second particle cavity way (26) that is provided with of second radioactive particle carrier, be provided with second side opening (25) that link up drainage cavity way on the second body, bifurcated pipe or bifurcated pipe.
9. The cavity drainage tube with radioactive particle carrier inside according to claim 8, wherein a second limiting plate (28) is disposed on the inner surface of the second tube.
10. The cavity drainage tube with a built-in radioactive particle carrier of claim 8, wherein the cross section of the second radioactive particle carrier is in a straight line shape, a cross shape, a Y shape or a regular triangle shape; the number of the second particle channels (26) is 1-8.
CN201910975383.7A 2019-10-14 2019-10-14 Cavity drainage tube with built-in radioactive particle carrier Pending CN110755761A (en)

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CN201910975383.7A CN110755761A (en) 2019-10-14 2019-10-14 Cavity drainage tube with built-in radioactive particle carrier

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Application Number Priority Date Filing Date Title
CN201910975383.7A CN110755761A (en) 2019-10-14 2019-10-14 Cavity drainage tube with built-in radioactive particle carrier

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CN110755761A true CN110755761A (en) 2020-02-07

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2441913C (en) * 2002-10-07 2011-11-15 Nucletron B.V. Device for implanting a row of radioactive seeds and non-radioactive spacers
CN104383620A (en) * 2014-11-20 2015-03-04 上海交通大学医学院附属新华医院 Novel dual-channel peritoneal dialysis catheter suitable for operation under endoscope
CN204745343U (en) * 2015-05-15 2015-11-11 台州市立医院 Biliary tract drainage device that can nimble load active particles
CN208641511U (en) * 2017-10-18 2019-03-26 焦德超 A kind of Modulatory character three-cavity structure bile duct brachytherapy drainage tube
CN209237197U (en) * 2018-12-28 2019-08-13 焦德超 A kind of biliary tract spiral support extends out formula particle conduit component

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2441913C (en) * 2002-10-07 2011-11-15 Nucletron B.V. Device for implanting a row of radioactive seeds and non-radioactive spacers
CN104383620A (en) * 2014-11-20 2015-03-04 上海交通大学医学院附属新华医院 Novel dual-channel peritoneal dialysis catheter suitable for operation under endoscope
CN204745343U (en) * 2015-05-15 2015-11-11 台州市立医院 Biliary tract drainage device that can nimble load active particles
CN208641511U (en) * 2017-10-18 2019-03-26 焦德超 A kind of Modulatory character three-cavity structure bile duct brachytherapy drainage tube
CN209237197U (en) * 2018-12-28 2019-08-13 焦德超 A kind of biliary tract spiral support extends out formula particle conduit component

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